Tag: M.W=200-250

Adegboyega, Abdullahi K. published the artcileReaction of Dioxazolones with Boronic Acids: Copper-Mediated Synthesis of N-Aryl Amides via N-Acyl Nitrenes, HPLC of Formula: 7465-88-5, the main research area is aryl amide preparation; dioxazolone boronic acid copper mediated reaction.

Dioxazolones, as direct amide sources, have been used with boronic acids in the presence of copper(I) chloride to access N-aryl amides at room temperature The versatility of the developed reaction is proven by ample scope having a wide range of functional group tolerance. The reaction optimization conditions revealed that a fluorine additive demonstrated improved reactivity toward the intended transformation. The addition of triphenylphosphine resulted in N-acyl iminophosphorane, suggesting the involvement of an N-acyl nitrene intermediate.

Organic Letters published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, HPLC of Formula: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zuo, Dongxu published the artcileHighly Chemoselective Transamidation of Unactivated Tertiary Amides by Electrophilic N-C(O) Activation by Amide-to-Acyl Iodide Re-routing, Category: amides-buliding-blocks, the main research area is tertiary amide transamidation cooperative catalysis chemoselective; Acyl Iodides; Amides; Cooperative Catalysis; N−C(O) Activation; Transamidation.

The challenging transamidation of unactivated tertiary amides has been accomplished via cooperative acid/iodide catalysis. Most crucially, the method provides a novel manifold to re-route the reactivity of unactivated N,N-dialkyl amides through reactive acyl iodide intermediates, thus reverting the classical order of reactivity of carboxylic acid derivatives This method provides a direct route to amide-to-amide bond interconversion with excellent chemoselectivity using equivalent amounts of amines. The combination of acid and iodide has been identified as the essential factor to activate the amide C-N bond through electrophilic catalytic activation, enabling the production of new desired transamidated products with wide substrate scope of both unactivated amides and amines, including late-stage functionalization of complex APIs (>80 examples). Authors anticipate that this powerful activation mode of unactivated amide bonds will find broad-ranging applications in chem. synthesis.

Angewandte Chemie, International Edition published new progress about Bond activation catalysts (N-C(O) activation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Zijun published the artcilePhotoinduced Transition-Metal-Free Chan-Evans-Lam-Type Coupling: Dual Photoexcitation Mode with Halide Anion Effect, Product Details of C14H13NO2, the main research area is photoinduced transition metal free Chan Evans Lam type coupling.

Herein, we report a photoinduced transition-metal-free C(aryl)-N bond formation between 2,4,6-tri(aryl)boroxines or arylboronic acids as an aryl source and 1,4,2-dioxazol-5-ones (dioxazolones) as an amide coupling partner. Chloride anion, either generated in situ by photodissociation of chlorinated solvent mols. or added sep. as an additive, was found to play a critical cooperative role, thereby giving convenient access to a wide range of synthetically versatile N-arylamides under mild photo conditions. The synthetic virtue of this transition-metal-free Chan-Evans-Lam-type coupling was demonstrated by large-scale reactions, synthesis of 15N-labeled arylamides, and applicability toward biol. relevant compounds On the basis of mechanistic investigations, two distinctive photoexcitations are proposed to function in the current process, in which the first excitation involving chloro-boron adduct facilitates the transition-metal-free activation of dioxazolones by single electron transfer (SET), and the second one enables the otherwise-inoperative 1,2-aryl migration of the thus-formed N-chloroamido-borate adduct.

Journal of the American Chemical Society published new progress about Boroxins Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Product Details of C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tang, Yanling published the artcileEfficient Pd-Catalyzed Hydrodehalogenation of o-Haloanilides in Water, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is anilide green preparation; haloanilide regioselective hydrodehalogenation palladium catalyst.

A practical methodol. for the synthesis of anilides RC(O)NHPh [R = Me, Bn, 4-FC6H4, etc.] via hydrodehalogenation of o-haloanilides using PdCl2 at 100°C under mild conditions in water was developed. The catalytic system could selectively dehalogenate both aryl chloride and aryl bromide and exhibit a broad functional group tolerance.

Synlett published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tian, Chao published the artcileVisible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives, Computed Properties of 7465-88-5, the main research area is visible light regioselective ortho trifluoromethylation aniline Langlois reagent photocatalyst.

A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the “”CF3″” source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives

Journal of Organic Chemistry published new progress about Photocatalysts. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zou, Long published the artcileVisible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst, Formula: C14H13NO2, the main research area is regioselective trifluoromethylation acetaniline photocatalysis.

A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Optimization. 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Formula: C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rottlander, Mario published the artcileMultiple cross-coupling reactions of aryl and benzylic zinc halides with aryl halides and triflates in solid-phase synthesis of polyfunctional aromatics, Formula: C5H4BrNOS, the main research area is aryl zinc halide aryl halide coupling; benzyl zinc halide aryl triflate coupling; cross coupling solid phase aryl halide; benzene solid phase synthesis.

Aryl and benzylic zinc bromides undergo efficient Pd(0)-catalyzed cross-coupling reactions on the solid-phase using either Rink or Wang resin. By performing the cross-couplings with the multi-coupling reagents 4-BrZnCH2C6H4O2CCF3 and 4-BrZnC6H4OSi(CHMe2)3, two successive C-C bond forming reactions are possible on the solid-phase.

Synlett published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 189329-94-0 belongs to class amides-buliding-blocks, name is 5-Bromothiophene-3-carboxamide, and the molecular formula is C5H4BrNOS, Formula: C5H4BrNOS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Dahyeon published the artcileNickel/briphos-catalyzed transamidation of unactivated tertiary amides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is tertiary amide transamidation primary amine nickel briphos catalyst.

The transamidation of tertiary amides was achieved via nickel catalysis in combination with briphos ligands. N-Methyl-N-phenylbenzamide derivatives reacted with primary amines in the presence of NiCl2/briphos ligand to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines.

Organic & Biomolecular Chemistry published new progress about Amides, tertiary Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rahman, Mahbubur Md. published the artcileSynthesis of Sulfoxonium Ylides from Amides by Selective N-C(O) Activation, SDS of cas: 7465-88-5, the main research area is sulfoxonium ylide preparation; amide trimethylsulfoxonium iodide nitrogen carbon cleavage.

The direct synthesis of sulfoxonium ylides from amides by selective N-C(O) cleavage is presented. The reaction proceeds through the nucleophilic addition of dimethylsulfoxonium methylide to the amide bond in acyclic twisted amides under exceedingly mild room temperature conditions. A variety of amides can be employed, and the protocol can be applied to the late-stage derivatization of pharmaceuticals. Mechanistic studies outline the relative order of reactivity of amides.

Organic Letters published new progress about Bond cleavage (N-C(O)). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Du, Jinze published the artcileElectrochemical Oxidative ortho-Selective Trifluoromethylation of N-Arylamides, SDS of cas: 7465-88-5, the main research area is trifluoromethyl arylamide preparation regioselective; arylamide sodium trifluoromethanesulfinate electrochem oxidative trifluoromethylation.

A metal-catalyst-free and external-oxidant-free electrochem. oxidative radical C-H ortho-trifluoromethylation is presented. The reaction specifically occurred at the ortho-position of anilides RC(O)NHC6H4R1 (R = Ph, 2-furyl, 2-naphthyl, Me, etc., R1 = 3-Me, 4-Me, 4-Cl) without directing groups. Various anilides showed good tolerance to provide the desired products I in moderate to good yields. In addition, the gram-scale amplified product of benzanilide was obtained with a yield of 64%, which proved that it has a certain application potential.

ChemElectroChem published new progress about Electrochemical reaction (regioselective). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, SDS of cas: 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics