Tag: M.W=50-100

Zhou, Jing published the artcileFructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism, Computed Properties of 123-39-7, the main research area is vitamin B phenylalanine arachidonic acid taurine hypotaurine metabolism; Fructus Gardeniae; Gastrointestinal injury; HPLC-TOF-MS/MS; Metabolomics.

Fructus Gardenia (FG) is a widely used bitter and cold herb for clearing heat and detoxicating. Currently, toxicity of FG and its relative formula has been reported in many clin. and animal studies. However, no systematic research has been carried out on FG-related gastrointestinal (GI) injury which has been emphasized in China since the Ming Dynasty. The purpose of this article is to investigate whether FG could damage GI and explore the mechanisms involved. FG was given to male mice by 7-day intragastric administration at average doses of 0.90 g (L group), 1.50 g (M group), and 3.00 g (H group) crude drug/kg FG. Comprehensive understanding of changes in weight, diarrhea degree, stool routine, histomorphol. and inflammatory factors of stomach, small intestine, and colon for evaluating the effect of different doses of FG on GI injury. Moreover, metabolomics-based mechanisms exploration of FG on GI injury was carried out via HPLC-Q-TOF/MS anal. on mice urine. High dose FG caused GI injury with serious diarrhea, decreased weight, abnormal stool routine, sever alteration in histomorphol. of small intestine and colon (mild change in stomach), and significant change in inflammatory factors. The results of metabolomics suggested that 55 endogenous metabolites dispersed in 21 significantly altered metabolic pathways in 3.00 g/kg crude FG treated mice. The hub metabolites of GI injury were mainly related with vitamin B6 metabolism, phenylalanine metabolism, arachidonic acid metabolism, and taurine and hypotaurine metabolism via correlated network anal. FG affected the normal functions of GI via the regulating a variety of metabolic pathways to an abnormal state, and our results provided a research paradigm for the GI-injury of the relative bitter and cold traditional Chinese medicines.

Journal of Ethnopharmacology published new progress about Biomarkers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zuo, Chenpeng published the artcileA theoretical study of hydrogen-bonded molecular clusters of sulfuric acid and organic acids with amides, Quality Control of 123-39-7, the main research area is hydrogen bond mol cluster sulfuric acid organic amide; Amides; Hydrogen bond; Nucleation; Organic acids; Sulfuric acid.

Amides, a series of significant atm. nitrogen-containing volatile organic compounds (VOCs), can participate in new particle formation (NPF) through interacting with sulfuric acid (SA) and organic acids. In this study, we investigated the mol. interactions of formamide (FA), acetamide (AA), N-methylformamide (MF), propanamide (PA), N-methylacetamide (MA), and N, N-dimethylformamide (DMF) with SA, acetic acid (HAC), propanoic acid (PAC), oxalic acid (OA), and malonic acid (MOA). Global min. of clusters were obtained through the association of the artificial bee colony (ABC) algorithm and d. functional theory (DFT) calculations The conformational anal., thermochem. anal., frequency anal., and topol. anal. were conducted to determine the interactions of hydrogen-bonded mol. clusters. The heterodimers formed a hepta or octa membered ring through four different types of hydrogen bonds, and the strength of the bonds are ranked in the following order: SO-HO > CO-HO > N-HO > C-HO. We also evaluated the stability of the clusters and found that the stabilization effect of amides with SA is weaker than that of amines with SA but stronger than that of ammonia (NH3) with SA in the dimer formation of nucleation process. Addnl., the nucleation capacity of SA with amides is greater than that of organic acids with amides.

Journal of Environmental Sciences (Beijing, China) published new progress about Bond angle. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Jian-Qiang published the artcileLead chlorine cluster assembled one-dimensional halide with highly efficient broadband white-light emission, Name: N-Methylformamide, the main research area is lead chlorine cluster halide broadband white light emission.

One new type of hybrid lead halide of [DTHPE]2Pb3Cl10 has been synthesized and characterized containing a one-dimensional (1D) wavelike [Pb3Cl10]4- chain based on a corner-shared [Pb3Cl11] cluster. Remarkably, this cluster-based 1D chain displays intrinsic broadband white light emission with a high quantum efficiency of 19.45% exceeding those of previously reported typical two-dimensional perovskites.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bond angle. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Hongxing published the artcilePigmentiphaga sp. strain D-2 uses a novel amidase to initiate the catabolism of the neonicotinoid insecticide acetamiprid, Application In Synthesis of 123-39-7, the main research area is Pigmentiphaga amidase neonicotinoid acetamiprid catabolism; AceAB; IM 1-4; Pigmentiphaga sp. strain D-2; acetamiprid; amidase; initial hydrolysis.

Acetamiprid, a chloronicotinyl neonicotinoid insecticide, is among the most commonly used insecticides worldwide, and its environmental fate has caused considerable concern. The compound 1-(6-chloropyridin-3-yl)-N-methylmethanamine (IM 1-4) has been reported to be the main intermediate during acetamiprid catabolism in microorganisms, honeybees, and spinach. However, the mol. mechanism underlying the hydrolysis of acetamiprid to IM 1-4 has not yet been elucidated. In this study, a novel amidase (AceAB) that initially hydrolyzes the C-N bond of acetamiprid to generate IM 1-4 was purified and characterized from the acetamiprid-degrading strain Pigmentiphaga sp. strain D-2. Based on peptide profiling of the purified AceAB and the draft genome sequence of strain D-2, aceA (372 bp) and aceB (2,295 bp), encoding the α and β subunits of AceAB, resp., were cloned and found to be necessary for acetamiprid hydrolysis in strain D-2. The characteristics of AceAB were also systematically investigated. Though AceA and AceB showed 35% to 56% identity to the α and β subunits of the N,N-dimethylformamidase from Paracoccus aminophilus, AceAB was specific for the hydrolysis of acetamiprid and showed no activities to N,N-dimethylformamide or its structural analogs.

Applied and Environmental Microbiology published new progress about Catabolism. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Silva, Murilo O. published the artcileEffect of single and double methylation on the position of the π* shape resonance of formamide and acetamide, Quality Control of 123-39-7, the main research area is formamide acetamide methylation ground state.

In this work we report calculated integral and differential cross sections for elastic electron collision with formamide, acetamide and their resp. methylated derivatives, for impact energies up to 6 eV. Our calculations were performed with the Schwinger multichannel method with pseudopotentials, in the static-exchange and static-exchange plus polarization approximations The aim of this work is to investigate the methylation effect on the π* shape resonance, which is present in the A’spm symmetry of all studied systems. Our results were compared with existent data from the literature and showed good agreement. Stabilization or destabilization of the π* resonance due to methylation occur, but there is no clear tendency on stabilization or destabilization among the methylated derivatives Changes in the widths of the resonance due to the Me group were also observed

Chemical Physics published new progress about Conformers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Evjen, Sigvart published the artcileDegradative Behavior and Toxicity of Alkylated Imidazoles, Formula: C2H5NO, the main research area is degradation toxicity corrosivity alkylated imidazole solvent carbon dioxide.

The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole (1,2,4,5MIm) were investigated in a CO2 rich environment. The imidazoles demonstrated high thermal stability in all solutions; however, Im and 2MIm were corrosive. Polyalkylated imidazoles were less stable toward oxidation compared to Im. Rat cell (PC-12) toxicol. screening of Im and 45 alkylated imidazoles showed reduced toxicity for polyalkylated imidazoles compared to Im. Cell viability correlated neg. with cLogP predictions when cLogP > 3. The high rate of oxidative degradation and formation of potentially carcinogenic degradation products will prevent the use of polyalkylated imidazoles in industrial processes directed toward CO2.

Industrial & Engineering Chemistry Research published new progress about Corrosives. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Munoz, Maria M. published the artcileEquilibrium solubility and apparent specific volume at saturation of sodium diclofenac in {formamide (1)/N-methylformamide (1)/or N,N,-dimethylformamide (1) + water (2)} mixtures at 298.2 K, HPLC of Formula: 123-39-7, the main research area is sodium diclofenac cosolvent equilibrium solubility specific volume.

Sodium diclofenac is an analgesic drug commonly used in current therapeutics. Solubility data of this drug in aqueous cosolvent mixtures are not abundant. The main objective of this research was to determine and correlate the equilibrium solubility of sodium diclofenac in some {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were formamide, N-methylformamide, and N,N-dimethylformamide. Classical shake-flask method was used to determine isothermal solubility Drug concentration measurements were performed by means of elec. conductivity determinations after adequate aqueous dilutions Solubility of sodium diclofenac increases non-linearly with the addition of cosolvent to water in almost all mixtures compositions Higher solubility values were found in {N,N-dimethylformamide (1) + water (2)} mixtures Jouyban-Acree model correlates solubility values with the mixtures composition for all cosolvent systems. Furthermore, the apparent sp. volume of this drug was also calculated from d. and mixtures compositions

Physics and Chemistry of Liquids published new progress about Cosolvents. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Zheng published the artcileEnhancing Metal Separations by Liquid-Liquid Extraction Using Polar Solvents, Name: N-Methylformamide, the main research area is cobalt manganese nickel extraction polar solvent chloride formamide methanol; metal separations; rare earths; solvent effects; solvent extraction; solvometallurgy.

The less polar phase of liquid-liquid extraction systems was studied extensively for improving metal separations; however, the role of the more polar phase was overlooked for far too long. Herein, we investigate the extraction of metals from a variety of polar solvents and demonstrate that, the influence of polar solvents on metal extraction is so significant that extraction of many metals can be largely tuned, and the metal separations can be significantly enhanced by selecting suitable polar solvents. Furthermore, a mechanism on how the polar solvents affect metal extraction is proposed based on comprehensive characterizations. The method of using suitable polar solvents in liquid-liquid extraction paves a new and versatile way to enhance metal separations

Chemistry – A European Journal published new progress about Extraction. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Ren-Xuan published the artcileHeterogeneous Metal Azolate Framework-6 (MAF-6) Catalysts with High Zinc Density for Enhanced Polyethylene Terephthalate (PET) Conversion, Category: amides-buliding-blocks, the main research area is heterogeneous metal azolate MAF6 glycolysis catalyst PET.

Polyethylene terephthalate (PET) has been extensively used for the fabrication of various packaging materials, creating million tons of waste per yr. Degrading and recycling PET waste has been identified as a prominent issue. Herein, we demonstrate an effective process to chem. convert PET to bis(2-hydroxyethyl) terephthalate (BHET) through the use of metal azolate framework-6 (MAF-6) as a catalyst in the presence of ethylene glycol. MAFs are a subclass of metal-organic frameworks (MOFs), with MAF-6 comprised of the metal ion Zn2+ and the organic ligand 2-ethylimidazole. We have optimized the reaction temperature, reaction time, and catalyst amount to achieve up to a 92.4% conversion of PET and an 81.7% yield of BHET at 180°C for 4 h. MAF-6 was easily recovered and reused for at least five times. We have also hypothesized a mechanism for the high conversion and yield of the PET glycolysis reaction catalyzed by MAF-6. The use of MAF-6 as a catalyst opens a new route for the postconsumer recycling of PET with remarkable practicality.

ACS Sustainable Chemistry & Engineering published new progress about Glycolysis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Herman, M. A. published the artcileHalogenated aliphatic compounds. III. Infrared spectra of solid halogenated acetamides, Application of 2,2-Difluoroacetamide, the main research area is .

Spectra of fluoro- (I), difluoro- (II), trifluoro- (III), chloro- (IV), dichloro- (V), and trichloroacetamide (VI) are determined in KBr pellets, with frequency in cm.-1, intensity, and assignment of bands given. The shift of the “”amide I”” band to higher frequencies with increasing halogen content, while the “”amide II”” band is displaced relatively little, supports the correlation of these bands with the CO and NH2 portions of the amide group, resp.

Bulletin des Societes Chimiques Belges published new progress about IR spectra. 359-38-6 belongs to class amides-buliding-blocks, name is 2,2-Difluoroacetamide, and the molecular formula is C2H3F2NO, Application of 2,2-Difluoroacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics