9/29/2021 News Discovery of 120157-97-3

According to the analysis of related databases, 120157-97-3, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120157-97-3 as follows. category: amides-buliding-blocks

Under nitrogen, compound X (from Example 38 part a) (5.0 g, 16.7 mmol) was mixed with toluene (80 mL) and 4-methoxy-3-phenylaniline hydrochloride (4.3 g, 18.3 mmol) was added to form a slurry. 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (1.6 g, 2.5 mmol) was added, followed by tris(dibenzylideneacetone)dipalladium(0) (760 mg, 0.83 mmol) and finally sodium tert-butoxide (5.3 g, 55 mmol). The mixture was heated at 90 C. for 150 min and then cooled to room temperature. Water (150 mL) was added followed by ethyl acetate (150 mL) and the phases partitioned. The aqueous layer was extracted with ethyl acetate (150 mL) and the combined organics washed three times with 0.5 M sodium bisulfate (200 mL), once with saturated sodium bicarbonate (150 mL) and twice with saturated sodium chloride (150 mL). The organics were dried over magnesium sulfate (50 g) and the volatiles removed under vacuum to give N-tert-butoxycarbonyl-2-[4-(3-[phenyl-4-methoxyphenyl)aminophenyl]ethylamine (LL) (8.4 g) which was used without further purification.

According to the analysis of related databases, 120157-97-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Moran, Edmund J.; Jacobsen, John R.; Leadbetter, Michael R.; Nodwell, Matthew B.; Trapp, Sean G.; Aggen, James; Church, Timothy J.; US2003/229058; (2003); A1;,
Amide – Wikipedia,
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Sep-21 News Extended knowledge of 26638-53-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine, other downstream synthetic routes, hurry up and to see.

Application of 26638-53-9, The chemical industry reduces the impact on the environment during synthesis 26638-53-9, name is 3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine, I believe this compound will play a more active role in future production and life.

6-Methyl-3- (methylthio) dibenzo [c, f] [1,2] thiazepin-11 ( 6H) -one 5,5-dioxide (3i) . To a solution of sodium thiomethoxide (116 mg, 1.65 mmol) in anhydrous DMF (2.0 mL) was added ketone 3d (462 mg, 1.50 mmol) and the resulting yellow suspension was stirred at room temperature for 1 h. Additional sodium thiomethoxide (26.3 mg, 0.375 mmol) was then added and stirring continued for a further 15 min. The reaction was then quenched with water (10 mL) and extracted with CH2CI2 (10 mL, 2 5 mL) . The combined organics were washed with water (20 mL) , dried over Na2SC>4, and concentrated to yield a yellow oil containing residual DMF. This crude was diluted with Et20 and chilled on ice causing the product to crystallize as pale-yellow needles. These crystals were washed with several small portions of ice-cold Et20 and dried to give the pure ketone 3i (331 mg, 69percent) . *H NMR (500 MHz, CDCI3) delta 8.31 (dd, J = 8.1, 1.6 Hz, 1H) , 7.92 (d, J = 8.3 Hz, 1H) , 7.73 (d, J = 2.0 Hz, 1H) , 7.62 (ddd, J = 8.0, 7.4, 1.7 Hz, 1H) , 7.48 (dd, J = 8.3, 2.0 Hz, 1H) , 7.40 – 7.33 (m, 2H) , 3.33 (s, 3H) , 2.59 (s, 3H) ; 13C NMR (126 MHz, CDC13) delta 189.5, 146.5, 141.4, 137.7, 134.7, 132.4, 132.2, 131.8, 131.7, 129.2, 126.4, 125.2, 121.4, 39.3, 15.0. LR-MS calcd. for C15H14NO3S2 [M+H]+ 320.04, found 320.75.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; KRUEGEL, Andrew; SAMES, Dalibor; JAVITCH, Jonathan A.; (187 pag.)WO2018/170275; (2018); A1;,
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24-Sep News Share a compound : 299430-87-8

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 299430-87-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 299430-87-8, name is (9H-Fluoren-9-yl)methyl (2-(2-hydroxyethoxy)ethyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 299430-87-8

To Example 2.62.3 (5.03 g) and triphenylphosphine (4.62 g) in toluene (88 mL) wasadded di -tert-butyl-azodicarboxylate ( 4.06 g) and the reaction was stirred for 30 minutes. (9H-20 Fluoren-9-yl)methyl (2-(2-hydroxyethoxy)ethyl)carbamate was added and the reaction was stirred for25an addition 1.5 hours. The reaction was loaded directly onto silica gel and was eluted with 1-50%ethyl acetate/heptanes to provide the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 299430-87-8.

Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; SOUERS, Andrew, J.; PHILLIPS, Andrew, C.; JUDD, Andrew, S.; BRUNCKO, Milan; (717 pag.)WO2017/214282; (2017); A1;,
Amide – Wikipedia,
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16-Sep-2021 News The important role of 159790-81-5

The synthetic route of 159790-81-5 has been constantly updated, and we look forward to future research findings.

159790-81-5, name is (9H-Fluoren-9-yl)methyl 4-aminobenzylcarbamate, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C22H20N2O2

N-Fmoc-para-(aminomethyl)phenylazobenzoic acid was prepared adapting literature procedures [1]. Para-nitrosobenzoic acid [2] (0.94 g, 6.2 mmol) and N-Fmoc-para-aminobenzylamine [3] (1.06 g, 3.1 mmol) were suspended in acetic acid/DMSO 1:1 (80 mL) and stirred at room temperature for 48 h. Water was added to the reaction mixture, the precipitate was filtered, washed with water several times, dried, and recrystallized from acetone/water mixtures yielding the desired azo compound (660 mg, 45%) as an orange solid.

The synthetic route of 159790-81-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ponader, Daniela; Igde, Sinaida; Wehle, Marko; Maerker, Katharina; Santer, Mark; Bleger, David; Hartmann, Laura; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1603 – 1612;,
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S News Simple exploration of 227940-71-8

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 227940-71-8, name is tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 227940-71-8

7-Benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester (0.49 g, 1.6 mmol) was dissolved in methanol (20 ml.) and 20% Pd(OH)2/C (wet) (~ 2 g) was added under a nitrogen atmosphere. This mixture was warmed to about 50 0C and shaken for 2 h under 55 psi of hydrogen. The resulting mixture was filtered and concentrated to give 0.32 g (94% yield) of the title compound (MS m/z 227 (M+H)).

The synthetic route of 227940-71-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGACEPT, INC.; WO2009/111550; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

13-Sep-21 News Sources of common compounds: 194920-62-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 194920-62-2, its application will become more common.

Some common heterocyclic compound, 194920-62-2, name is tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, molecular formula is C15H32N2O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 194920-62-2

To a 25 mL round bottomed flask equipped with a magnetic stir bar, rubber septum, and argon inlet containing tert-butyl 3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propylcarbamate (amine, 160 mg, 0.5 mmol), 2-azidoacetic acid (56 mg, 0.55 mmol, in 50% DCM solution), NaHCO3 (168 mg, 2 mmol), and 1 mL DMF was added EDC (115 mg, 0.6 mmol). The mixture was stirred at rt for 3 h and concentrated in vacuo. The crude product was purified by silica chromatography (gradient 5% to 90% EtOAc in hexane) to afford compound 141 as a clear oil (130 mg, 65%). MS(ESI) m/z 426 (M+Na+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 194920-62-2, its application will become more common.

Reference:
Patent; SIEMENS MEDICAL SOLUTIONS USA, INC.; WO2008/124703; (2008); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

9/13/21 News Share a compound : 316146-27-7

The synthetic route of N-(4-Bromophenyl)-3-phenylpropanamide has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 316146-27-7, name is N-(4-Bromophenyl)-3-phenylpropanamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C15H14BrNO

General procedures:; Scheme 2; An acid (1 equiv), HATU (1 equiv) and DIEA (3 equiv) were added to a solution of 4-bromo-aniline (1 equiv) in DMF. The mixture was stirred at room temperature until the starting material disappeared (detection by LC-MS). The solution was diluted with EtOAc and washed with saturated aqueous NaHCO3. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give the crude bromide 2-1. The bromide 2-1 (1 equiv) and the boronic acid ester (1.5 equiv) were dissolved in degassed dioxane/H2O (5:1 by volume) in a sealed tube. Pd(PPh3)4 (0.03 equiv) and 2M solution Of K2CO3 (3 equiv) were added sequentially. The mixture was heated at 95 0C for 2h. After cooling to room temperature, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined, dried over sodium sulfate and concentrated in vacuo. The residue was then purified by preparative HPLC to give the product 2-2 as a solid (65percent-80percent yield in two steps).; Example 27. N-(4-(lH-pyrazol-4-yl)phenv0-3-phenylpropanamide; Procedures in Scheme 2 were utilized to synthesize this compound. LC/MS: Ci8HnN3O (M+l) 292. Single peak at both 215 nm and 254 nm in analytical HPLC traces.

The synthetic route of N-(4-Bromophenyl)-3-phenylpropanamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FENG, Yangbo; LOGRASSO, Philip; SCHROETER, Thomas; YIN, Yan; WO2010/36316; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

9/9/2021 News Simple exploration of 1195768-19-4

The synthetic route of 1195768-19-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1195768-19-4, name is Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate

To a dry three-necked flask, 3- (2,6-difluorophenyl) -2- fluorobenzoate (2.05 g, 5.94 mmol), N, O- dimethylhydroxylamine hydrochloride ( under 743 mg, 7.62 mmol), nitrogen was added distilled tetrahydrofuran (15 mL), and the system was cooled to -15C , slowly dropping 3 M methyl magnesium bromide (9.9 mL), and then the addition was complete 0C transferred to conditions, for 5 hours, quenched with saturated aqueous ammonium chloride added, tetrahydrofuran was removed by rotary evaporation after extraction with ethyl acetate, the solvent was removed by rotary evaporation, the residue was purified by silica gel column chromatography (PE: EA = 10: 1 -1: 2) was isolated as a product (600mg, 31% yield).

The synthetic route of 1195768-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tonghua Jida Pharmaceutical Co., Ltd.; Wu, yongqian; (22 pag.)CN103936728; (2016); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

9/9/21 News The important role of 26638-53-9

The synthetic route of 26638-53-9 has been constantly updated, and we look forward to future research findings.

Reference of 26638-53-9, A common heterocyclic compound, 26638-53-9, name is 3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine, molecular formula is C14H10ClNO3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-bromosuccinimide (187 mg, 1.05 mmol) was added portionwise to a solution of ketone 3f (308 mg, 1.0 mmol) and FeCla (324 mg, 2.0 mmol) in CH2CI2 (10 mL) and CH3CN (5 mL) , and the reaction mixture was stirred at room temperature for 3 h. Additional W-bromosuccinimide (187 mg, 1.05 mmol) was then added and the reaction mixture was stirred at room temperature for a further 14 h. The reaction mixture was washed with water and brine and dried over NaSCli. The crude product was purified by column chromatography ( CH2CI2 : hexane – 2:1) followed by crystallization from MeOH. The product 3k was obtained as a white solid (290 mg, 75 percent) . XH NMR (400 MHz, Acetone-dg) 3 8.31 (d, J = 2.5 Hz, 1H) , 8.00 – 7.96 (m, 1H) , 7.95 – 7.89 (m, 3H) , 7.58 (d, J = 8.7 Hz, 1H) , 3.44 (s, 3H) ; 13C NMR (101 MHz, Acetone-dg) delta 189.6, 142.0, 139.1, 139.0, 138.4, 135.3, 134.7, 134.3, 132.8, 127.9, 125.8, 119.4, 39.3; LR-MS calcci. for C ,HioBrClN03S [M+H]+ 387.92, found 388.63.

The synthetic route of 26638-53-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; KRUEGEL, Andrew C.; HENKE, Adam; GASSAWAY, Madalee M.; RIVERS, Marie-laure; JAVITCH, Jonathan A.; SAMES, Dalibor; WO2015/138791; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

7-Sep-21 News Simple exploration of 194920-62-2

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 194920-62-2, name is tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate, A new synthetic method of this compound is introduced below., Recommanded Product: tert-Butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate

In four flasks (20mL), compound IX (0.45mmol in each) was dissolved in DMF (5mL in each) and afterwards, compounds I, II, V, or VI (2mmol), HOAt (3mmol), PyAOP (2mmol) and DIPEA (8mmol), were added to each flask. The reaction mixture of each flask was heated at 100C for 12h, diluted with water and extracted three times with DCM. Each organic layer was dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. Finally, each residue was purified by column chromatography using hexane/ethyl acetate as the solvent and thus compounds 5 (94%), 6 (91%), 7 (86%), or 8 (90%) were yielded, respectively.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Medina-O’Donnell, Marta; Rivas, Francisco; Reyes-Zurita, Fernando J.; Martinez, Antonio; Martin-Fonseca, Samuel; Garcia-Granados, Andres; Ferrer-Martin, Rosa M.; Lupianez, Jose A.; Parra, Andres; European Journal of Medicinal Chemistry; vol. 118; (2016); p. 64 – 78;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics