Tag: M.W=250-300

Bojarska, Joanna; Fruzinski, Andrzej; Sieron, Leslaw; Maniukiewicz, Waldemar published the artcile< The first insight into the supramolecular structures of popular drug repaglinide: Focus on intermolecular interactions in antidiabetic agents>, SDS of cas: 94-20-2, the main research area is antidiabetic drug repaglinide crystal structure.

This work is the first, according to our knowledge, complete structural report on the solid-state supramol. architecture of antidiabetic drug repaglinide. Here, we present a series of four crystal structures, namely: an un-solvated form of repaglinide (1), repaglinide hydrochloride (2), repaglinide monohydrate (3) and repaglinide methanol solvate (4), successfully determined and fully characterized by the single-crystal X-ray diffraction method (SC-XRD) at 100 K. The (1) and (2) crystallize in the orthorhombic P212121 space group with Z = 1, while solvates exist in triclinic P-1 with Z = 2. The hierarchy and interplay of various intra- and intermol. interactions in the creation of a 3-D supramol. assembly using different finite groups (D), rings (R) and infinite chains (C) graph-set motifs are discussed in detail. A particular focus is put on unique halogen-bonded supramol. synthons. Interestingly, in (2) structure, an intramol. cyclic ring S(8) synthon was found as a consequence of the NH+ group. Solvent and water mols. play a significant role in the formation of supramol. architectures in the context of large synthons, the so-called long-range synthon Aufbau modules (LSAM) at the higher level of the crystal organization. A qual. and quant. comparative investigation of intercontacts nature between the adjacent mols. in the crystal, govering the supramol. assemblies, with respect to other members of the glinides family – nateglinide and also related antidiabetic benzoic acid derivatives, retrieved from the Cambridge Structural Database (version 5.39, update Feb. 2018 release) was supported by 3-D Hirshfeld surface maps and the associated 2-D fingerprint plots anal. visualizing all intercontacts at once and contributing them to the total surface for each compound It revealed numerous interactions mainly H···H, O···H, C···H (C-H…π), but also Cl···H(O, C) C···C (π…π), N···H(O), C···O (π…lone pair), O···O (lone pair…lone pair) cooperatively participating in stabilization of the supramol. structures of this class of APIs.

Journal of Molecular Structure published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, SDS of cas: 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Momoh, T. B.; Hassan, A. O.; Abaniwo, R. M.; Ojade, F. E.; Olorunnado, G. B. published the artcile< Effect of aqueous leaf extract of Uvariaopsis tripetala on hyperglycaemia, weight loss, polydipsia and polyphagia in alloxan- induced diabetic Wistar rats>, Synthetic Route of 94-20-2, the main research area is Uvariopsis leaf antidiabetic hyperglycemia weight loss polydipsia polyphagi diabetes.

Diabetes, a disorder characterized by hyperglycemia is the leading cause of death in developed, developing and underdeveloped nations around the world today. According to World Health Organization (WHO), its incidence is increasing and assuming epidemic proportions. In this chronic study the antidiabetic effect of orally administered aqueous crude leaf extract of the Uvariopsis tripetala was investigated in Alloxan (150mg/kg) induced diabetic albino rats. The results obtained indicated that after administration of the aqueous extract at different dosages (100, 200, 400 mg/kg body weight) for twenty eight (28) days, there was a time and dosedependent significant (P< 0.05) reduction in FBS on days 7, 14, 21 and 28 compared to diabetic control. The body weight of rats in the treatment groups showed no statistically significant (P>0.05) difference on days 7 and 14 compared to diabetic control. However, a dose-dependent significant (P<0.05) increase was produced by the extract when compared to the diabetic control on days 21 and 28. The extract also showed time and dose-dependent significant (P< 0.05) reduction in food and water consumption in weeks 1, 2, 3 and 4 compared to diabetic control. It was concluded that the aqueous extract of U. tripetala exhibited anti-diabetic properties. Hence this plant may serve as a good candidate for alternative and/or complimentary medicine in the management of diabetes. International Journal of Current Research in Chemistry and Pharmaceutical Sciences published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Synthetic Route of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Satibi, Satibi; Fudholi, Achmad; Amrullah, Hafizh; Itsnayain, Aya Shaufia published the artcile< The impact of training on the storage of high alert drugs: a quasi experimental study>, SDS of cas: 94-20-2, the main research area is training impact high alert drug storage.

A medication error can cause severe injury for the patient, even mortality, and that can be prevented. Preventing medication error is done by upgrading the drugs administrators knowledge at the Community Health Center in handling the high alert drugs. One of the possibility is by training. This research is conducted to understand the influence of training toward the suitability of high alert drugs storage. This research constitutes quasi-exptl. design with pre and post-anal. approach along with by using a control group as a comparison. The population of research consists of all of community health center drugs administrators in Ogan Komering Ilir Regency and Mataram City. The sample of research are the drugs administrators, Human Resources, who work at the Community health center of Ogan Komering Ilir and Mataram city were chosen to use non-probability sample. The intervention was conducted toward the drugs administrators with the material that has been standardized by the Ministry of Health of the Republic of Indonesia. The instrument is in the form of List of Visit that has been validated to assess the suitability of high alert drugs storage at Community health center by using SPSS-23 with Wilcoxon Signed Rank and Mann-Whitney U tests. The result of the research shows that the majority of the Intervention group of Community health center (83,33%) the storage of high alert drugs is appropriate with the standard after training. The percentage difference of the appropriate high alert drugs storage test between intervention group and control group after the training (p<0,05). International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about Chemists. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, SDS of cas: 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kennedy, Kaitlin E.; Teng, Chengwen; Patek, Taylor M.; Frei, Christopher R. published the artcile< Hypoglycemia Associated with Antibiotics Alone and in Combination with Sulfonylureas and Meglitinides: An Epidemiologic Surveillance Study of the FDA Adverse Event Reporting System (FAERS)>, Electric Literature of 94-20-2, the main research area is clarithromycin antibiotic sulfonylureas hypoglycemia.

Fluoroquinolones, clarithromycin, linezolid, tigecycline, cefditoren, doxycycline, and trimethoprim-sulfamethoxazole are known to be associated with hypoglycemia, but few studies have considered concomitant glucose-lowering medications. The objective of this study was to evaluate the association between hypoglycemia and antibiotics using the US Food and Drug Administration Adverse Event Reporting System (FAERS), while accounting for concomitant glucose-lowering medications including sulfonylureas and meglitinides. FAERS reports from 1 Jan. 2004 to 31 Dec. 2017 were included in the study. Reporting odds ratios (RORs) and corresponding 95% confidence intervals (CIs) for the association between antibiotics and hypoglycemia were calculated An association was considered to be statistically significant when the lower limit of the 95% CI was > 1.0. A total of 2,334,959 reports (including 18,466 hypoglycemia reports) were considered, after inclusion criteria were applied. Statistically significant hypoglycemia RORs (95% CI) for antibiotics were: cefditoren 14.03 (8.93-22.03), tigecycline 3.32 (1.95-5.65), clarithromycin 2.41 (1.89-3.08), ertapenem 2.07 (1.14-3.75), moxifloxacin 2.06 (1.59-2.65), levofloxacin 1.66 (1.37-2.01), and linezolid 1.54 (1.07-2.20). After adjusting for concomitant sulfonylureas and meglitinides, the following antibiotics were still significantly associated with hypoglycemia: cefditoren 14.25 (9.08-22.39), tigecycline 3.34 (1.96-5.68), ertapenem 1.93 (1.03-3.60), and clarithromycin 1.56 (1.15-2.11). Conclusion: In many patients, antibiotics, including fluoroquinolones, are associated with hypoglycemia when they are also taking sulfonylureas or meglitinides. Cefditoren, tigecycline, ertapenem, and clarithromycin are associated with hypoglycemia even if not taken with sulfonylureas or meglitinides. The association between ertapenem and hypoglycemia has not been previously reported.

Drug Safety published new progress about Antibiotics. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Belenguer, Ana M.; Cruz-Cabeza, Aurora J.; Lampronti, Giulio I.; Sanders, Jeremy K. M. published the artcile< On the prevalence of smooth polymorphs at the nanoscale: implications for pharmaceuticals>, SDS of cas: 94-20-2, the main research area is polymorph D sorbitol chlorpropamide acetonitrile anthranilic acid nanoscale crystallite.

We demonstrate, for four different systems of pharmaceutical relevance, that ball mill grinding leads to different polymorphic transformations depending on the milling conditions. In all four cases, the com. polymorph converts to a different polymorph upon ball-mill neat grinding (NG). This transformation can be reversed by grinding the so obtained polymorph in the presence of small amounts of solvent (LAG), leading back to the com. polymorph. Scherrer particle size determinations reveal that NG conditions almost always lead to smaller particle sizes in the nanometer length scales. Computational studies confirm that polymorphs obtained by the specific ball mill LAG conditions reported correspond to the lowest lattice energy forms. Our study further confirms our earlier conclusions that, at the nanoscale, polymorphs with higher lattice energies can become the thermodynamically stable forms if their surfaces are more stable than those of the polymorphs obtained by LAG. We found, however, one exception to this trend in D-sorbitol. We observe that polymorphs with smoother surfaces (low roughness) are usually the ones observed by NG. This observation points to a link between surface roughness and surface stability.

CrystEngComm published new progress about Cell morphology. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, SDS of cas: 94-20-2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics