Tag: M.W=50-100

Liu, Junwei published the artcileAnaerobic biodegradation and detoxification of chloroacetamide herbicides by a novel Proteiniclasticum sediminis BAD-10^T, Application In Synthesis of 79-07-2, the publication is Environmental Research (2022), 112859, database is CAplus and MEDLINE.

Chloroacetamide herbicides (CAAHs) are important herbicides that were widely used to control agricultural weeds. However, their mass applications have seriously contaminated environment, and they are toxic to living beings. CAAHs are easy to enter anoxic environments such as subsoil, wetland sediment, and groundwater, where CAAHs are mainly degraded by anaerobic organisms. To date, there are no research on the anaerobic degradation of CAAHs by pure isolate and toxicity of anaerobic metabolites of CAAHs. In this study, the anaerobic degradation kinetics and metabolites of CAAHs by an anaerobic isolate BAD-10T and the toxicity of anaerobic metabolites were studied. Isolate BAD-10T could degrade alachlor, acetochlor, propisochlor, butachlor, pretilachlor and metolachlor with the degradation kinetics fitting the pseudo-first-order kinetics equation. The degradation rates of CAAHs were significantly affected by the length of N-alkoxyalkyl groups, the shorter the N-alkoxyalkyl groups, the higher the degradation rates. Four metabolites 2-ethyl-6-methyl-N-(ethoxymethyl)-acetanilide (EMEMA), N-(2-methyl-6-ethylphenyl)-acetamide (MEPA), N-2-ethylphenyl acetamide and 2-ethyl-N-carboxyl aniline were identified during acetochlor degradation, and an anaerobic catabolic pathway of acetochlor was proposed. The toxicity of EMEMA and EMPA for zebrafish, Arabidopsis and Chlorella ellipsoidea were obviously lower than that of acetochlor, indicating that the anaerobic degradation of acetochlor by isolate BAD-10T is a detoxification process. The work reveals the anaerobic degradation kinetics and catabolic pathway of CAAHs and highlights a potential application of Proteiniclasticum sediminis BAD-10T for bioremediation of CAAHs residue-contaminated environment.

Environmental Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application In Synthesis of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Jiafu published the artcileAre Disinfection Byproducts (DBPs) Formed in My Cup of Tea? Regulated, Priority, and Unknown DBPs, Name: 2-Chloroacetamide, the publication is Environmental Science & Technology (2021), 55(19), 12994-13004, database is CAplus and MEDLINE.

Globally, tea is the second most consumed nonalcoholic beverage next to drinking water and is an important pathway of disinfection byproduct (DBP) exposure. When boiled tap water is used to brew tea, residual chlorine can produce DBPs by the reaction of chlorine with tea compounds In this study, 60 regulated and priority DBPs were measured in Twinings green tea, Earl Gray tea, and Lipton tea that was brewed using tap water or simulated tap water (nanopure water with chlorine). In many cases, measured DBP levels in tea were lower than in the tap water itself due to volatilization and sorption onto tea leaves. DBPs formed by the reaction of residual chlorine with tea precursors contributed ~12% of total DBPs in real tap water brewed tea, with the remaining 88% introduced by the tap water itself. Of that 12%, dichloroacetic acid, trichloroacetic acid, and chloroform were the only contributing DBPs. Total organic halogen in tea nearly doubled relative to tap water, with 96% of the halogenated DBPs unknown. Much of this unknown total organic halogen (TOX) may be high-mol.-weight haloarom. compounds, formed by the reaction of chlorine with polyphenols present in tea leaves. The identification of 15 haloarom. DBPs using gas chromatog.-high-resolution mass spectrometry indicates that this may be the case. Further studies on the identity and formation of these aromatic DBPs should be conducted since haloarom. DBPs can have significant toxicity.

Environmental Science & Technology published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dabaeva, V. V. published the artcileSynthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3′,2′:4,5]-thieno[3,2-D]pyrimidine Derivatives, Recommanded Product: 2-Chloroacetamide, the publication is Pharmaceutical Chemistry Journal (2020), 54(7), 707-713, database is CAplus.

2-Oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine was used as the starting point to develop an accessible synthesis of condensed cyclopentanopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine derivatives I [R = NHNH₂, SC₄H₉, SCH₂CONH₂, etc.] and II [R¹ = C₅H₁₁, CH₂CONH₂, CH₂CH₂OMe, etc.]. The neurotropic activity of these compounds was studied, and a number of them showed anticonvulsant activity as antagonism to corasol. 2-Chloro-6,7-dihydro-5H-cyclepenta[b]pyridine-3-carbonitrile like diazepam, had anti-anxiety and activating effects, while the other compounds had sedative activity.

Pharmaceutical Chemistry Journal published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dabaeva, V. V. published the artcileSynthesis, Neurotropic Activity, and Molecular Docking of New Condensed Thieno[2,3-b]pyridine Derivatives, SDS of cas: 79-07-2, the publication is Russian Journal of Bioorganic Chemistry (2022), 48(1), 125-134, database is CAplus.

Methods for the preparation of new condensed derivatives of pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were developed. Substitution reactions in the 3rd and 4th positions of 7,8-dimethylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one were conducted. The neurotropic activity of 12 obtained compounds was studied in vivo in rats and mice. Eight compounds were found to have an anticonvulsant effect of antagonism with corazole. Four selected compounds had anxiolytic and behavior activating effects. Mol. docking of the synthesized compounds was performed to predict their interaction with the GABAA receptor. Five compounds were identified, the complexation of which with the GABAA receptor occurs in two places: the benzamidine site of subsite 1 and subsite 3 of the ECD interface, which indicates the inhibitory effect of the compounds on the target.

Russian Journal of Bioorganic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, SDS of cas: 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Abuelhassan, Suzan published the artcileSynthesis, characterization, and biological activities of some novel thienylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and related heterocycles, Formula: C2H4ClNO, the publication is Journal of Heterocyclic Chemistry (2021), 58(9), 1784-1801, database is CAplus.

3-Cyano-5-ethoxycarbonyl-6-methyl-4-(2′-thienyl)-pyridine-2(1H)-thione was synthesized and reacted with chloroacetonitrile or chloroacetamide to give I [R¹ = cyano, carbamoyl; R² = amino], resp. Cyclocondensation of I [R¹ = carbamoyl; R² = amino] with triethylorthoformate produced the corresponding pyridothienopyrimidineone II [R³ = hydroxy], which on heating with phosphorus oxychloride gave 4-chloropyrimidine derivative II [R³ =chloro]. Compound II [R³ = chloro] was used as key intermediate for synthesizing compounds II [R³ = sulfanyl, hydrazino, piperidyl, morpholino, (3-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl] upon treatment with some nucleophilic reagents such as thiourea, hydrazine hydrate, piperidine, morpholine, or 5-phenyl-s-triazole-3(1H)-thione, resp. Reaction of pyridothienopyrimidinethione II [R³ = sulfanyl] with N-(4-tolyl)-2-chloroacetamide or Et bromoacetate afforded the corresponding S-substituted methylsulfanylpyrimidines II [R³ = [2-(4-methylanilino)-2-oxo-ethyl]sulfanyl, (2-ethoxy-2-oxo-ethyl)sulfanyl]. The condensation of I [R¹ = cyano; R² = amino] with triethylorthoformate gave azomethine derivative I [R¹ = cyano; R² = ethoxymethyleneamino], which was reacted with hydrazine hydrate to give compound III [R⁴ = amino]. Compounds II [R³ = hydrazino] and III [R⁴ = amino] were used as precursors for synthesizing other new thienylpyridothienopyrimidines as well as isomeric thienyl-s-triazolopyridothieno- pyrimidines. All synthesized compounds were characterized by elemental and spectral analyses such as IR, ¹H NMR, and ¹³C NMR. In addition, majority of synthesized compounds were tested for their antifungal activity against five strains of fungi. Moreover, compounds I [R¹ = carbamoyl; R² = amino], II [R³ = chloro, sulfanyl, (2-ethoxy-2-oxo-ethyl)sulfanyl], and III [R⁴ = 2-thienylmethyleneamino] were screened for their anticancer activity against HEPG-2 and MCF-7 cell lines.

Journal of Heterocyclic Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mohi El-Deen, Eman M. published the artcileNovel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents, Recommanded Product: 2-Chloroacetamide, the publication is Molecules (2022), 27(3), 803, database is CAplus and MEDLINE.

The growing risk of antimicrobial resistance besides the continuous increase in the number of cancer patients represents a great threat to global health, which requires intensified efforts to discover new bioactive compounds to use as antimicrobial and anticancer agents. Thus, a new set of pyridothienopyrimidine derivatives 2a,b-9a,b was synthesized via cyclization reactions of 3-amino-thieno[2,3-b]pyridine-2-carboxamides 1a,b with different reagents. All new compounds were evaluated against five bacterial and five fungal strains. Many of the target compounds showed significant antimicrobial activity. In addition, the new derivatives were further subjected to cytotoxicity evaluation against HepG-2 and MCF-7 cancer cell lines. The most potent cytotoxic candidates (3a, 4a, 5a, 6b, 8b and 9b) were examined as EGFR kinase inhibitors. Mol. docking study was also performed to explore the binding modes of these derivatives at the active site of EGFR-PK. Compounds 3a, 5a and 9b displayed broad spectrum antimicrobial activity with MIC ranges of 4-16 μg/mL and potent cytotoxic activity with IC₅₀ ranges of 1.17-2.79 μM. In addition, they provided suppressing activity against EGFR with IC₅₀ ranges of 7.27-17.29 nM, higher than that of erlotinib, IC₅₀ = 27.01 nM.

Molecules published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liman, Recep published the artcileGenotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism, Safety of 2-Chloroacetamide, the publication is Environmental Science and Pollution Research, database is CAplus and MEDLINE.

Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alk. comet assays, resp. Furthermore, mol. docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Mol. docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases.

Environmental Science and Pollution Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Safety of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wiktelius, Daniel published the artcileIn Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design, Related Products of amides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2021), 60(2), 813-819, database is CAplus and MEDLINE.

The potential drug target choline acetyltransferase (ChAT) catalyzes the production of the neurotransmitter acetylcholine in cholinergic neurons, T-cells, and B-cells. Herein, we show that arylvinylpyridiniums (AVPs), the most widely studied class of ChAT inhibitors, act as substrate in an unusual CoA-dependent hydrothiolation reaction. This in situ synthesis yields an adduct that is the actual enzyme inhibitor. The adduct is deeply buried in the active site tunnel of ChAT and interactions with a hydrophobic pocket near the choline binding site have major implications for the mol. recognition of inhibitors. Our findings clarify the inhibition mechanism of AVPs, establish a drug modality that exploits a target-catalyzed reaction between exogenous and endogenous precursors, and provide new directions for the development of ChAT inhibitors with improved potency and bioactivity.

Angewandte Chemie, International Edition published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C6H8BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Abdellattif, Magda H. published the artcileNovel 2-hydroselenonicotinonitriles and selenopheno[2, 3-b]pyridines: efficient synthesis, molecular docking-DFT modeling, and antimicrobial assessment, Application of 2-Chloroacetamide, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2021), 672503, database is CAplus and MEDLINE.

Selenium containing heterocyclic compounds gained great interest as bioactive mols. as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed to afford this series. The spectroscopic techniques were exploited to verify the structures of the synthesized derivatives Addnl., the agar diffusion method was employed to determine the antimicrobial activity of all the desired compounds Of all the synthesized mols., few compounds exhibited well to remarkable antibacterial and antifungal activities. Moreover, derivative (E)-4,6-dimethyl-2-selenoxo-5-((3,4,5-trimethoxyphenyl)diazenyl)-1,2-dihydropyridine-3-carbonitrile demonstrated the most potent antibacterial and antifungal performance. The results were also supported by mol. docking studies, utilizing the MOE (mol. operating environment) which revealed the best binding mode with the highest energy interaction within the binding pocket. Lastly, theor. DFT calculations were carried out in a gas phase at B3LYP 6-311G (d,p) basis set to predict the mol. geometries and chem. reactivity descriptors. DFT results have been used to illustrate that mol. docking findings and biol. activity assessments.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Application of 2-Chloroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zaki, Remon M. published the artcileA convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents, Application In Synthesis of 79-07-2, the publication is Medicinal Chemistry Research (2020), 29(12), 2130-2145, database is CAplus.

A novel series of 5-amino-6-substituted-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]selenolo[3,2-e]pyrazines was synthesized by the reaction of the chloro pyrazolo[3,4-b]pyrazine carbonitrile with selenium element in the presence of sodium borohydride and ethanol, followed by the reaction with α-halo alkylating agents to produce the selanyl-alkylated derivatives The latter compounds underwent Thorpe-Ziegler cyclization upon heating with ethanolic sodium ethoxide solution to afford the target selenolopyrazolopyrazine compounds The 5-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]selenolo[3,2-e]pyrazine-6-carboxamide was used as a versatile precursor for synthesis of new heterocyclic fused to the pyrazoloselenolopyrazine moiety namely: pyrimidine and imidazopyrimidine. Assignment of the chem. structures for the newly synthesized compounds was confirmed on the bases of elemental and spectral techniques including FT-IR, ¹H NMR, ¹³C NMR, and mass spectra. Furthermore, certain compounds were screened for their antimicrobial activity which revealed remarkable activities against various pathogenic strains of bacteria and fungi. Alternatively, some of these compounds exhibited promising anticancer action against some colon and breast cancer cells.

Medicinal Chemistry Research published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C25H23NO4, Application In Synthesis of 79-07-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics