Tag: M.W=200-250

Yi, Xuewen published the artcileCopper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant, Related Products of amides-buliding-blocks, the main research area is copper catalyzed radical demethylation amide fluorobenzenesulfonimide.

An unprecedented N-demethylation of N-Me amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (carbinol). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Ze-Ming published the artcileExogenous Photosensitizer-, Metal-, and Base-Free Visible-Light-Promoted C-H Thiolation via Reverse Hydrogen Atom Transfer, Safety of 4-Methoxy-N-phenylbenzamide, the main research area is benzothiazole preparation; photochem oxidative cyclization arylthioamide TEMPO catalyst; oxidative photochem intramol thiolation arylthioamide TEMPO catalyst; mechanism kinetics kinetic isotope effect photochem oxidative cyclization arylthioamide; reduction oxidation potential arylthioamide TEMPO.

N-Arylthioamides such as N-phenylthiobenzamide underwent photochem. visible-light oxidative cyclization reactions in the presence of TEMPO to yield benzothiazoles such as 2-phenylbenzothiazole without added photosensitizer, metal catalyst, or base. The mechanism of the reaction was studied by evaluation of the oxidation and reduction potentials of TEMPO and of selected reactants, determination of the kinetics of and kinetic isotope effects on the reaction, and mass spectrometric identification of reaction intermediates. The reaction likely occurs by absorption of visible light by thioamides to generate their excited states which undergo reverse hydrogen-atom transfer (RHAT) with 2,2,6,6-tetramethylpiperidine N-oxyl to form sulfur radicals; cyclization of the sulfur radicals onto the aryl ring followed by rearomatization via RHAT yields the benzothiazole products.

Organic Letters published new progress about Isotope effect. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Safety of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Manohar, Smitha; Sharma, J. N.; Shah, B. V.; Wattal, P. K. published the artcile< Process development for bulk separation of trivalent actinides and lanthanides from radioactive high-level liquid waste>, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide, the main research area is actinide lanthanide solvent extraction radioactive liquid waste.

Inhouse R and D studies resulted in the development of processes for the bulk separation of trivalent actinides and lanthanides from radioactive high-level liquid waste. Synthesis of solvents, namely, n-octyl (phenyl)-N,N-di-iso-Bu carbamoyl Me phosphine oxide and diglycolamide-based tetra (2-ethylhexyl) diglycolamide (TEHDGA), at the required purity was carried out, and a suitable process for their resp. use in actual application was developed. Inactive scale engineering runs comprised of simultaneous extraction and stripping operations were carried out to establish the process on an engineering scale, including reuse of the solvent system. The composition of surrogate high-level waste (HLW) used at engineering-scale studies corresponds to 1st-cycle raffinate from reprocessing of long-cooled pressurized D2O reactor fuel with a burnup of 6500 MWd/ton. Since trivalent lanthanides and actinides exhibits similar extraction behavior at higher acidity, Ce and La were only used in making surrogate HLW to represent all the trivalent lanthanides and actinides. Indigenously developed mixer-settlers using a passive system of mixing were used for these runs. Over a period of ∼10 h, ∼ 300 e of surrogate HLW solutions were contacted with solvent. The results of such repeated trials showed near-total removal of Ce and La (>99.8% and 97%, resp.) at aqueous-to-organic ratio of 2.5:1 for a TEHDGA system. As the distribution coefficient values for trivalent actinide (241Am) are significantly higher than those for trivalent lanthanides for both of the solvent systems under consideration, it can be inferred that separation of trivalent actinides along with lanthanides could be feasible using these solvent systems.

Nuclear Science and Engineering published new progress about Actinides Role: REM (Removal or Disposal), PROC (Process). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Recommanded Product: 2-Chloro-N,N-diisobutylacetamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gao-Lei; Chen, Xi; Chang, Ya-Ning; Du, Dan; Li, Zhong; Xu, Xiao-Yong published the artcile< Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation>, Safety of 2-Amino-4-bromobenzamide, the main research area is spirocycle indolinone benzotriazinone derivative preparation nematicidal.

To discover new chemotypes of nematicides with proper toxicol. profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 1-(4-(4-oxo-7-methoxylbenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one and 1-(4-(4-oxo-7-nitrobenzo[d][1,2,3]triazin-3(4H)-yl)butyl)spiro[indoline-3,2′-[1,3]dioxolan]-2-one displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

Chinese Chemical Letters published new progress about Nematocides. 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Safety of 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Shikha; Ghosh, Sunil K.; Anitha, M.; Sharma, Joti N. published the artcile< α-Dialkylamino N,N-diisobutylacetamides: a new class of anion exchanger with intramolecular buffering properties>, Reference of 5326-82-9, the main research area is molybdenum dialkylamino diisobutylacetamide anion exchanger intramol buffering.

A new class of ammonium based anion exchangers embedded with a terminal amide group, viz. α-dialkylamino N,N-diisobutylacetamides was designed, synthesized and tested for their ability to extract oxometalate anions from HNO3 medium. As a representative example, the molybdate anion was chosen for the present studies and its extraction behavior was compared with routinely used anion exchangers like Alamine 336, Aliquat 336 and Primene JMT having no amide functionality. A higher %E value for molybdate was observed with α-dialkylamino N,N-diisobutylacetamides compared to Alamine 336, Aliquat 336 and Primene JMT, from the same HNO3 acidity. The presence of amide group in the ligand is the key to the success of extraction from a relatively higher concentration of HNO3 medium. The amide group in the extractant leads to extra acidity through the intramol. buffering effect thus enabling the ligand to extract the molybdate anion at higher acidities. Stoichiometry of the ion pair formed during extraction was ascertained by the slope anal. method. The composition of the complex is (LH)2MoO4·HNO3. FTIR and NMR of the loaded extractant indicated that MoO42- is associated with the ammonium site while binding of HNO3 occurred at the amide group.

RSC Advances published new progress about Amines, C16-22-tert-alkyl Role: RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (Primene JMT). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Reference of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Gaolei; Chen, Xiulei; Deng, Yayun; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is nematicide benzotriazinone derivative preparation Meloidogyne pest control; 1,2,3-benzotriazin-4-one; 2-cyanoiminothiazolidin-4-one; Meloidogyne incognita; in vivo; nematicide.

A series of novel 1,2,3-benzotriazin-4-one derivatives (I) where R is H, Cl, Br, etc.; and n = 1,2,3,or 4; were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the mol. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.

Journal of Agricultural and Food Chemistry published new progress about Cucumis sativus, disease (root knot nematode, control of). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rittner, Roberto; Canto, Eduardo L.; Grehs, Juares; Zanatta, Nilo published the artcile< Carbon-13 NMR chemical shift substituent effects. α-Mono-substituted N-acetyl-2,2-dimethylaziridines>, Application In Synthesis of 5326-82-9, the main research area is NMR acetyldimethylaziridine.

1H and 13C NMR chem. shifts for N-acetylaziridine, N-acetyl-2-methylaziridine and from some α-monosubstituted-N-acetyl-2,2-dimethylaziridines were recorded. The carbonyl carbon shieldings were compared to the corresponding shieldings of mono-substituted propanones, Me acetates and N,N-diethylacetamides, and were also empirically estimated by Tanaka et al.’s equation. A non-additivity of substituent chem. shifts was observed for the α-methylene carbon, but both the α-methylene carbon as the proton chem. shifts, correlate well with the same nuclei shifts of the three series of monosubstituted carbonyl compounds The Me group’s additivity effects on the remaining carbons are briefly discussed.

Spectroscopy (Amsterdam, Netherlands) published new progress about NMR (nuclear magnetic resonance). 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Application In Synthesis of 5326-82-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheng, Dongping; Yan, Xianhang; Pu, Yueqi; Shen, Jing; Xu, Xiaoliang; Yan, Jizhong published the artcile< 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-Mediated Tandem Oxidative Annulation for Preparing 2,2-Disubstituted 2,3-Dihydroquinazolin-4(1H)-ones>, Product Details of C7H7BrN2O, the main research area is aminobenzamide diarylpropene DDQ tandem oxidative annulation; dihydroquinazolinone preparation.

An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described. This transformation proceeds from easily available o-aminobenzamides and 1,3-diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.

European Journal of Organic Chemistry published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (1,3-diarylpropenes). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Product Details of C7H7BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bhargava, P. N.; Singh, H. D. published the artcile< Synthesis of 3-aryl-6-bromo-2-(substituted)-thio-4(3H)-quinazolones as CNS depressants>, Application of C10H20ClNO, the main research area is quinazolone preparation central depressant.

Fourteen new 3-aryl-6-bromo-2-(N,N-dialkylcarboxamidomethylthio)-4(3H)quinazolones were prepared Pharmacol. screening indicates that 6-bromo-2-(N,N-diisobutylcarboxamidomethylthio)-3-phenyl-, 6-bromo-2-(N,N-dibenzylcarboxamidomethylthio)-3-p-chlorophenyl- and 6-bromo-2-(N,N-dibenzylcarboxamidomethylthio)-3-p-methoxyphenyl-4(3H)quinazolones possess CNS depressant activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Nervous system depressants. 5326-82-9 belongs to class amides-buliding-blocks, and the molecular formula is C10H20ClNO, Application of C10H20ClNO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Weikang; Meng, Chong; Liu, Yan; Tang, Yawen; Li, Feng published the artcile< Auto-Tandem Catalysis with Ruthenium: From o-Aminobenzamides and Allylic Alcohols to Quinazolinones via Redox Isomerization/Acceptorless Dehydrogenation>, Recommanded Product: 2-Amino-4-bromobenzamide, the main research area is quinazolinone preparation; aminobenzamide alc tandem redox isomerization dehydrogenation ruthenium catalyst microwave.

A strategy for the synthesis of quinazolinones I [R = H, 7-Me, 6,8-di-Cl, etc.; R1 = Et, i-Pr, n-Bu, etc.; R2 = H, n-Bu, Bn] was proposed via Ru-catalyzed redox isomerization/acceptorless dehydrogenation of o-aminobenzamides with allylic alcs. and was obtained in moderate to high yields. This strategy was attractive due to high atom efficiency, minimal consumption of chems. and energy.

Advanced Synthesis & Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112253-70-0 belongs to class amides-buliding-blocks, and the molecular formula is C7H7BrN2O, Recommanded Product: 2-Amino-4-bromobenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics