Tag: M.W=200-250

Deb, S. B.; Gamare, J. S.; Kannan, S.; Drew, M. G. B. published the artcile< Uranyl(VI) and lanthanum(III) thio-diglycolamides complexes: Synthesis and structural studies involving nitrate complexation>, Application of C10H20ClNO, the main research area is thiodiglycolamide preparation complexation uranyl lanthanum nitrate; crystal structure uranyl lanthanum thiodiglycolamide nitrato complex; solvent extraction uranyl cation nitric acid medium thiodiglycolamide ligand.

New tri-functional ligands R2NCOCH2SCH2CONR2 (R = iso-Pr, Bu or iso-butyl) were prepared and characterized. The coordination chem. of these ligands with uranyl and lanthanum(III) nitrates was studied by using the IR, 1H NMR and elemental anal. methods. Structures for [UO2(NO3)2(iPr2NCOCH2SCH2CONiPr2)], [UO2(NO3)2(iBu2NCOCH2SCH2CONiBu2)], [La(NO3)3(iPr2NCOCH2SCH2CONiPr2)2] and [La(NO3)3(iBu2NCOCH2SCH2CONiBu2)2] were determined by single crystal x-ray diffraction. These structures show that the ligand acts as a bidentate chelating ligand and bonds through both the carbamoyl groups to the uranyl and La(III) nitrate groups. Solvent extraction studies show that the ligand can extract the uranyl ion from the HNO3 medium but does not show any ability to extract the Am(III) ion.

Polyhedron published new progress about Crystal structure. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Application of C10H20ClNO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moss, Steven J.; Bobardt, Michael; Leyssen, Pieter; Coates, Nigel; Chatterji, Udayan; Xie, Dejian; Foster, Teresa; Liu, Jinlun; Nur-e-Alam, Mohammad; Suthar, Dipen; Chen, Yongsheng; Warneck, Tony; Zhang, Ming-Qiang; Neyts, Johan; Gallay, Philippe; Wilkinson, Barrie; Gregory, Matthew A. published the artcile< Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection>, Category: amides-buliding-blocks, the main research area is sangamide cyclophilin inhibitor HCV antiviral.

Sangamides are amide derivatives of sanglifehrin A, a cyclophilin-binding polyketide natural product which is structurally distinct from cyclosporine A. Cyclosporine A is the starting point for the synthesis of cyclophilin inhibitors such as alisporivir, currently in development for the treatment of HCV infection. We report here initial results of the optimization program which led to identification of the sangamides, compounds that exhibit significantly improved potential for the treatment of chronic HCV infection.

MedChemComm published new progress about Antiviral agents. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Fan; Wu, Dang; Wang, Gao-Lei; Hou, Shuang; Ping, Ou-Yang; Huang, Jin; Xu, Xiao-Yong published the artcile< Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors>, COA of Formula: C7H7BrN2O, the main research area is thiazolidinyl benzotriazinone preparation leukotriene hydrolase inhibition mol docking SAR.

A series of novel 1,2,3-benzotriazin-4-one derivatives I [R = H, 6-O2N, 7-Cl, etc.; X = (CH2)n; n = 0, 1, 2, 3, 4] were designed, synthesized and their inhibitory activities against leukotriene A4 hydrolase aminopeptidase in-vitro were evaluated. Many compounds showed moderate to good activities at the concentration of 10 μmol/L. Among them, compound I [R = 7-Cl; X = (CH2)4 (II)] exhibited the highest inhibitory activity up to 80.6% with an IC50 of 1.30 ± 0.20 μmol/L. The compound II was also tested for the proliferation inhibitory activities in THP1 human AML cell line and its binding model with LTA4H enzyme by mol. docking was studied. It indicated that 1,2,3-benzotriazin-4-one was a promising scaffold for further study. The relationship between structure and inhibitory activity was also preliminarily discussed.

Chinese Chemical Letters published new progress about Alkylation. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, COA of Formula: C7H7BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Raut, Dhaval R.; Sharma, Shikha; Ghosh, Sunil K.; Mohapatra, Prasanta K. published the artcile< Glycolamide-functionalized ionic liquid: Synthesis and actinide ion extraction studies>, Related Products of 5326-82-9, the main research area is glycolamide ionic liquid fission product actinide ion extraction enthalpy.

A glycolamide-functionalized ionic liquid (G-FIL) was synthesized for the first time and was evaluated for the extraction of actinide ions such as Am3+, Pu4+ and UO22+ and fission product element ions such as Eu3+, Sr2+ and Cs+. The extraction of the trivalent metal ions was found to be exceptionally high at low acid concentrations, which rapidly decreased with increasing acidity. In view of the high viscosity of the G-FIL, the studies were carried out using its diluted solution in a com. ionic liquid, viz. 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C4mim][Tf2N]).

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Actinide ions. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Related Products of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Peng; Wang, Xiangzhu; Zhuang, Linghang; Huang, Song; Zhou, Yu; Yan, Yuna; Shen, Ru; Zhang, Fan; Li, Jie; Hu, Qiyue; Liu, Suxing; Zhang, Rumin; Dong, Ping; Wan, Hong; Bai, Chang; He, Feng; Tao, Weikang published the artcile< Discovery of novel spiro compound as RAF kinase inhibitor with in vitro potency against KRAS mutant cancer>, Synthetic Route of 112253-70-0, the main research area is RAF kinase inhibitor KRAS mutant cancer; Kinase inhibitor; Mutation; Paradoxical activation; RAF; RAS; Spiro compound.

The development of RAF inhibitors targeting cancers with wild type RAF kinase and/or RAS mutation has been challenging due to the paradoxical activation of the RAS-RAF-MEK-ERK cascade following RAF inhibitor treatment. Herein is the discovery and optimization of a series of RAF inhibitors with a novel spiro structure. The most potent spiro mol. 9 showed excellent in vitro potency against b/c RAF enzymes and RAS mutant H358 cancer cells with minimal paradoxical RAF signaling activation. Compound 9 also exhibited good drug-like properties as demonstrated by in vitro cytochrome P 450 (CYP), liver microsome stability (LMS) data and moderate oral pharmacokinetics (PK) profiles in rat and mouse.

Bioorganic & Medicinal Chemistry Letters published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (KRAS). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Synthetic Route of 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Chao-Jie; Guo, Xinxin; Zhai, Rui-Qin; Sun, Changning; Xiao, Guokai; Chen, Jin; Wei, Mei-Yan; Shao, Chang-Lun; Gu, Yuchao published the artcile< Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells>, SDS of cas: 112253-70-0, the main research area is trimethoxybenzoyl quinazolinone anticancer discovery preparation human apoptosis; Apoptosis; Cell cycle; Hepatocellular carcinoma; Penipanoid C; Quinazoline.

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the fourth leading cause of cancer-related death worldwide. First-line drugs such as sorafenib provide only a modest benefit to HCC patients. In this study, the gram-scale synthesis of 2-benzoylquinazolin-4(3H)-one skeleton was achieved successfully via the I2/DMSO catalytic system. A series of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives was synthesized and evaluated for their cytotoxic activities against four cancer cell lines, HepG2, Bel-7402, A549, and U251. Among these compounds, I was the most effective one with IC50 values of 1.22μM and 1.71μM against HepG2 and Bel-7402 cells, resp. Mechanistic studies showed that I inhibited hepatocellular carcinoma cell proliferation via arresting cell cycle. Addnl., I induced HepG2 cells apoptosis by inducing reactive oxygen species production and elevating the expression of apoptosis-related proteins. More importantly, I displayed significant in vivo anticancer effects in the HepG2 xenograft models. This suggests that I is a promising lead compound with the potential to be developed as a chemotherapy agent for hepatocellular carcinoma.

European Journal of Medicinal Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, SDS of cas: 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mohiuddin, Ghulam; Reddy, Padala Satyanarayana; Ahmed, Khalil; Ratnam, Chengalvala Venkata published the artcile< Intramolecular 1,3-dipolar cycloadditions. Part 1. A facile synthesis of benzimidazo[1,2-d]- and quinazolino[3,2-d][1,2,3]triazolo[1,5-a][1,4]benzodiazepines>, SDS of cas: 112253-70-0, the main research area is cycloaddition propargyl bromide azidophenylbenzimidazole azidophenylquinazolinone; benzimidazotriazolobenzodiazepine; quinazolinotriazolobenzodiazepine; triazolobenzodiazepine; benzodiazepinotriazole; cyclization azidobenzoate phenylenediamine; aminobenzamide cyclization azidobenzoate; benzamidobenzamide cyclization.

Cyclization of x,2-R1(N3)C6H3CO2H (R1 = H, 5-Br, 4-NO2) with diamine I (R2, R3 = H, Me) gave benzimidazole II, which cyclized with BrCH2CCH to give 9 III. IV (R1 = H, Me, Br, Cl; R2 = H, Br) were similarly prepared

Journal of Chemical Research, Synopses published new progress about 1,3-Dipolar cycloaddition reaction, intramolecular. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, SDS of cas: 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kamlar, Martin; Reiberger, Robert; Nigrini, Martin; Cisarova, Ivana; Vesely, Jan published the artcile< Enantioselective PCCP Bronsted acid-catalyzed aminalization of aldehydes>, Synthetic Route of 112253-70-0, the main research area is dihydroquinazolinone preparation enantioselective; aldehyde anthranilamide aminalization pentacarboxycyclopentadiene Bronsted acid catalyst; Brønsted acid; PCCP; aminalization; organocatalysis; pentacarboxycyclopentadiene.

Here an enantioselective aminalization of aldehydes catalyzed by Bronsted acids based on pentacarboxycyclopentadienes (PCCPs) is presented. The cyclization reaction using readily available anthranilamides as building blocks provides access to valuable 2,3-dihydroquinazolinones containing one stereogenic carbon center with good enantioselectivity (ee up to 80%) and excellent yields (up to 97%).

Beilstein Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Synthetic Route of 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gatrone, Ralph C.; Rickert, Paul G.; Horwitz, E. Philip; Smith, Barbara F.; Bartholdi, Catherine S.; Martinez, Aaron M. published the artcile< Analysis of n-octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide and TRUEX process solvent by gas and liquid chromatography>, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide, the main research area is fuel reprocessing TRUEX solvent analysis chromatog; GC HPLC TRUEX solvent analysis; CMPO extractant analysis GC HPLC; octylphenyldiisobutylcarbamoylmethylphosphine oxide analysis GC HPLC; gas chromatog solvent analysis; liquid chromatog solvent analysis; phosphine oxide organic derivative analysis chromatog.

Complementary anal. procedures using capillary gas chromatog. (GC) and high-performance liquid chromatog. (HPLC) have been developed for the anal. of the TRUEX process solvents (CMPO-TBP-tetrachloroethylene or normal paraffinic hydrocarbons) and the extractant CMPO. GC analyses are accomplished in 20 min using a 15 m × 0.25 μm I.D. DB-5 capillary column with flame ionization detection. The anal. requires derivatization with diazomethane. HPLC analyses are performed in 10 min using a C18 reversed-phase column and a mobile phase consisting of acetonitrile-water-triethylamine (79:29.5:0.5) with refractive index and UV detection. The methods provide information regarding the presence of acidic and neutral impurities in stock extractant, fresh process solvent, and recovered TRUEX solvent.

Journal of Chromatography published new progress about Capillary gas chromatography. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics