Tag: M.W=100-150

Takahashi, Hitoe published the artcileSelenoureas and thioureas are effective superoxide radical scavengers in vitro, Formula: C5H10N2OS, the publication is Life Sciences (2005), 76(19), 2185-2192, database is CAplus and MEDLINE.

The authors investigated scavenging of superoxide radicals by selenoureas and thioureas using a highly sensitive and quant. chemiluminescence method. At 330 nM, five selenoureas and five thioureas scavenged fractions of superoxide radicals (O^–₂) ranging from 8.4% to 87.6%. Among five N,N-unsubstituted selenoureas and N,N-unsubstituted thioureas, 1-selenocarbamoylpiperidine and 1-thiocarbamoylpyrrolidine were the most effective scavengers. The study showed that selenoureas could be used as new superoxide anion-scavenging substances.

Life Sciences published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H20O6, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hickey, Shane M. published the artcileCross-Coupling of Amide and Amide Derivatives to Umbelliferone Nonaflates: Synthesis of Coumarin Derivatives and Fluorescent Materials, Recommanded Product: Isonicotinamide, the publication is Journal of Organic Chemistry (2020), 85(12), 7986-7999, database is CAplus and MEDLINE.

The Buchwald-Hartwig cross-coupling reaction between 4-methylumbelliferone-derived nonaflates with amides, carbamates, and sulfonamides is described. A wide variety of N-substituted 7-amino coumarin analogs was prepared in good to excellent yields. The photophys. properties of aqueous-soluble derivatives were determined, and they displayed auxochrome-based variations. Gram-scale synthesis provided an acrylamide analog, which was used to fabricate a fluorescent poly(2-hydroxylethyl methacrylate) (pHEMA) hydrogel that was resistant to leaching in ultrapure H₂O. We envisage that our reported protocol to access 7-amino-4-methylcoumarin derivatives will find use toward the development of new fluorescent coumarin-based probes by researchers in the field.

Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hartmann, Horst published the artcileAlkylene-bridged N,N,N’,N’-tetrasubstituted bis(2-amino-5-thiazolyl)methinium salts – a new class of strongly fluorescent dyes, Synthetic Route of 14294-10-1, the publication is Angewandte Chemie, International Edition (2001), 40(3), 552-554, database is CAplus and MEDLINE.

N,N-Disubstituted thioureas were cyclocondensed with 1,5-dibromo-3,3-dimethyl-2,4-pentanedione or 4,6-dibromo-2,2-dimethyl-1,3-cyclohexanedione and the products were converted into the title benzobisthiazole methinium dyes.

Angewandte Chemie, International Edition published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Guo, Hui published the artcileHydrogels with Dual Thermoresponsive Mechanical Performance, Category: amides-buliding-blocks, the publication is Macromolecular Rapid Communications (2017), 38(17), n/a, database is CAplus and MEDLINE.

Dual thermoresponsive chem. hydrogels, combining poly(N-isopropylacrylamide) side-chains within a poly(N-acryloylglycinamide) network, are designed following a simple and versatile procedure. These hydrogels exhibit two phase transitions both at low (upper critical solution temperature) and high (lower critical solution temperature) temperatures, thereby modifying their swelling, rheol., and mech. properties. These novel thermo-schizophrenic hydrogels pave the way for the development of thermotoughening wet materials in a broad range of temperatures

Macromolecular Rapid Communications published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Richter, Adrian published the artcileEfficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis, SDS of cas: 14294-10-1, the publication is ChemMedChem (2022), 17(6), e202100733, database is CAplus and MEDLINE.

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.

ChemMedChem published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Aleksandar, D. published the artcileCorrelation analysis of IR, ¹H-and ¹³C-NMR spectral data of N-alkyl and N-cycloalkyl cyanoacetamides, Formula: C5H8N2O, the publication is Chemical Industry & Chemical Engineering Quarterly (2011), 17(3), 307-314, database is CAplus.

Linear free energy relations (LFER) were applied to the IR, ¹H- and ¹³C-NMR spectral data in N-alkyl and N-cycloalkyl cyanoacetamides. N-alkyl and N-cycloalkyl cyanoacetamides were synthesized from corresponding amine and Et cyanoacetate. A number of substituents were employed for alkyl substitution, and fairly good correlations were obtained, using simple Hammett equation. In N-alkyl and N-cycloalkyl cyanoacetamides substituent cause SCS of N-H hydrogen primarily by steric interaction, polar substituent effect influences SCS shift of C=O carbon, while steric effect of N-alkyl substituent causes IR stretching frequencies of N-H, C=O and CN group. The conformations of studied compounds were studied using semiempirical PM6 method, and together with LFER anal., give a better insight into the influence of such a structure on the transmission of electronic substituent effects. Neg. ρ values for several correlations (reverse substituent effect) were found.

Chemical Industry & Chemical Engineering Quarterly published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Burger, Klaus published the artcileApplication of hexafluoroacetone as protecting and activating reagent in amino acid and peptide chemistry. N-Substituted glycine derivatives from iminodiacetic acid, Name: Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (1993), 48(1), 107-20, database is CAplus.

3-Carboxymethyl-2,2-bis(trifluoromethyl)-5-oxazolidinone, obtained on reaction of HN(CH₂CO₂H)₂ with (CF₃)₂CO, represents a preparatively useful intermediate for the synthesis of unsym. substituted derivatives of HN(CH₂CO₂H)₂. The N-substituted glycine derivatives obtained are interesting candidates for peptide modification.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Burger, Klaus published the artcileA surprising access route to α-hetero-substituted methylphosphonate esters, Synthetic Route of 14294-10-1, the publication is Chemiker-Zeitung (1988), 112(3), 108-9, database is CAplus.

A mixture of 2,2-bis(trifluoromethyl)oxazolone I and P(OMe)₃ reacts with thiourea, as well as with N,N-dimethylthiourea, morpholinothioamide, and thioacetamide to give 65% (MeO)₂P(O)CH(SMe)NHCH(CF₃)₂.

Chemiker-Zeitung published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pantwalawalkar, Jidnyasa published the artcileNovel curcumin ascorbic acid cocrystal for improved solubility, Formula: C6H6N2O, the publication is Journal of Drug Delivery Science and Technology (2021), 102233, database is CAplus.

The present investigation aims to develop novel curcumin-ascorbic acid cocrystal for enhancing the solubility, stability, and complementary biol. activities for curcumin. Based on in silico approach to screen ascorbic acid as a coformer for curcumin, cocrystals were prepared by the solvent evaporation method, and further evaluated for saturation solubility, cocrystal propensity, physicochem. interactions (FTIR and DSC), XRD, drug dissolution, etc. In silico findings confirmed the suitability (H_ex, G_mix) of ascorbic acid for the cocrystn. of curcumin. The DSC and XRD data of the solvent evaporated curcumin-ascorbic acid mixture confirmed the formation of cocrystal, eutectic, and binary mixture with an excess of coformer. The binary phase diagram implied 0.5 to the 0.65-mol fraction of curcumin, essential for cocrystn. with ascorbic acid. The novel curcumin ascorbic acid cocrystals revealed extraordinary improvement in aqueous solubility of curcumin, especially, 576 fold in distilled water, 10 fold in the buffer pH 1.2, and 9 fold in the buffer pH 6.8. The curcumin-ascorbic acid cocrystal system exhibited a superior dissolution profile compared to neat curcumin. Thus, ascorbic acid has enunciated its role as a coformer for curcumin in cocrystal formation, which has been complemented by predicted complementary biol. activities, and stability (acidic milieu).

Journal of Drug Delivery Science and Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zubenko, Alexander A. published the artcileThiourea assisted recyclization of 1-(chloromethyl)dihydroisoquinolines: a convenient route to β-(o-thiazolylaryl)ethylamines, Recommanded Product: Morpholine-4-carbothioamide, the publication is Mendeleev Communications (2021), 31(1), 125-127, database is CAplus.

Synthesis of new β-(o-thiazolylaryl)ethylamines such as I [R¹ = H, OMe; R² = H, Me; R³ = H, Ph, 4-BrC₆H₄, etc. R⁴ = H, CH₂CH₂OCH₂CH₂; Hal = Cl, Br; n = 1, 2] was afforded via recyclization of 1-chloromethyl-3,4-dihydroisoquinolines upon treatment with thioureas under acidic conditions.

Mendeleev Communications published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C3H5F3O, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics