Tag: M.W=200-250

Joshi, Vidya; Chaudhari, Rajendra P. published the artcile< Synthesis of some new 4-quinazolinone-2-carboxylic acid esters, -2-carboxamides, -2-carbohydrazides and their tosyl derivatives having potential biological activity>, Formula: C7H7BrN2O, the main research area is quinazolinecarbohydrazide preparation antitubercular.

Quinazolinecarbohydrazides I [R1 = H, Me, OMe, halo, and R2 = H; R1R2 = (CH2O2)] were prepared from the resp. anthranilamides by cyclocondensation with EtO2CCO2Et and subsequent amidation with N2H4; I showed antitubercular activity. Also prepared were tosyl derivatives II.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Tuberculostatics. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Formula: C7H7BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reany, Ofer; Blair, Stephanie; Kataky, Ritu; Parker, David published the artcile< Solution complexation behavior of 1,3,5-trioxycyclohexane based ligands and their evaluation as ionophores for Group IA/IIA metal cations>, Category: amides-buliding-blocks, the main research area is metal selectivity cyclohexanetriol solution complexation ligand conformation hydrogen bond.

A new series of cis,cis-cyclohexane-1,3,5-triol derivatives bearing one, two and three carbamoylalkyl substituents is reported. Ring interconversion promoted by intramol. hydrogen bonding is observed for the mono- and di-alkylated derivatives 3 and 4 depending on solvent polarity. 1H NMR parameters obtained have allowed the calculation of the Gibbs free energy change (ΔG 0) for the trioxa-equatorial ↔ trioxa-axial equilibrium, modeling the conformational changes promoted by ion binding. Selectivity coefficients have been assessed electrochem. using fixed interference methods for the detection of biol. relevant IA/IIA metal cations. Ionophore 4 displays a Nernstian response towards the detection of Ca2+ and logKCa,Mpot values are calculated Solution NMR studies confirm the formation of 1:1 complexes for 4 with lithium, while 2:1 complexation is favored with Ca2+. Detailed ES-MS studies performed under controlled conditions revealed similar trends in ion binding.

Perkin 2 published new progress about Alkali metal ions Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vats, Bal Govind; Gamare, Jayashree S.; Kannan, S.; Pius, I. C.; Noronha, D. M.; Kumar, M. published the artcile< Synthesis, structural and extraction studies of new bifunctional ligand with uranium>, Related Products of 5326-82-9, the main research area is crystal structure uranyl isobutylcarbamoylthio pyridyloxide; uranyl alkylcarbamoylthio pyridyloxide preparation; actinide solvent extraction alkylcarbamoylthio pyridyloxide.

A new bifunctional ligand system (N,N-dialkyl carbamoyl Me) (2-pyridyl-N-Oxide) sulfide C5H4NOSCH2CONR2, (R = isopropyl (L1), isobutyl (L2) and Bu (L3) and octyl (L4)) were synthesized. The coordination chem. of this ligand system with UO2(NO3)2·6H2O was studied. All the ligands and complexes were characterized by CHN, IR and NMR techniques. Single crystal x-ray study of 2 shows that the U atom is surrounded by eight O atoms in a hexagonal-bi-pyramidal geometry. The ligand is bonded to metal through carbamoyl and N-oxide groups in a chelating fashion. Thermogravimetric studies of the complexes shows that the ligands are completely incinerable. Extraction studies of the actinides with ligand L4 show that this new bifunctional ligand has very good distribution ratio (D) values for tetravalent and hexavalent actinides ions from HNO3 medium.

Inorganica Chimica Acta published new progress about Actinides Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Related Products of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Zhiqing; Chen, Haiying; Wang, Pingyuan; Li, Yi; Wold, Eric A.; Leonard, Paul G.; Joseph, Sarah; Brasier, Allan R.; Tian, Bing; Zhou, Jia published the artcile< Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation>, SDS of cas: 112253-70-0, the main research area is arylquinazolinone arylchromone preparation inhibitor BRD4 antiinflammatory agent; structure arylquinazolinone arylchromone antiinflammatory activity inhibition BRD4; selectivity arylchromone inhibition BRD4 pharmacokinetics metabolism hERG CYP.

Arylquinazolinones and arylchromenones such as I (X = CH2, MeN) were prepared as selective inhibitors of bromodomain-containing protein 4 (BRD4) for potential use as orally bioavailable antiinflammatory agents. I inhibited BRD4 with IC50 values of 67-84 nM and were selective for BRD1 over binding domains of BRD2, BRD3, and BRDT and over CBP; I inhibited the expression of Toll-like receptor (TLR3)-induced inflammatory genes in vitro and inhibited airway inflammation in mice. The pharmacokinetics (t1/2, AUC, Cmax, and clearance), metabolic stability of I (X = NMe) in murine and human cells, and inhibition of cytochrome P450 enzymes and hERG by I (X = MeN) were determined The structure of I (X = NMe) bound to human BRD4 binding domain 1 was determined by X-ray crystallog.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, SDS of cas: 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Sharma, Joti N. published the artcile< Sorption of ruthenium by dipropylmethyl-2-(N,N-diisobutyl) acetamidoammonium iodide impregnated Amberlite XAD-4 resin from nitric acid medium>, Safety of 2-Chloro-N,N-diisobutylacetamide, the main research area is ruthenium dipropylmethyldiisobutyl acetamidoammonium iodide Amberlite impregnation nitric acid sorption.

Dipropylmethyl-2-(N,N-diisobutyl)acetamidoammonium iodide has been impregnated on Amberlite XAD-4 resin and investigated for sorption of Ru from nitric acid medium. Equilibrium sorption data for Ru uptake were represented well by the Langmuir isotherm equation (R2 = 0.98) compared to Freundlich isotherm equation (R2 = 0.86). The maximum monolayer coverage (Q0) value of 6.25 mg/g as obtained from Langmuir isotherm was close to the exptl. value (5.63 mg/g). The heterogeneity parameter (1/n) = 0.37 obtained from the slope of Freundlich isotherm indicates slight heterogeneity in sorption process. Aqueous solutions of 5% ammonia or 10% sodium hydroxide were found suitable for desorption. The method can be applied for separation of Ru from acidic waste solutions

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Desorption. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Safety of 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gao, Zhenhua; Guo, Huichuang; Guo, Yongbiao; Zhu, Xiaxia published the artcile< General and Efficient Synthesis of Quinazolinones under CF3COOH Catalysis and Solvent-Free Conditions>, Computed Properties of 112253-70-0, the main research area is quinazolinone green preparation; benzamide ortho ester condensation trifluoroacetic acid catalyst.

Herein, the general and facile synthesis of quinazolinones I [R = H, 7-OH, 4-F, etc.; X = N, NH; R1 = H, Ph, 4-MeC6H4, etc.] by condensation of ortho ester as C1 synthon wirh 2-aminobenzamides and CF3COOH as the catalyst under solvent-free conditions was reported. This represented one of the most mild, practical and user-friendly methodologies with easy-separation procedure.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Computed Properties of 112253-70-0.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Ruifeng; Guo, Wei; Wang, Gaolei; Chen, Xiulei; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is benzotriazinone benzothiadiazole derivative preparation nematocide Meloidogyne; 1,2,3-benzotriazin-4-one; Benzo[d][1,2,3]thiadiazole; Meloidogyne incognita; Nematicidal activity; Plant activator.

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, I and II showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, resp. The influence of substituent type and position was studied. The relation between structure and activity was also preliminary analyzed.

Bioorganic & Medicinal Chemistry Letters published new progress about Meloidogyne incognita. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Crowe, Matthew C.; Kapoor, Ramesh N.; Cervantes-Lee, Francisco; Parkanyi, Laszlo; Schulte, Louis; Pannell, Keith H.; Brodbelt, Jennifer S. published the artcile< Investigating Bidentate and Tridentate Carbamoylmethylphosphine Oxide Ligand Interactions with Rare-Earth Elements Using Electrospray Ionization Quadrupole Ion Trap Mass Spectrometry>, Safety of 2-Chloro-N,N-diisobutylacetamide, the main research area is bidentate tridentate carbamoylmethylphosphine oxide ligand extractant rare earth element.

Electrospray ionization (ESI) quadrupole ion trap mass spectrometry (QIT-MS) and collisionally activated dissociation (CAD) were used to evaluate the rare-earth binding properties of two hydrophobic carbamoylmethylphosphine oxide (CMPO) ligands, the normal bidentate variety, (t-BuC6H4)2P(O)CH2C(O)N(i-Bu)2 (A), a new potentially tridentate extractant, (t-BuC6H4)2P(O)CH[CH2C(O)N(i-Bu)2]C(O)N(i-Bu)2 (B), and tri-Bu phosphate. The mass spectral results obtained from anal. of 1% HNO3/methanol solution containing the ligands and dissolved lanthanide salts reveal that the favorable stoichiometries of the ligand/metal/nitrate complexes are 2:1:2 for the bidentate ligand A, 1:1:2 for the tridentate ligand B, and 3:1:2 for the monodentate tri-Bu phosphate. These observed stoichiometries correlate with the number of available binding sites on each ligand as well as with potential steric effects. Energy-variable collisionally activated dissociation experiments showed that for the 2:1:2 complexes involving ligand A or B, as the ionic radius of the bound metal decreased, the removal of nitric acid required less energy and resulted in less extensive spontaneous solvent coordination. This exptl. trend suggests that, as the ionic radius of the lanthanide ion decreases, a pair of the carbamoylmethylphosphine ligands is able to more completely solvate the bound metal ion thereby weakening the nitrate-metal interaction.

Inorganic Chemistry published new progress about Chelating agents. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Safety of 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Kumar, Mukesh; Sharma, Joti N. published the artcile< Synthesis and X-ray crystallographic characterization of two different inorganic-organic hybrid isopolyoxomolybdates with α-dipropylammonium N,N-diisobutylacetamide by varying reaction conditions>, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide, the main research area is propylammonium diisobutylacetamide polyoxomolybdate complex preparation crystal structure.

Two new polyoxomolybdate based inorganic-organic hybrid compounds were obtained from same ammonium ion ligand 1 and molybdate source just by altering reaction conditions. The new hybrid polyoxomolybdate complexes (LH)2[Mo6O19] 3 and (LH)4[Mo8O26](MeCN)2 4 have distinct structural features revealed by x-ray crystallog. studies. The complex 3 contains two ammonium ligands to balance the charge on hexamolybdate dianion. The most striking feature of (LH)2[Mo6O19] is the presence of inter-ligand hydrogen bonding (N-H···O:C) between two ligands arranged in an antiparallel fashion that favors the formation of a net like structure which embeds the Mo6O19 dianion. The complex 4 contains four ammonium ligands to balance the charge on β-octamolybdate tetraanion. Complex 4 exhibits strong hydrogen-bonding interactions between ammonium ligand and octamolybdate anion (N-H···O-Mo) and no inter-ligand H-bonding interaction. The different structural features of hybrid compounds 3 and 4 suggest that different polyoxomolybdate clusters play a key role in the process of assembling of ligands.

Polyhedron published new progress about Crystal structure. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V. published the artcile< Iridium(III)-Catalyzed Alkynylation of 2-(Hetero)arylquinazolin-4-one Scaffolds via C-H Bond Activation>, Product Details of C7H7BrN2O, the main research area is alkynylarylquinazolinone derivative preparation; arylquinazolinone ethynylbenziodoxolone alkynylation iridium catalyst.

The directed C-H alkynylation of 2-(hetero)arylquinazolin-4-ones has been explored with the ethynylbenziodoxolone reagent TIPS-EBX employing an Ir(III) catalyst. Complementary conditions for either monoalkynylation or dialkynylation have been developed. Also demonstrated is the broad scope of this reaction and the compatibility of various functional groups such as -F, -Cl, -Br, -CF3, -OMe, -NO2, and alkyl, etc.

Journal of Organic Chemistry published new progress about Alkynylation. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Product Details of C7H7BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics