Tag: M.W=50-100

Dyachenko, I. V. published the artcileSynthesis of functionalized tetrahydropyridones by the tandem Knoevenagel-Michael-intramolecular ammonolysis-alkylation reaction, SDS of cas: 79-07-2, the publication is Russian Chemical Bulletin (2021), 70(11), 2145-2155, database is CAplus.

The tandem Knoevenagel-Michael-intramol. ammonolysis-alkylation reaction was used to synthesize functionalized tetrahydropyridones. The mol. and crystal structures of four pyridone derivatives were studied by X-ray diffraction.

Russian Chemical Bulletin published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dyachenko, Ivan V. published the artcileNovel multicomponent synthesis of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, Formula: C2H4ClNO, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(12), 1592-1598, database is CAplus.

The multicomponent condensation of malononitrile, hydrogen sulfide, aldehydes RCHO (R = Et, cyclohex-3-en-1-yl, Ph, 4-hydroxyphenyl, etc.), 1-(cyclopent-1-en-1-yl)pyrrolidine, and alkylating agents XCH₂Z (X = Br, Cl, I; Z = H, ethoxycarbonyl, CN, Ph, etc.) leads to the formation of 6,7-dihydro-5H-cyclopenta[b]pyridine derivatives, e.g., I.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Abulkhair, Hamada S. published the artcileIn vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors, Recommanded Product: 2-Chloroacetamide, the publication is Archiv der Pharmazie (Weinheim, Germany) (2021), 354(5), 2000449, database is CAplus and MEDLINE.

The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after, to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists with an efficient anticonvulsant activity, the present work reports the design and synthesis of two novel sets of quinoxaline derivatives The anticonvulsant activity of the synthesized compounds was evaluated in vivo according to the pentylenetetrazol-induced seizure protocol, and the results were compared with those of perampanel as a reference drug. Among the synthesized compounds, four showed promising activities with ED₅₀ values of 37.50, 23.02, 29.16, and 23.86 mg/kg. Docking studies of these compounds suggested that AMPA binding could be the mechanism of action of these derivatives Overall, the pharmacophore-based structural optimization, in vivo and in silico docking, and druglikeness studies indicated that the designed compounds could serve as promising candidates for the development of effective anticonvulsant agents with good pharmacokinetic profiles.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hassan, Aisha Y. published the artcilePotential antiviral and anticancer effect of imidazoles and bridgehead imidazoles generated by HPV-Induced cervical carcinomas via reactivating the P53/pRb pathway and inhibition of CA IX, Application of 2-Chloroacetamide, the publication is Journal of Molecular Structure (2021), 129865, database is CAplus.

Human papillomaviruses E6 and E7 oncoproteins are crucial to viral-induced cervical cancers and targeting E6/E7 leads to safer and better treatment for cervical cancer. Hence, a simple and green solvent-free protocol was applied for the synthesis of novel imidazoles e.g., I, and bridgehead imidazoles (purine analogs), e.g., II, via versatile straightforward synthetic routes. All the synthesized compounds have been characterized by IR, ¹H NMR, ¹³C NMR, mass spectroscopy, and elemental analyses and then have been examined for their in vitro antiviral activity against HPV, genotype 18. Two compounds, I and II, were the most promising HR-HPV inhibitors with a percentage of 95.00 and 96.84%, resp. Both compounds demonstrated a substantial down-regulation of HPV oncoproteins E6 and E7 with up-regulation of tumor suppressor proteins, p53, and pRb, resp. using western blot technique. Furthermore, the cytotoxicity of compounds I and II against the cervical cancer Hela cell line was further examined Compound I exhibited strong anticancer activity with IC₅₀ 0.08μM, which is equivalent to 5-FU (IC₅₀ 0.09μM). The cell cycle anal. was performed for investigating the potential mechanism of compound I, resulting in a significant accumulation of the cell population in both pre-G1 and G0-G1 phases and arrest the cell cycle at G1 phase. Addnl., compound I induced apoptosis, triggering cell death via increasing the early and late apoptotic rates by approx. 16 and 188 folds compared with the control. The most cytotoxic agent, I, revealed a remarkable inhibition of the targeted carbonic anhydrase IX enzyme with an IC₅₀ value of 0.12μM comparable to the standard drug. In addition, the ADME profiles of the most highly successful derivatives have been studied in order to determine their ability to be produced as good drug candidates.

Journal of Molecular Structure published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Di published the artcileCatalytic hydrolysis: A novel role of zero-valent iron in haloacetonitrile degradation and transformation in unbuffered systems, HPLC of Formula: 79-07-2, the publication is Science of the Total Environment (2021), 149537, database is CAplus and MEDLINE.

Efforts to remove highly toxic haloacetonitriles (HANs) is an important step to reduce health risks associated with disinfection by product exposure. Zero valent iron (ZVI) is a versatile material, whose reductant, sorbent and coagulant role has been well understood. However, their catalytic role is less known. In this study, the degradation and transformation of HANs in ZVI system were investigated. Significant decreases of the four HANs in ZVI system were observed, and haloacetamides and haloacetic acids (hydrolysis products of HANs) were the dominant transformation products of HANs. However dehalogenated HANs, Fe (II) and Fe (III) were rarely detected after reaction, indicating that the ZVI acted as a catalyst to promote the hydrolysis of HANs, rather than other previously reported causes (dehalogenation or redox reaction). The HAN degradation rates were dramatically affected by the initial pH, ZVI doses and initial HAN concentration Kinetic anal. indicated that HAN removal was enhanced with the increase of initial pH (5-9), ZVI doses (1-10 g/L), and initial HAN concentration (25-200μg/L). ZVI induced the transformation of HANs to haloacetamides, haloacetic acids and other de-halogenated compounds, which reduced the cytotoxicity and genotoxicity by 88% and 85%, resp. This study helped to understand the fate of HAN during the transmission in cast iron pipes, and provided a theor. foundation for future HAN control and monitoring efforts.

Science of the Total Environment published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C10H11NO4, HPLC of Formula: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Krivokolysko, D. S. published the artcileSynthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters, Synthetic Route of 79-07-2, the publication is Russian Journal of General Chemistry (2021), 91(12), 2588-2605, database is CAplus.

A series of new hybrid mols. containing fragments of anesthesin and 4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting from diketene, Et 4-aminobenzoate, cyanothioacetamide, and furfural. The obtained compounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain and acetic acid induced writhing tests. The compounds exhibiting analgesic effect superior to that of the reference drug (metamizole sodium) have been revealed. Mol. docking has been performed for the considered compounds with respect to a wide range of protein targets, including cyclooxygenases COX-1 and COX-2.

Russian Journal of General Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics