Tag: 200-300

Changes in physicomechanical properties and structures of jute fibers after tetraacetylethylenediamine activated hydrogen peroxide treatment was written by Wang, Weiming;Xu, Meng;Lou, Jiahao;Dong, Aixue. And the article was included in Journal of Materials Research and Technology in 2020.Category: amides-buliding-blocks This article mentions the following:

Tetraacetylethylenediamine (TAED) activated hydrogen peroxide (H₂O₂) was tentatively used in the bleaching of scoured jute fibers, and the effects of this method on the physicomech. properties, main chem. compositions, and structures during bleaching were evaluated and compared with conventional H₂O₂ bleaching. By comparing with H₂O₂ bleached jute fibers, the TAED-activated H₂O₂ bleached jute fibers were found to have a better storage stability of whiteness and yellowness, higher breaking tenacity, lower fineness value and breaking extension. The differences in morphol. structure and thermogravimetric anal. showed that the TAED-activated H₂O₂ bleaching system had a stronger ability for the removal of noncellulosic materials than conventional H₂O₂ bleaching system. The changes in main chem. compositions and Fourier transform IR spectra further indicated that the removal ability of TAED-activated bleaching for lignin was obviously stronger than that of conventional bleaching, but it had a similar removal ability for hemicellulose. Furthermore, when the whiteness and yellowness values were similar, the amount of H₂O₂, bleaching temperature, and time of TAED-activated H₂O₂ bleaching were obviously less than those of H₂O₂ bleaching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cold pad-batch pretreatment of cotton fabrics with H₂O₂/TBCC activation system was written by Liang, Xiao-ling;Hou, Ai-qin. And the article was included in Yinran in 2012.Recommanded Product: 10543-57-4 This article mentions the following:

The hydrogen peroxide/TBCC activation system is used to cold pad-batch pretreatment of cotton fabrics. The influences of the dosage of activator, hydrogen peroxide and sodium hydroxide in hydrogen peroxide/TBCC system, temperature and time on fabric whiteness, capillary effect and breaking strength are investigated and compared with hydrogen peroxide/TAED activation system. The optimized cold pad-batch pretreatment of cotton fabric is as follows: H₂O₂ (30%) 40 g/L,TBCC 4 g/L, scouring agent LFD 5 g/L, NaOH 10 g/L, Na₂SiO₃ 5 g/L, penetrating agent JFC 5 g/L, batching at 25 °C for 8 h. The effects of the hydrogen peroxide/TBCC activation system is better than those of hydrogen peroxide/TAED system. Compared with traditional process, hydrogen peroxide /TBCC process features less alkali dosage, shortened time and lower temperature in batching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Research on FTIR analysis of Populus nigra L. lignin structure changes in different bleaching processes was written by Zhao, Qiang;Sun, Dezhi;Pu, Junwen;Jin, Xiaojuan;Xing, Mian. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.Reference of 10543-57-4 This article mentions the following:

To study the bleaching mechanisms of H₂O₂ bleaching, H₂O₂ displacement bleaching and H₂O₂/TAED bleaching, three kinds of lignin bleached with above processes were obtained. Three types of treated Populus nigra L lignins structure were identified and the functional groups were quantitied by FTIR. In contrast, the deacetylation and the breakage of ester bonds in H₂O₂/TAED bleaching system was much more significant. The total carbonyl group of H₂O₂ bleached lignin decreased 6.6% while displacement bleached lignin and H₂O₂/TAED bleached lignin decreased 9.2% and 15.8% resp. The PT bleaching process had stronger oxidability to destroy the syringyl units in lignin. The breakage of ether bonds and alc. hydroxyl dehydration in side chain increased after bleaching. In contrast, the stronger destroyed effect on guaiacyl dialkyl ether bond with PT bleaching processes. The conclusions obtained may interpret H₂O₂ displacement bleaching and H₂O₂/TAED bleaching systems have better bleaching efficiency than H₂O₂ bleaching system. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity was written by Gohlsch, Katrin;Mueckter, Harald;Steinritz, Dirk;Aufderheide, Michaela;Hoffmann, Sebastian;Gudermann, Thomas;Breit, Andreas. And the article was included in Toxicology Letters in 2019.Category: amides-buliding-blocks This article mentions the following:

In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and data leading to CLP classifications are available. The authors exposed A549 cells to 19 CLP-classified substances with doses of 25, 50, and 100μg/Cm² either under submerged (SME) condition or with aerosols at the air-liquid interface (ALIF) and determined accuracy, precision, sensitivity and the F1 score with the CLP classifications H330, H332, or H335. When data from both exposure methods were combined, the authors found accuracies of 0.84, precisions of 0.74, sensitivities of 0.93 and F1 scores of 0.82. Separated from each other, ALIF exposure was more sensitive at any dose but, at higher doses, also less accurate and precise compared to SME. Considering the 19 substances tested, the authors’ data suggest that cytotoxicity in A549 cells could be a reliable in vitro indicator for in vivo toxicity. Thus, the authors discuss how A549 could be integrated into validation test guidelines. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Photodegradation of herbicide triasulfuron was written by Pusino, Alba;Braschi, Ilaria;Petretto, Salvatore;Gessa, Carlo. And the article was included in Pesticide Science in 1999.Formula: C8H10ClNO3S This article mentions the following:

Triasulfuron was degraded in aqueous solution by UV irradiation to yield 2-chloroethoxybenzene and (4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea. The reaction followed first-order kinetics. In sunlight, the reaction was slower and afforded these two photoproducts together with 2-amino-4-methoxy-6-methyltriazine and 2-(2-chloroethoxy)benzenesulfonamide. The latter compounds arise from hydrolytic cleavage of the sulfonylurea bridge of triasulfuron, because of the acidity of the reaction medium due to the release of sulfur dioxide. A mechanism which accounts for the formation of the photoproducts is proposed. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6Formula: C8H10ClNO3S).

2-(2-Chloroethoxy)benzenesulfonamide (cas: 82097-01-6) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C8H10ClNO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis was written by Alves Esteves, C. Henrique;Hall, Christopher J. J.;Smith, Peter D.;Donohoe, Timothy J.. And the article was included in Organic Letters in 2017.Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

The protected pyruvate equivalent I (R = H) underwent chemoselective monoarylation with aryl bromides and selected aryl chlorides in the presence of Pd(dtbpf)Cl₂ {dtbpf = 1,1′-bis[di(tert-butyl)phosphino]ferrocene} using NaOt-Bu as base in THF to yield protected arylpyruvates such as I [R = 4-MeC₆H₄, 2-MeC₆H₄, 2,4,6-Me₃C₆H₂, 2-FC₆H₄, 4-F₃CC₆H₄, 4-ClC₆H₄, 3-MeOC₆H₄, 4-TBDMSOC₆H₄, 4-Me₂NC₆H₄, 2-H₂C:CHC₆H₄, 4-H₂C:CHC₆H₄, 4-MeOMeNCOC₆H₄, 2-thienyl, 4-(4-morpholinylcarbonyl)C₆H₄, 5-benzothienyl, 1-Me-5-indolyl, 8-isoquinolinyl, Ph, 9-anthracenyl, 4-MeOC₆H₄]. Sequential diarylations or one-pot arylation-alkylation sequences were also performed to yield a variety of substituted protected arylpyruvates such as II. Arylpyruvate orthoesters were converted to Et arylpyruvates using p-toluenesulfonic acid and ethanol in 63-91% yields; a protected arylpyruvate orthoester was converted directly to the corresponding arylpyruvic acid. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Quality Control of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Regioselective Synthesis of Enones via a Titanium-Promoted Coupling of Unsymmetrical Alkynes with Weinreb Amides was written by Silwal, Sajan;Rahaim, Ronald J.. And the article was included in Journal of Organic Chemistry in 2014.Application of 116332-61-7 This article mentions the following:

A modular titanium-promoted coupling of unsym. internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regioselectivity. E.g., in presence of Ti(OiPr)₄ and i-PrMgCl in Et₂O at room temperature, coupling of 1-phenyl-1-propyne and 4-FC₆H₄CONMeOMe gave 60% (E)-I. The system shows moderate chemoselectivity. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper(I)-catalyzed site-selective C(sp³)-H bond chlorination of ketones, (E)-enones and alkylbenzenes by dichloramine-T was written by Jin, Jianwen;Zhao, Yichao;Kyne, Sara Helen;Farshadfar, Kaveh;Ariafard, Alireza;Chan, Philip Wai Hong. And the article was included in Nature Communications in 2021.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

Here, a copper(I)-catalyzed synthetic method for the efficient site-selective C(sp³)-H bond chlorination of ketones, (E)-enones and alkylbenzenes by dichloramine-T at room temperature were reported. A key feature of the broad substrate scope is tolerance to unsaturation, which would normally pose an immense challenge in chemoselective aliphatic C-H bond functionalization. By unlocking dichloramine-T’s potential as a chlorine radical atom source, the product site-selectivities achieved were among the most selective in alkane functionalization and should find widespread utility in chem. synthesis. This was exemplified by the late-stage site-selective modification of a number of natural products and bioactive compounds and gram-scale preparation and formal synthesis of two drug mols. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Intermolecular cyclotrimerization of haloketoalkynes and internal alkynes: facile access to arenes and phthalides was written by Silvestri, A. P.;Oakdale, J. S.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Recommanded Product: 2387-23-7 This article mentions the following:

A highly chemo- and regioselective cyclo(co)trimerization between 3-halopropiolamides RC(O)CCX [R = dimethylaminyl, morpholin-4-yl, 4-(ethoxycarbonyl)piperidin-1-yl, 4-([3-(propan-2-yloxy)propyl]carbamoyl)piperidin-1-yl, etc.; X = H, Br, Cl] and internal alkynes R¹CCR² [R¹ = H, n-Bu, 4-cyanophenyl, thiophen-3-yl, etc.; R² = H, Me, 4-methoxyphenyl, thiophen-3-yl, etc.; R¹R² = -(CH₂)₁₀-] is reported. The reaction is catalyzed by CpRuCl(COD) and proceeds under air at ambient temperature in ethanol with no addnl. precautions. Iodo-, bromo-, and chloropropiolamides, esters, and ketones are viable coupling partners and, in a 2:1 stoichiometry relative to internal alkyne, yield fully-substituted arenes I and II in a single step. The highest regioselectivities (96% single isomer) were observed when employing 2° and 3°-halopropiolamides. A mechanistic hypothesis accounting for this selectivity is proposed. Notably, by using 1,4-butynediol as the internal alkyne, in situ lactonization following [2+2+2]-cycloaddition generates therapeutically-relevant phthalide pharmacophores III directly. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives was written by Schwaerzer, Kuno;Bellan, Andreas;Zoeschg, Maximilian;Karaghiosoff, Konstantin;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2019.Category: amides-buliding-blocks This article mentions the following:

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines I [R = n-Bu, Ph, Me₂NC₆H₄, etc.] was reported. These aldimines reacted with Weinreb amides, ketones or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allowed for an efficient synthesis of 1,2-dicarbonyl compounds II [R¹ = c-hexyl, Ph, 4-MeOC₆H₄, etc.] and α-hydroxy ketones III [R²R³ = (CH₂)₅, R² = R³ = Ph, R² = c-Pr, R³ = 4-FC₆H₄]. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Category: amides-buliding-blocks).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics