Tag: M.W=50-100

He, Kan published the artcileIdentification of the Heme-Modified Peptides from Cumene Hydroperoxide-Inactivated Cytochrome P450 3A4, Related Products of amides-buliding-blocks, the main research area is cytochrome P450 3A4 heme peptide cumene hydroperoxide inactivation.

Cumene hydroperoxide-mediated (CuOOH-mediated) inactivation of cytochromes P 450 (CYPs) results in destruction of their prosthetic heme to reactive fragments that irreversibly bind to the protein. We have attempted to characterize this process structurally, using purified, 14C-heme labeled, recombinant human liver P 450 3A4 as the target of CuOOH-mediated inactivation, and a battery of protein characterization approaches [chem. (CNBr) and proteolytic (lysylendopeptidase-C) digestion, HPLC-peptide mapping, microEdman sequencing, and mass spectrometric analyses]. The heme-peptide adducts isolated after CNBr/lysylendopeptidase-C digestion of the CuOOH-inactivated P 450 3A4 pertain to two distinct P 450 3A4 active site domains. One of the peptides isolated corresponds to the proximal helix L/Cys-region peptide 429-450 domain and the others to the K-region (peptide 359-386 domain). Although the precise residue(s) targeted remain to be identified, we have narrowed down the region of attack to within a 17 amino acid peptide (429-445) stretch of the 55-amino acid proximal helix L/Cys domain. Furthermore, although the exact structures of the heme-modifying fragments and the nature of the adduction remain to be established conclusively, the incremental masses of ≈ 302 and 314 Da detected by electrospray mass spectrometric analyses of the heme-modified peptides are consistent with a dipyrrolic heme fragment comprised of either pyrrole ring A-D or B-C, a known soluble product of peroxidative heme degradation, as a modifying species.

Biochemistry published new progress about Enzyme functional sites, active. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Nan published the artcileA Strategy for Amide to β-Oxo Ester Transformation via N-Alkenoxypyridinium Salts as the Activator and H2O as the Nucleophile, Name: N-Methylformamide, the main research area is amide alkenoxypyridinium salt water coupling; ester oxo preparation.

N-Alkenoxypyridinium salts were found to be highly active electrophilic reagents that could be used to activate the C-N bond of amides. Both aromatic amides and aliphatic amides could be transformed into the corresponding β-oxo esters with good yields via the combined use of N-alkenoxypyridinium salts and water. The methodol. proceeds under mild reaction conditions and is tolerant of various functional groups in both reaction partners.

Organic Letters published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Hao published the artcileGeneral Construction of Thioamides under Mild Conditions: A Stepwise Proton Transfer Process Mediated by EDTA, Application of N-Methylformamide, the main research area is thioamide preparation green chem DFT; ester amide sulfur one pot coupling EDTA catalyst.

A general and clean method for the one-pot synthesis of thioamides, e.g., I, was investigated using a combination of experiments and quantum chem. calculations Esters RCH2OCHO (R = Pr, cyclohexyl, Ph, etc.), amides, e.g., 4-morpholinecarboxaldehyde and elemental sulfur were employed as starting materials and ethylene diamine tetraacetic acid (EDTA) as catalyst. Both alkyl and aryl thioamides with various functional groups were obtained in moderate to good yields. Neither transition metals nor external oxidants were required in this reaction. The catalytic performance of EDTA originates from a stepwise, proton transfer process in which EDTA transports a proton from the benzyl carbon to a sulfur atom. Such a process is concerted by discrete charge transfer such that the associated barrier gets lowered.

European Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bonciolini, Stefano published the artcileA scalable continuous photochemical process for the generation of aminopropylsulfones, Recommanded Product: N-Methylformamide, the main research area is aminopropylsulfone preparation; amide vinyl sulfone coupling reaction tetrabutylammonium decatungstate photocatalyst.

An efficient continuous photochem. process that delivers a series of novel γ-aminopropylsulfones RSO2CH2CH2CH(R1)N(R2)C(O)R3 (R = Ph, Et; R1 = H, Me; R2 = Me, Et; R3 = H, Ph, cyclohexyl, etc.) and RSO2CH2CH2CH(O)NHMe via a tetrabutylammonium decatungstate (TBADT) catalyzed HAT-process is presented. Crucial to this success is the exploitation of a new high-power LED emitting at 365 nm that was found to be superior to an alternative medium-pressure Hg lamp. The resulting flow process enabled the scale-up of this transformation reaching throughputs of 20 mmol h-1 at substrate concentrations up to 500 mM. Addnl., the substrate scope of this transformation was evaluated demonstrating the straightforward incorporation of different amine substituents as well as alkyl appendages next to the sulfone moiety. It is anticipated that this methodol. will allow for further exploitations of these underrepresented γ-aminopropylsulfone scaffolds in the future.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jin, Hao published the artcileTransition-Metal-Free, General Construction of Thioamides from Chlorohydrocarbon, Amide and Elemental Sulfur, Related Products of amides-buliding-blocks, the main research area is thioamide preparation; chlorohydrocarbon amide sulfur coupling three component reaction.

A general method for one-pot synthesis of thioamides is developed through a three-component reaction involving chlorohydrocarbon, amide and elemental sulfur. Such a strategy does not only avoid residual transition metal in the product but also prevent the generation of C-N coupling byproduct. The latter is prone to be generated when alkane halide and amine are present. With the protocol proposed in this work, both alkyl and aryl thioamides can be obtained in moderate to excellent yields with a high tolerance of various functional groups. External oxidants are not required in the reaction. In addition, the reaction mechanisms are addressed using a combination of controlling experiments and quantum chem. calculations

European Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiong, Yang published the artcileVisible Light-Mediated Dearomative Hydrogen Atom Abstraction/ Cyclization Cascade of Indoles, Product Details of C2H5NO, the main research area is oxospiro dioxospiro dihydrospiro indoline preparation photochem; indole amine dearomative hydrogen transfer spirocyclization tandem reaction; C−H Activation; Heterocycles; Hydrogen Transfer; Photochemistry; Sensitizers.

The photochem. synthesis of yet unknown 2-oxospiro[azetidine-3,3′-indolines] (17 examples, 80-95% yield), 2,4-dioxospiro[azetidine-3,3′-indolines] (eight examples, 87-97% yield), and 1-oxo-1,3-dihydrospiro[indene-2,3′-indolines] (17 examples, 85-97% yield) is described. Starting from readily accessible 3-substituted indoles, a dearomatization of the indole core was accomplished upon irradiation at λ=420 nm in the presence of thioxanthen-9-one (10 mol%) as the sensitizer. Based on mechanistic evidence (triplet energy determination, deuteration experiments, byproduct anal.) it is proposed that the reaction proceeds by energy transfer via a 1,4- or 1,5-diradical intermediate. The latter intermediates are formed by excited state hydrogen atom transfer from suitable alkyl groups within the C3 substituent to the indole C2 carbon atom. Subsequent ring closure proceeds with pronounced diastereoselectivity to generate a 4- or 5-membered spirocyclic dearomatized product with several options for further functionalization.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Falcinelli, Stefano published the artcileThe Fragmentation Dynamics of Simple Organic Molecules of Astrochemical Interest Interacting with VUV Photons, Product Details of C2H5NO, the main research area is propylene oxide methylformamide vacuum extreme UV double photoionization fragmentation.

An exptl. investigation on the fragmentation dynamics following the double photoionization of simple organic mols. of astrochem. interest, propylene oxide and N-methylformamide mols., induced by VUV photons has been reported. Experiments used linearly polarized light in the 18-37 eV (propylene oxide) and 26-45 eV (N-methylformamide) photon energy range at the ELETTRA Synchrotron Facility of Trieste (Italy), coupling ion imaging and electron-ion-ion coincidence techniques with time-of-flight mass spectrometry. In the case of propylene oxide, six different two-body fragmentation processes have been recorded with the formation of CH2+/C2H4O+, CH3+/C2H3O+, O+/C3H6+, OH+/C3H5+, C2H3+/CH3O+, C2H4+/CH2O+ ion pairs. On the other hand, the double photoionization of N-methylformamide occurs producing two main fragmentation reactions, forming CH3+ + CH2NO+ and H+ + C2H4NO+. The relative cross sections and the threshold energies for all fragmentation channels are recorded as a function of the photon energy. Furthermore, in the case of the double photoionization of propylene oxide, the measure of the kinetic energy released distribution for the CH3+/C2H3O+ final ions with their angular distributions allowed the identification of a bimodal behavior indicating the possible formation of two different stable isomers of C2H3O+: acetyl and oxiranyl cations. The obtained results are important to clarify the phys. chem. of the elementary processes induced by the interaction of ionizing radiations with simple organic mols. of astrochem. interest: propylene oxide and N-methylformamide.

ACS Earth and Space Chemistry published new progress about Angular distribution function (kinetic energy release). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Noori, Abdolvahed published the artcileQuorum quenching bacteria isolated from industrial wastewater sludge to control membrane biofouling, Recommanded Product: N-Methylformamide, the main research area is quorum quenching bacteria industrial wastewater sludge membrane biofouling; Biofouling; Industrial wastewater; Quorum quenching; Quorum sensing; Tetramethylammonium hydroxide.

N-acylhomoserine lactone (AHL)-based bacterial communication through quorum sensing (QS) is one of the main causes of biofouling. Although quorum quenching (QQ) has proven to be an effective strategy against biofouling in membrane bioreactors (MBRs) for municipal wastewater treatment, its applicability for industrial wastewater treatment has rarely been studied. This is the first study to isolate QQ strains from the activated sludge used to treat industrial wastewater containing toxic tetramethylammonium hydroxide (TMAH) and 1-methyl-2-pyrrolidinone. The two QQ strains from genus Bacillus (SDC-U1 and SDC-A8) survived and effectively degraded QS signals in the presence of TMAH. They also showed resistance to toxic byproducts of TMAH degradation such as ammonium and formaldehyde. They effectively reduced the biofilm formation of Pseudomonas aeruginosa PAO1 and mixed community of activated sludge. The strains isolated in this study thus have the potential to be employed to reduce membrane biofouling in MBRs during the treatment of TMAH-containing wastewater.

Bioresource Technology published new progress about Activated-sludge process wastewater treatment. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Xiaoyi published the artcileA novel solid-liquid ‘phase controllable’ biphasic amine absorbent for CO2 capture, COA of Formula: C2H5NO, the main research area is solid liquid phase controllable biphasic amine absorbent; carbon dioxide capture.

The main issues in the application of biphasic amine absorbent include the inconvenient separation of the liquid-liquid biphase and the clogging that is associated with the solid-liquid mixture A novel solid-liquid ‘phase controllable’ biphasic amine absorbent was therefore developed, in which the phase separation occurred only when the absorbent was near saturation The absorbent, composed of triethylene tetramine (TETA), 2-amino-2-methyl-1-propanol (AMP), and N-methylformamide (NMF), turned into solid-liquid biphase under CO2 loading of 0.85 mol mol-1, which is close to saturation (0.92 mol mol-1). The solid phase comprised white powder that accounted for only 42% of the total volume while absorbing 91% of the total load. Turbidity and particle size tests showed that the phase separation was self-aggregating. The mechanisms of absorption and regulation were obtained using 13C NMR and mol. simulation. During the absorption, CO2 first combined with TETA to generate TETAH+CO-2/TETACO-2 through the zwitterion mechanism, and then combined with AMP to generate AMPCO-2 because of the lower reaction activity between CO2 and AMP. The TETA-carbamate was found to greatly weakened the strength of the hydrogen bonds and the van der Waals forces between AMPH+ and AMPCO-2, increasing the solubility of the intermediate products, and therefore achieved the purpose of controlling the phases separation inherent in the reaction.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Absorbents (solid-liquid biphasic, amine). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Flores-Holguin, Norma published the artcileConceptual DFT-Based Computational Peptidology, Pharmacokinetics Study and ADMET Report of the Veraguamides A-G Family of Marine Natural Drugs, Application of N-Methylformamide, the main research area is veraguamide natural drug density functional theory pharmacokinetics computational peptidol; ADMET; KID (Koopmans In DFT); Veraguamides A–G; computational peptidology; computational pharmacokinetics; conceptual DFT.

As a continuation of our research on the chem. reactivity, pharmacokinetics and ADMET properties of cyclopeptides of marine origin with potential therapeutic abilities, in this work our already presented integrated mol. modeling protocol has been used for the study of the chem. reactivity and bioactivity properties of the Veraguamides A-G family of marine natural drugs. This protocol results from the estimation of the conceptual d. functional theory (CDFT) chem. reactivity descriptors together with several chemoinformatics tools commonly considered within the process of development of new therapeutic drugs. CP-CDFT is a branch of computational chem. and mol. modeling dedicated to the study of peptides, and it is a protocol that allows the estimation with great accuracy of the CDFT-based reactivity descriptors and the associated phys. and chem. properties, which can aid in determining the ability of the studied peptides to behave as potential useful drugs. Moreover, the superiority of the MN12SX d. functional over other long-range corrected d. functionals for the prediction of chem. and phys. properties in the presence of water as the solvent is clearly demonstrated. The research was supplemented with an investigation of the bioactivity of the mol. systems and their ADMET (absorption, distribution, metabolism, excretion, and toxicity) parameters, as is customary in medicinal chem. Some instances of the CDFT-based chem. reactivity descriptors’ capacity to predict the pKas of peptides as well as their potential as AGE inhibitors are also shown.

Marine Drugs published new progress about Advanced glycation end product inhibitors. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics