Tag: M.W=100-150

Nair, G. Vijayakumaran published the artcileTert-butyl and tert-amyl isothiocyanates as novel reagents for the preparation of 1-substituted thiocarbamide derivatives, Recommanded Product: Morpholine-4-carbothioamide, the publication is Indian Journal of Chemistry (1966), 4(12), 516-20, database is CAplus.

cf. Neville and McGee, CA 59: 8715f. tert-Butyl (I) and tert-amyl isothiocyanates (II) on treating with amino compounds, aliphatic and aromatic primary and secondary amines, heterocyclic primary amines and imines and cyclic amines, in which the amino group is part of the ring system, afforded the related tertiary alkyl thiocarbamide derivatives [TABLE OMITTED] I was prepared as follows: A mixture of 27.4 g. NH4CNS, 10 g. ZnCl2, 27.8 g. tert-BuCl, and 100 ml. H2O was shaken 96 hrs. at intervals. The upper organic layer was separated, washed with H2O, dried and shaken 1 hr. with 5 g. powd. anhydrous ZnCl2 for 96 hrs. The decanted liquid was washed with H2O and dried with CaCl2 to yield 29.5 g. I, which was used directly for condensation. II was similarly prepared using tert-AmCl. Molar quantities of aliphatic primary and secondary amines and I reacted rapidly at room temperature in petroleum ether solution giving quant. yields of the desired tertiary alkyl thiocarbamide derivatives Aromatic primary and secondary amines, heterocyclic amines, and mono- and diarylguanidines, however, reacted only when the reactants were heated 1.5-5 hrs. in C6H6 solution II also reacted similarly. These derivatives were easily and quant. heterolyzed by treating with concentrated HCl at 90-95° for 2-30 min. to the corresponding thiocarbamides and tertiary alkyl chloride. 1-Substituted-3-tert-butylthiocarbamides (III) prepared are listed in the first table. 1-Substituted-3-tert-amylthiocarbamides (IV) prepared by the reaction of II and amines are listed in the 2nd table. (Ts stands for thiosemicarbazide). [TABLE OMITTED] The reaction of I with N2H4.H2O for 30 min. yielded 90% 4-tert-butylthiosemicarbazide (V), m. 143° (dilute EtOH). Similar reaction with PhNHNH2 yielded 91% 2-phenyl-4-tert-butylthiosemicarbazide (VI), m. 177° (absolute EtOH). Heterolysis of V and VI yielded H2NNHCSNH2, m. 180°, and PhNHNHCSNH2, m. 201°, in 67 and 94% resp. This procedure provides a novel and economic method of wider applicability for the preparation of 1-substituted thiocarbamides.

Indian Journal of Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

O’Callaghan, C. N. published the artcileReaction of ethyl cyanoacetate with 2-iminochromene derivatives, Name: 2-Cyano-N-ethylacetamide, the publication is Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science (1977), 77B(19-47), 533-8, database is CAplus.

The carbamoyliminochromones I (R = H, 8-MeO, 8-EtO, 6-Cl) condensed with EtO₂CCH₂CN to give the benzopyranopyridines II. The coumarins III was also formed by a competing reaction.

Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Musalov, M. V. published the artcileOne-Pot Synthesis of Functionalized 1,1′-(9-Selenabicyclo[3.3.1]nonane-2,6-diyl)dipyridinium Dibromides, Quality Control of 1453-82-3, the publication is Russian Journal of Organic Chemistry (2021), 57(4), 668-670, database is CAplus.

Previously unknown functionally substituted 1,1′-(9-selenabicyclo[3.3.1]nonane-2,6-diyl)dipyridinium dibromides were synthesized in 90-98% yields by one-pot condensation of selenium dibromide, cycloocta-1,5-diene, and substituted pyridines.

Russian Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mu, Ruixu published the artcileDiscovery of novel triazole compounds as selective IL-1β releasement inhibitors, HPLC of Formula: 15029-36-4, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128415, database is CAplus and MEDLINE.

Inflammation and immunity are closely related to the occurrence and development of a variety of immune diseases. Although IL-1β has been identified as a key cytokine in many immune diseases, safe and specific small mol. IL-1β releasement inhibitors are still scarce and urgently required in clinic. The investigation prospect of triazoleis limited by its complicated pharmacol. effect which exhibited inferior effects on IL-1β and TNF-α. Herein, 36 novel derivatives were designed and synthesized, and nearly half of the derivatives exhibited much better selectivity on IL-1β releasement inhibition as well as keep similar inhibitory activities to lead compound In 20 μM, compound 19 exhibited IL-1β releasement inhibitory activity (IC50 = 5.489 μM) which closed to the original compound, and 4.5-fold superior selectivity (SI = 4.71) to the lead compound (SI = 0.82). A probable SAR model of triazole derivatives for IL-1β releasement inhibition and selectivity was also proposed, which might promote the discovery of more effective and specific IL-1β releasement inhibitors in the future.

Bioorganic & Medicinal Chemistry Letters published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Al-Etaibi, Alya M. published the artcileSynthesis and antimicrobial activity of some disperse dyes derived from pyridones, Related Products of amides-buliding-blocks, the publication is International Journal of ChemTech Research (2019), 12(5), 129-133, database is CAplus.

Pyridone derivatives 4a,b are prepared by reacting N-alkyl-2-cyanoacetamide 1a,b with Me propionylacetate. Compounds 4a,b are coupled with aromatic diazonium salts to produce the corresponding new azo disperse dyes 6a,b. The antimicrobial activity of the synthesized azo disperse dyes are evaluated.

International Journal of ChemTech Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bianchi, Maria C. published the artcileSome Aliphatic Cyanoacetylamines, SDS of cas: 15029-36-4, the publication is Atti accad. sci. Torino (1913), 654-9, database is CAplus.

5 cc. CNCH₂CO₂Et in 35 cc. Et₂O + 20 cc. absolute alc. after a passage of an excess of NH₃ gave 3 g. NCCH₂CONH₂, crystals from MeOH, m. 124-5°. 7 g. CNCH₂CO₂Et in 25 cc. Et₂O + 17 cc. absolute alc. and 25 cc. of 20% MeNH₂ gave 5 g. of cyanoacetmethylamide, CNCH₂CONHMe, m. 104-5°, decompose with KOH, neutralized with HCl its solution becomes yellow. Similarly, the ethylamide, colorless prisms from EtOH, m. 74-50. CNCH₂CO₂Et (2 mol.) + propylenediamine (1 mol.) gives dicyanoacetopropylenediamide, (CNCH₂CONH)₂C₂H₆, m. 161-2°, with KMnO₄ gives HCN and the corresponding propyleneoxamic acid. Similarly the trimethylenediamide, CH₂(CH₂NHCOCH₂CN)₂, m. 163-5°, decompose 200-10°, giving NH₃, gives a neutral H₂O solution, gives HCN and the corresponding oxamic acid with KMnO₄.

Atti accad. sci. Torino published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hayat, Waseem published the artcileInsight into the degradation of methomyl in water by peroxymonosulfate, Application In Synthesis of 14294-10-1, the publication is Journal of Environmental Chemical Engineering (2021), 9(4), 105358, database is CAplus.

Methomyl (MET) is a carbamate pesticide frequently used in agriculture, globally. Its high solubility makes it a potential water pollutant. MET can be removed by peroxymonosulfate (PMS)-based advanced oxidation processes. This study explains MET degradation by PMS-Only, pyrite (PyR)-PMS and zero-valent iron (ZVI)-PMS systems. The degradation by PMS-Only, PyR-PMS and ZVI-PMS systems was 85.4%, 94.9% and 87.0%, resp. The generation of reactive oxygen species (ROS) and their role in degradation was elucidated by ESR (EPR) and free-radical quenching analyses, resp. EPR anal. indicated the presence of sulfate (SO•^–₄) and hydroxyl (•OH) radicals. The degradation in PMS-Only and ZVI-PMS systems was not significantly inhibited by tert-Bu alc. (TBA) and methanol (MeOH), which suggests that the degradation in both systems was not majorly carried out by SO•^–₄ and •OH. However, furfuryl acid (FFA) resulted in reduced degradation by applied systems, which showed that singlet oxygen (¹O₂) was mainly responsible for degradation in all systems. These results showed that MET was majorly degraded by non-radical PMS oxidation PMS-Only system resulted in an almost equal degradation, compared with PyR-PMS and ZVI-PMS systems. So, detailed anal. was carried out for PMS-Only system. Hence, experiments were conducted to investigate the effect of PMS concentration, MET concentration, pH and temperature on the degradation by PMS-Only system, which showed that PMS-Only system was efficient from pH 5.0 to pH 9.0, and from 10.0 °C to 40.0 °C. Further, PMS-Only system has a potential for effective degradation in real waters because it resulted in 66.5%, 63.7% and 60.4% degradation in tap water, lake water and sewage water, resp.

Journal of Environmental Chemical Engineering published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wang, Pengfei published the artcileThe fingerprints of nifedipine/isonicotinamide cocrystal polymorph studied by terahertz time-domain spectroscopy, Product Details of C6H6N2O, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2022), 121759, database is CAplus and MEDLINE.

Cocrystal is constructed to improve physicochem. properties of active pharmaceutical ingredient and prevent polymorphism via intermol. interactions. However, recent examples on cocrystal polymorphs display significantly different properties. Even though some anal. techniques have been used to characterize the cocrystal polymorphic system, it remains unclear how intermol. interactions drive and stabilize the structure. In this work, we study the cocrystal polymorphs of nifedipine (NFD) and isonicotinamide (INA) using terahertz (THz) spectroscopy. Form I and form II of NFD-INA cocrystals show spectral fingerprints in THz region. Temperature-dependent THz spectra display distinguished frequency shifts of each fingerprint. Combined with solid-state d. functional theory (DFT) calculations, the exptl. fingerprints and their distinct responses to temperature are elucidated by specific collective vibrational modes. The vibrations of hydrogen bonding between dihydropyridine ring of NFD and INA are generally distributed below 1.5 THz, which play important roles in stabilizing cocrystal and preventing the oxidation of NFD. The rotations of Me group in NFD are widely distributed in the range of 1.5-4.0 THz, which helps the steric recognition. The results demonstrate that THz spectroscopy is a sensitive tool to discriminate cocrystal polymorphs. It has the potential to be used as a non-invasive technique for pharmaceutical screening.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C15H20N2O2, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

You, Tingjie published the artcileRuthenium(II)-catalyzed reductive N-O bond cleavage of N-OR (R = H, alkyl, or acyl) substituted amides and sulfonamides, Category: amides-buliding-blocks, the publication is Organic Chemistry Frontiers (2021), 8(1), 112-119, database is CAplus.

With a com. available ruthenium(II) catalyst and a mixture of HCOOH/NEt₃ as the hydride source under an air atm., a convenient method for the reductive cleavage of N-O bonds was described. This catalytic system was applicable for a variety of N-oxygen-substituted amides, as well as N-alkoxy sulfonamides, efficiently delivering the corresponding amide RCONHR¹R² [R = Ph, 1-naphthyl, 2-thienyl, etc.; R¹ = H, Me; R² = OH, OMe, OEt, etc.] or primary sulfonamide R³SO₂NH₂ [R³ = Ph, 2-MeC₆H₄, 4-MeC₆H₄, Bn] products with good functional group tolerance in moderate to good yields.

Organic Chemistry Frontiers published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C12H6NNaO4, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tu, Shun published the artcileN-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors, Synthetic Route of 1453-82-3, the publication is Bioorganic Chemistry (2021), 105181, database is CAplus and MEDLINE.

Our previous work demonstrated that amide is an efficient linker to explore chem. space of xanthine oxidase (XO) inhibitors that are entirely different from febuxostat and topiroxostat. In this effort, with 3-cyano-1H-indol-5-yl as a key moiety, two series of amide-based XO inhibitors, N-(3-cyano-1H-indol-5-yl)isonicotinamides and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamides, were designed and synthesized. The structure-activity relationship investigation identified N-(3-cyano-1-cyclopentyl-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide (I, IC₅₀ = 0.62μM) as the most promising compound, with 14.4-fold higher in vitro inhibitory potency than allopurinol (IC₅₀ = 8.91μM). Mol. simulations provided reasonable interaction modes for the representative compounds Furthermore, in vivo activity evaluation demonstrated that compound I (oral dose of 12.8 mg/kg) has obviously hypouricemic effect on a potassium oxonate induced hyperuricemic rat model. Cytotoxicity assay and ADME prediction also supported that I is an excellent lead for further exploration of amide-based XO inhibitors.

Bioorganic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C17H28ClNO3, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics