Tag: 300-400

On May 4, 2012, Hou, Wenduan; Zheng, Bo; Chen, Jun; Peng, Yungui published an article.COA of Formula: C15H15F3N2O2S The title of the article was Asymmetric Synthesis of Polysubstituted 4-Amino- and 3,4-Diaminochromanes with a Chiral Multifunctional Organocatalyst. And the article contained the following:

A series of multifunctional catalysts with two chiral diaminocyclohexane units were developed and successfully applied in the asym. oxa-Michael-aza-Henry cascade reaction of salicylaldimines with nitroolefins. This approach provides a simple and efficient entry to polysubstituted chiral 4-aminobenzopyrans with three consecutive stereocenters and in high yield (up to 97%) with excellent stereoselectivity (up to 98% ee and >99:1 dr). Facile access to the nonsym. optically pure 3,4-diaminochromanes was also obtained. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).COA of Formula: C15H15F3N2O2S

The Article related to nitroolefin salicylaldimine chiral diaminocyclohexane thiourea asym michael henry, aminochromane stereoselective preparation, chiral diaminocyclohexane thiourea enantioselective diastereoselective michael henry catalyst and other aspects.COA of Formula: C15H15F3N2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 21, 2001, Mohar, Barbara; Valleix, Alain; Desmurs, Jean-Roger; Felemez, Marc; Wagner, Alain; Mioskowski, Charles published an article.Electric Literature of 167316-28-1 The title of the article was Highly enantioselective synthesis via dynamic kinetic resolution under transfer hydrogenation using Ru(η6-arene)-N-perfluorosulfonyl-1,2-diamine catalysts: a first insight into the relationship of the ligand’s pKa and the catalyst activity. And the article contained the following:

β-(3,4-Dimethoxyphenyl)serine Me ester was obtained in high diastereomeric and enantiomeric excesses under transfer hydrogenation using chiral Ru(η6-arene)-N-perfluorosulfonyl-1,2-diamine catalysts. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Electric Literature of 167316-28-1

The Article related to serine dimethoxyphenyl methyl ester enantioselective synthesis ruthenium biphosphane catalyst, keto amino acid dynamic kinetic resolution catalytic transfer hydrogenation, ruthenium biphosphane catalyst activity pk basicity acidity and other aspects.Electric Literature of 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 12, 2000, Matsubara, Koki; Kida, Hitoshi published a patent.HPLC of Formula: 167316-28-1 The title of the patent was Method for the preparation of tricyclic amino alcohol derivatives through azides. And the patent contained the following:

Tricyclic amino alc. derivatives represented by general formula [I; wherein R1 is lower alkyl or benzyl; *1 represents an asym. carbon atom; R2 is hydrogen, halogeno or hydroxyl; and A is a substituent represented by general formula Q or Q1 (wherein X is NH, O, or S; R5 is hydrogen, hydroxyl, amino, or acetylamino; and *2 represents an asym. carbon atom when R5 is not hydrogen)] are prepared via asym. reduction of phenacyl azides (II; R21 is hydrogen, halogeno or (un)protected hydroxyl; R3 is hydrogen or amino-protecting group; and R1 is lower alkyl or benzyl) to chiral azido alcs. (III) or amino alcs. (IV; R21, R1, R3 are same as above). This process makes it possible to prepare the derivatives I by a short, easy, inexpensive, and practical production process excellent in industrial workability. Compounds I are useful in the treatment and prevention of diabetes, obesity, hyperlipidemia, and so on (no data). Thus, 58 mg [(S,S)-N-methanesulfonyl-1,2-diphenylethylenediamine](p-cymene)ruthenium (preparation given) was added to a solution of 3.6 g 2-azido-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanone (preparation given) in 2.5 mL formic acid/triethylamine solution (Fluka) in 6.5 mL THF and stirred at 5° for 43 h to give 95.0% (R)-2-azido-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanol (94.2 %e.e.). In another example, 2-amino-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanone hydrochloride (1.0 g) and 2 μL Et3N were added to a solution of 133 mg chloro(1,5-cyclooctadiene)rhodium(II) dimer and 397 mg (2R,4R)-N-(tert-butoxycarbonyl)-4-dicyclohexylphosphino-2-diphenylphosphinopyrrolidine and stirred under hydrogen atm. at room temperature for 24 h to give 94.0% (R)-2-amino-1-(4-benzyloxy-3-methylsulfonylaminophenyl)ethanol (V). Reductive benzylation of V with benzaldehyde in the presence of Pt2O under hydrogen atm. at room temperature for 15 h followed by amidation with (9H-carbazol-2-yloxy)acetic acid using DCC in THF at room temperature for 24 h, borane reduction in THF, and hydrogenolysis over 10% Pd-C in MeOH gave (R)-2-[N-[2-(9H-carbazol-2-yloxy)]ethyl]amino-1-(4-hydroxy-3-methylsulfonylaminophenyl)ethanol. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).HPLC of Formula: 167316-28-1

The Article related to tricyclic amino alc preparation treatment diabetes obesity hyperlipidemia, asym reduction phenacyl azide, ruthenium complex asym reduction catalyst, carbazolyloxyethylaminophenylethanol preparation antidiabetic, phenylethanolamine carbazolyloxyethyl preparation antidiabetic and other aspects.HPLC of Formula: 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Psychotropic drugs. 18. Synthesis and structure-activity relations of 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-ones》 were Nakanishi, Michio; Tahara, Tetsuya; Araki, Kazuhiko; Shiroki, Masami; Tsumagari, Tatsumi; Takigawa, Yukio. And the article was published in Journal of Medicinal Chemistry in 1973. Category: amides-buliding-blocks The author mentioned the following in the article:

Several thienodiazepinones showed central nervous depressant activity in mice comparable to that of diazepam. One of the most active compounds, 5-o-fluorophenyl-7-ethyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-one (I) [41191-07-5], inhibited fighting at 0.4 mg/kg orally and counteracted the lethal effects of pentetrazole at 0.3 mg/kg i.p. Some compounds, including I, also showed anticonvulsant, muscle-relaxant, and narcotic-potentiating activity in mice and a taming effect in olfactory bulbectomized rats. To synthesize I, o-fluoro-ω-cyanoacetophenone [31915-26-1] was condensed with butyraldehyde [123-72-8] and powd. S in DMF-NEt3 to form 2-amino-3-o-fluorobenzoyl-5-ethylthiophene [41191-09-7], converted to 2-chloroacetamido-3-o-fluorobenzoyl-5-ethylthiophene [41191-10-0] by reaction with ClCH2COCl, then to the iodoacetamido compound by exchange with NaI and to the aminoacetamido compound with NH3 gas, and cyclized by refluxing in pyridine-AcOH-C6H6. In the experiment, the researchers used 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Category: amides-buliding-blocks)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vejdelek, Zdenek; Rajsner, Miroslav; Svatek, Emil; Holubek, Jiri; Protiva, Miroslav published their research in Collection of Czechoslovak Chemical Communications on December 31 ,1979. The article was titled 《Benzocycloheptenes and heterocyclic analogs as potential drugs. XIV. Synthesis of 7-chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-(methylamino)-3H-1,4-benzodiazepine 4-oxide and of some related compounds》.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide The article contains the following contents:

The base-catalyzed condensation of 4-ClC6H4NO2 with 2-(cyanomethyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene afforded the 2,1-benzisoxazole derivative I, which was reduced with Fe in AcOH to the ketone II. Its oxime was treated with ClCH2COCl in AcOH and gave 6-chloro-2-(chloromethyl)-4-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)quinazoline 3-oxide. Treatment with MeNH2 in MeOH led to the substitution reaction with a simultaneous ring enlargement and the title compound III was formed. A similar reaction with 1-methylpiperazine proceeded without rearrangement resulting in the quinazoline derivative IV. III and IV were devoid of anticonvulsant activity. 7-Chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-one (mol. complex with II), 6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl 3′-(4-ethoxycarbonyl 4-phenylpiperidino)propyl ketone (an analog of pethidine devoid of analgetic activity), and intermediates useful in the synthesis of 5-(2-chlorophenyl)-7-ethyl-1,3-dihydrothieno[2,3-e]-1,4-diazepin-2-ones were also prepared In the experiment, the researchers used 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamideOn March 31, 1984, Polivka, Zdenek; Holubek, Jiri; Svatek, Emil; Metys, Jan; Protiva, Miroslav published an article in Collection of Czechoslovak Chemical Communications. The article was 《Potential hypnotics and anxiolytics: synthesis of 2-bromo-4-(2-chlorophenyl)-9-[4-(2-methoxyethyl)piperazino]-6H-thieno[3,2-f]-1,2,4-triazolo[4,3-a]-1,4-diazepine and of some related compounds》. The article mentions the following:

Title compounds I (R = MeO, EtO, MeS, n = 2; R = MeO, n = 3) were prepared by alkylation of thienotriazolodiazepine II (R1 = R2 = Br) with substituted piperazines. I (R = PhO, PhS, n = 2) were prepared by alkylation of I (R1 = piperazino, R2 = Br). Cyclization of hydrazinothienodiazepine III with ClC(OEt)3 gave II (R1 = R2 = H), which could only be brominated to give I (R1 = Br, R2 = H). Some intermediates were prepared for the synthesis etizolam. I had less anticonvulsant activity than 8-chloro-6-(2-chlorophenyl)-1-piperazino-4H-s-triazolo[4,3-a]-1,4-benzodiazepines. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fun, Hoong-Kun; Chantrapromma, Suchada; Dayananda, A. S.; Yathirajan, H. S.; Ramesha, A. R. published their research in Acta Crystallographica, Section E: Structure Reports Online on February 29 ,2012. The article was titled 《2-Amino-N-[3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl]acetamide》.COA of Formula: C15H15ClN2O2S The article contains the following contents:

In the title compound, C15H15ClN2O2S, the 2-aminoacetamide N-C(=O)-C-N unit is approx. planar, with an root-mean-square deviation of 0.020(4) Å. The central thiophene ring makes dihedral angles of 7.84(11) and 88.11(11)°, resp., with the 2-aminoacetamide unit and the 2-chloropenyl ring. An intramol. N-H···O H bond generates an S(6) ring motif. In the crystal, mols. are linked by an N-H···O H bond and weak C-H···O interactions into a chain along the c axis. A C-H···π interaction is also present. Crystallog. data and at. coordinates are given. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6COA of Formula: C15H15ClN2O2S)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.COA of Formula: C15H15ClN2O2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamideOn September 30, 2014 ,《Crystal structure of N-[3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl]-2-[(E)-(2-hydroxybenzylidene)amino]acetamide》 was published in Acta Crystallographica, Section E: Structure Reports Online. The article was written by Kaur, Manpreet; Jasinski, Jerry P.; Kavitha, Channappa N.; Yathirajan, Hemmige S.; Byrappa, K.. The article contains the following contents:

In the title compound, C22H19ClN2O3S, the dihedral angle between the mean planes of the thiophene ring and the chlorophenyl and hydroxyphenyl rings are 70.1(1) and 40.2(4)°, resp. The benzene rings are twisted with respect to each other by 88.9(3)°. The imine bond lies in an E conformation. Intramol. O-H···N and N-H···O H bonds each generate S(6) ring motifs. In the crystal, weak C-H···O interactions link the mols., forming chains along the c axis and zigzag chains along the b axis, generating sheets lying parallel to (100). Crystallog. data and at. coordinates are given. The results came from multiple reactions, including the reaction of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)

2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Application In Synthesis of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of cis-13-DocosenamideIn 2021, Li, Wengkun;Li, Jia;Wu, Bingmin;Lin, Ying;Kang, Huasheng;Liu, Li;Zhang, Guifang published 《Analysis of liposoluble components of cultivated and wild Lignosus rhinocerus》. 《Zhongyao Xinyao Yu Linchuang Yaoli》published the findings. The article contains the following contents:

Objective Analyzing the differences in fat-soluble chem. composition between cultivated and wild Lignosus rhinocerus. Methods The sclerotium of Lignosus rhinocerus was artificially cultivated, and then, the liposol. components were extracted from sclerotium by refluxing extraction with petroleum ether, and the difference in chem. compositions between cultivated (in rice and in sawdust, resp.) and wild Lignosus rhinocerus were analyzed by gas chromatog.-mass spectrometry (GC-MS). The relative percentages of components were also calculated Results Eleven, 10 and 14 compounds were identified from the ingredients in petroleum ether extracts of the rice group (RP), sawdust group (SP), and wild group (WP) resp. The majority of them are hydrocarbon compounds The common components are 2, 4-Di-tert-butylphenol, pentacosane and hentriacontane. The relative percentage contents of pentacosane and hentriacontane were 15.85%, 17.36%, 16.43% and 12.01%, 11.58%, 19.29% for RP, SP and WP, resp. The difference of these three are:the ingredients of the rice group mainly contain Ergosterol and Nonacosane; those of the sawdust group mainly contain Docosane, Tricosane, Tetracosane; those of wild group varieties mainly contain Tetracosane, Erucylamide, Di-Bu phthalate, and 9, 12-Octadecadienoic acid (Z, Z) -, Et ester. Conclusion The lipophilic composition in petroleum ether extracts of cultivated and wild Lignosus rhinocerus are identical, which included 2, 4-Di-tertbutylphenol, pentacosane and hentriacontane; but there are clear differences. These findings provide reference for the quality evaluation and utilization of cultivated products of Lignosus rhinocerus. The experimental procedure involved many compounds, such as cis-13-Docosenamide (cas: 112-84-5) .

cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Reference of cis-13-Docosenamide It has a role as a human metabolite, a rat metabolite, a mammalian metabolite, a plant metabolite and an EC 3.1.1.7 (acetylcholinesterase) inhibitor.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Kang-He;Ma, Yu-Long;Lin, Feng;Ge, Shao-Ying;Zhu, Li published 《Refractory organic compounds in coal chemical wastewater treatment by catalytic ozonation using Mn-Cu-Ce/Al₂O₃》 in 2021. The article was appeared in 《Environmental Science and Pollution Research》. They have made some progress in their research.Reference of cis-13-Docosenamide The article mentions the following:

A composite Mn-Cu-Ce tri-metal oxide supported on γ-Al₂O₃ (Mn-Cu-Ce/Al₂O₃) catalyst was prepared by an impregnation-calcination method and investigated in the catalytic ozonation treatment of real coal chem. wastewater (CCW). The catalyst was characterized by XRD, SEM, TEM, XRF, BET, and XPS techniques. The results showed that Mn, Cu, and Ce metal oxides were evenly distributed on the Al₂O₃ surface and the catalyst maintained a large surface area and a high pore volume compared with the pristine Al₂O₃. The synergy between Mn, Cu, and Ce oxides greatly enriched the catalytic active sites and enhanced the ozonation performance. The catalytic ozonation process with Mn-Cu-Ce/Al₂O₃ increased the removal rate of total organic carbon (TOC) by 31.6% compared with ozonation alone. The ketones, aromatic compounds, phenols, and nitrogen-containing heterocyclic compounds in CCW have been effectively degraded and mineralized by Mn-Cu-Ce/Al₂O₃ catalytic ozonation process, and its biodegradability has also been significantly improved. The exptl. results of ·OH scavengers revealed that the mechanism of Mn-Cu-Ce/Al₂O₃ catalytic ozonation was to promote the generation of ·OH radicals. The catalytic activity of Mn-Cu-Ce/Al₂O₃ was only a slight decrease in six consecutive catalytic ozonation treatments, showing good stability. Therefore, Mn-Cu-Ce/Al₂O₃ can be used as a candidate catalyst for the advanced treatment of refractory organic wastewaters upon catalytic ozonation. And cis-13-Docosenamide (cas: 112-84-5) was used in the research process.

cis-13-Docosenoamide(cas: 112-84-5) was employed as: standard in determination of fatty acid amides in polyethylene packaging film by GC/MS;slip agent for polymers to reduce their friction coefficient and to make films easier to handle.Reference of cis-13-Docosenamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics