Tag: 200-300

In 2022,Biomaterials Science included an article by Dong, Peng; Liu, Jiaojiao; Lv, Hongshuai; Wu, Jiaan; Zhang, Naining; Wang, Si; Li, Xiaohai; Hu, Jinghua; Wang, Anny; Li, Daisy J.; Wang, Dandan; Cao, Shengnan; Xie, Liangyu; Shi, Yikang. Recommanded Product: H-Lys(Boc)-OH. The article was titled 《The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid》. The information in the text is summarized as follows:

Docetaxel (DTX) has been widely used for the treatment of many types of cancer. However, DTX is poorly water-soluble and com. DTX is formulated in non-ionic surfactant polysorbate 80 and ethanol, thereby leading to hypersensitivity and serious side effects. Herein, a polymer dual drug conjugate was synthesized by coupling DTX and docosahexaenoic acid (DHA) with bifunctionalized dextran. The polysaccharide conjugate dextran-DHA-DTX possessed high water solubility and was self-assembled into nanoparticles with a diameter of 98.0 ± 6.4 nm. Pharmacokinetic and biodistribution studies showed that the dextran-DHA-DTX dual drug conjugate not only had significantly prolonged blood circulation but was also selectively accumulated in the tumor with reduced drug distribution in normal tissues. The conjugate exhibited a superior therapeutic effect in both xenograft nude mice models without causing any systemic side effects. Notably, the conjugate nearly eliminated all xenograft tumors in nude mice bearing breast cancer cells MCF-7. This study revealed that the dextran-based dual drug delivery system may provide an effective strategy to selectively deliver DTX to tumor sites. In the experimental materials used by the author, we found H-Lys(Boc)-OH(cas: 2418-95-3Recommanded Product: H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Recommanded Product: H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Peptide Science included an article by Deguchi, Ayaka; Hattori, Yasunao; Konno, Hiroyuki; Nosaka, Kazuto; Akaji, Kenichi. Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide. The article was titled 《Syntheses of hydroxyethylamine derivatives containing side-chain mimetic substituent and peptide sequence》. The information in the text is summarized as follows:

A symposium report. Aspartic protease (AP) plays an essential role in serious diseases such as AIDS, ATL (Adult T-cell Leukemia), and Alzheimer’s disease, and is thought to be a suitable target to design therapeutic inhibitors. In the present study, we developed a synthetic route using Mannich-type reaction to construct hydroxyethylamine scaffold containing side-chain mimetic substituent and peptide sequence. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Alemany, Carme; Bach, Jordi; Farras, Jaume; Garcia, Jordi published their research in Organic Letters on December 2 ,1999. The article was titled 《A versatile approach to N-Boc-statine and N-Boc-norstatine based on the reduction of 1-trialkylsilyl acetylenic ketones. Strong remote effect of the C(1) substituent on the stereoselectivity》.Safety of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The article contains the following contents:

An efficient, unified approach to chiral, protected β-hydroxy-γ-amino and α-hydroxy-β-amino acids derived from Boc-L-leucine has been accomplished on the basis of the oxazaborolidine-controlled, stereoselective reduction of 1-trialkylsilyl acetylenic ketones; stereoselectivity in the reduction step has shown strong dependence upon C(1) substitution. For example, trimethylsilyl acetylenic ketone I [prepared from Boc-Leu-N(Me)OMe with TMSCCH] was stereoselectively reduced to the alc. II using BH3:SMe2 with catalyst oxazaborolidine III. Next, hydroboration of II with dicyclohexylborane followed by oxidative workup gave statine derivative IV. In addition to this study using (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide, there are many other studies that have used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Safety of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide) was used in this study.

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Safety of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamideAmides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schaefer, Olga; Schollmeyer, Dieter; Birke, Alexander; Holm, Regina; Johann, Kerstin; Muhl, Christian; Seidl, Christine; Weber, Benjamin; Barz, Matthias published an article on January 17 ,2019. The article was titled 《Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization》, and you may find the article in Tetrahedron Letters.Reference of H-Lys(Boc)-OH The information in the text is summarized as follows:

The need for a scalable synthesis of not sequence defined polypeptides as biomaterials is met by the ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Even though this polymerization technique appears straight forward, it holds pitfalls in terms of reproducibility and overall control over the polymerization conditions, which depends, beside choice of solvent or initiator, significantly on reagent purity. In addition, the synthesis of monomers can lead to the formation of racemic amino acids. Thus, in this work, we describe the benefits of highly pure monomers in order to control nucleophilic ring-opening polymerization NCAs. Hereby, monomer purity is investigated by relating m.ps. of NCAs with single-crystal and powder X-ray diffraction crystallog. data, which further proves retained stereo-information of NCAs. In the experimental materials used by the author, we found H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Reference of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,Biomaterials Science included an article by Ma, Pengcheng; Wu, Yueming; Jiang, Weinan; Shao, Ning; Zhou, Min; Chen, Yuan; Xie, Jiayang; Qiao, Zhongqian; Liu, Runhui. Application of 2418-95-3. The article was titled 《Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture》. The information in the text is summarized as follows:

The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use of antibiotics in feed. Therefore, it is an urgent need to develop alternatives to antibiotics to control infectious diseases in feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent and broad-spectrum activity against common pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and do not induce bacteria to develop resistance or cross-resistance to antibiotics. The optimal peptide polymer demonstrates strong in vivo therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Application of 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application of 2418-95-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 2418-95-3On November 30, 2020 ,《Structure-activity relationship studies of prostate-specific membrane antigen (PSMA) inhibitors derived from α-amino acid with (S)- or (R)-configuration at P1′ region》 appeared in Bioorganic Chemistry. The author of the article were Kwon, Hongmok; Lim, Hyunwoong; Ha, Hyunsoo; Choi, Doyoung; Son, Sang-Hyun; Nam, Hwanhee; Minn, Il; Byun, Youngjoo. The article conveys some information:

Prostate-specific membrane antigen (PSMA), a type II membrane glycoprotein, is considered an excellent target for the diagnosis or treatment of prostate cancer. We previously investigated the effect of β- and γ-amino acids with (S)- or (R)-configuration in the S1 pocket on the binding affinity for PSMA. However, comprehensive studies on the effect of α-amino acid with (R)-configuration in the S1′ pocket has not been reported yet. We selected ZJ-43 (1) and DCIBzL (5) as templates and synthesized their analogs with (S)- or (R)-configuration in the P1 and P1′ regions. The PSMA-inhibitory activities of compounds with altered chirality in the P1′ region were dropped dramatically, with their IC50 values changing from nM to μM ranges. The compounds with (S)-configuration at both P1 and P1′ regions were more potent than the others. The findings of this study may provide insights regarding the structural modification of PSMA inhibitor in the S1′ binding pocket. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Related Products of 2418-95-3)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. These amino acids may be present in low concentrations and play a vital part as an intermediate in a biosynthetic pathway, e.g., ornithine, homoserine, or cystathionine. In contrast they may act as a major storage form of nitrogen, e.g., canavanine in the seed of Canavalia ensiformis, or may be formed in high amounts in response to an external stress, e.g., γ-aminobutyrate.Related Products of 2418-95-3 It is possible that some of these nonprotein amino acids may serve as insecticidal or fungicidal agents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ogawa, Hidetoshi; Iwasaki, Arihiro; Sumimoto, Shimpei; Iwatsuki, Masato; Ishiyama, Aki; Hokari, Rei; Otoguro, Kazuhiko; Omura, Satoshi; Suenaga, Kiyotake published an article on February 17 ,2017. The article was titled 《Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium》, and you may find the article in Organic Letters.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The information in the text is summarized as follows:

In the search for new antiprotozoal substances, hoshinolactam, an antitrypanosomal lactam, was isolated from a marine cyanobacterium. The gross structure was elucidated by spectroscopic analyses, and the absolute configuration was determined by the first total synthesis. Hoshinolactam showed potent antitrypanosomal activity with an IC50 value of 3.9 nM without cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 >25 μM). The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)

(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of H-Lys(Boc)-OHOn May 17, 2019 ,《Construction of bacterial cells with an active transport system for unnatural amino acids》 appeared in ACS Synthetic Biology. The author of the article were Ko, Wooseok; Kumar, Rahul; Kim, Sanggil; Lee, Hyun Soo. The article conveys some information:

Engineered organisms with an expanded genetic code have attracted much attention in chem. and synthetic biol. research. In this work, engineered bacterial organisms with enhanced unnatural amino acid (UAA) uptake abilities were developed by screening periplasmic binding protein (PBP) mutants for recognition of UAAs. A FRET-based assay was used to identify a mutant PBP (LBP-AEL) with excellent binding affinity (Kd ≈ 500 nM) to multiple UAAs from 37 mutants. Bacterial cells expressing LBP-AEL showed up to 5-fold enhanced uptake of UAAs, which was determined by genetic incorporation of UAAs into a green fluorescent protein and measuring UAA concentration in cell lysates. To the best of our knowledge, this work is the first report of engineering cellular uptake of UAAs and could provide an impetus for designing advanced unnatural organisms with an expanded genetic code, which function with the efficiency comparable to that of natural organisms. The system would be useful to increase mutant protein yield from lower concentrations of UAAs for industrial and large-scale applications. In addition, the techniques used in this report such as the sensor design and the measurement of UAA concentration in cell lysates could be useful for other biochem. applications. In the experimental materials used by the author, we found H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH)

H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. Amino acids are not generally considered to be electrochemically active because products of the oxidation accumulate on the electrode surface and prevent it from participating in any further electrochemical processes.Reference of H-Lys(Boc)-OH

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Hirai, Toshihiro; Shibata, Kohki; Niwano, Yohei; Shiozaki, Masao; Hashimoto, Yoshimitsu; Morita, Nobuyoshi; Ban, Shintaro; Tamura, Osamu published 《Total synthesis of neodysiherbaine A via 1,3-dipolar cycloaddition of a chiral nitrone template》.Organic Letters published the findings.SDS of cas: 71432-55-8 The information in the text is summarized as follows:

The total synthesis of neodysiherbaine A was achieved via 1,3-dipolar cycloaddition of a chiral nitrone template with a sugar-derived allyl alc. in the presence of MgBr2·OEt2. This cycloaddition constructed the C2 and C4 asym. centers in a single step. Then reductive cleavage, intramol. SN2 reaction of the tertiary alc., and oxidation of the primary alc. afforded neodysiherbaine A. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8SDS of cas: 71432-55-8)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.SDS of cas: 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2010,Vanek, V.; Picha, J.; Budesinsky, M.; Sanda, M.; Jiracek, J.; Holz, R. C.; Hlavacek, J. published 《Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection》.Protein & Peptide Letters published the findings.Computed Properties of C11H24N2O The information in the text is summarized as follows:

The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodol. for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing different carboxyl groups or lipophilic moieties on their amino group. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Computed Properties of C11H24N2O) was used in this study.

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C11H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics