Tag: 200-300

Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water was written by Bou-Maroun, Elias;Dahbi, Laurence;Gomez-Berrada, Marie-Pierre;Pierre, Philippine;Rakotomalala, Sandrine;Ferret, Pierre-Jacques;Chagnon, Marie-Christine. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2017.Related Products of 2387-23-7 This article mentions the following:

The objective of the work was to check the presence of Non-Intended Added Substances (NIAS) with hormonal activities in aluminum coatings extracts coded: AA, BBF, MC and RR, furnished by four different suppliers. Water samples were prepared at room temperature or at 40° for three months to verify the storage effect on the coatings. Solid phase extraction was used to concentrate and to extract coating substances. Hormonal activities were checked in vitro using reporter gene bioassays. Except BBF, all extracts induced a weak but significant estrogenic agonist activity in the human cell line. Using an estrogenic antagonist (ICI-182, 780), the answer was demonstrated specific in the bioassay. RR was the only extract to induce a concentration dependent anti-androgenic response in the MDA-KB2 cell line. Anal. performed using GC-MS and HPLC-MS detected 12 substances in most of the extracts 8 NIAS were present. Among them, 4 were identified with certainty: HMBT, BGA, DCU and BPA. Estrogenic potency was BPA > DCU > BGA > HMBT. HMBT was also anti-androgenic at high concentration Combining chem. anal. and bioassays data, the authors demonstrated that in the RR and the RR40 extracts, the observed estrogenic response was mainly due to BPA, the anti-androgenic activity of RR could be due to a synergism between HMBT and BPA. For MC and AA, estrogenic responses appear to be due to the presence of DCU. Except BBF, storage conditions tended to increase estrogenic activities in all extracts However, in term of risk assessment, activities observed were negligible. This work demonstrated that sensitive bioassays are pertinent tools in complement to chem. anal. to monitor and check the presence of NIAS with hormonal activity in coating extracts In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides was written by Phetcharawetch, Jongkonporn;Betterley, Nolan M.;Soorukram, Darunee;Pohmakotr, Manat;Reutrakul, Vichai;Kuhakarn, Chutima. And the article was included in European Journal of Organic Chemistry in 2017.Related Products of 192436-83-2 This article mentions the following:

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF₂SiMe₃) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones I (R = Ph, 3-MeOC₆H₄, 2-BrC₆H₄, cyclohexyl, n-heptyl, etc.). These were converted into difluoromethyl ketones through selective reductive cleavage of the phenylsulfanyl group. The reaction of o-alkynyl Weinreb amides derived from benzoic acid derivatives resulted in the formation of cyclized products II (R = Ph, 4-MeOC₆H₄, 4-BrC₆H₄, etc.) through a 5-exo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Related Products of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Imino exchange reaction in a dearomatization strategy: synthesis of N-acyl diarylamines and phenothiazines from two anilines was written by Zhang, Li;Wang, Huiqing;Yang, Bo;Fan, Renhua. And the article was included in Organic Chemistry Frontiers in 2014.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide This article mentions the following:

N-Sulfonyl cyclohexadienimines generated from an iodine(III)-induced oxidative dearomatization of N-sulfonyl protected para-substituted anilines are ready to undergo an imino exchange reaction with another aniline, which provides an alternative way to access N-acyl diarylamines and phenothiazines. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Quality Control of N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of TAED/H₂O₂ system for low temperature bleaching of crude cellulose extracted from jute fiber was written by Wen, Zuoqiang;Zou, Linbo;Wang, Weiming. And the article was included in IOP Conference Series: Materials Science and Engineering in 2018.Category: amides-buliding-blocks This article mentions the following:

Tetraacetylethylenediamine (TAED) activated hydrogen peroxide system had been applied for bleaching of crude cellulose extracted from jute fiber. Comparing with conventional hydrogen peroxide bleaching system, those results showed that bleaching temperature and time could be effectively reduced, and a preferable whiteness could be produced under faint alk. condition. And the optimum conditions for activated bleaching system could be summarized as molar ratio of H₂O₂/TAED 1:0.7, pH 8, pure hydrogen peroxide 0.09 mol/L, temperature 70°C and time 60min. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dealkenylative Alkynylation Using Catalytic Fe^II and Vitamin C was written by Swain, Manisha;Bunnell, Thomas B.;Kim, Jacob;Kwon, Ohyun. And the article was included in Journal of the American Chemical Society in 2022.Safety of 1,3-Dicyclohexylurea This article mentions the following:

In this paper, synthesis of alkyl-tethered alkynes, e.g. I through ozone-mediated and Fe^II-catalyzed dealkenylative alkynylation of unactivated alkenes in presence of alkynyl sulfones was reported. This one-pot reaction, which employed a combination of a catalytic Fe^II salt and L-ascorbic acid, proceeded under mild conditions with good efficiency, high stereoselectivity, and broad functional group compatibility. In contrast to previous Fe^II-mediated reductive fragmentation of α-methoxyhydroperoxides, Fe^II-catalyzed process was devised through a thorough kinetic anal. of multiple competing radical (redox) pathways. The potential of this dealkenylative alkynylation through multiple post-synthetic transformations and late-stage diversifications of complex mols., including natural products and pharmaceuticals was highlighted. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Safety of 1,3-Dicyclohexylurea).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of 1,3-Dicyclohexylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Visible light-driven [3 + 3] annulation reaction of 2H-azirines with Huisgen zwitterions and synthesis of 1,2,4-triazines was written by Cao, Shixuan;Tang, Tong;Li, Jiatian;He, Zhengjie. And the article was included in Organic Chemistry Frontiers in 2022.Recommanded Product: 116332-61-7 This article mentions the following:

A visible light-driven [3 + 3] annulation reaction of 2H-azirines with in-situ generated Huisgen zwitterions from azodicarboxylates and phosphines was herein described. Under very mild conditions and irradiation of blue LED light, disubstituted 2H-azirines readily undergo a formal [3 + 3] annulation reaction with in-situ generated Huisgen zwitterions, affording polysubstituted dihydro-1,2,4-triazines in 51-97% yields with a broad substrate scope. Mechanistic studies unveil that this annulation reaction proceeded through a cascade sequence of nucleophilic addition, light-driven 1,3-ester migration and aza-Wittig-like cyclization. The light-driven ester migration step was believed to be a photochem. process of an intramol. electron donor-acceptor (EDA) complex. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Recommanded Product: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palladium-Catalyzed α-Arylation of Vinylogous Esters for the Synthesis of γ,γ-Disubstituted Cyclohexenones was written by Johnson, Thomas;Pultar, Felix;Menke, Friedericke;Lautens, Mark. And the article was included in Organic Letters in 2016.Category: amides-buliding-blocks This article mentions the following:

A palladium-catalyzed α-arylation of cyclic vinylogous esters to form products that are converted in one step to γ-alkyl-γ-aryl-substituted cyclohexenones is reported. This Pd-catalyzed reaction proceeds at room temperature, is generally high-yielding, and uses an amount of a com. available catalyst as low as 0.25 mol %. The scope of aryl bromides is particularly broad, and alkenyl bromides can also be used. This two-step protocol, comprising α-arylation and reductive transposition, can be performed in one pot and is applicable to gram-scale synthesis. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Category: amides-buliding-blocks).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A comparative study of several activator in enzyme peroxide one bath low temperature pretreatment was written by Zhu, Jun-ping. And the article was included in Yinran Zhuji in 2015.Application of 10543-57-4 This article mentions the following:

The application effect of four hydrogen peroxide activators in enzyme one bath pretreatment was investigated. The results showed that the effect of TAED was good. Enzyme peroxide one bath could reduce the alkali dosage and reduce the burden on sewage treatment. The application process was as follows: gray fabric padding the first working fluid (two-dip-two-nip, padding rate 90% ∼ 100%, the working fluid temperature 50 ∼ 55 °C) → curled batching (50 °C,12 h) → padding the second working fluid (two-dip-two-nip, padding rate 90% ∼ 100%, the working fluid temperature 40 °C) → steaming (80 °C,10 min) → washing → drying. The first working fluid: KDN scouring enzyme 2 g/L, low temperature scouring penetrant GR-01 10 g/L, hydrogen peroxide solution 36 mL/L, activator 18 g/L, pH = 8. The second working fluid: low temperature scouring penetrant GR-01 10 g/L, hydrogen peroxide solution 44 mL/L, activator 22 g/L, pH = 8 ∼ 9. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel applications of eureco RP 103 was written by Garaffa, Roberto;Warunek, Magda;Findlay, Paul;Pears, David;Scullion, Lisa;Hughes, Melanie. And the article was included in IP.com Journal in 2016.SDS of cas: 10543-57-4 This article mentions the following:

Eureco RP 103 is a new free flowing, boron free particle containing 6-phthalimidoperoxyhexanoic acid (PAP). The particle is stable on its own and when formulated with various other media under ambient and elevated temperature and humidity conditions. It is a versatile material that can be used in a wide range of different product formulations and applications. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4SDS of cas: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.SDS of cas: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease was written by Keenan, Martine;Abbott, Michael J.;Alexander, Paul W.;Armstrong, Tanya;Best, Wayne M.;Berven, Bradley;Botero, Adriana;Chaplin, Jason H.;Charman, Susan A.;Chatelain, Eric;von Geldern, Thomas W.;Kerfoot, Maria;Khong, Andrea;Nguyen, Tien;McManus, Joshua D.;Morizzi, Julia;Ryan, Eileen;Scandale, Ivan;Thompson, R. Andrew;Wang, Sen Z.;White, Karen L.. And the article was included in Journal of Medicinal Chemistry in 2012.COA of Formula: C10H10F3NO2 This article mentions the following:

We report the discovery of nontoxic fungicide fenarimol (1, I) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogs with low nM IC₅₀s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chem. tractable, allowing rapid optimization of target biol. activity and drug characteristics. Chem. and biol. studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7COA of Formula: C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics