Tag: 200-300

N′Diaye, Katharina;Debong, Marcel;Behr, Juergen;Dirndorfer, Sebastian;Duggan, Tara;Beusch, Anja;Schlagbauer, Verena;Dawid, Corinna;Loos, Helene M.;Buettner, Andrea;Lang, Roman;Hofmann, Thomas published 《Dietary Piperine is Transferred into the Milk of Nursing Mothers》. The research results were published in《Molecular Nutrition & Food Research》 in 2021.Electric Literature of C17H27NO3 The article conveys some information:

The diet of breastfeeding mothers could bring nurslings into contact with flavor compounds putatively contributing to early sensory programming of the infant. The study investigates whether tastants from a customary curry dish consumed by mothers are detectable in their milk afterwards and can be perceived by the infant. Sensory evaluation identifies pungency as the dominating taste impression of the curry dish. Its ingredients of chili, pepper, and ginger suggest the flavor compounds capsaicin, piperine, and 6-gingerol as anal. targets. Breastfeeding mothers are recruited for an intervention trial involving the consumption of the curry dish and subsequent collection of milk samples for flavor compound anal. Targeted and untargeted mass spectrometric (MS)- investigations identify exclusively piperine as an intervention-derived compound in human milk. However, concentrations are below the human taste threshold. Piperine from pepper-containing foods transfers into the mothers milk within 1 h and is delivered to the nursling. Concentrations of 50 and 200 nM of piperine are 70-350 times below the human taste threshold, but TRPV1 (Transient Receptor Potential Vanilloid-1 ion channel) desensitization through frequent exposure to sub-taste-threshold concentrations could contribute to an increased tolerance at a later age. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Electric Literature of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chanquia, Santiago N.;Boscaro, Nadia;Alche, Laura;Baldessari, Alicia;Linares, Guadalupe Garcia published 《An Efficient Lipase-Catalyzed Synthesis of Fatty Acid Derivatives of Vanillylamine with Antiherpetic Activity in Acyclovir-Resistant Strains》 in 2017. The article was appeared in 《ChemistrySelect》. They have made some progress in their research.Synthetic Route of C17H27NO3 The article mentions the following:

A series of eleven N-fatty acid derivatives of vanillylamine I was synthesized following an enzymic approach, in excellent yield and a chemoselective way. The excellent results obtained by catalysis of Thermomyces lanuginosus lipase made the procedure very efficient, considering the low amount of enzyme required and its lower price in comparison with other com. lipases. The influence of various reaction parameters in the lipase-catalyzed reactions, such as enzyme source, nucleophile/substrate ratio, enzyme/substrate ratio, solvent and temperature, was studied. To evaluate the influence of the fatty acid chain length and configuration on the reaction rate and yield, HPLC anal. and mol. modeling experiments were performed. The results showed that a chain length between 12-14 carbon atoms favors the activity of the enzyme, while insatn. had no effect on the reaction rate. These facts confirm the exptl. results. In addition, some of the evaluated compounds exhibited antiviral activity against Herpes simplex virus type 1 (HSV-1) KOS strain (TK+) and Field and B2006 strains (TK-) in Vero cells. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Synthetic Route of C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C17H27NO3《Rapid Screening for Exposure to “Non-Target” Pharmaceuticals from Wastewater Effluents by Combining HRMS-Based Suspect Screening and Exposure Modeling》 was published in 2016. The authors were Singer, Heinz P.;Wossner, Annika E.;McArdell, Christa S.;Fenner, Kathrin, and the article was included in《Environmental Science & Technology》. The author mentioned the following in the article:

Active pharmaceutical ingredients (APIs) have raised considerable concern over the past decade due to their widespread detection in water resources and their potential to affect ecosystem health. This triggered many attempts to prioritize the large number of known APIs to target monitoring efforts and testing of fate and effects. However, so far, a comprehensive approach to screen for their presence in surface waters has been missing. We explore a combination of an automated suspect screening approach based on liquid chromatog. coupled to high-resolution mass spectrometry and a model-based prioritization using consumption data, readily predictable fate properties and a generic mass balance model for activated sludge treatment to comprehensively detect APIs with relevant exposure in wastewater treatment plant effluents. The procedure afforded the detection of 27 APIs that had not been covered in our previous target method, which included 119 parent APIs. The newly detected APIs included 7 compounds with a high potential for bioaccumulation and persistence, and also 3 compounds that were suspected to stem from point sources rather than from consumption as medicines. Anal. suspect screening proved to be more selective than model-based prioritization, making it the method of choice for focusing anal. method development or fate and effect testing on those APIs most relevant to the aquatic environment. However, we found that state-of-the-practice exposure modeling used to predict potential high-exposure substances can be a useful complement to point toward oversights and known or suspected detection gaps in the anal. method, most of which were related to insufficient ionization. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Formula: C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martins, Samantha Eslava;Fillmann, Gilberto;Lillicrap, Adam;Thomas, Kevin V. published 《Review: ecotoxicity of organic and organo-metallic antifouling co-biocides and implications for environmental hazard and risk assessments in aquatic ecosystems》 in 2018. The article was appeared in 《Biofouling》. They have made some progress in their research.Related Products of 2444-46-4 The article mentions the following:

A review. Hazard assessments of Irgarol 1051, diuron, 2-(thiocyanomethylthio)benzothiazole (TCMTB), dichloro-octylisothiazolin (DCOIT), chlorothalonil, dichlofluanid, thiram, zinc pyrithione, copper pyrithione, triphenylborane pyridine (TPBP), capsaicin, nonivamide, tralopyril and medetomidine were performed to establish robust environmental quality standards (EQS), based on predicted no effect concentrations (PNECs). Microalgae, zooplankton, fish and amphibians were the most sensitive ecol. groups to all the antifoulants evaluated, especially in the early life stages. No differences were identified between freshwater and seawater species. The use of toxicity tests with non-standard species is encouraged because they increase the datasets, allowing EQS to be derived from probabilistic-based PNECs while reducing uncertainties. The global ban of tributyltin (TBT) has been heralded as a major environmental success; however, substitute antifoulants may also pose risks to aquatic ecosystems. Environmental risk assessments (ERAs) have driven decision-makings for regulating antifouling products, but in many countries there is still a lack of regulation of antifouling biocides which should be addressed. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Related Products of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Qingqing;Zhu, Jianguo;Ma, Fei;Li, Peiwu;Zhang, Liangxiao;Zhang, Wen;Ding, Xiaoxia;Zhang, Qi published 《Quantitative determination of major capsaicinoids in serum by ELISA and time-resolved fluorescent immunoassay based on monoclonal antibodies》. The research results were published in《Biosensors & Bioelectronics》 in 2016.Application In Synthesis of N-Vanillylnonanamide The article conveys some information:

To monitor capsaicinoids in serum on-site, three new monoclonal antibodies (mAbs) were firstly proposed using a conjugate of 4-[(4-hydroxy-3-methoxybenzyl) amino]-4-oxobutanoic acid as the immunogen. Among them, the YQQD8 mAb showed the highest sensitivity and cross-reactivity to major capsaicinoids, such as capsaicin, dihydrocapsaicin and N-vanillylnonanamide. A competitive indirect ELISA (icELISA) and a time-resolved fluorescent immunochromatog. assay (TRFICA) were established based on this mAb. The linear range was 1.1-27.0 ng mL^-1 for icELISA and 1.9-62.5 ng mL^-1 for TRFICA and the limit of detection (LOD) of TRFICA was 1.5 ng mL^-1. To decrease the interference of sample components and increase accuracy, serum samples were diluted four times before assays. As a result, the linear range of serum samples was 4.6-107.9 ng mL^-1 for icELISA and 7.6-250.0 ng mL^-1 for TRFICA. Both icELISA and TRFICA showed good recoveries (91.0-112.8% for icELISA and 87.6-111.5% for TRFICA) and concordant results in spiked experiments Overall, this is the first report of immunoassay based on the mAbs for quant. determination of major capsaicinoids, and the results demonstrate that both methods can meet the demands of rapid on-site assay for capsaicinoids in serum samples.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Application In Synthesis of N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Today I want to share an article with you. The article is 《A UHPLC-HRMS based metabolomics and chemoinformatics approach to chemically distinguish ′super foods′ from a variety of plant-based foods》,you can find this article in 《Food Chemistry》. The following contents are mentioned:

The aim of this study was to investigate if the declared benefits associated with superfoods are related to a specific mol. composition For this purpose, untargeted metabolomics and mol. networking were used to obtain an overview of all features, focusing on compounds with anti-inflammatory, antioxidant or antimicrobial properties.565 plant-based food samples were analyzed using UHPLC-HRMS and advanced data anal. tools. The mol. networking of the whole dataset allowed identification of a greater diversity of mols., in particular, prenol lipids, isoflavonoids and isoquinolines in superfoods, when compared with non-superfood species belonging to the same botanical family. Furthermore, in silico tools were used to expand our chem. knowledge of compounds observed in superfood samples. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.COA of Formula: C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics