Tag: 200-300

COA of Formula: C17H27NO3《Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking》 was published in 2022. The authors were He, Yue;Zhang, Xiaoyin;Li, Ming;Zheng, Nan;Zhao, Shengguo;Wang, Jiaqi, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

Inhibition of ruminal bacterial urease activity could slow down the decomposition of urea to ammonia, which would lead to a decrease in urea synthesis in the liver and urea-N emission in the urine. In order to find a rumen bacterial urease specific inhibitor that is environmentally friendly, we used the homol. model of rumen bacterial urease as the target to screen natural compounds from plants by mol. docking. The screening results showed that coptisine had the most potential to inhibit the activity of rumen bacterial urease with an IC50 of 2.45μM, which was superior to the traditional inhibitor acetohydroxamic acid. The enzyme kinetics results indicated coptisine was mixed type inhibitor of rumen bacterial urease with a Ki value of 0.68μM. Coptisine significantly decreased the release of NH3 and decomposition of urea and improved microbial fermentation in a rumen fermentation system in vitro. Thiol-containing compounds or boric acid significantly decreased the inhibitory capacity of coptisine toward rumen bacterial urease, which indicated that coptisine could interact with both the urease active center Ni and amino acid residues possessing sulfhydryl groups in the flap area. The mol. docking results showed that coptisine acted as the metal acceptor for one nickel ion in the active site, and formed hydrogen bonds with the amino acid residues His320 and His362, which were located in the active site and flap region, resp. These findings emphasized the potential role of coptisine in reducing nitrogen emissions that originate from ruminants by regulating rumen bacterial urease activity. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.COA of Formula: C17H27NO3 It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 2444-46-4《Voltammetric determination of capsaicin using CeO₂-surfactant/SWNT-modified electrode》 was published in 2020. The authors were Ziyatdinova, Guzel;Ziganshina, Endzhe;Shamsevalieva, Aliya;Budnikov, Herman, and the article was included in《Arabian Journal of Chemistry》. The author mentioned the following in the article:

Glassy carbon electrodes (GCE) modified with carboxylated single-walled carbon nanotubes (SWNT-COOH) and CeO₂-surfactants dispersions are developed for the capsaicin quantification. The effect of cationic cetylpyridinium bromide (CPB), anionic sodium dodecylsulfate (SDS) and nonionic Triton X100 as co-modifiers are tested. CeO₂-CPB/SWNT-COOH/GCE provides 2.8- and 1.9-fold increase of capsaicin oxidation currents in comparison to bare GCE and SWNT-COOH/GCE, resp., confirming the synergetic effect of the modifiers. SEM (SEM) data confirm successful immobilization of the nanomaterials on the electrode surface leading to the significant changes in its morphol. The parameters of capsaicin electrooxidation are found. Differential pulse mode is applied for the capsaicin determination The pulse parameters are optimized. The linear dynamic ranges of 0.10-7.5 and 7.5-500μM of capsaicin with the limits of detection and quantification of 28 and 92 nM resp. confirm the high sensitivity of the method developed. The selectivity of the electrode toward capsaicinoids is proved. The method was applied for the total capsaicinoids quantification in real samples (red hot pepper spices and tinctures of Capsicum annuum L.). A good agreement with the UV-spectroscopic data is obtained.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.SDS of cas: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Qin, Yeyu;Xie, Jing;Zheng, Ruihe;Li, Yuhang;Wang, Haixia published 《Oleoylethanolamide as a new therapeutic strategy to alleviate doxorubicin-induced cardiotoxicity》 in 2022. The article was appeared in 《Frontiers in Pharmacology》. They have made some progress in their research.COA of Formula: C17H27NO3 The article mentions the following:

Doxorubicin (DOX) is one of the most common chemotherapeutic anti-cancer drugs. However, its clin. use is restricted by serious cardiotoxicity. Oleoylethanolamide (OEA), a structural congener of endocannabinoid anandamide, is the endogenous agonist of peroxisome proliferator activated-receptor α (PPARα) and transient receptor potential cation channel vanilloid-1 (TRPV1), and involved in many physiol. processes. The present study aimed to determine whether OEA treatment protects against DOX-induced cytotoxicity (DIC) and gain insights into the underlying mechanism that mediate these effects. Our data revealed that Oleoylethanolamide treatment improved the myocardial structure in DOX-challenged mice by attenuating cardiac oxidative stress and cell apoptosis. OEA also alleviated DOX-induced oxidative stress and apoptosis dysregulation in HL-1 cardiomyocyte. These effects were mediated by activation of TRPV1 and upregulation of PI3K/ Akt signaling pathway. Inhibition of TRPV1 and PI3K reversed the protective effects of OEA. Taken together, our data suggested that OEA protects against DIC through a TRPV1- mediated PI3K/ Akt pathway. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.COA of Formula: C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chiang, Chengyao;Zhang, Min;Wang, Dian;Xiao, Tian;Zhu, Lizhi;Chen, Kai;Huang, Junrong;Huang, Jingying;Zhu, Jiang;Li, Li;Chen, Cheng;Chen, Yangchao;Hu, Hongyi;Jiang, Wenqi;Zou, Yongdong;Wang, Ting;Zheng, Duo published 《Therapeutic potential of targeting MKK3-p38 axis with capsaicin for nasopharyngeal carcinoma》. The research results were published in《Theranostics》 in 2020.Recommanded Product: 2444-46-4 The article conveys some information:

Background: Capsaicin is an active compound found in plants of the Capsicum genus; it has a range of therapeutic benefits, including anti-tumor effects. Here we aimed to delineate the inhibitory effects of capsaicin on nasopharyngeal carcinoma (NPC). Methods: The anti-cancer effects of capsaicin were confirmed in NPC cell lines and xenograft mouse models, using CCK-8, clonogenic, wound-healing, transwell migration and invasion assays. Co-immunoprecipitation, western blotting and pull-down assays were used to determine the effects of capsaicin on the MKK3-p38 axis. Cell proliferation and EMT marker expression were monitored in MKK3 knockdown (KD) or over-expression NPC cell lines treated with or without capsaicin. Finally, immunohistochem. was performed on NPC specimens from NPC patients (n = 132) and the clin. relevance was analyzed. Results: Capsaicin inhibited cell proliferation, mobility and promoted apoptosis in NPC cells. Then we found that capsaicin directly targets p38 for dephosphorylation. As such, MKK3-induced p38 activation was inhibited by capsaicin. Furthermore, we found that capsaicin-induced inhibition of cell motility was mediated by fucokinase. Xenograft models demonstrated the inhibitory effects of capsaicin treatment on NPC tumor growth in vivo, and anal. of clin. NPC samples confirmed that MKK3 phosphorylation was associated with NPC tumor growth and lymphoid node metastasis. Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin. MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Recommanded Product: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xie, Dandan;Yang, Zaiping;Hu, Xin;Wen, Yin published 《Synthesis, antibacterial and insecticidal activities of novel capsaicin derivatives containing a sulfonic acid esters moiety》 in 2022. The article was appeared in 《Frontiers in Chemistry (Lausanne, Switzerland)》. They have made some progress in their research.Product Details of 2444-46-4 The article mentions the following:

In order to develop an efficient and broad-spectrum bactericide, a series of novel capsaicin derivatives containing a sulfonic acid esters moiety was synthesized. The structure of these compounds were confirmed by NMR spectroscopy (NMR) and high-resolution mass spectrum (HRMS). The results of the bioactivities revealed that some target compounds exhibited remarkable antibacterial activity. Compound 3b exhibited the highest activities against Pseudomonas syringae pv. actinidiae (Psa), Xanthomonas oryzae pv. oryzae (Xoo), and Xanthomonas axonopodis pv. citri (Xac), and the values were 86, 54, and 92% at 50 μg/mL, resp., which were higher than were for thiodiazole copper (87, 34, and 77%) and bismerthiazol (87, 37 and 75%). Although some compounds also showed certain activity against Spodoptera frugiperda, it was weaker than the pos. controls monosultap and mulfoxaflor. Thus, the bioassay results recommend that these newly designed and synthesized scaffolds should be used as a bactericide lead compound rather than an insecticide lead compound And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 2444-46-4In 2021, Fadladdin, Yousef Abdal Jalil published 《Antischistosomal activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa plant extracts on hamster infected with Schistosoma haematobium》. 《BioMed Research International》published the findings. The article contains the following contents:

World Health Organization (WHO) has approved only one treatment for schistosomiasis, praziquantel (PZQ), but some poor efficacy was noticed in patients during the early stage of infection. Therefore, researchers have intensified their efforts to research new alternative medicines to treat schistosomiasis. In the present study, in vitro as well as in vivo studies have been accomplished to evaluate the effect of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa extracts in a different concentration 500, 250, 125, 62.5, and 31.25 μg/mL on golden hamster infected by Egyptian strains of schistosome (Schistosoma haematobium). In vitro, the adult worms and schistosomula of S. haematobium were investigated in RPMI-1640 medium for 48 h. The results showed that the concentration 500, 250, and 125 μg/mL of Origanum majorana, and Ziziphus spina-christi caused dead of 100% of Egyptian Schistosoma strains of adult worm and schistosomula of S. haematobium within 6 to 12 h of incubation. On the other hand, the extract of Salvia fruticosa at concentrations 500, 250, and 125 μg/mL showed death 100% parasites after 12 to 24 h of incubation. Inclusion, Origanum majorana, and Ziziphus spina-christi showed effectiveness against Egyptian Schistosoma strains (S. haematobium), a slight decrease in Salvia fruticosa was observed Therefore, these medical plant extracts may be used as a safe and effective treatment for schistosomiasis. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Sujing;Zhou, Jun;Ma, Xuanxuan;Liu, Ying;Ma, Xing;Xia, Chuanhai published 《Ecotoxicity and preliminary risk assessment of nonivamide as a promising marine antifoulant》. The research results were published in《Journal of Chemistry》 in 2016.Category: amides-buliding-blocks The article conveys some information:

The unclear environmental performance of nonivamide limits its application as a marine antifoulant. In this study, the natural degradation of nonivamide was studied in seawater and tap water. The half-life was 5.8 d, 8.8 d, 12.2 d, and 14.7 d in seawater and tap water in photolysis and biolysis, resp. Furthermore, the ecotoxicity of nonivamide was assessed using marine microalgae, Chlorella vulgaris and Platymonas sp.; EC50,6 d values on the growth of Chlorella vulgaris and Platymonas sp. were 16.9 mg L^-1 and 19.21 mg L^-1, resp. The toxicity and environmental risk of nonivamide on microalgae were significantly decreased due to the natural degradation in seawater. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Category: amides-buliding-blocks Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Palo-Nieto, Carlos;Afewerki, Samson;Anderson, Mattias;Tai, Cheuk-Wai;Berglund, Per;Cordova, Armando published 《Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis》. The research results were published in《ACS Catalysis》 in 2016.Recommanded Product: 2444-46-4 The article conveys some information:

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymic multiple relay catalysis for eco-friendly and asym. synthesis of valuable mols. (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biol. and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcs., resp.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Recommanded Product: 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of C17H27NO3In 2019, Sarpras, M.;Ahmad, Ilyas;Rawoof, Abdul;Ramchiary, Nirala published 《Comparative analysis of developmental changes of fruit metabolites, antioxidant activities and mineral elements content in Bhut jolokia and other Capsicum species》. 《LWT–Food Science and Technology》published the findings. The article contains the following contents:

Humans are directly or indirectly dependent on plant foods for their nutritional health. Hence it is important to characterize the macro and micro nutrients and mineral-elements of commonly consumed dietary vegetables like Capsicum (Chilli). In the present study global metabolites, total ascorbic acid, phenols, flavonoids, capsaicinoids, mineral-elements and antioxidant activities were determined on different developmental stages of Capsicum fruits (immature, breaker and mature) belonging to three Capsicum species namely Capsicum chinense, C. frutescens, and C. annuum. The results obtained from the present study showed the maturity dependent increase in the sugar and fatty acid metabolites, capsaicinoids, ascorbic acid and phenol content, and antioxidant activities. Similarly, essential mineral-elements also increased during the fruit maturation in C. chinense, however, contrasting results was observed in C. annuum. In addition to that some health beneficial compounds such as antibacterial and antifungal metabolites exclusively observed in matured C. chinense. These interesting observations have opened the possibility to understand and manipulate biosynthesis of macro/micronutrients and mineral elements in order to improve nutritional quality of Capsicum (Chilli) species.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Electric Literature of C17H27NO3 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Chuan;Ma, Dianping;Cao, Wenming;Shi, Haiming;Jiang, Yuanrong published 《Fast simultaneous determination of capsaicin, dihydrocapsaicin and nonivamide for detecting adulteration in edible and crude vegetable oils by UPLC-MS/MS》 in 2018. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Safety of N-Vanillylnonanamide The article mentions the following:

Capsaicinoids are pungent components in hot peppers, which have been detected in waste cooking oil. However, trace anal. of capsaicinoids in edible and crude vegetable oils is a challenging task due to the complex matrix. In this study, a simple liquid-liquid extraction and solid phase extraction (SPE) coupled with RP-UPLC-ESI-MS/MS method was developed for the quantification of capsaicinoids in edible and crude vegetable oils to screen the adulteration with waste cooking oil. This method was used to simultaneously determine 3 capsaicinoids (capsaicin, dihydrocapsaicin, and nordihydrocapsaicin) with capsaicin-d₃, and dihydrocapsaicin-d₃ as internal standards This method allows the complete anal. of a sample in only an hour, even including sample preparation and chromatog. separation The linear range of 3 capsaicinoids ranged between 0.5 and 40 μg/kg. The limit of detection (LOD) and limit of quantification (LOQ) for capsaicinoids were calculated as 0.15 and 0.5 μg/kg, resp. Quant. recoveries ranging from 92.9% to 105% were obtained by the anal. of spiked oil. The relative standard deviations were less than 5% (n = 6). The established method can potentially overcome the interference of triacylglycerols and fatty acids in edible and crude vegetable oils, and have been successfully applied to analyze real oil samples. This method provided a rapid and reliable method for the detection of adulteration of vegetable oils with waste cooking oils.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Safety of N-Vanillylnonanamide It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics