Tag: M.W=100-200

758-96-3, Adding a certain compound to certain chemical reactions, such as: 758-96-3, name is N,N-Dimethylpropionamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 758-96-3.

7-Methoxy-4-propionyl-2-trifluoromethylbenzofuran The compound of Example 16 (500 mg) was dissolved in THF (10 mL) under an argon gas flow, and an n-butyl lithium hexane solution (1.21 mL, 1.54 mol/L) was added dropwise thereto at -78C, followed by stirring for 5 minutes. To this was added N,N-dimethyl propionic acid amide (513 mg), followed by slowly returning to room temperature. A saturated aqueous ammonium chloride solution was added to the reaction liquid, followed by extraction with ethyl acetate and washing with saturated brine. It was dried over anhydrous sodium sulfate, and the solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1?10:1) to obtain the desired product (162 mg) as a colorless powder. 1H-NMR (CDCl3, 400 MHz): delta 1.26 (3H, t, J=7.3 Hz), 3.05 (2H, q, J=7.3 Hz), 4.10 (3H, s), 6.93 (1H, d, J=8.6 Hz), 7.90 (1H, d, J=8.6 Hz), 8.01 (1H, d, J=1.2 Hz).

According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; EP2168960; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 53297-70-4, name is 4-Amino-3-methylbenzenesulfonamide, I believe this compound will play a more active role in future production and life. 53297-70-4

General procedure: The chlorides 9a-j was dissolved in CH2Cl2 (20 mL) andadded dropwise to a stirred solution of 4-anilinesulfonamide(10.0 mmol) and NaHCO3 (1.26 g, 15.0 mmol) in CH3CN(80 mL). The mixture was heated at 70 C for 2h. The solution solutionwas evaporated, and poured to water, filtered to give asolid. This was purified by chromatography on silica gelusing CH2C12-MeOH (30: l) to give the title molecules 10a-t.The typical compound 10c was characterized with NMR andMS techniques. The detailed data is below.

The chemical industry reduces the impact on the environment during synthesis 53297-70-4. I believe this compound will play a more active role in future production and life.

Reference:
Article; Song, Zhendong; Wang, Ping; Huang, Shanshan; Wang, Changyuan; Wang, Rui-Rui; Yang, Liu-Meng; Zhen, Yuhong; Liu, Kexin; Zheng, Yong-Tang; Ma, Xiaodong; Medicinal Chemistry; vol. 13; 4; (2017); p. 398 – 405;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics