Tag: 100-200

《Copper-catalyzed tandem cis-carbometalation/cyclization of imine-ynamides with arylboronic acids》 was written by Wang, Hao-Ran; Huang, En-He; Luo, Chen; Luo, Wen-Feng; Xu, Yin; Qian, Peng-Cheng; Zhou, Jin-Mei; Ye, Long-Wu. Related Products of 70-55-3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Indoles I (Ar1, Ar2 = Ph, substituted Ph; X = H, OMe, Me, Br) were prepared by copper(I) acetate-catalyzed tandem carboboration-cyclization of imino-ynamides 2-tBuN:CHC6H4N(PG)CCAr1 (PG = arenesulfonyl) with areneboronic acids Ar2B(OH)2. An efficient copper-catalyzed tandem regioselective cis-carbometalation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to excellent yields and features a broad substrate scope and wide functional group tolerance. Other significant features of this protocol include the use of readily available starting materials, high flexibility, simple procedure and mild reaction conditions. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Related Products of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Treating water containing elevated bromide and iodide levels with granular activated carbon and free chlorine: impacts on disinfection byproduct formation and calculated toxicity》 was published in Environmental Science: Water Research & Technology in 2020. These research results belong to Zhang, Chuhui; Maness, J. Clark; Cuthbertson, Amy A.; Kimura, Susana Y.; Liberatore, Hannah K.; Richardson, Susan D.; Stanford, Benjamin D.; Sun, Mei; Knappe, Detlef R. U.. SDS of cas: 683-57-8 The article mentions the following:

We evaluated the efficacy of granular activated carbon (GAC) adsorption for mitigating formation of chlorine disinfection byproducts (DBPs) in water with a wide range of bromide (20-1000μg L-1) and iodide (<5-100μg L-1) concentrations GAC effectiveness was assessed by determining speciated total organic halogen (TOX), 70 DBPs, and calculated cyto- and genotoxicity. Overall, GAC treatment effectively lowered formation of TOX and the majority of targeted DBPs over the evaluated service time (>30 000 bed volumes). In the GAC influent, total organic bromine increased from 10 to 84% of TOX as bromide levels increased from 20 to 1000μg L-1. Dissolved organic carbon (DOC) removal by GAC increased the bromide-to-DOC (Br/DOC) concentration ratio in GAC effluent relative to influent. As a result, bromine incorporation into DBPs increased after GAC treatment, especially at early GAC service times and low bromide levels. Total organic iodine was <3.5% of TOX, and iodo-DBP formation was low because elevated iodide was only evaluated in the presence of high bromide and free chlorine, a scenario that favors iodate formation. Although trihalomethanes (THMs) and haloacetic acids (HAAs) consistently formed at the highest molar concentrations, they were not major contributors to calculated cyto- and genotoxicity. Principal contributors to calculated cytotoxicity included haloacetaldehydes (HALs), haloacetamides (HAMs), and haloacetonitriles (HANs), while the main drivers of genotoxicity were HALs, HAMs, HANs, and halonitromethanes (HNMs) despite lower concentrations Because bromine incorporation into DBPs increased nonlinearly with increasing Br/DOC concentration ratios, GAC more effectively controlled calculated toxicity at elevated bromide levels. Calculated cyto- and genotoxicity did not vary strongly with GAC service life, suggesting that GAC treatment can effectively lower calculated toxicity over long periods of operation. The majority of TOX remained unknown (>50%) in all samples despite the quantification of 70 DBPs targeted in this study, highlighting the need to assess toxicity associated with unknown DBPs. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8SDS of cas: 683-57-8)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.SDS of cas: 683-57-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Orooji, Yasin; Pakzad, Khatereh; Nasrollahzadeh, Mahmoud; Tajbakhsh, Mahmood published an article in 2021. The article was titled 《Novel magnetic lignosulfonate-supported Pd complex as an efficient nanocatalyst for N-arylation of 4-methylbenzenesulfonamide》, and you may find the article in International Journal of Biological Macromolecules.Recommanded Product: 4-Methylbenzenesulfonamide The information in the text is summarized as follows:

This study presented a novel and economical technique for synthesizing magnetic palladium complex conjugated to activated calcium lignosulfonate with triethylenetetramine (Fe3O4@lignosulfonate@triethylenetetramine@Pd complex (FLT-Pd complex)) as a practical and air-stable catalyst. FLT-Pd complex was used as a catalyst for the fabrication of 4-methyl-N-aryl-benzenesulfonamide derivatives I [Ar = Ph, 4-MeC6H4, 2-H2NC6H4, etc.] via N-arylation of 4-methylbenzenesulfonamide with aryl halides in good yields. Furthermore, because of the complex magnetic reparability and high stability, it could be removed easily from the reaction media using a magnet and reused 5 cycles without a remarkable loss of catalytic prowess. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《One-pot aerobic oxidative sulfonamidation of aromatic thiols with ammonia by a dual-functional β-MnO2 nanocatalyst》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hayashi, Eri; Yamaguchi, Yui; Kita, Yusuke; Kamata, Keigo; Hara, Michikazu. Electric Literature of C7H9NO2S The article mentions the following:

High-surface-area β-MnO2nanoparticles could act as effective heterogeneous catalysts for the one-pot oxidative sulfonamidation of various aromatic and heteroaromatic thiols to give corresponding sulfonamides ArSO2NH2 [Ar = Ph, 2-thienyl, 4-BrC6H4, etc.] using mol. oxygen and ammonia as resp. oxygen and nitrogen sources, without the need for any additives. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Electric Literature of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Angewandte Chemie, International Edition included an article by Ziegler, Dorothee S.; Karaghiosoff, Konstantin; Knochel, Paul. Synthetic Route of C4H9NO2. The article was titled 《Generation of Aryl and Heteroaryl Magnesium Reagents in Toluene by Br/Mg or Cl/Mg Exchange》. The information in the text is summarized as follows:

The alkylmagnesium alkoxide sBuMgOR·LiOR (R = 2-ethylhexyl), which was prepared as a 1.5M solution in toluene, undergoes very fast Br/Mg exchange with aryl and heteroaryl bromides, producing aryl and heteroaryl magnesium alkoxides (ArMgOR·LiOR) in toluene. These Grignard reagents react with a broad range of electrophiles, including aldehydes, ketones, allyl bromides, acyl chlorides, epoxides, and aziridines, in good yields. Remarkably, the related reagent sBu2Mg·2LiOR (R = 2-ethylhexyl) undergoes Cl/Mg exchange with various electron-rich aryl chlorides in toluene, producing diorganomagnesium species of type Ar2Mg·2LiOR, which react well with aldehydes and allyl bromides. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2022,de Jesus Cruz, Pedro; Cassels, William R.; Chen, Chun-Hsing; Johnson, Jeffrey S. published an article in Science (Washington, DC, United States). The title of the article was 《Doubly stereoconvergent crystallization enabled by asymmetric catalysis》.Synthetic Route of C4H9NO2 The author mentioned the following in the article:

Herein, discovery and development of a catalyst-mediated asym. Michael addition/crystallization-induced diastereomer transformation of broad scope was reported. The sequence controlled three stereogenic centers, two of which were stereochem. labile. The configurational instability of 1,3-dicarbonyls and nitroalkanes, typically considered a liability in stereoselective synthesis, was productively leveraged by merging enantioselective Bronsted base organocatalysis and thermodn. stereocontrol using a single convergent crystallization The synthesis of useful γ-nitro β-keto amides containing three contiguous stereogenic centers was thus achieved from Michael acceptors containing two prochiral centers. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Synthetic Route of C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Bosnidou, Alexandra E.; Muniz, Kilian. Computed Properties of C7H9NO2S. The article was titled 《Intermolecular Radical C(sp3)-H Amination under Iodine Catalysis》. The information in the text is summarized as follows:

Alkanes and aryl alkanes such as ethylbenzene underwent regioselective amination with sulfonamides such as trifluoromethanesulfonamide in the presence of I2 using iodobenzene bis(4-bromobenzoate) as the stoichiometric oxidant in anhydrous dichloromethane under blue LED irradiation to yield N-sulfonyl benzylic and alkyl amines such as PhCH(NHTf)Me. The method was used to prepare aminated amino acids and racemic arylglycinates and β-aryl-β-alaninates as well as memantine, rasagiline, and racemic sertraline. The method was also used to prepare trans-2,5-disubstituted pyrrolidines by iodine-catalyzed photochem. amination of phenylalkanes with methanesulfonamide followed by intramol. amination in the presence of I2 using phenyliodine bis(3-chlorobenzoate) as the stoichiometric oxidant; the method was also used to prepare the dibenzoazabicyclooctane anticonvulsant MK-801. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Valderrey, Virginia; Bonasera, Aurelio; Fredrich, Sebastian; Hecht, Stefan published 《Light-Activated Sensitive Probes for Amine Detection》.Angewandte Chemie, International Edition published the findings.Recommanded Product: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

The authors’ new, simple, and accurate colorimetric method is based on diarylethenes (DAEs) for the rapid detection of a wide range of primary and secondary amines. The probes consist of aldehyde- or ketone-substituted diarylethenes, which undergo an amine-induced decoloration reaction, selectively to give the ring-closed isomer. Thus, these probes can be activated at the desired moment by light irradiation, with a sensitivity that allows the detection of amines at concentrations as low as 10-6 M in solution In addition, the practical immobilization of DAEs on paper makes it possible to detect biogenic amines, such as cadaverine, in the gas phase above a threshold of 12 ppbv within 30 s. In the part of experimental materials, we found many familiar compounds, such as N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Andres, J. Ignacio; Alonso, Jose M.; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F.; Sipido, Victor K. published their research in Bioorganic & Medicinal Chemistry Letters on December 16 ,2002. The article was titled 《2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT2C antagonist with potential anxiolytic properties》.Application of 70298-88-3 The article contains the following contents:

The synthesis of 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,4-c]-[2]benzazepine and 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,2-c]-[2]benzazepine via a new route is reported. The affinities for several receptors as well as the m-chlorophenylpiperazine antagonistic activity of the compounds synthesized are described. After reading the article, we found that the author used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Different Metal Aggregation in Copper Acetate Chain Coordination Polymers with Dipyridyl Tethers Bearing Hydrogen Bonding Capable Functional Groups》 were Uebler, Jacob W.; Stone, Brandon S.; LaDuca, Robert L.. And the article was published in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2013. Recommanded Product: N-(Pyridin-4-yl)isonicotinamide The author mentioned the following in the article:

Hydrothermal synthesis has afforded a pair of divalent copper acetate coordination polymers containing either 4,4′-dipyridylamine (dpa) or 4-pyridylisonicotinamide (4-pina), both of which have H-bonding-capable central functional groups. X-ray crystallog. revealed that both exhibit a 1-dimensional chain structure. Use of the kinked tethering ligand dpa produced [Cu(OAc)2(dpa)]n (1), which possesses a simple chain based on dpa linkage of isolated Cu ions. However, employing the straighter amide ligand 4-pina generated {[Cu(OAc)2(4-pina)]·0.5H2O}n (2), which exhibits {Cu2O2} rhomboid dimers formed through bridging acetate ligands. Weak antiferromagnetic coupling [g = 1.984(3), J = -3.2(3) cm-1] was observed within the axial-equatorial bridged {Cu2O2} dimers in 2, with possible ferrimagnetism due to spin canting <11 K.N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Recommanded Product: N-(Pyridin-4-yl)isonicotinamide) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Recommanded Product: N-(Pyridin-4-yl)isonicotinamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics