Tag: M.W=200-250

Slowinski, Franck published the artcileExpeditive Access to 2-Substituted 4H-Pyrido[1,3]oxazin-4-ones via an Intramolecular O-Arylation, COA of Formula: C6H5BrN2O, the main research area is aroyl nicotinamide intramol arylation heterocyclization microwave irradiation; pyrido oxazinone preparation mol crystal structure; microwave irradiation intramol arylation heterocyclization mediator.

Unreported 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones, e.g., I (X-rays single crystal structure shown), are synthesized via an unprecedented intramol. O-arylation of N-aroyl- and N-heteroaroyl-(iso)nicotinamides under microwave irradiations, in good to excellent yields. The broad applicability was demonstrated by 24 examples with a variety of substituents at the 2-position of the final compounds and 3 possible positions for the nitrogen atom of the pyridine ring. In addition, transformation of one of these compounds into 2-hydroxypyridyl-substituted 1,2,4-triazole and 1,2,4-oxazinone was realized. This approach opens a rapid access to a new bicyclic heteroaromatic chem. series with high potential in medicinal chem.

Organic Letters published new progress about Arylation (intramol., O-). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, COA of Formula: C6H5BrN2O.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mkhonazi, Blessing D. published the artcilePalladium-Catalysed Reductive Aminocarbonylation of Aryl Bromides and Iodides with Nitroarenes, Application of 4-Methoxy-N-phenylbenzamide, the main research area is aryl amide preparation; nitroarene bromide aryl iodide palladium catalyzed reductive aminocarbonylation.

Herein, a palladium-catalyzed reductive aminocarbonylation of aryl bromides and iodides with nitroarenes to afford the resp. amides RC(O)NHR1 [R = Ph, 4-MeOC6H4, 3,5-diMeC6H3, etc.; R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.] was reported. The developed protocol employed Mo(CO)6 as a carbonyl source and a combination of Zn and TMSCl as co-reducing agents. For most substrates, the anticipated amide products were obtained in modest to high amide product yields.

SynOpen published new progress about Aminocarbonylation (reductive). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Application of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Rong published the artcileActivated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is aryl benzamide preparation; primary amide aryl iodide Goldberg reaction copper catalyst; lactam aryl iodide Goldberg reaction copper catalyst.

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides RC(O)NH2 (R = Ph, pyridin-3-yl, 3-nitrophenyl, etc.) and lactams such as 3-morpholinone, 2-azaspiro[4.5]decan-1-one, 2-pyridinone with aryl iodides 4-R1C6H4I (R1 = H, OMe, Ac, Br, NO2).

Tetrahedron published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lei, Peng published the artcileProtocol for Palladium/N-Heterocyclic Carbene-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation, Quality Control of 7465-88-5, the main research area is diaryl ketone green preparation; amide arylboronic acid Suzuki Miyaura cross coupling palladium catalyst.

A protocol for the Suzuki-Miyaura cross-coupling of amides by selective N-C(O) bond activation catalyzed by com. available, air- and moisture-stable palladium/N-heterocyclic carbene (NHC) complexes was described to obtain diaryl ketones ArC(O)Ar1 [Ar = Ph, 2-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4; Ar1 = Ph, 2-MeC6H4, 4-MeC6H4, 4-MeOC6H4, 4-CO2MeC6H4]. The procedure described involved [Pd(IPr)(cin)Cl] [IPr = 2,6-(diisopropylphenyl)imidazol-2-ylidene, cin = cinnamyl] at 0.10 mol% at room temperature and was performed on decagram scale. Furthermore, a procedure for the synthesis of amide starting materials was accomplished via selective N- tert-butoxycarbonylation, which was the preferred method over N-acylation. The present protocol carried advantages of operational simplicity, com. availability of catalysts and excellent conversions at low catalyst loadings. The method was generally useful for activation of N-C(O) amide bonds in a broad spectrum of amide precursors. The protocol should facilitate the implementation of amide cross-coupling reactions.

Synthesis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Quality Control of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Joseph, Devaneyan published the artcileMetal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions, Recommanded Product: 4-Methoxy-N-phenylbenzamide, the main research area is benzoylpyrrolidinone benzoylpiperidinone benzoylazepanone amine transamidation green chem.

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

Organic & Biomolecular Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Recommanded Product: 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reitz, David B. published the artcile1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560, Application of 3-Bromoisonicotinamide, the main research area is triazole angiotensin receptor antagonist preparation structure; phenylpyridinylmethyl triazole angiotensin receptor antagonist preparation; pyridinylphenylmethyl triazole angiotensin receptor antagonist preparation; antihypertensive triazole angiotensin receptor antagonist structure.

Substituting nitrogen for carbon in the four pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental to the angiotensin II receptor-antagonist activity; however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties in the rat angiotensin II pressor assay.

Bioorganic & Medicinal Chemistry Letters published new progress about Angiotensin receptors Role: BIOL (Biological Study). 13958-99-1 belongs to class amides-buliding-blocks, name is 3-Bromoisonicotinamide, and the molecular formula is C6H5BrN2O, Application of 3-Bromoisonicotinamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Song, Wangze published the artcileVisible Light-Induced Amide Bond Formation, Category: amides-buliding-blocks, the main research area is amide preparation green chem; thioacid aniline amide bond formation photoredox catalyst.

A metal-, base-, and additive-free amide bond formation reaction was developed under an organic photoredox catalyst. This green approach showed excellent functional selectivity without affecting other functional groups such as alcs., phenols, ethers, esters, halogens, or heterocycles. This method featured a broad substrate scope, good compatibility with water and air, and high yields (Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sun, Shaofa published the artcileFrom imines to amides via NHC-mediated oxidation, Synthetic Route of 7465-88-5, the main research area is amide preparation green chem; imine oxidation heterocyclic carbene.

The unprecedented NHC-mediated oxidation of imines RCH=NR1 (R = Ph, 1-naphthyl, 4-pyridyl, etc.; R1 = Ph, Tosyl, Boc, etc.) to amides RC(O)NHR1 is described. This protocol features broad substrate scope and allows rapid assembly of amides in good to high yields. Notably, this process includes not only the umpolung of imines, but also the discovery of NHC-bound 1,2-dioxetane intermediates.

Organic Chemistry Frontiers published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Synthetic Route of 7465-88-5.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Jianzhong published the artcileNitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles, Related Products of amides-buliding-blocks, the main research area is nitrile preparation; amide preparation; ketone aldehyde alkyne alkylarene nitroalkane Schmidt like reaction.

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chem. nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.

Science (Washington, DC, United States) published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Singh, Ashmita published the artcileOxidative Amidation of Aldehydes with Amines Catalysed by Fe(II) – Hydride Complex and N- Heterocyclic Carbenes (NHC), Safety of 4-Methoxy-N-phenylbenzamide, the main research area is primary secondary amide preparation; aldehyde amine oxidative amidation iron catalyst NHC ligand.

Oxidative amidation reaction of aldehydes with amines, by tert Bu hydrogen peroxide in toluene was achieved. The reaction utilized the in situ generated catalyst produced by Fe(II) – hydride complex [FeH2(PPh3)4], and N-heterocyclic carbene (NHC) ligand. The catalytic system was found efficient for the synthesis of wide variety of mono and disubstituted amides.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 7465-88-5 belongs to class amides-buliding-blocks, name is 4-Methoxy-N-phenylbenzamide, and the molecular formula is C14H13NO2, Safety of 4-Methoxy-N-phenylbenzamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics