Tag: M.W=150-200

An article Absolute asymmetric Strecker synthesis in a mixed aqueous medium: reliable access to enantioenriched alpha-aminonitrile WOS:000457797000024 published article about CHIRAL-SYMMETRY-BREAKING; AMINO-ACIDS; ENANTIOSELECTIVE SYNTHESIS; ENANTIOMERIC EXCESS; PYRIMIDYL ALKANOL; AMPLIFICATION; AUTOCATALYSIS; ORIGIN; CRYSTALLIZATION; CONJUNCTION in [Miyagawa, Shinobu; Aiba, Shohei; Kawamoto, Hajime; Tokunaga, Yuji] Univ Fukui, Dept Mat Sci & Engn, Bunkyo Ku, Fukui 9108507, Japan; [Kawasaki, Tsuneomi] Tokyo Univ Sci, Dept Appl Chem, Shinjyuku Ku, Tokyo 1628601, Japan in 2019.0, Cited 48.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Category: amides-buliding-blocks

Without using chiral sources, the Strecker reaction of achiral hydrogen cyanide, p-tolualdehyde and benzhydrylamine gave enantioenriched L- or D-N-benzhydryl-alpha-( p-tolyl) glycine nitriles with up to > 99% ee in a mixed solvent of water and methanol. Therefore, total spontaneous resolution of alpha-aminonitriles could occur through a prebiotic mechanism of alpha-amino acid synthesis. Moreover, it was demonstrated that the repetition of partial dissolution and crystallization of a suspended conglomerate of aminonitrile under solution-phase racemization could generate the enantiomeric imbalance to afford, in combination with the amplification of chirality, an enantioenriched product in every case. Among the 73 experiments that were carried out, D-and L-enriched isomers occurred 36 and 37 times, respectively. This stochastic behavior, under achiral or racemic starting conditions, meets the requirements of the spontaneous absolute asymmetric Strecker synthesis. The implications of the present results for the origin of chirality of alpha-amino acids are discussed.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Miyagawa, S; Aiba, S; Kawamoto, H; Tokunaga, Y; Kawasaki, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Dithiin diisoimides: Synthesis and their antimicrobial studies WOS:000576795600004 published article about SUCCINAMIC ACID; 1,4-DITHIINS; BINDING; ESTER in [Ahme, Sumbul; Perveen, Shahnaz] Pakistan Council Sci & Ind Res, Labs Complex, Karachi 75280, Pakistan; [Perveen, Shahnaz; Khan, Khalid Mohammed; Naz, Farzana] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Ali, Rahat Azher] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ajaz, Munazza; Shah, Samreen] Fed Urdu Univ Arts Sci & Technol, Dept Chem, Univ Rd,Gulshan E Iqbal Campus, Karachi, Pakistan; [Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, Dammam, Saudi Arabia in 2020.0, Cited 28.0. Application In Synthesis of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Sixteen derivatives of dithiin diisoimide 2a-2p have been synthesized and screened for antibacterial and antifungal activity. Compounds 2a-2g and 2i-2p are almost same or more active than gentamicine against Acinetobacter. Whereby compound 2,6-didodecyl-1H,5H-pyrrolo[3′,4′,5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone (2d) having zone of inhibition 20 mm against Acinetobacter is the most potent among all these compounds and can be used as lead compound for the treatment of Acinetobacter infection.

About Diphenylmethanamine, If you have any questions, you can contact Ahme, S; Perveen, S; Khan, KM; Naz, F; Ali, RA; Ajaz, M; Shah, S or concate me.. Application In Synthesis of Diphenylmethanamine

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Amide – Wikipedia,
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Quality Control of Diphenylmethanamine. Recently I am researching about CATALYZED TRANSFER HYDROGENATION; STEREOSELECTIVE TRANSFER SEMIHYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; SITE COBALT CATALYSTS; BORANE-AMINE ADDUCTS; SELECTIVE HYDROGENATION; CONJUGATE REDUCTION; AMMONIA-BORANE; ASYMMETRIC HYDROGENATION, Saw an article supported by the Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFE0132600]; Henan Center for Outstanding Overseas Scientists [GZS2020001]; National Innovation and Entrepreneurship Training Program for College students [201910459064]; Zhengzhou University. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A generalized, simple and efficient transfer hydrogenation of unsaturated bonds has been developed using HBP in and various proton reagents as hydrogen sources. The substrates, including alkenes, alkynes, aromatic heterocycles, aldehydes, ketones, imines, azo, nitro, epoxy and nitrile compounds, are all applied to this catalytic system. Various groups, which cannot survive under the Pd/C/H-2 combination, are tolerated. The activity of the reactants was studied and the trends are as follows:styrene>diphenylmethanimine>benzaldehyde>azobenzene>nitrobenzene>quinoline>acetophenone>benzonitrile. Substrates bearing two or more different unsaturated bonds were also investigated and transfer hydrogenation occurred with excellent chemoselectivity. Nano-palladium catalystin situgenerated from Pd(OAc)(2) and HBP in extremely improved the TH efficiency. Furthermore, chemoselective anti-Markovnikov hydrodeuteration of terminal aromatic olefins was achieved using D2O and HBP in via in situ HD generation and discrimination.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Wang, Y; Cao, XY; Zhao, LY; Pi, C; Ji, JF; Cui, XL; Wu, YJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about FISCHER CARBENE COMPLEXES; ARYL; ISOINDOLE; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; ANNULATION; CASCADE; KETONES; ALKYNES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21425415, 21774056]; National Basic Research Program of ChinaNational Basic Research Program of China [2015CB856303]; Science and Technology Department of Jiangsu Province [BRA2017360, BK20181255]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Qi, B; Li, L; Wang, Q; Zhang, WJ; Fang, LL; Zhu, J. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Safety of Diphenylmethanamine

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with alpha-diazo-alpha-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

Safety of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Qi, B; Li, L; Wang, Q; Zhang, WJ; Fang, LL; Zhu, J or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article 2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B WOS:000481206700001 published article about MAO INHIBITORS; PROTEIN; DISCOVERY; DERIVATIVES; DOCKING; ANALOGS; TARGET; POTENT; CELLS; PC12 in [Dalla Via, Lisa] Univ Padua, Dipartimento Sci Farmaco, Via F Marzolo 5, I-35131 Padua, Italy; [Di Paolo, Maria L.] Univ Padua, Dipartimento Med Mol, Via G Colombo 3, I-35131 Padua, Italy; [Christodoulou, Michael S.] Univ Milan, DISFARM, Sez Chim Gen & Organ A Marchesini, Via Venezian 21, I-20133 Milan, Italy; [Calogero, Alessandra M.; Cappelletti, Graziella] Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy; [Pinzi, Luca; Rastelli, Giulio] Univ Modena & Reggio Emilia, Dipartimento Sci Vita, Via Campi 103, I-41125 Modena, Italy; [Passarella, Daniele] Univ Milan, Dipartimento Chim, Via C Golgi 19, I-20133 Milan, Italy in 2019.0, Cited 70.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Formula: C13H13N

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K-i) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Di Paolo, ML; Christodoulou, MS; Calogero, AM; Pinzi, L; Rastelli, G; Passarella, D; Cappelletti, G; Dalla Via, L or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. In 2019.0 ORG LETT published article about DIRECT AMIDE FORMATION; MECHANISTIC INSIGHTS; BOND FORMATION; BORONIC ACIDS; CONDENSATION; ALPHA; CYCLOADDITIONS; ACTIVATION; CHEMISTRY; AMINES in [Shimada, Naoyuki] Kitasato Univ, Dept Pharmaceut Sci, Lab Organ Chem Drug Dev, Tokyo 1088641, Japan; Kitasato Univ, Dept Pharmaceut Sci, Med Res Labs, Tokyo 1088641, Japan in 2019.0, Cited 72.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The direct catalytic dehydrative amidation of beta-hydroxycarboxylic acids with amines is described. A biphenyl-based diboronic acid anhydride with a B-O-B skeleton is shown to be an exceptionally effective catalyst for the reaction, providing beta-hydroxycarboxylic amides in high to excellent yields with a low catalyst loading (minimum of 0.01 mol %, TON up to 7,500). This hydroxy-directed amidation shows excellent chemoselectivity and is applicable to gram-scale drug synthesis.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Shimada, N; Hirata, M; Koshizuka, M; Ohse, N; Kaito, R; Makino, K or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids WOS:000526406600040 published article about N-ACYLIMINIUM IONS; OXIDATIVE DECARBOXYLATION; RADICAL CHEMISTRY; ARYL; DERIVATIVES; ALDEHYDES; ALCOHOLS; KETONES; MILD; HYDROGENATION in [Khan, Shah Nawaz; Zaman, Muhammad Kashif; Li, Ruining; Sun, Zhankui] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China; [Sun, Zhankui] Chinese Acad Sci, Huzhou Res & Industrializat Ctr Technol, Huzhou 313000, Peoples R China in 2020, Cited 49. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

About Diphenylmethanamine, If you have any questions, you can contact Khan, SN; Zaman, MK; Li, RN; Sun, ZK or concate me.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. I found the field of Chemistry very interesting. Saw the article Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts published in 2019.0, Reprint Addresses Chen, F; Fan, QH (corresponding author), Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Zhang, SS; Chen, F; He, YM; Fan, QH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article An Improved Class of Phosphite-Oxazoline Ligands for Pd-Catalyzed Allylic Substitution Reactions WOS:000474812400025 published article about MOLECULAR-ORBITAL METHODS; FORCE-FIELD PARAMETERS; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; ENANTIOSELECTIVE ALLYLATION; CYCLOBUTANE BACKBONE; MODULAR LIGANDS; BASIS-SETS; AB-INITIO; ALKYLATION in [Biosca, Maria; Salto, Joan; Magre, Marc; Pamies, Oscar; Dieguez, Montserrat] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, C Marcel Li Domingo 1, E-43007 Tarragona, Spain; [Norrby, Per-Ola] AstraZeneca Gothenburg, R&D BioPharmaceut, Pharmaceut Sci, Data Sci & Modelling, Pepparedsleden 1, S-43150 Molndal, Sweden; [Norrby, Per-Ola] Univ Gothenburg, Dept Chem & Mol Biol, Kemigarden 4, S-41296 Gothenburg, Sweden in 2019.0, Cited 129.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A method for generation of Pd/phosphite-oxazoline catalysts containing an alkyl backbone chain has been successfully applied to Pd-catalyzed allylic substitution reactions. By carefully selecting the substituents at both the alkyl backbone chain and the oxazoline of the ligand, as well as the configuration of the biaryl phosphite group, high activities (TOF > 8000 mol substrate X (mol Pd X h)(-1)) and excellent enantioselectivities (ee’s up to 99%) have been achieved for many hindered and unhindered substrates with a wide range of C-, O-, and N-nucleophiles (73 substitution products in total). Moreover, DFT and NMR studies of the key Pd-allyl complexes allowed us to better understand the origin of the excellent enantioselectivities observed experimentally. The useful application of the Pd/phosphite-oxazoline catalysts was demonstrated by the syntheses of many chiral carbobicycles, with multiples stereocenters, by simple sequential reactions involving Pd-allylic substitution and either 1,6-enyne cyclization or Pauson-Khand enyne cyclization.

About Diphenylmethanamine, If you have any questions, you can contact Biosca, M; Salto, J; Magre, M; Norrby, PO; Pamies, O; Dieguez, M or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. Recently I am researching about BOC PROTECTION; IONIC LIQUID; ORGANIC-SYNTHESIS; GREEN CHEMISTRY; ACID CATALYST; BUTOXYCARBONYLATION; MILD; TRANSAMIDATION; ORGANOCATALYST; TECHNOLOGY, Saw an article supported by the Planning and Development, Savitribai Phule Pune University, Pune under ASPIRE-Research Mentorship Program [18TEC001308]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Ingale, AP; Shinde, SV; Thorat, NM. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Ingale, AP; Shinde, SV; Thorat, NM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics