Tag: M.W=100-150

Yilmaz, Sakir published the artcileBentonite grafted with poly(N-acryloylglycineamide) brush: A novel clay-polymer brush hybrid material for the effective removal of Hg(II) and As(V) from aqueous environments, Name: N-(2-Amino-2-oxoethyl)acrylamide, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2021), 125979, database is CAplus.

The present work was conducted to indicate bentonite grafted with poly(N-acryloylglycineamide) (PNAGA@BNT) could be applied as a novel clay-polymer brush hybrid material for the removal of Hg(II) and As(V) from aqueous environments. The PNAGA@BNT synthesized via the surface initiated reversible addition fragmentation chain transfer (SI-RAFT) polymerization method was characterized by BET anal., Fourier transform IR spectrometry (FTIR), X-ray diffraction (XRD), XPS, SEM (SEM) and water contact angle measurements. Hg(II)% and As(V)% removal onto PNAGA@BNT was carried out with response surface methodol. (RSM). The effects of the operating parameters, like pH, heavy metal ion concentration (Co), PNAGA@BNT amount, and mixing time were evaluated by central composite design (CCD). The optimum Hg(II) adsorption conditions from the CCD were found to be 6.54, 24.46 mg/L, 23.98 mg, and 106.83 min for pH, Co, PNAGA@BNT dosage, and mixing time, resp. On the other hand, the optimum points obtained for As(V) adsorption from CCD were 4.36, 7.30 mg/L, 25.75 mg, and 83.37 min for pH, Co, PNAGA@BNT dosage, and mixing time, in their given order. At the optimal points obtained for Hg(II) and As(V) adsorption, the maximum Hg(II)% and As(V)% removal efficiencies were 98.58% and 90.95%, resp. The kinetic models with best fit were the pseudo-second-order kinetic model for Hg(II) and As(V) and Weber-Morris intraparticle diffusion was the dominant mechanism for As(V) and Hg(II). Among the isotherms, the equilibrium data best fit the Langmuir and Freundlich models for Hg(II), and the Dubinin-Radushkevich (D-R) and Freundlich models for As(V). Moreover, thermodn. studies suggested the adsorption process was exothermic and spontaneous.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C24H29N5O3, Name: N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fellah, Noalle published the artcileHighly Polymorphous Nicotinamide and Isonicotinamide: Solution versus Melt Crystallization, Name: Isonicotinamide, the publication is Crystal Growth & Design (2021), 21(8), 4713-4724, database is CAplus.

The crystallization of nicotinamide (NA) and its constitutional isomer, isonicotinamide (INA), is compared. NA formed eight polymorphs from the melt and two from solution, whereas INA formed two polymorphs from the melt and six from solution This anal. was provoked by the observation that NA is highly polymorphic from the melt, while the closely related INA is highly polymorphous from solution A combination of hot stage polarized light microscopy, powder X-ray diffraction, and Raman spectroscopy revealed that the polymorph selectivities are not related to supramol. self-association in the growth media. The larger estimated free energy gap separating NA polymorphs, compared with that of the INA polymorphs, is consistent with the smaller number of NA polymorphs generated from solution Phenomenol. analyses of crystallization kinetics suggest that cross nucleation is the most likely reason more polymorphs of NA than INA crystallize from the melt.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Name: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dai, Xia-Lin published the artcileSolubility and Permeability Improvement of Allopurinol by Cocrystallization, Category: amides-buliding-blocks, the publication is Crystal Growth & Design (2020), 20(8), 5160-5168, database is CAplus.

Allopurinol is a xanthine oxidase inhibitor with poor solubility and permeability, which severely limit its drug absorption following the administration of some dosage forms, such as tablets and rectal suppositories. To improve the physicochem. properties, three cocrystals of allopurinol with isonicotinamide (ALP-INA), piperazine (ALP-PIP), and 2,4-dihydroxybenzoic acid (ALP-24DHBZA) were successfully prepared by a slurry or liquid-assisted grinding method. The obtained cocrystal materials were characterized by single-crystal X-ray diffraction, powder X-ray diffraction, IR spectroscopy, differential scanning calorimetry, and thermogravimetric analyses and were subjected to dynamic vapor sorption, dissolution, and membrane permeability studies. ALP-INA showed solubility and diffusion/membrane permeability similar to those of the parent drug. In contrast, ALP-PIP exhibited improved diffusion/membrane permeability, and ALP-24DHBZA exhibited improved dissolution behavior, resp. These results suggest that ALP-PIP and ALP-24DHBZA have the potential to be developed as new, more efficient formulations of allopurinol. Three cocrystals of allopurinol (ALP) with isonicotinamide (ALP-INA), piperazine (ALP-PIP), and 2,4-dihydroxybenzoic acid (ALP-24DHBZA) were synthesized, and ALP-PIP and ALP-24DHBZA resp. showed significant improvement in membrane permeability and dissolution behaviors in comparison to the original ALP.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mallikarjuna, Rangisetty published the artcileSynthesis and biological evaluation of some new 3-cyano-2-amino substituted chromene derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Pharma Chemica (2015), 7(11), 117-129, database is CAplus.

Chromenes are the one of the important class of heterocyclic compounds which poses wide range of pharmaceutical and biol. importance. Different functional groups at different positions in the core structure of chromene deliberately yields novel derivatives which play a prominent role in in the field of medicinal chem. One pot synthesis of a few new series of 2-amino-3-cyano-4H-chromene derivatives were designed, synthesized, characterized and biol. activity like anti-bacterial and anti-fungal studies were screened, where most of the compounds showed good growth inhibition activity.

Pharma Chemica published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shaik, Jeelan Basha published the artcileSynthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase, Related Products of amides-buliding-blocks, the publication is Bioorganic Chemistry (2019), 102960, database is CAplus and MEDLINE.

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate anti-oxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the Aβ aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i (I; NR₁R₂ correspond to methanamine, cyclopropamine, cyclohexamine, benzenemethanamine, and α-methylbenzenemethanamine, resp.) with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 × 10⁴, 2.22 × 10⁴, 1.18 × 10⁴, 9.8 × 10³ and 3.2 × 10⁴ M^-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M^-1 at 25 °C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with I.

Bioorganic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C7H5ClN2S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Qing Yu published the artcileT-shaped trifunctional crosslinker-toughening hydrogels, Name: N-(2-Amino-2-oxoethyl)acrylamide, the publication is Science China: Technological Sciences (2020), 63(9), 1721-1729, database is CAplus.

Abstract: Currently, development of a single network hydrogel with a high fracture toughness in swelling equilibrium remains challenging. In this work, a novel T-shaped trifunctional crosslinker (T-NAGAX) with dual vinyl on the backbone and dual amide group on the side chain is synthesized by Michael addition and acylation. The T-NAGAX is used to prepare chem. crosslinked hydrogel by one-pot photo-initiated polymerization The resulting single network hydrogels of representative polyacrylamide (PAAm), poly(N-acryloyl 2-glycine) (PACG), and poly(N-iso-Pr acrylamide) (PNIPAM) crosslinked with T-NAGAX with addnl. hydrogen-bonds exhibit much better fracture toughness than that of the corresponding hydrogels crosslinked by N,N’ -methylene bisacrylamide, a conventional crosslinker; higher mech. strengths are observed in the T-NAGAX crosslinked hydrogels. These hydrogels are promising to be exploited as load-bearing soft tissue substitutes. This T-NAGAX crosslinker can be expanded to toughen various types of hydrogels.

Science China: Technological Sciences published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Name: N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yao, Yuan published the artcileMultiple H-Bonding Chain Extender-Based Ultrastiff Thermoplastic Polyurethanes with Autonomous Self-Healability, Solvent-Free Adhesiveness, and AIE Fluorescence, Recommanded Product: N-(2-Amino-2-oxoethyl)acrylamide, the publication is Advanced Functional Materials (2021), 31(4), 2006944, database is CAplus.

Developing an autonomous room temperature self-healing supramol. polyurethane (PU) with toughness and stiffness remains a great challenge. Herein, a novel concept that utilizes a T-shaped chain extender with double amide hydrogen bonds in a side chain to extend PU prepolymers to construct highly stiff and tough supramol. PU with integrated functions is reported. Mobile side-chain H-bonds afford a large flexibility to modulate the stiffness of the PUs ranging from highly stiff and tough elastomer (105.87 MPa Young’s modulus, 27 kJ m^-2 tearing energy), to solvent-free hot-melt adhesive, and coating. The dynamic side-chain multiple H-bonds afford an autonomous self-healability at room temperature (25°C). Due to the rapid reconstruction of hydrogen bonds, this PU adhesive demonstrates a high adhesion strength, fast curing, reusability, long-term adhesion, and excellent low-temperature resistance. Intriguingly, the PU emits intrinsic blue fluorescence presumably owing to the aggregation-induced emission of tertiary amine domains induced by side-chain H-bonds. The PU is explored as a counterfeit ink coated on the predesigned pattern, which is visible-light invisible and UV-light visible. This work represents a universal and facile approach to fabricate supertough supramol. PU with tailorable functions by chain extension of PU prepolymers with multiple H-bonding chain extenders.

Advanced Functional Materials published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C18H28B2O4, Recommanded Product: N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhong, Yuhua published the artcileNovel ¹⁸F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3β, Formula: C6H6N2O, the publication is Molecular Pharmaceutics (2021), 18(3), 1277-1284, database is CAplus and MEDLINE.

Glycogen synthase kinase-3β (GSK-3β), a cytoplasmic serine/threonine protein kinase, is involved in several human pathologies including Alzheimer’s disease, bipolar disorder, diabetes, and cancer. Positron emission tomog. (PET) imaging of GSK-3β could aid in investigating GSK-3β levels under normal and pathol. conditions. In this study, we designed and synthesized fluorinated PET radioligands starting with recently identified isonicotinamide derivatives that showed potent affinity to GSK-3β. After extensive in vitro inhibitory activity assays and analyzing U87 cell uptake, we identified [¹⁸F]10a-d as potential tracers with good specificity and high affinity. They were then subjected to further in vivo evaluation in rodent brain comprising PET imaging and metabolism studies. The radioligands [¹⁸F]10b-d penetrated the blood-brain barrier and accumulated in GSK-3β-rich regions, including amygdala, cerebellum, and hippocampus. Also, it could be specifically blocked using the corresponding standard compounds With these results, this work sets the basis for further development of novel ¹⁸F-labeled GSK-3β PET probes.

Molecular Pharmaceutics published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C7H11Br, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chen, Jiajia published the artcileTransamidation for the Synthesis of Primary Amides at Room Temperature, HPLC of Formula: 1453-82-3, the publication is Organic Letters (2020), 22(9), 3504-3508, database is CAplus and MEDLINE.

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH₄)₂CO₃ reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25°C, the desired primary amide product is formed in good yield with good functional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.

Organic Letters published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Fang, Lan published the artcileIntermolecular interactions and solubility behavior of multicomponent crystal forms of 2,4-D: design, structure analysis, and solid-state characterization, Product Details of C6H6N2O, the publication is CrystEngComm (2021), 23(43), 7615-7627, database is CAplus.

2,4-Dichlorophenoxyacetic acid (2,4-D) is a kind of plant growth regulator which exhibits hormesis effects at low dosages, while high dosages adversely affect the exposed organisms and act as herbicide. 2,4-D has low solubility, therefore, it is a good candidate for crystal engineering research to improve its solubility This paper presents the preparation of five new multicomponent crystals of 2,4-D, including three salts with imidazole (IMZ), 2-aminopyridine (AAP), and 3-aminopyridine (BAP), and two cocrystals with isonicotinamide (ISO) and pyrazinamide (PYM) as coformers (CCFs). The five multicomponent crystals were first characterized by single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric anal. Mol. interactions, crystal packing, and structure similarity analyses performed using Hirshfeld surface and CrystalCMP confirmed the charge-assisted H-bonding sites and structural similarity among the solved crystal structures. The stability tests show that all five multi-component crystals exhibit excellent stability within 12 wk under accelerated storage conditions (40°C and 75% RH). Moreover, all the five multicomponent crystals of 2,4-D exhibit increased solubility, especially (2,4-D)⁺(IMZ)^– that increased the solubility of the resulting salt by 70 times compared to the free acid 2,4-D. From the perspective of single-crystal structure and intermol. interaction, the reasons for these changes in phys. and chem. properties are further clarified.

CrystEngComm published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics