Tag: M.W=100-150

Saha, Rumpa published the artcileDevelopment of a ruthenium-aquo complex for utilization in synthesis and catalysis for selective hydration of nitriles and alkynes, COA of Formula: C6H6N2O, the publication is New Journal of Chemistry (2022), 46(19), 9098-9110, database is CAplus.

Synthesis of a ruthenium(II)-aquo complex bearing 2,2′ : 6′,2”-terpyridine and a 1,4-diazabutadiene ligand, and exploration of its synthetic utility and catalytic activity are described. Ag⁺-assisted displacement of the coordinated chloride from the previously reported [Ru(trpy)(L-OCH₃)Cl]ClO₄ complex [denoted as complex 1; where L-OCH₃ represents 1,4-di-(p-methoxyphenyl)azabutadiene] in aqueous ethanol affords the [Ru(trpy)(L-OCH₃)(H₂O)]²⁺ complex cation, which was isolated as a perchlorate salt (complex 1a). Complex 1a undergoes facile substitution of the aquo ligand by neutral monodentate ligands giving complexes of type [Ru(trpy)(L-OCH₃)(L’)]²⁺, also isolated as perchlorate salts [L’ = acetonitrile (complex 1b); L’ = DMSO (complex 1c); L’ = 4-picoline (complex 1d) and L’ = PPh₃ (complex 1e)]. Complexes 1b–1e can also be synthesized directly from complex 1via the Ag⁺-assisted displacement of coordinated chloride by the resp. monodentate L’ ligand. The crystal structures of complexes 1a, 1b and 1d were determined The complexes show intense absorptions in the visible and UV regions, the origin of which was probed into with the help of the TDDFT method. Cyclic voltammetry of the complexes shows an irreversible Ru(II)-Ru(III) oxidation within 0.9-1.6 v vs. SCE, and two ligand (trpy and L-R) based reductions on the neg. side of the SCE. The aquo-complex (1a) is found to serve as an efficient catalyst for the hydration of aryl nitriles to the corresponding amides, and aryl alkynes to aldehydes.

New Journal of Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Surikova, O. V. published the artcileSynthesis, Antihelminthic and Insecticidal Activity of 2-[3-Methyl-6-Methoxy-7-(n-Propoxy)-3,4-Dihydroisoquinolin-1]Ethanoic Acid Amides, HPLC of Formula: 15029-36-4, the publication is Pharmaceutical Chemistry Journal (2017), 51(1), 22-25, database is CAplus.

Cyclocondensation of O-n-propylated eugenol with cyanoacetamides was used to synthesize 2-[3-methyl-6-methoxy-7-(n-propoxy)-3,4-dihydroisoquinolin-1]ethanoic acid amides. The hydrochlorides of these compounds were tested for antihelminthic and insecticidal activity. The most active compounds were amides containing a cyclic amine fragment (pyrrolidine, piperidine, morpholine), which had greater activity than Pyrantel. Compounds without substituents at the amide nitrogen and the N-ethylamide had insecticidal activity at the levels of diazinon and pirimiphos.

Pharmaceutical Chemistry Journal published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C20H18BrN3, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mijin, Dusan Z. published the artcileSynthesis of substituted 3-cyano-2-pyridones. Part IV. Influence of 3-alkyl-2,4-pentanedione and N-alkylcyanoacetamide structure on the enzyme-catalyzed synthesis of substituted 3-cyano-2-pyridones, SDS of cas: 15029-36-4, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2006), 45B(4), 993-1003, database is CAplus.

Lipase from Candida rugosa was used to study the influence of 3-alkyl-2,4-pentanedione and N-alkylcyanoacetamide structure on the enzyme-catalyzed reaction of pyridone ring formation in water at 40°. Starting with 1,3-diketones and cyanoacetamides and for comparison, the expected corresponding 3-cyano-2-pyridones were synthesized by chem. methods. Bulkier substituents lower the initial reaction rate of the enzyme-catalyzed reactions and consequently the yield of the corresponding pyridones. N-alkylcyanoacetamides are more reactive in comparison to the corresponding 3-alkyl-2,4-pentanediones with respect to the obtained yields of 3-cyano-2-pyridones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Basha, Shaik Jeelan published the artcileNew Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer’s Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase, Synthetic Route of 15029-36-4, the publication is Molecular Pharmaceutics (2018), 15(6), 2206-2223, database is CAplus and MEDLINE.

In line with the modern multi target-directed ligand paradigm of Alzheimer’s disease (AD), a series of nineteen compounds composed of flavone and cyanoacetamide groups have been synthesized and evaluated as multifunctional agents against AD. Biol. evaluation demonstrated that compounds 7j, 7n, 7o, 7r and 7s exhibited excellent inhibitory potency (AChE, IC50 0.271 ± 0.012 to ± 0.075 M) and good selectivity toward acetylcholinesterase, significant antioxidant activity, good modulation effects on self-induced Aβ aggregation, low cytotoxicity and neuroprotection in human neuroblastoma SK-N-SH cells. Further, an inclusive study on the interaction of 7j, 7n, 7o, 7r and 7s with AChE at physiol. pH 7.2 using fluorescence, CD and mol. docking methods suggesting that these derivatives bind strongly to peripheral anionic site of AChE mostly through hydrophobic interactions. Overall, the multifunctional profiles and strong AChE binding affinity highlight these compounds as promising prototypes for further pursuit of innovative multifunctional drugs for AD.

Molecular Pharmaceutics published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Synthetic Route of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Saravanan, Janardhanan published the artcileSynthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents, Formula: C5H8N2O, the publication is European Journal of Medicinal Chemistry (2010), 45(9), 4365-4369, database is CAplus and MEDLINE.

3-Substituted 4,5-tetramethylene thieno[2,3-d][1,2,3]-triazin-4(3H)-ones I have been synthesized from cyclohexanone and N-substituted 2-cyanoacetamides via the Gewald reaction followed by diazotization. Compounds I were evaluated for their antimicrobial activity by the agar diffusion method against four bacteria and three fungi, with Ampicillin and Miconazole nitrate as standards I (R = 4-FC₆H₄ and 2-, 3-, and 4-ClC₆H₄) showed an antimicrobial efficacy considerably greater than the compounds with hydrogen, Ph, and electron donating (activating) R groups like Me, Et, and tolyl. This suggests that lipophillic groups like chloro and fluoro substituted on the Ph ring play an important role in enhancing the antimicrobial properties of this class of compounds From the screening results it is shown that the compounds having lipophillic R groups like chlorophenyl and fluorophenyl exhibit appreciable antimicrobial activities.

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Funnell, Richard A. published the artcileThree reactions leading to isomeric 2-(N,N-disubstituted amino)thiazol-5-yl ketones, Recommanded Product: Morpholine-4-carbothioamide, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1987), 2311-15, database is CAplus.

N-Imidoyl-N,N-disubstituted thioureas PhNHCR:NCSR¹ (R = CMe₃, Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 2-thienyl, R¹ = NMe₂, NPhMe, pyrrolidino, piperidino, morpholino, hexahydroazepino) react with α-halo ketones R²COCH₂R³ (I, R² = Me, R³ = Cl; R² = Me, CMe₃, Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄, Me₂CH, R³ = Br) in the presence of Et₃N to give the expected 2-(N,N-disubstituted amino)thiazol-5-yl ketones II in high yield. The corresponding reactions of N-acyl-N,N-disubstituted thioureas RCONHCSR¹ with I lead to mixtures of II and III, which arise from rearrangement between cyclic intermediates. Mixtures of II and III are also formed by treating N,N-disubstituted thioureas R¹CSNH₂ with 2-bromo-1,3-diketones RCOCHBrCOR². The mixtures from the second and third routes contain the same products but in significantly different proportions. A mechanistic scheme which accounts for the main findings was developed. Characteristic mass spectral fragmentation patterns were particularly useful in identifying the substituents at positions 4 and 5 of the thiazole ring.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Coeck, Robin published the artcileGold and Silver-Catalyzed Reductive Amination of Aromatic Carboxylic Acids to Benzylic Amines, Safety of Isonicotinamide, the publication is ACS Catalysis (2021), 11(13), 7672-7684, database is CAplus.

The reductive amination of benzoic acid and its derivatives was an effective addition to current synthesis methods for benzylamine. However, with current technol. it was very difficult to keep the aromaticity intact when starting from benzoic acid, and salt wastes were often generated in the process. Here, a heterogeneous catalytic system for such a reductive amination, requiring solely H₂ and NH₃ as the reactants was reported. The Ag/TiO₂ or Au/TiO₂ catalysts can be used multiple times, and very little noble metal was required, only 0.025 mol % Au. The catalysts were bifunctional: the support catalyzes the dehydration of both the ammonium carboxylate to the amide and of the amide to the nitrile, while the sites at the metal-support interface promote the hydrogenation of the in situ generated nitrile. Yields of up to 92% benzylamine were obtained.

ACS Catalysis published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wicht, Merrill M. published the artcileCobalt Werner hosts with nicotinamides: Characterisation of mixed ligand complexes and their selectivity towards ortho xylene, Category: amides-buliding-blocks, the publication is Polyhedron (2021), 115202, database is CAplus.

Cobalt host complexes which form novel Werner structures with nicotinamides were analyzed and characterized, the formation of mixed ligand complexes by crystallization with substitution of two nicotinamide ligands was achieved and selectivity toward a xylene isomer from a mixture was elucidated. Inter- and intra-mol. hydrogen bonding interactions which formed amide dimers, ring structures, discrete bonds and chains were described. In some cases, the packing was stabilized by π···π interactions between the aromatic rings of the nicotinamides. Three mixed ligand crystal structures were formed when two nicotinamide ligands in host complexes were replaced with two DMSO mols. or two methanol mols. via oxygen bridging. This formation required an understanding of the strength of interaction between the ligand and the metal ion. The investigation of pK_a, the dipole moment and electronegativity values for the interacting elements clarified the substitution process. A mixed ligand Werner clathrate [Co(NCS)₂(isonic)₂(C₂H₆OS)₂]·2(ortho-C₈H₁₀), showing characteristics both of a mixed ligand structure and a clathrate, presented a preference towards ortho-xylene from a 50:50 mixture of ortho/meta-xylenes. The single crystal structure, its thermal behavior and the Hirshfeld surfaces were used for confirmation of this finding. This study of cobalt Werner complexes with nicotinamides has explored mixed ligand complexes and the property of discrimination towards a xylene isomer from a mixture of two different isomers.

Polyhedron published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C7H8BClO2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Spitzner, R. published the artcileKetovinylization of thiocarbamides and thioureas. On the ambidence of the thioamido function, Product Details of C5H10N2OS, the publication is Tetrahedron (1982), 38(7), 927-36, database is CAplus.

Thiocarbamides and thioureas reacted as ambident systems with β-chlorovinyl ketones to give (S)-[(Z)-ketovinyl] salts. E.g., addition reaction of PhCSNH₂ with PhCOCH:CHCl in HCO₂H/HClO₄ for 1-2 h gave 78% (Z)-PhCOCH:CHSCPh:N⁺H₂ ClO₄^–. The ketovinyl salts obtained from monoprotic thiocarbamides and thioureas underwent deprotonation to give (S)-[(Z)-ketovinyl]thioimidate esters or -isothioureas, which isomerized intramolecularly on heating. E.g., deprotonation of (Z)-4-MeOC₆H₄COCH:CHSCPh:N⁺HPh ClO₄^– gave 82% (Z)-4-MeOC₆H₄COCH:CHSCPh:NPh, which on heating in PhMe gave (E)-4-MeOC₆H₄COCH:CHSCPh:NPh. Lithiated monoprotic thiocarbonamides reacted with β-chlorovinyl ketones to give N-[(E)-ketovinyl]thiocarbonamides, whereas lithiated thioureas gave S-[(E)-ketovinyl]isothioureas, which rearranged to the N-[(E)-ketovinyl]thioureas under mild conditions. E.g., lithiation and addition reaction of PhCSNHPh with PhCOCH:CHCl gave 59% (E)-PhCOCH:CHNPhCSPh, whereas similar treatment of Me₂NC(S)NHPh gave (E)-PhCOCH:CHSC(:NPh)NMe₂, which above room temperature gave (E)-PhCOCH:CHNPhC(S)NMe₂.

Tetrahedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H13NO2, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Surikova, O. V. published the artcileSynthesis, anthelmintic, and insecticidal activity of 2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinol-1-yl)acetamides, Product Details of C5H8N2O, the publication is Pharmaceutical Chemistry Journal (2015), 48(10), 665-668, database is CAplus.

A series of 2-(3-methyl-6-methoxy-7-ethoxy-3,4-dihydroisoquinol-1-yl)acetamides of formula I •HCl [R¹ = NH₂, NHEt, 1-morpholino, etc.] were synthesized via cyclocondensation of O-ethylated eugenol with cyanoacetamides. Hydrochlorides of the synthesized compounds exhibited anthelmintic activity. The unsubstituted amide was the most active and exhibited activity equal to that of levamisole and significantly greater than that of pyrantel. The insecticidal activity of the synthesized compounds was inferior to that of imidacloprid.

Pharmaceutical Chemistry Journal published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C15H14O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics