Tag: M.W=50-100

Antonsen, Simen Gjelseth published the artcileAtmospheric Chemistry of Methyl Isocyanide-An Experimental and Theoretical Study, HPLC of Formula: 123-39-7, the main research area is methyl isocyanide atm chem exptl theor assessment; reaction kinetics methyl isocyanide atm reaction hydroxyl radical.

The reaction of Me isocyanide (CH3NC) with OH- was examined in smog chamber experimentsusing proton transfer reaction/time of flight mass spectrometry and long-path Fourier transform IR detection. The rate coefficient was determined to be kCH3NC+OH = (7.9 ± 0.6) x 10-11 cm3/mol.-s at 298 ± 3° K and 1013 ± 10 hPa; CH3NC was the sole observed reaction product. Exptl. results were supported by CCSD(T*)-F12a/aug-cc-pVTZ//M06-2X/aug-cc-pVTZ quantum chem. calculations which showed the reaction proceeded primarily via electrophilic addition to the isocyanide carbon atom. Based on quantum chem. data, kinetics of the OH- reaction, simulated using a master equation model, showed the rate coefficient was nearly independent of pressure at tropospheric conditions and had a neg. temperature dependence with kOH = 4.2 x 10-11 cm3/mol.-s at 298° K. Addnl. quantum chem. calculations for CH3NC reactions with O3 and NO3 showed these reactions are of little importance for atm. conditions. The atm. fate of CH3NC is also discussed.

Journal of Physical Chemistry A published new progress about Air (Me isocyanide atm. fate experiments using synthetic). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Pin published the artcileScalable Photoelectrochemical Dehydrogenative Cross-Coupling of Heteroarenes with Aliphatic C-H Bonds, HPLC of Formula: 123-39-7, the main research area is heteroarene photoelectrochem dehydrogenative radical cross coupling light; alkylated heteroarene preparation; C−H functionalization; electrochemistry; heterocycles; photoelectrochemistry; radical reactions.

Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross-coupling of heteroarenes with aliphatic C-H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chem. oxidants under conditions of heating or light irradiation By merging electrochem. and photochem., we have achieved efficient photoelectrochem. dehydrogenative cross-coupling of heteroarenes and C(sp3)-H donors through H2 evolution, without the addition of metal catalysts or chem. oxidants. Mechanistically, the C(sp3)-H donor is converted to a nucleophilic carbon radical through H-atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl2 from Cl-. The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bruffaerts, Jeffrey published the artcileFormamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles, Recommanded Product: N-Methylformamide, the main research area is amine formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; urea green preparation; alc formamide ruthenium pincer complex catalyst dehydrogenative coupling DFT; carbamate green preparation; aminoalc formamide ruthenium pincer complex catalyst dehydrogenative coupling tandem; nitrogen heterocycle green preparation.

Despite the hazardous nature of isocyanates, they remain key building blocks in bulk and fine chem. synthesis. By surrogating them with less potent and readily available formamide precursors, we herein demonstrate an alternative, mechanistic approach to selectively access a broad range of ureas, carbamates, and heterocycles via ruthenium-based pincer complex catalyzed acceptorless dehydrogenative coupling reactions. The design of these highly atom-efficient procedures was driven by the identification and characterization of the relevant organometallic complexes, uniquely exhibiting the trapping of an isocyanate intermediate. D. functional theory (DFT) calculations further contributed to shed light on the remarkably orchestrated chain of catalytic events, involving metal-ligand cooperation.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Long, Lipeng published the artcileHypervalent iodine(III) promoted tandem reaction of o-fluoroanilines with formamides to construct 2-aminobenzoxazoles, Synthetic Route of 123-39-7, the main research area is aminobenzoxazole preparation; fluoroaniline formamide tandem reaction hypervalent iodine.

A simple and practical synthesis of 2-aminobenzoxazoles I (R = H, Br, F, etc; R1 = H, Cl, COOMe, etc; R2 = R3 = H, Et, Ph, -(CH2)2O(CH2)2-, etc; R4 = H, I, CF3, etc; R5 = Cl, Br, Me, etc;) has been developed from com. available o-fluoroanilines 2-R-3-R1-4-R4-5-R5C6(F)NH2, and formamides HC(O)N(R2)(R3). This process can be performed in the absence of metal catalysts with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a Lewis acid for this reaction. A variety of substituents can be introduced into each position of the benzoxazole backbone (C-4 to C-7), providing handles for further elaboration.

Organic Chemistry Frontiers published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Dong-Sheng published the artcileStop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp3)-H Bonds, Related Products of amides-buliding-blocks, the main research area is alkyl heteroarene preparation; heteroarene alkane photochem hydrogen evolution cross coupling.

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp3)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR1 (R1 = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols.

ACS Catalysis published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Hao published the artcileEnantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups, Recommanded Product: N-Methylformamide, the main research area is ferrocene based formamide preparation nickel catalyzed oxidative annulation alkyne; chiral benzyldiphenyl ferrocenopyridinone preparation crystal structure; mol structure chiral benzyldiphenyl ferrocenopyridinone; aluminum; annulation; ferrocenes; formamides; nickel.

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved. Ni-Al bimetallic catalysis enabled by a bulky BINOL-derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40-98% yield and 93-99% ee.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Rong-Hua published the artcileSelective C(sp3)-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-enabled Ni-Al Bimetallic Catalysis, Application of N-Methylformamide, the main research area is pyridone preparation regioselective; formyl enamide alkyne cyclization nickel aluminum catalyst.

Herein, a selective C(sp3)-H cleavage of N-formyl enamides R(R1)C=C(CH2(R2))N(CHO)R3 [R = H, Me; R1 = H, propan-2-yl, 4-methoxyphenyl, etc.; R2 = H; R1R2 = -((CH2)2)-, -((CH2)3)-, -(CH2CH(C6H5)CH2)-; R3 = Me, n-Pr, Ph, Bn, 3-methylbut-3-en-1-yl] without backbone modification, providing a series of 2-pyridones I [R4 = Me, Ph, thiophen-2-yl, etc.; R5 = n-Bu, Ph, thiophen-2-yl, etc.] in 58-99% yields was reported. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.

ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Molaei Yielzoleh, Fatemeh published the artcileTitanomagnetite functionalized by amino acid-based ionic liquid and cobalt (Fe3-xTixO4-SiO2@TrpBu+3I–Co(II)): A reusable bio-nanocomposite for the synthesis of aryl thioamides, Safety of N-Methylformamide, the main research area is cobalt titanomagnetite ionic liquid nanocomposite functionalized amino acid preparation; reusable bio nanocomposite preparation catalyst aryl thioamide; tributyltryptophanium cobalt titanomagnetite ionic liquid bio nanocomposite preparation catalyst.

An efficient and straightforward three-component reaction of alkynes (terminal and internal), elemental sulfur, and amides using novel bio-nanocomposite is described. The bio-nanostructure obtained from step-by-step coating the titanomagnetite core by silica, N,N,N-tributyltryptophanium iodide ionic liquid, and cobalt resp. The Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) characterized though FT-IR, FESEM, EDAX, XRF, TGA/DTG, VSM, and XPS techniques. Its catalytic efficacy examined successfully in the solvent-free three-component reaction of alkynes (terminal and internal), S8, and amides to prepare the corresponding aryl thioamides via the C-C triple bond cleavage. The reusability examination of the Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) bio-nanocomposite proceeded successfully within two runs. The recovered nanostructure characterized through EDAX and FESEM techniques that demonstrated no significant changes in the morphol. and constitutive elements.

Journal of Molecular Structure published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Magsumov, Timur I. published the artcileDevelopment of Abraham model correlations for enthalpies of solvation of solutes dissolved in N-methylformamide, 2-pyrrolidone and N-methylpyrrolidone, Related Products of amides-buliding-blocks, the main research area is methylformamide pyrrolidone methylpyrrolidone solute solvation enthalpy Abraham model correlation.

Enthalpies of solution at infinite dilution have been determined for 2-propanol, ethylene glycol, 1,3-butanediol, 1,4-butanediol, phenol, 1-naphthol, 3-nitrophenol, 4-nitrophenol, 4-chlorophenol, and formamide dissolved in N-methylformamide, 2-pyrrolidone, and N-methylpyrrolidone at 298.15 K, as well as for N-methylformamide dissolved in 2-pyrrolidone and N-methylpyrrolidone, based on solution calorimetric measurements. Results of our exptl. measurements, combined with published literature data, have been used to derive Abraham model expressions for predicting the enthalpies of solvation of solutes dissolved in the three fore-mentioned amide solvents. Our derived math. expressions back-calculated the observed enthalpy of solvation data to within a standard deviation of 3.1 kJ mol-1 or less.

Journal of Molecular Liquids published new progress about Amides Role: NUU (Other Use, Unclassified), USES (Uses). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khaliullin, F. A. published the artcileUnusual Reaction of 8-Bromo-3-methyl-7-(thietan-3-yl)3,7-dihydro-1H-purine-2,6-diones with Trisamine in Dimethylformamide, Related Products of amides-buliding-blocks, the main research area is dimethylamino methylthietanyl dihydropurine dione preparation; bromo methylthietanyl dihydropurine dione DMF nucleophilic substitution reaction.

The reaction of title compounds I (R = H, Et, pentyl, benzyl, etc.; R1 = Br) with trisamine in DMF gave, instead of the expected 8-tris(hydroxymethyl)methylamino-substituted products I (R1 = NHC(CH2OH)3), 8-dimethylamino-substituted products I (R1 = N(CH3)2). The formation of unusual reaction products was explained by the initial reaction of DMF with trisamine to form dimethylamine and subsequent nucleophilic substitution reaction of the latter with the bromine atom.

Russian Journal of Organic Chemistry published new progress about Formamides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics