Tag: 200-300

Name: N-VanillylnonanamideIn 2016, Heck, Rouven;Hermann, Sabrina;Lunter, Dominique J.;Daniels, Rolf published 《Film-forming formulations containing porous silica for the sustained delivery of actives to the skin》. 《European Journal of Pharmaceutics and Biopharmaceutics》published the findings. The article contains the following contents:

The purpose of this study was to develop film-forming formulations facilitating long-term treatment of chronic pruritus with capsaicinoids. To this end, an oily solution of nonivamide was loaded into porous silica particles which were then suspended in the dispersion of a sustained release polymer. Such formulations form a film when applied to the skin and encapsulate the drug loaded silica particles in a dry polymeric matrix. Dermal delivery and permeation of the antipruritic drug nonivamide (NVA) are controlled by the matrix. The film-forming formulations were examined regarding homogeneity, storage stability, substantivity and ex vivo skin permeation. Confocal Raman spectral imaging proved the stability of silica-based film-forming formulations over a period of 6 mo. Substantivity was found to be enhanced substantially compared to a conventional semisolid formulation. Permeation rates of nonivamide from film-forming formulations through the skin are much lower compared to those achieved with a conventional immediate release formulation with the same drug amount Due to the drug reservoir in the polymer matrix, a sustained permeation is enabled. Film-forming formulations may therefore improve the treatment of chronic pruritus with capsaicinoids by enhancing patient compliance through a sustained release regime. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Name: N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Wenjie;Zhang, Xing;Knochenmuss, Richard;Siems, William F.;Hill, Herbert H. Jr. published 《Multidimensional Separation of Natural Products Using Liquid Chromatography Coupled to Hadamard Transform Ion Mobility Mass Spectrometry》. The research results were published in《Journal of the American Society for Mass Spectrometry》 in 2016.Synthetic Route of C17H27NO3 The article conveys some information:

A high performance liquid chromatograph (HPLC)was interfaced to an atm. drift tube ion mobility time of flight mass spectrometry. The power of multidimensional separation was demonstrated using chili pepper extracts The ambient pressure drift tube ion mobility provided high resolving powers up to 166 for the HPLC eluent. With implementation of Hadamard transform (HT), the duty cycle for the ion mobility drift tube was increased from <1% to 50%, and the ion transmission efficiency was improved by over 200 times compared with pulsed mode, improving signal to noise ratio 10 times. HT ion mobility and TOF mass spectrometry provide an addnl. dimension of separation for complex samples without increasing the anal. time compared with conventional HPLC. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Synthetic Route of C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schmidberger, Markus;Daniels, Rolf;Lunter, Dominique Jasmin published 《Method to determine the impact of substantivity on ex vivo skin-permeation》 in 2018. The article was appeared in 《European Journal of Pharmaceutics and Biopharmaceutics》. They have made some progress in their research.Recommanded Product: 2444-46-4 The article mentions the following:

Topical formulations are the most common therapeutic agents in the treatment of skin diseases. They contain one or more active pharmaceutical ingredients (API) which need to penetrate or permeate the skin in order to exert their effect. However, after application a part of the formulation is removed from the skin due to contact with the environment. Therefore, a part of the active is then not available for penetration and thus, a loss in therapeutic effect will result. To achieve the desired therapeutic outcome a sufficient fraction of the formulation must remain on the skin. The extent to which the loss of preparation affects penetration and permeation is less investigated. This work presents a method to examine the influence of mech. stress and formulation loss on skin permeation. A movable punch with a defined weight simulated contact between clothing or skin and the applied formulation. Weight of the tool, number of contacts and speed settings were variable and were investigated. Ex vivo permeation experiments were performed in Franz diffusion cells using porcine skin. Three preparations with nonivamide as active ingredient were chosen as model formulations: A semisolid cream, an oil-in-oil emulsion and a film-forming formulation. The last two show sustained permeation profiles. The method uses skin-to-formulation and clothing-to-formulation contact to simulate the removal of the formulations from the skin.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Recommanded Product: 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 2444-46-4In 2022, Zhang, Hongliang;Wang, Weijin;Wang, Bingding;Tan, Hui;Jiao, Ning;Song, Song published 《Electrophilic amidomethylation of arenes with DMSO/MeCN reagents》. 《Organic Chemistry Frontiers》published the findings. The article contains the following contents:

An efficient electrophilic amidomethylation of aromatics was described to construct N-benzylic amides, which are core structures in drugs and natural products. The simple combination of DMSO (DMSO, as the CH₂ unit) and acetonitrile (MeCN, as the nitrogen unit) as a highly active amidomethylation reagent enables the efficient C-C, C-N and C=O bond construction. Notably, this method provides a practical protocol for the efficient preparation of deuterated benzylamine derivatives with easily available d₆-DMSO or d₃-MeCN, and is also applied in the concise synthesis of Nonivamide and Pimavanserin. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Related Products of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of N-Vanillylnonanamide《Molecular basis and potential applications of capsaicinoids and capsinoids against the elongation of etiolated wheat (Triticum aestivum L.) coleoptiles in foods》 was published in 2019. The authors were Chen, Kexian;Ying, Qian;Ge, Zhen;Chen, Hong;Qian, Chaowei;Li, Yunyou;Chen, Zhongxiu, and the article was included in《Food Chemistry》. The author mentioned the following in the article:

Capsaicinoids and capsinoids from dietary peppers have promising sensory properties and bioactivity, but the mol. basis of their penetration mechanism through cell lipid bilayers and its relationship to their bioavailability as food constituents are still poorly understood. Herein, statistically significant linear and quadratic quant. structure-activity relationships were constructed to derive the essential structural elements required for their bioactivity against the elongation of etiolated wheat coleoptiles that mainly occurs via penetration. The resultant optimal models had high predictivity and reliability (r² > 0.825 and r²_pred > 0.950), which elucidate the importance of steric structural elements. Besides, their mechanistic hypothesis and rational design strategy were proposed, and the correlation between this bioactivity and their food-sensory properties was supposed. Finally, the bioactivity of newly designed analogs with Me terminals and/or conjugated C=C links was screened. Hopefully, this work would benefit the better understanding of their penetration mechanism and facile identification of bioactive analogs for designing food/drug formulations. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Safety of N-Vanillylnonanamide It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Stoeger, Verena;Lieder, Barbara;Riedel, Johanna;Schweiger, Kerstin;Hoi, Julia;Ruzsanyi, Veronika;Klieber, Martin;Rust, Petra;Hans, Joachim;Ley, Jakob P.;Krammer, Gerhard E.;Somoza, Veronika published 《Wheat Protein Hydrolysate Fortified With L-Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects》 in 2019. The article was appeared in 《Molecular Nutrition & Food Research》. They have made some progress in their research.Application of 2444-46-4 The article mentions the following:

Increasing the intake of satiety-enhancing food compounds represents a promising strategy for maintaining a healthy body weight Recently, satiating effects for the capsaicinoid nonivamide have been demonstrated. As various proteins and amino acids have also been demonstrated to decrease energy intake, oral glucose tolerance test (oGTT)-based bolus interventions of 75 g glucose + 0.15 mg nonivamide (NV control) are tested with/without combination of a wheat protein hydrolyzate (WPH: 2 g) and/or L-arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects. Compared to NV control intervention, ARG and WPH + ARG treatment both reduce (p < 0.01) total calorie intake from a standardized breakfast by -5.9 ± 4.15% and -6.07 ± 4.38%, resp. For the WPH + ARG intervention, increased mean plasma serotonin concentrations (AUC: 350 ± 218), quantitated by ELISA, and delayed gastric emptying, assessed by ¹³C-Na-acetate breath test (-2.10 ± 0.51%, p < 0.05), are demonstrated compared to NV control. Correlation anal. between plasma serotonin and gastric emptying reveals a significant association after WPH ± ARG intervention (r = -0.396, p = 0.045). Combination of WPH and ARG enhances the satiating effect of nonivamide, providing opportunities to optimize satiating food formulations by low amounts of the individual food constituents. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Application of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Satpute, Ravindra M.;Kushwaha, Pramod K.;Nagar, D. P.;Rao, P. V. L. published 《Comparative safety evaluation of riot control agents of synthetic and natural origin》 in 2018. The article was appeared in 《Inhalation Toxicology》. They have made some progress in their research.Application In Synthesis of N-Vanillylnonanamide The article mentions the following:

Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecol. compatibility. Presently, we have evaluated the safety of CR, OC, and PAVA on inhalation variables along with oral lethality. Addnl., the liver function test (LFT) in serum and lungs function was evaluated in broncho-alveolar-lavage fluid (BALF), both collected on the 14th day after RCA exposure. Animals then sacrificed and histopathol. of liver and lungs was carried out. Results showed OC and PAVA to be more toxic than CR with an oral LD₅₀ of 150 and 200 mg/kg body weight, resp., while CR was safe at >3 g/kg body weight All three agents caused severe impairment of respiratory variables bringing down normal respiration by >80% with rise in sensory irritation. Recovery from the irritating effect of CR was more rapid than OC and PAVA. LFT and BALF variables were not significantly different from that of control. There were no remarkable histopathol. changes in liver and lungs. Hence, as per results, CR is safest among all synthetic and natural origin RCAs and can be safely used for effective dispersion of disobedient mob. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Application In Synthesis of N-Vanillylnonanamide Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Borusiewicz, Rafal;Martyna, Agnieszka;Zadora, Grzegorz;Zahrebelna, Anastasiia published 《Differentiation of oleoresin capsicum sprays based on their capsaicinoid profiles》 in 2021. The article was appeared in 《Forensic Science International》. They have made some progress in their research.Electric Literature of C17H27NO3 The article mentions the following:

Oleoresin capsicum (OC) sprays, often referred to as pepper sprays, contain a solution of active compounds, exerting an irritating effect on the human body. The active component of OC sprays are capsaicinoids, obtained by extraction from peppers. The profiles (quant. relations) of natural capsaicinoids depend on the plant material, they were extracted from. Pepper spray is a non-lethal weapon that should only be used for self-defense but is often used by criminals to attack and incapacitate victims. Evidence related to these types of incidents, such as containers, clothes of victims or suspects, as well as traces of substances found at the scene, are submitted to the forensic laboratory The purpose of the anal. is to identify the ingredients of the preparation (especially active components) and compare the traces found on objects from the victim or the scene of the incident with the preparation from the can or traces found on objects related to the suspect. The study aimed to investigate the possibility of differentiating OC gases based on capsaicinoid profiles recorded in GC-MS analyses. Sixty-four gases from 12 different manufacturers were purchased and tested. The likelihood ratio (LR) approach was applied to the data expressing the relative capsaicinoids contents computed by integrating GC-MS signals. Two hypotheses were assumed that stated either common or different origins of the samples. Several LR models have been developed, and their performance has been controlled by the number of false positives and false negatives as well as empirical cross entropy. The research results showed that differentiation was very successful, with more than 90% of correct responses. The results obtained show that OC sprays may be distinguished, even if they were produced by the same producer presumably if produced using different batches of pepper extract To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Electric Literature of C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Qian;Yao, Li;Qin, Panzhu;Xu, Jianguo;Sun, Xun;Yao, Bangben;Ren, Fei;Chen, Wei published 《Time-resolved fluorescent lateral flow strip for easy and rapid quality control of edible oil》 in 2021. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Name: N-Vanillylnonanamide The article mentions the following:

Gutter oil is strictly prohibited from being reprocessed back to the catering and food industry. Extensive attention has been paid to rapid screening of gutter oil to guarantee the safety of edible oil. Capsaicin, a special component of condiments, has been adopted as the marker of gutter oil. The time-resolved fluorescent microspheres are utilized for labeling of antibody to capsaicin, which are further applied for the construction of fluorescent lateral-flow-strip (LFS). By simple extraction of capsaicin with ethanol (or liquor) from the edible oil, the capsaicin can be rapid determined with the fluorescent LFS in less than 10 min. As low as 20 ng/mL capsaicin can be visually judged and 2.3 ng/mL is achieved as the detection limit by ImageJ anal. The illegal gutter oil is also well screened with this time-resolved LFS. This method can be a useful candidate for routine quality monitoring of edible oil and a powerful tool for self-inspection at home.N-Vanillylnonanamide (cas: 2444-46-4) were involved in the experimental procedure.

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Guo, Zhen;Li, Xiu-qin;Gao, Fang-yuan;Zhang, Qing-he;Li, Hong-mei published 《Determination of capsaicinoids in edible oil by liquid chromatography-isotope dilution mass spectrometry》. The research results were published in《Huaxue Shiji》 in 2016.Name: N-Vanillylnonanamide The article conveys some information:

A method was developed on determination of capsaicinoids (capsaicin, dihydrocapsaicin, nordihydrocapsaicin and n-vanillvlnonanamide) in edible oil by liquid chromatog.-isotope dilution mass spectrometry (LC-IDMS). The sample was firstly extracted with sodium hydroxide solution, and then the extract was cleaned-up by auto solid phase extraction (SPE) before the LC-IDMS anal. The limit of detection (LOD, S/N>3) for capsaicinoids was 0.015 μg/kg, and the recoveries of the 4 kinds of capsaicinoids in edible oil samples were 96.2%-105% with the RSDs ranging 0.5%-3.8% (n = 6). Edible oils and illegal edible oils were both analyzed using this method, and significant differences were observed The results showed that there were no capsaicinoids in most kinds of edible oils. Peanut oil contained little capsaicinoids ranging 0-1.8 μg/kg which might come from peanut. The content of capsaicinoids was above 600 μg/kg in most illegal cooking oils. This method can be used as one of identification methods on illegal cooking oil. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .

N-Vanillylnonanamide(cas:2444-46-4) has antifouling properties.Name: N-Vanillylnonanamide It acts as an nicotinamide adenine dinucleotide phosphate (NADPH) inhibitor.N-Vanillylnonanamide has been used for the preparation of spicules.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics