Tag: M.W=150-200

In 2019.0 SYNLETT published article about FORMYLMETHYL-SUBSTITUTED ENAMIDES; HIGHLY EFFICIENT; BRONSTED ACID; DIASTEREOSELECTIVE SYNTHESIS; BETA-HYDROXY; CYCLOADDITION; BIOTRANSFORMATIONS; PIPERIDINES; CYCLIZATION; PYRIDINES in [Tong, Shuo; Wang, Mei-Xiang] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China in 2019.0, Cited 54.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. Authors Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ in WILEY-V C H VERLAG GMBH published article about in [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Chen, Dong-Huang; Sun, Wei-Ting; Zhu, Cheng-Jie; Lu, Guang-Sheng; Wu, Dong-Ping; Wang, Ai-E; Huang, Pei-Qiang] Xiamen Univ, Fujian Prov Key Lab Chem Biol, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; [Wang, Ai-E; Huang, Pei-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China in 2021.0, Cited 89.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral alpha-aminonitriles and alpha-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active alpha-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Chen, DH; Sun, WT; Zhu, CJ; Lu, GS; Wu, DP; Wang, AE; Huang, PQ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about SOLID-STATE SYNTHESIS; TEMPERATURE SENSOR; CATALYZED POLYCONDENSATION; CONJUGATED POLYMER; POLY(3,4-ETHYLENEDIOXYTHIOPHENE); POLY(IMINOARYLENE)S; POLYTHIOPHENE; CELLS, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21875173]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Peng, K; Luo, Q; Zhang, YC; Xia, JB. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Recommanded Product: 91-00-9

C-Br/N-H bulk polycondensation is firstly proposed and corresponding poly(3,4-dinitm-thiophen-2-yl aryl-amine)s derivatives have been successfully obtained with quantitative yield. Typical crystal analysis reveals that its effective reaction points distance (RPD, distance between Br and H atom) is 5.083 angstrom, which is 66.7% longer than the sum of van der Waals radius (r(w)) of bromine and hydrogen atoms (3.05 angstrom). Carbazole-based monomer was explored as a thermalsensor with excellent relative sensitivity (S-a) of 0.45% K-1.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Peng, K; Luo, Q; Zhang, YC; Xia, JB or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Science & Technology – Other Topics very interesting. Saw the article Modular click chemistry libraries for functional screens using a diazotizing reagent published in 2019. Product Details of 91-00-9, Reprint Addresses Sharpless, KB; Dong, JJ (corresponding author), Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of alpha-Tertiary Amino Ketones from Sulfonium Ylides WOS:000563079000043 published article about N-H BONDS; BRONSTED ACID; METAL CATALYSIS; AMINATION; INSERTION; DERIVATIVES; COMPLEXES; CARBENE; MODE in [Luo, Yuzheng; Li, Pingfan] Beijing Univ Chem Technol, Coll Chem, Dept Organ Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China; [Guo, Wengang; Sung, Herman H-Y; Williams, Ian D.; Sun, Jianwei] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China in 2020.0, Cited 50.0. Name: Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Herein we disclose a new catalytic asymmetric approach for the synthesis of chiral alpha-amino ketones, which is particularly useful for the less accessible acyclic alpha-tertiary cases. By a protonation-amination sequence, our approach represents a rare asymmetric H-heteroatom bond insertion by alpha-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermolecular C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug molecules and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Guo, WG; Luo, YZ; Sung, HHY; Williams, ID; Li, PF; Sun, JW or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. I found the field of Chemistry very interesting. Saw the article Diboronic Acid Anhydrides as Effective Catalysts for the Hydroxy-Directed Dehydrative Amidation of Carboxylic Acids published in 2019.0, Reprint Addresses Shimada, N (corresponding author), Kitasato Univ, Dept Pharmaceut Sci, Lab Organ Chem Drug Dev, Tokyo 1088641, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

The direct catalytic dehydrative amidation of beta-hydroxycarboxylic acids with amines is described. A biphenyl-based diboronic acid anhydride with a B-O-B skeleton is shown to be an exceptionally effective catalyst for the reaction, providing beta-hydroxycarboxylic amides in high to excellent yields with a low catalyst loading (minimum of 0.01 mol %, TON up to 7,500). This hydroxy-directed amidation shows excellent chemoselectivity and is applicable to gram-scale drug synthesis.

About Diphenylmethanamine, If you have any questions, you can contact Shimada, N; Hirata, M; Koshizuka, M; Ohse, N; Kaito, R; Makino, K or concate me.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. Recently I am researching about SIMILARITY/DIVERSITY ANALYSIS; MOLECULAR DESCRIPTORS; GETAWAY DESCRIPTORS; PREDICTION; DOCKING; INDEXES; ASSAY; RICE, Saw an article supported by the Tarbiat Modares University. Published in SPRINGER in NEW YORK ,Authors: Gholivand, K; Abbod, M; Valmoozi, AAE; Barzegar, O; Tabar, HN; Yaghoubi, R; Hosseini, M; Safaie, N; Dashtaki, MR; Dusek, M; Mani-Varnosfaderani, A. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A series of phosphonic acid and bisphosphoramidate derivatives were synthesized and characterized. The bioactivities against the fungal pathogen Macrophomina phaseolina and human acetylcholinesterase AChE enzyme were studied using QSAR based on multiple linear regression. L17, with (p-Cl-C6H4-NH) (p-Cl-C6H4)C(H)P(O)(OC2H5)(2) skeleton, demonstrated a great mortality on the M. phaseolina mycelial growth by 83% inhibition at 150 mg/L; the other tested derivative showed moderate to weak antifungal activity against the fungus. QSAR model based on the GA-MLR method revealed the importance of 3D descriptors (De, Mor18e, H8m, and Mor30p) on the antifungal activity. It showed good capability in predicting the fungicidal activity of the studied molecules. Another derivative, L5, with (m-CH3-NC5H4-NH)(m-CH3-C6H4)C(H)P(O)(OCH3)(2) skeleton displays the most potent anti-AChE activity. The electronic parameters, Delta EL-H, and E-LUMO, have the highest contribution of human AChE. The authors suggest that these models could be usefully employed in designing more effective crop protection compounds without side effects on non-target organisms.

About Diphenylmethanamine, If you have any questions, you can contact Gholivand, K; Abbod, M; Valmoozi, AAE; Barzegar, O; Tabar, HN; Yaghoubi, R; Hosseini, M; Safaie, N; Dashtaki, MR; Dusek, M; Mani-Varnosfaderani, A or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about NUCLEOTIDE-BINDING-SITES; MULTIDRUG-RESISTANCE; AUTOMATED DOCKING; DRUG-RESISTANCE; FLEXIBLE LIGANDS; TRANSPORT; OPTIMIZATION; PURIFICATION; MTT; CHEMORESISTANCE, Saw an article supported by the National Institute of General Medical Sciences (NIH/NIGMS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R15 GM094771-02]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wise, JG; Nanayakkara, AK; Aljowni, M; Chen, G; De Oliveira, MC; Ammerman, L; Olengue, K; Lippert, AR; Vogel, PD. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Application In Synthesis of Diphenylmethanamine

Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in combination therapy have not led to clinically approved inhibitors to date. Here, we describe computational approaches combined with structure-based design to improve the characteristics of a P-gp inhibitor previously identified by us. This hit compound represents a novel class of P-gp inhibitors that specifically targets and inhibits P-gp ATP hydrolysis while not being transported by the pump. We describe here a new program for virtual chemical synthesis and computational assessment, ChemGen, to produce hit compound variants with improved binding characteristics. The chemical syntheses of several variants, efficacy in reversing multidrug resistance in cell culture, and biochemical assessment of the inhibition mechanism are described. The usefulness of the computational predictions of binding characteristics of the inhibitor variants is discussed and compared to more traditional structure-based approaches.

About Diphenylmethanamine, If you have any questions, you can contact Wise, JG; Nanayakkara, AK; Aljowni, M; Chen, G; De Oliveira, MC; Ammerman, L; Olengue, K; Lippert, AR; Vogel, PD or concate me.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III) WOS:000487140200001 published article about ONE-POT SYNTHESIS; CATALYZED KNOEVENAGEL CONDENSATION; METAL-ORGANIC FRAMEWORK; FACILE SYNTHESIS; CHEMOSELECTIVE REDUCTION; GREEN PROCEDURE; IONIC LIQUID; EFFICIENT; NITRILES; HYDRATION in [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Dr Homi Bhaba Rd, Pune 411008, Maharashtra, India; [Rupanawar, Bapurao D.; Suryavanshi, Gurunath] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India; [Veetil, Sruthi M.] CSIR, Natl Chem Lab, Cent NMR Facil, Dr Homi Shaba Rd, Pune 411008, Maharashtra, India in 2019, Cited 74. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Application In Synthesis of Diphenylmethanamine

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Application In Synthesis of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Rupanawar, BD; Veetil, SM; Suryavanshi, G or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline WOS:000585492000001 published article about PHOSPHONIC ACID ANTIBIOTICS; ISOPRENOID BIOSYNTHESIS; ANTIMALARIAL; FR900098; ANALOGS; INHIBITORS; FR-31564; PATHWAY; ANTIBACTERIAL; DESIGN in [Palla, Despina; Antoniou, Antonia I.; Athanassopoulos, Constantinos M.] Univ Patras, Dept Chem, Synthet Organ Chem Lab, GR-26504 Patras, Greece; [Baltas, Michel; Menendez, Christophe] Univ Paul Sabatier Toulouse III, UMR CNRS 5068, LSPCMIB, F-31062 Toulouse 9, France; [Baltas, Michel; Menendez, Christophe] Univ Tolouse, CNRS, LCC Lab Chim Coordinat, UPS,INPT, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France; [Grellier, Philippe; Mouray, Elisabeth] Museum Natl Hist Nat, CNRS, UMR 7245, MCAM, CP52,63 Rue Buffon, F-75005 Paris, France in 2020.0, Cited 45.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Safety of Diphenylmethanamine

Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by Plasmodium falciparum. The antibiotic fosmidomycin (FSM) is also known for its antimalarial activity by targeting the non-mevalonate isoprenoid synthesis pathway, which is essential for the malaria parasites but is absent in mammalians. In this study, we synthesized and evaluated against the chloroquine-resistant P. falciparum FcB1/Colombia strain, a series of FSM analogs, derivatives, and conjugates with other antimalarial agents, such as artemisinin (ART) and aminochloroquinoline (ACQ). The biological evaluation revealed four new compounds with higher antimalarial activity than FSM: two FSM-ACQ derivatives and two FSM-ART conjugates, with 3.5-5.4 and 41.5-23.1 times more potent activities than FSM, respectively.

Safety of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Palla, D; Antoniou, AI; Baltas, M; Menendez, C; Grellier, P; Mouray, E; Athanassopoulos, CM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics