Tag: 300-400

Rashwan, Hanan M.;Mohammed, Hagar E.;El-Nekeety, Aziza A.;Hamza, Zeinab K.;Abdel-Aziem, Sekena H.;Hassan, Nabila S.;Abdel-Wahhab, Mosaad A. published 《Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats》. The research results were published in《Environmental Science and Pollution Research》 in 2021.Recommanded Product: 112-84-5 The article conveys some information:

This study was conducted to identify the bioactive phytochems. in Salvia officinalis essential oil, to determine the polyphenols in the aqueous extract (SOE), and to evaluate their protective role against cadmium (Cd)-induced oxidative damage and genotoxicity in rats. Six groups of female rats were treated orally for 2 wk including the control group, CdCl2-treated group, SOE-treated groups at low or high dose (100 and 200 mg/kg b.w), and CdCl2 plus SOE-treated groups at the two doses. The GC-MS anal. identified 39 compounds; the main compounds were 9-octadecenamide, eucalyptol, palmitic acid, and oleic acid. However, the HPLC anal. showed 12 polyphenolic compounds and the majority were coumaric acid, chlorogenic acid, coffeic acid, catechin, vanillin, gallic acid, ellagic acid, and rutin. In the biol. study, rats received CdCl2 displayed severe disturbances in liver and kidney indexes alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), total protein (TP), total bilirubin (T. Bil), direct bilirubin (D. Bil), creatinine, uric acid, and urea, lipid profile, tumor necrosis factor-alpha (TNF-α), alpha-fetoprotein (AFP) and CEA), glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), malondialdehyde (MDA), nitric oxide (NO), gene expressions, DNA fragmentation, and histol. alterations in the liver and kidney tissue. SOE showed a potent antioxidant and mitigated these alterations in serum and tissue. Moreover, the high dose succeeded to normalize most of the tested parameters and histol. features. It could be concluded that S. officinalis is a promising source for bioactive compounds with therapeutic benefits against environmental toxicants.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Recommanded Product: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 112-84-5In 2021, Younis, Waqas;Alamgeer;Schini-Kerth, V. B.;Junior, Arquimedes Gasparotto;Nocchi, Samara Requena;Silva, Denise Brentan;Roberts, Richard E. published 《Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery》. 《Journal of Ethnopharmacology》published the findings. The article contains the following contents:

Asphodelus tenuifolius Cav. (Asphodelaceae), a wild, terrestrial, annual stemless herb, is widely used in traditional medicine for the treatment of hypertension, diabetes, atherosclerosis and circulatory problems. A previous research study from our laboratory revealed that A. tenuifolius has beneficial effects in reducing blood pressure and improves aortic endothelial dysfunction in chronically glucose fed rats. Despite the fact that A. tenuifolius reduces blood pressure and improves endothelial function in vivo, there are no detailed studies about its possible mechanism of action. This study was designed to provide pharmacol. basis and mechanism of action for the traditional use of A. tenuifolius in hypertension and circulatory problems. We explored the vasorelaxant effect of A. tenuifolius and its underlying vasorelaxation mechanism in porcine coronary artery rings. Aqueous methanolic crude extract of A. tenuifolius was prepared by maceration process and then activity guided fractionation was carried out by using different polarity based solvents. Phytochem. studies were carried out using LC-DAD-MS. Segments of porcine distal coronary artery were set up in a wire myograph for isometric force measurements. Extract/fractions of A. tenuifolius seeds were tested for vasodilator activity by measurement of changes in tone after pre-contraction with the thromboxane mimetic U46619 in the presence or absence of inhibitors of intracellular signaling cascades.Crude extract/fractions of A. tenuifolius produced dose dependent endothelium independent vasorelaxant response in coronary rings, whereas, the butanol fraction of A. tenuifolius (BS-AT) produced the largest relaxation response with 100% relaxation at 1 mg/mL, therefore the mechanism of relaxation of this fraction was determined The relaxation to BS-AT was unaffected by removal of the endothelium, pre-contraction with KCl, or the presence of the non-selective potassium channel blocker tetraethylammonium, indicating that the relaxation was endothelium-independent, and does not involve activation of potassium channels. BS-AT (1 mg/mL) inhibited the contractile response to calcium, the L-type calcium channel activator BAY K8664,and ionomycin, indicating that it inhibits calcium-induced contractions. The relaxation response to BS-AT was attenuated in the absence of extracellular calcium. However, relaxations to BS-AT were also reduced after deletion of calcium from intracellular stores with cyclopiazonic acid. Incubation with 1 mg/mL BS-AT also inhibited phosphorylation of myosin light chains in homogenates of coronary artery. The butanol extract of Asphodelus tenuifolius produces a large endothelium-independent relaxation of the porcine coronary artery through inhibition of calcium-induced contractions. The effect appears to be downstream of calcium influx, possibly through inhibition of myosin light chain kinase. This study supports previous studies demonstrating that A. tenuifolius reduces blood pressure. Future studies will aim to determine the active compounds underlying this response. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.SDS of cas: 112-84-5 It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Noh, Kwanghae;Fincher, Jason;Mimms, Robert;Sue, Hung-Jue published 《Effect of mold temperature and additive migration on scratch behavior of TPOs at elevated temperatures》 in 2021. The article was appeared in 《Polymer》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Scratch performance of thermoplastic olefins (TPOs) has been considered one of the required properties for automotive applications. The scratch resistance of TPOs can be enhanced by utilization of commonly used slip additives such as erucamide. When TPOs are injection molded, the mold temperature impacts the migration of the slip additive toward the surface and the surface crystallinity of the TPOs, which has been shown to influence scratch resistance. In order to evaluate the effect of the mold temperature and erucamide migration on scratch behavior at elevated temperatures, this research has adopted the ASTM D7027/ISO 19252 linearly increasing normal load scratch test methodol. to investigate the scratch behavior of the model TPOs at 25°C, 50°C, and 75°C. This study provides a comprehensive understanding on the effects of mold temperature, slip additive, elevated testing temperature, and thermal aging on scratch behavior of TPOs.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Cui;He, Qian;Zeng, Linlin;Shen, Ling;Luo, Qiaomei;Zhang, Wentao;Zhou, Xia;Wan, Jun published 《Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus》 in 2021. The article was appeared in 《Chemistry & Biodiversity》. They have made some progress in their research.Computed Properties of C22H43NO The article mentions the following:

Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatog.-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathol. changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota anal. revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Computed Properties of C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 112-84-5In 2022, Fu, Yong-Ping;Yuan, Huan;Xu, Yan;Liu, Ru-Ming;Luo, Yi;Xiao, Jian-Hui published 《Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings》. 《Phytomedicine》published the findings. The article contains the following contents:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by high levels of proinflammatory cytokines and epithelial barrier dysfunction. The root of Ligularia fischeri (Ledeb.) Turcz. is a traditional Chinese medicinal herb with diverse therapeutic properties, which has been successfully used to treat inflammation-related diseases. However, little is known about its effect and mechanism against UC. To investigate the efficacy and mechanism of L. fischeri root extracts against UC. L. fischeri root samples were prepared using the alc. extraction method and liquid-liquid extraction method. A dextran sodium sulfate-induced UC mouse model and a lipopolysaccharide (LPS)-induced inflammatory cell model were employed in the present study. Cell apoptosis was detected by TUNEL staining, and an ELISA was used to quantify the abundance of inflammatory factors in tissues. Hematoxylin and eosin staining and Masson staining were employed to analyze drug toxicity to the liver and kidney. A myeloperoxidase (MPO) assay kit was used to detect neutrophil infiltration in colon tissues. RT-qPCR was then employed to quantify the transcriptional levels of proinflammatory and apoptotic-related genes, while tight junction and apoptosis-related proteins were quantified via western blotting. Gas Chromatog./Mass Spectrometry anal. was then performed to identify the natural compounds in L. fischeri root extracts The water decoction extract, methanol extract, and especially the chloroform extract (CE) exerted potent therapeutic effects in UC mice. Similar to the pos. control group (5-aminosalicylic acid), oral administration of CE (30, 60, and 90 mg/kg/d) elicited distinct therapeutic effects on UC mice in the medium- and high-dose groups. CE decreased disease activity index, histopathol. score, and MPO level significantly, and effectively retained the colon length. Furthermore, CE significantly reduced the levels of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α and enhanced the expression of tight junction proteins, such as zonula occludens (ZO)-1, ZO-2, claudin-1, and occludin, as well as the transcriptional levels of mucins, such as MUC-1 and MUC-2, in UC mice. Notably, CE prevented apoptosis of colonic epithelial cells by up-regulating Bcl-2 and down-regulating Bax. Also, CE inhibited the secretion of pro-inflammatory cytokines and apoptosis in LPS-induced RAW264.7 macrophages via the activation of Bcl-2/Bax signals.Collectively, L. fischeri root extracts, especially CE, have obvious therapeutic effects against UC. CE reduces inflammation and protects the intestinal epithelial cells and intestinal epithelial barrier via activation of the Bcl-2/Bax signaling pathway, and may be a promising therapeutic agent for UC treatment. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Viererbl, L.;Kolros, A.;Vin, M.;Klupak, V. published 《Detection of neutrons emitted from reactor primary circuit water by discontinuing flow method》 in 2021. The article was appeared in 《Journal of Nuclear Engineering and Radiation Science》. They have made some progress in their research.Reference of cis-13-Docosenamide The article mentions the following:

Online activity measurement of fission products in a primary circuit water is often used for a fuel failure detection in research and power nuclear reactors. When gamma spectrometry is used for the activity measurement, high signal from 16N radionuclide and other activation products make the detection of fission products difficult. The detection of delayed neutrons emitted from several fission products is also used; however, if the detector is placed near the outlet coolant pipe, the signal from the delayed neutrons cannot be distinguished from the neutrons emitted due to ¹⁷N decay and deuterium photofission, with exception of a reactor scram condition. In this paper, a method of discontinuing the flow of primary circuit water is described. This method is based on the water flowing through a bypass on the outlet pipe to the sampling container and the flow is periodically temporarily interrupted, e.g., using 200s + 200 s cycles. Neutrons located in the vicinity of the sampling container are continuously detected with a measuring sampling time of less than 2s. The signal part, corresponding to the delayed neutrons, is evaluated by the signal decay analyzing during the flow interruption. The main sources of delayed neutrons suitable for this method are ¹³⁷I, ⁸⁷Br, and ⁸⁸Br radionuclides with half-lives of 24.5 s, 55.7 s, and 16.5 s, resp. The method was theor. analyzed and exptl. verified in the LVR-15 research reactor.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Reference of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HPLC of Formula: 112-84-5In 2022, Navratilova, Klara;Hurkova, Kamila;Hrbek, Vojtech;Uttl, Leos;Tomaniova, Monika;Valli, Enrico;Hajslova, Jana published 《Metabolic fingerprinting strategy: Investigation of markers for the detection of extra virgin olive oil adulteration with soft-deodorized olive oils》. 《Food Control》published the findings. The article contains the following contents:

As extra virgin olive oil (EVOO) is a high value commodity, it might be subject of various fraudulent practices. This study is focused on a challenging authentication issue, addition of lower grade, soft-deodorized olive oil to EVOO. In the first step, sample sets of authentic EVOOs, soft-deodorized oils and their admixtures were extracted by aqueous methanol; obtained polar fractions were then analyzed by ultra-high performance liquid chromatog. coupled to hybrid quadrupole time-of-flight high-resolution tandem mass spectrometry (UHPLC-QTOF-HRMS/MS). Subsequent chemometric evaluation of metabolic fingerprints enabled suggestion of several ions that might be characteristic for deodorized oils; most of tentatively identified compounds were oxidized fatty acid derivatives In the second phase, the marker ions were employed for target anal. by ultra-high performance liquid chromatog. coupled to triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS) what enabled achieving lower the detection limits. Two compounds were selected as the best markers for detection of soft-deodorized olive oil addition, tentatively identified as Me ester of hydroxy octadecenoic acid and ester derivative of oleic acid. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.HPLC of Formula: 112-84-5 It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of C22H43NOIn 2021, McPartlin, Michael W.;Italiano, Brandon R.;Tiano, Thomas M.;Pilkenton, Sarah J.;Lawton, Timothy J. published 《An approach to identifying fibers and evolved compounds from flame resistant fabrics》. 《Journal of Analytical and Applied Pyrolysis》published the findings. The article contains the following contents:

Flame resistant (FR) fabrics have use in civilian, military, and industrial applications. This work describes the development of a methodol. aimed at identifying the fiber composition of blended fabrics of unknown composition Here, FR fabrics used in military uniforms, are studied using a combination of XPS, isothermal thermogravimetric anal. (TGA) and pyrolysis gas chromatog./mass spectrometry (Py-GC-MS). Elemental anal. of the fabrics using XPS yielded a preliminary determination of the composition of the polymer(s) and aided in the identification of FR additives. TGA and Py-GC-MS experiments were used for subsequent compound identification. In TGA the temperature of mass loss events was compared to reference materials, and in Py-GC-MS the pyrolysis products of the blended FR fabrics were compared to those from a series of potential parent fibers. It was possible to discern the composition of the parent fibers and the type of FR treatment added to fabrics because the thermal decomposition chem. did not significantly change by blending the fibers to make fabrics. To complete the study, the researchers used cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Synthetic Route of C22H43NO

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of cis-13-DocosenamideIn 2021, Liu, Zhengqi;Zhang, Yujiao;Ai, Chunqing;Wen, Chengrong;Dong, Xiuping;Sun, Xiaona;Cao, Cui;Zhang, Xueqian;Zhu, Beiwei;Song, Shuang published 《Gut microbiota response to sulfated sea cucumber polysaccharides in a differential manner using an in vitro fermentation model》. 《Food Research International》published the findings. The article contains the following contents:

Sea cucumber Stichopus japonicus has been consumed as high-valued seafood in Asian, and its sulfated polysaccharide (SCSPsj) has been inferred to benefit the host health via modulating gut microbiota composition The present study compared the responses of gut microbiota communities from different donors to SCSPsj, and the key bacteria were identified by 16S rRNA gene sequencing anal. and in vitro fermentation with specific bacteria. Gut microbiota communities from 6 donors (A ∼ F) utilized the polysaccharides to different degrees in vitro fermentation Further comparison of Samples A and C demonstrated that Sample C with the relatively strong SCSPsj utilization capability possessed more Parabacteroides while Sample A contained more Bacteroides. Further in vitro fermentation of SCSPsj with 10 Parabacteroides and Bacteroides species suggests that Parabacteroides distasonis, enriched in Sample C, plays a critical role in the utilization of the polysaccharides. Moreover, short chain fatty acids and the metabolite profiles of Samples A and C were also compared, and the results showed that more beneficial metabolites were accumulated by the microbiota community consuming more sulfated sea cucumber polysaccharides. Our findings revealed that certain key members of gut microbiota, such as Parabacteroides distasonis, are critical for SCSPsj utilization in gut so as to influence the benefits of the polysaccharide supplement for host. Thus, to obtain better functional outcome for sulfated sea cucumber polysaccharides and sea cucumber, more attention needs to be paid to the effects of inter-individual differences in microbiota community structure. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Quality Control of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Eysseric, Emmanuel;Gagnon, Christian;Segura, Pedro A. published 《Identifying congeners and transformation products of organic contaminants within complex chemical mixtures in impacted surface waters with a top-down non-targeted screening workflow》 in 2022. The article was appeared in 《Science of the Total Environment》. They have made some progress in their research.Product Details of 112-84-5 The article mentions the following:

Over 350,000 compounds are registered for production and use including a high number of congeners found in complex chem. mixtures (CCMs). With such a high number of chems. being released in the environment and degraded into transformation products (TPs), the challenge of identifying contaminants by non-targeted screening (NTS) is massive. “Bottom-up” studies, where compounds are subjected to conditions simulating environmental degradation to identify new TPs, are time consuming and cannot be relied upon to study the TPs of hundreds of thousands of compounds Therefore, the development of “top-down” workflows, where the structural elucidation of unknown compounds is carried directly on the sample, is of interest. In this study, a top-down NTS workflow was developed using mol. networking and clustering (MNC). A total of 438 compounds were identified including 176 congeners of consumer product additives and 106 TPs. Reference standards were used to confirm the identification of 53 contaminants among them lesser-known pharmaceuticals (aliskiren, sitagliptin) and consumer product additives (lauramidopropyl betaine, 2,2,4-trimethyl-1,2-dihydroquinoline). The MNC tools allowed to group similar TPs and congeners together. As such, several previously unknown TPs of pesticides (metolachlor) and pharmaceuticals (gliclazide, irbesartan) were identified as tentative candidates or probable structures. Moreover, some congeners that had no entry on global repositories (PubChem, ChemSpider) were identified as probable structures. The workflow worked efficiently with oligomers containing ethylene oxide moieties, and with TPs structurally related to their parent compounds The top-down approach shown in this study addresses several issues with the identification of congeners of industrial compounds from CCMs. Furthermore, it allows elucidating the structure of TPs directly from samples without relying on bottom-up studies under conditions discussed herein. The top-down workflow and the MNC tools show great potential for data mining and retrospective anal. of previous NTS studies. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Product Details of 112-84-5

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics