Tag: M.W=0-100

In an article, author is Dawelbeit, Ahmed, once mentioned the application of 598-50-5, Name is 1-Methylurea, molecular formula is C2H6N2O, molecular weight is 74.08, MDL number is MFCD00007950, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Recommanded Product: 1-Methylurea.

A novel, efficient, and simple procedure to synthesize diverse ketonitriles by palladium-catalyzed Suzuki coupling of amides through N-C cleavage has been developed. This procedure features mild conditions, a broad substrate scope, and easily prepared substrates, providing a simple and efficient access to a variety of ketonitriles.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

593-81-7, Name is Trimethylamine hydrochloride, molecular formula is C3H10ClN, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is da Luz, Shirlley F. M., once mentioned the new application about 593-81-7, Computed Properties of https://www.ambeed.com/products/593-81-7.html.

The role of molecular dipole orientations and intermolecular interactions in a derivative of pyrene on its supramolecular self-assembly in solution has been investigated using quantum chemical and force field based computational approaches. Five possible dipole configurations of the molecule have been examined, among which the one in which adjacent dipole vectors are antiparallel to each other is determined to be the ground state, on electrostatic grounds. Self-assembly of this molecule under realistic conditions has been studied using MD simulations. Dipolar relaxation in its liquid crystalline (LC) phase has been investigated and contrasted against that in the well-established benzene-1,3,5-tricarboxamide (BTA) family. The dihedral barrier related to the amide dipole flip is larger in the pyrene system than in BTA which explains the differences in their dipolar relaxation behaviors. The mechanism underlying polarization switching upon the application of an external electric field in the LC phase is investigated. Unlike in BTA, this switching is not associated with a reversal of the helical sense of the hydrogen bonded chains, due to differences in molecular symmetry. The observations enable general conclusions on the relationship between electric field induced chiral enhancement and symmetry to be drawn.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Achanta, Prabhakar S., once mentioned the application of 5813-64-9, Name is 2,2-Dimethylpropan-1-amine, molecular formula is C5H13N, molecular weight is 87.1634, MDL number is MFCD00008134, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/5813-64-9.html.

Exogenous antioxidants may be beneficial therapeutic tools to tackle the oxidative damage in neurodegenerative diseases by regulation of the redox state that is critical for cell viability and organ function. Inspired by natural plant polyphenols, a series of cinnamic acid-based thiophenolic and phenolic compounds were synthesized and their antioxidant and neuroprotective properties were studied. In general, our results showed that the replacement of the hydroxyl group (OH) by a sulfhydryl group (SH) increased the radical scavenging activity and enhanced the reaction rate with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH center dot) and galvinoxyl radical (GO(center dot)). These results correlated well with the lower oxidation potential (E-p) values of thiophenols. However, a lower peroxyl radical (ROO center dot) scavenging activity was observed for thiophenols in oxygen radical absorbance capacity (ORAC-FL) assay. Furthermore, the introduction of 5-methoxy and 5-phenyl groups in the aromatic ring of 4-thioferulic acid (TFA) 2 and ferulic acid (FA) 1 did not significantly improve their antioxidant activity, despite the slight decrease of E-p observed for compounds 5, 6, and 9. Concerning cinnamic acid amides, the antioxidant profile was similar to the parent compounds. None of the compounds under study presented significant cytotoxic effects in human differentiated neuroblastoma cells. Thiophenolic amide 3 stands out as the most promising thiophenol-based antioxidant, showing cellular neuroprotective effects against oxidative stress inducers (hydrogen peroxide and iron).

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Synthetic Route of 2749-11-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 2749-11-3, Name is (S)-2-Aminopropan-1-ol, SMILES is C[C@H](N)CO, belongs to amides-buliding-blocks compound. In a article, author is Cao, Ke, introduce new discover of the category.

In the present report, we describe the synthesis of the amide derivative, N-(2,4-dichlorophenyl)-1-naphthamide, 3, via a facile chemical route. The title compound was isolated in 86% yield. The structure of compound 3 was established using spectroscopic methods and X-ray crystallography. In the crystal structure of 3, supramolecular assembly is dominated by classical N-H center dot center dot center dot O hydrogen bonding and C-Cl center dot center dot center dot pi halogen bonding interactions which were examined in detail using several theoretical methods and DFT calculations. The optimized geometric parameters of compound 3 were calculated using density functional theory (DFT/B3LYP and DFT/M06-2X) quantum chemical methods with the 6-311++G(d,p) basis set using the crystallographic coordinates. Additionally, fragments contributing to the HOMO and LUMO molecular orbitals were investigated at the same level of theory. The nature and various types of intermolecular interactions in the crystal structure were also realized by Hirshfeld surface analysis. The biological properties such as anti-Alzheimer’s potential were also assessed which reveals strong acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory effects. Compound 3 was 16-fold more active inhibitor of acetylcholinesterase compared to neostigmine with an IC50 value of 1.044 +/- 0.76 mu M in addition to 21-fold strong inhibition against butyrylcholinesterase. The in vitro bioactivity results were further strengthened by the molecular docking analysis revealing the presence of several important interactions with the active site residues from cholinesterase (AChE & BChE) enzymes. (C) 2019 Elsevier B.V. All rights reserved.

Synthetic Route of 2749-11-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2749-11-3 is helpful to your research.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Andrade, Laize A. F., once mentioned the application of 57-13-6, Name is Urea, molecular formula is CH4N2O, molecular weight is 60.0553, MDL number is MFCD00008022, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/57-13-6.html.

The temperature dependence of the rheological properties of poly(ether-b-amide) (PEBA) segmented copolymer under oscillatory shear flow has been investigated. The magnitude of the dynamic storage modulus is affected by the physical microphase separation and irreversible crosslinking network, with the latter spontaneously forming between the polyamide segments and becoming the dominant factor in determining the microstructural evolution at temperatures well above the melting point of PEBA. From the rheological results, the initial temperature of the rheological properties dominated by the microphase separation and crosslinking (T-cross) structures were determined, respectively. Based on the two obtained temperatures, the microstructure evolution upon the heating can be separated into the ternary microstructure domains: homogenous (temperature below ), microphase separation dominating (between and T-cross), and crosslinking dominating domains (above T-cross). When the PEBA is heated to above T-cross, the content of crosslinking network increases with time and temperature, leading to an irreversible and non-negligible influence on the rheological, crystallization, and mechanical properties. A more pronounced strain-hardening phenomenon during the uniaxial stretching is observed for the sample with a higher content of crosslinking network.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Related Products of 123-39-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 123-39-7, Name is N-Methylformamide, SMILES is O=CNC, belongs to amides-buliding-blocks compound. In a article, author is Priest, Christina, introduce new discover of the category.

Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed -arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of aromatic esters, the present work will allow for rapid access to valuable -aryl carbonyl compounds.

Related Products of 123-39-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 123-39-7 is helpful to your research.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In an article, author is Sutera, Flavia Maria, once mentioned the application of 57-13-6, Formula: https://www.ambeed.com/products/57-13-6.html, Name is Urea, molecular formula is CH4N2O, molecular weight is 60.0553, MDL number is MFCD00008022, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

The removal and recovery of highly potent endocrine disrupting chemicals (EDCs) estrone (E1), 17 beta-estradiol (E2) and 17 alpha-ethinylestradiol (EE2) and the oxidation product 2-hydroxyestradiol (2OHE2) in water was achieved on polyamide 6 (PA6) particles. Hydrogen bonding was the main mechanism driving the adsorption of these EDCs on PA6 at pHs lower than the EDCs pKas (similar to 10.5) and their adsorption was not affected by the water matrix nor by solute-solute interaction. The adsorption isotherms were linear and the values of the linearity constants for E2 and EE2 were almost double those for E1 and 2OHE2. This was correlated to the number of intermolecular hydrogen bonds via -OH groups of the EDCs (H-bond donors) available for interaction with PA6’s surface via the amide groups (H-bond acceptors). The effect of pH on the adsorption of the EDCs on PA6 was significant only at pHs > EDCs pKa (similar to 10.5). The breakthrough curves of the EDCs on PA6 particles in a fixed-bed column were successfully modelled using a linearised mass transfer model. This study shows that PA6 appears an effective sorbent for the removal as well as the enrichment and pre-concentration of EDCs in wastewater samples. (c) 2017 Elsevier B.V. All rights reserved.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Reference of 2799-16-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2799-16-8, Name is (R)-1-Aminopropan-2-ol, SMILES is C[C@@H](O)CN, belongs to amides-buliding-blocks compound. In a article, author is Shi, Wei-Min, introduce new discover of the category.

The nucleophilic attack step of the hydrolysis reaction mechanism of the glycine-glycine peptide bond mediated by the enzymatic action of various proteases was elucidated by means of DFT calculations. Five different protease models were considered; namely: cysteine (Cys), threonine (Thr), serine (Ser), aspartyl (Asp) proteases, and a metalloprotease containing zinc (Zn). The model was simplified in order to gain information about the nucleophilic attack in this type of reaction. As a comparative study, this work is focused on the trend in the reactivity of the models. According to the computed activation energies, the reactivity order was determined as follows Cys < Thr < Ser < Zn < Asp, being in all cases faster than the uncatalysed spontaneous hydrolysis. A further analysis of the reactions by means of the reaction force approach showed that the structural changes accounts for 65-90% of the total activation energy. Moreover, a natural bond orbital analysis allows the reactions to be classified as synchronous with a late transition state for all cases. Systems analogous to the Cys-protease can be proposed as a promising candidate for the design of mimetic systems capable to cleavage amide bonds. Reference of 2799-16-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2799-16-8 is helpful to your research.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 3144-09-0, Name is Methylsulfonamide, formurla is CH5NO2S. In a document, author is Li, Ying, introducing its new discovery. Safety of Methylsulfonamide.

Chemoselective copper-catalyzed synthesis of diverse N-arylindole-3-carboxamides, beta-oxo amides and N-arylindole-3-carbonitriles from readily accessible indole-3-carbonitriles, alpha-cyano ketones and diaryliodonium salts has been developed. Diverse N-arylindole-3-carboxamides and beta-oxo amides were successfully achieved in high yields under copper-catalyzed neutral reaction conditions, and the addition of an organic base (DIPEA) resulted in a completely different selectivity pattern to produce N-arylindole-3-carbonitriles. Moreover, the importance of the developed methodology was realized by the synthesis of indoloquinolones and N-((1H-indol-3-yl)methyl)aniline and by a single-step gram-scale synthesis of the naturally occurring cephalandole A analogue.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Related Products of 127-19-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 127-19-5, Name is N,N-Dimethylacetamide, SMILES is CC(N(C)C)=O, belongs to amides-buliding-blocks compound. In a article, author is Stolarska, Magdalena, introduce new discover of the category.

Colchicine is the major alkaloid isolated from the plant Colchicum autumnale, which shows strong therapeutic effects towards different types of cancer. However, due to the toxicity of colchicine towards normal cells its application is limited. To address this issue we synthesized a series of seven triple-modified 4-bromothiocolchicine analogues with amide moieties. These novel derivatives were active in the nanomolar range against several different cancer cell lines and primary acute lymphoblastic leukemia cells, specifically compounds: 5-9 against primary ALL-5 (IC50 = 5.3-14 nM), 5, 7-9 against A549 (IC50 = 10 nM), 5, 7-9 against MCF-7 (IC50 = 11 nM), 5-9 against LoVo (IC50 = 7-12 nM), and 5, 7-9 against LoVo/DX (IC50 = 48-87 nM). These IC50 values were lower than those obtained for unmodified colchicine and common anticancer drugs such as doxorubicin and cisplatin. Further studies revealed that colchicine and selected analogues induced characteristics of apoptotic cell death but manifested their effects in different phases of the cell cycle in MCF-7 versus ALL-5 cells. Specifically, while colchicine and the studied derivatives arrested MCF-7 cells in mitosis, very little mitotically arrested ALL-5 cells were observed, suggesting effects were manifest instead in interphase. We also developed an in silico model of the mode of binding of these compounds to their primary target, beta-tubulin. We conducted a correlation analysis (linear regression) between the calculated binding energies of colchicine derivatives and their anti-proliferative activity, and determined that the obtained correlation coefficients strongly depend on the type of cells used.

Related Products of 127-19-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 127-19-5.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics