Tag: M.W=200-250

Li, Qingyao published the artcilePhotomediated reductive coupling of nitroarenes with aldehydes for amide synthesis, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is aryl amide preparation; aldehyde nitroarene reductive coupling photomediated hydrogen atom transfer catalysis.

In view of the widespread significance of amide functional groups in organic synthesis and pharmaceutical studies, an efficient and practical synthetic protocol that avoids the use of stoichiometric activating reagents or metallic reductants is highly desirable. A straight-forward pathway to access amides from abundant chem. feedstock would offer a strategic advantage in the synthesis of complex amides. Authors herein disclose a direct reductive amidation reaction using readily available aldehydes and nitroarenes enabled by photo-mediated hydrogen atom transfer catalysis. It avoids the use of metallic reductants and production of toxic chem. waste. While aldehydes represent a classic class of electrophilic synthons, the corresponding nucleophilic acyl radicals could be directly accessed by photo hydrogen atom transfer catalysis, enabling polarity inversion. Authors method provides an orthogonal strategy to conventional amide couplings, tolerating nucleophilic substituents such as free alcs. and sensitive functional groups to amines such as carbonyl or formyl groups. The synthetic utilization of this reductive amidation is demonstrated by the late-stage modification of complex biol. active mols. and direct access of drug mols. leflunomide and lidocaine.

Chemical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xiong, Ni published the artcileMild Amide Synthesis Using Nitrobenzene under Neutral Conditions, Related Products of amides-buliding-blocks, the main research area is aryl aldehyde nitroarene iron catalyst photochem amidation; aryalkyl alc nitroarene iron catalyst photochem amidation; diaryl amide preparation.

In this report, a mild protocol for amide formation using the readily available nitroarenes as nitrogen sources and an inexpensive iron complex as a catalyst was described. Because of the use of the pH-neutral conditions and the avoidance of the strong oxidant or reductant, a wide range of aromatic and aliphatic aldehydes as well as nitroarenes with various functional groups could be tolerated well. A plausible mechanism was proposed based on the detailed studies, in which iron catalyst initiates the radical process and the solvent plays a key role as O-atom acceptor.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Guoqi published the artcileRedox-Noninnocent Ligand-Supported Vanadium Catalysts for the Chemoselective Reduction of C=X (X = O, N) Functionalities, Computed Properties of 7465-88-5, the main research area is vanadium ligand catalyst reduction ketone aldehyde imine ester carboxamide.

Catalysis is the second largest application for V after its use as an additive to improve steel production Mol. complexes of vanadium(V) are particularly useful and efficient catalysts for oxidation processes; however, their ability to catalyze reductive transformations has yet to be fully explored. Here the authors report the first examples of polar organic functionality reduction mediated by V. Open-shell VIII complexes that feature a π-radical monoanionic 2,2′:6′,2”-terpyridine ligand (Rtpy•)- functionalized at the 4′-position (R = (CH3)3SiCH2, Ph) catalyze mild and chemoselective hydroboration and hydrosilylation of functionalized ketones, aldehydes, imines, esters, and carboxamides with turnover numbers (TONs) of up to ∼1000 and turnover frequencies (TOFs) of up to ∼500 h-1. Computational evaluation of the precatalyst synthesis and activation revealed underappreciated complexity associated with the redox-active tpy chelate.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Computed Properties of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ning, Yunyun published the artcileSite-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis, Quality Control of 7465-88-5, the main research area is nitroalkane carboxylic acid iridium phosphine iron catalyst Umpolung amidation; carboxylic acid nitroarene iridium phosphine iron catalyst Umpolung amidation; aralkyl amide preparation photochem.

In this paper, an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI2, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents were disclosed. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participated smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield). This Umpolung amidation strategy opened a method to address challenging regioselectivity issues between nucleophilic functional groups and complemented the functional group compatibility of the classical amidation protocols. The synthetic robustness of the reaction was demonstrated by late-stage modification of complex mols. and gram-scale applications.

Nature Communications published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sorribes, Ivan published the artcilePalladium doping of In2O3 towards a general and selective catalytic hydrogenation of amides to amines and alcohols, Category: amides-buliding-blocks, the main research area is palladium doping indium oxide catalyst hydrogenation amide amine alc.

Herein, the first general heterogeneous catalytic protocol for the hydrogenation of primary, secondary and tertiary amides to their corresponding amines and alcs. is described. Advantageously, this catalytic protocol works under additive-free conditions and is compatible with the presence of aromatic rings, which are fully retained in the final products. This hydrogenative C-N bond cleavage methodol. is catalyzed by a Pd-doped In2O3 catalyst prepared by a microwave hydrothermal-assisted method followed by calcination. This catalyst displays highly dispersed Pd2+ ionic species in the oxide matrix of In2O3 that have appeared to be essential for its high catalytic performance.

Catalysis Science & Technology published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Le Falher, Laetitia published the artcilePreparation of Halogen-Containing 4H-Pyrido[e][1,3]oxazin-4-ones and Their Transformation into 2-Hydroxypyridinyl-Substituted 1,2,4-Oxadiazoles and 1,2,4-Triazoles, SDS of cas: 13958-99-1, the main research area is pyridylimide sodium salt intramol arylation; pyridooxazinone halo preparation microwave irradiation hydroxylamine cyclocondensation hydrazine; oxadiazole hydroxypyridyl triazole preparation regioselective.

A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones I (R = C6H5, 2-H3CC6H4, 4-ClC6H4, 4-H3COC6H4, etc.; R1 = H, Br) and their transformation into 2-hydroxypyridinyl-substituted 1,2,4-oxadiazoles II (W = O) and 1,2,4-triazoles II (W = NH, NC6H5) is presented. The efficiency of the intramol. O-arylation of pyridyl-imide sodium salts e.g., III was studied on three series of compounds, with different fluoro-, chloro-, and bromophenyl substituents at the C-2 position. The final halogenated compounds I are of interest as new synthons for future functionalization. A rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones IV (R2 = 2-bromo-4-pyridyl, phenyl) were discovered. Finally, the one-step transformation of some of these pyrido-oxazinones I into the corresponding II was explored, and the regioselectivity of the reaction was proved by X-ray crystallog.

European Journal of Organic Chemistry published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, SDS of cas: 13958-99-1.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Rongxiang published the artcileCopper-Catalyzed Regio- and Stereoselective Sulfonylation of Alkynyl Imines with Sulfonyl Hydrazides: Access to (E)-β-Sulfonyl Enones, Related Products of amides-buliding-blocks, the main research area is sulfonyl enone diastereoselective regioselective preparation; alkynyl imine sulfonyl hydrazide stereoselective sulfonylation copper catalyst.

A copper-catalyzed sulfonylation of alkynyl imines with sulfonyl hydrazides was developed, which exhibited excellent regio- and stereoselectivity and furnished a series of (E)-β-sulfonyl enones I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = Ph, 4-ClC6H4, 4-FC6H4, etc.; R = Ph, 4-MeC6H4, 4-BrC6H4, etc.] in moderate to good yields. Mechanistic studies suggested that this strategy goes through a radical process.

Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Shi-Meng published the artcileClickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages, Product Details of C14H13NO2, the main research area is peptide linkage click coupling carboxylic acid amine; amide preparation click coupling carboxylic acid amine sulfonyl fluoride; amine carboxylic acid click coupling sulfonyl fluoride.

A mild, simple, efficient and robust protocol was developed for the synthesis of amides RC(O)NR1R2 [R = Et, Ph, 2-furyl, 4-pyridyl, etc., R1 = H, Et, Bn, etc., R2 = Et, Ph, 3-pyridyl, etc.] via SO2F2-mediated clickable coupling of carboxylic acids with amines. Peptide linkages were also prepared using this methodol. The direct click reactions of acids and amines on gram scale were also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

Organic & Biomolecular Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Product Details of C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Jin published the artcileSynthesis of Amides by Mild Palladium-Catalyzed Aminocarbonylation of Arylsilanes with Amines Enabled by Copper(II) Fluoride, Formula: C14H13NO2, the main research area is preparation amides palladium catalyzed aminocarbonylation arylsilanes amines.

A general Pd-catalyzed synthesis of amides by oxidative aminocarbonylation of arylsilanes under mild conditions was accomplished for the first time. The reaction is promoted by a com. available copper(II) fluoride, which acts as a dual silane activator and mild oxidant, enabling highly efficient aminocarbonylation of versatile arylsilanes at atm. CO pressure. The reaction is tolerant of a wide range of arylsilanes and various sensitive halide functional groups as well as a broad scope of amines are compatible with this oxidative process using cheap CO. A significant aspect involves the increased efficiency by the catalyst system. The reaction represents a segue into the powerful Pd-catalyzed oxidative transformations of organosilanes.

Journal of Organic Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Formula: C14H13NO2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Maegawa, Tomohiro published the artcileThe Reaction of Ketoximes with Hypervalent Iodine Reagents: Beckmann Rearrangement and Hydrolysis to Ketones, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is ketoxime hypervalent iodine Beckmann rearrangement; amide preparation; oxime hypervalent iodine reagent hydrolysis; ketone preparation.

The reaction of ketoximes with hypervalent iodine reagents was investigated. A combination of PhI(OAc) 2 and BF3·Et2O promoted the Beckmann rearrangement of ketoximes, thus yielding the corresponding amides. From a detailed investigation of the reaction, it was determined that the Beckmann rearrangement is preceded by acetylation of the hydroxy group of the ketoxime in situ, accelerating the Beckmann rearrangement. The acetylated ketoxime undergoes the Beckmann rearrangement with BF3·Et2O was confirmed. The reaction of ketoximes with Koser’s reagent [PhI(OH)OTs] in the presence of THF results in hydrolysis, affording the corresponding ketones in high yields at room temperature

Synthesis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics