Tag: 100-200

《3D Printed High-Throughput Hydrothermal Reactionware for Discovery, Optimization, and Scale-Up》 was published in Angewandte Chemie, International Edition in 2014. These research results belong to Kitson, Philip J.; Marshall, Ross J.; Long, Deliang; Forgan, Ross S.; Cronin, Leroy. Quality Control of N-(Pyridin-4-yl)isonicotinamide The article mentions the following:

3D printing techniques allow the laboratory-scale design and production of reactionware tailored to specific exptl. requirements. To increase the range and versatility of reactionware devices, sealed, monolithic reactors suitable for use in hydrothermal synthesis were digitally designed and realized. The fabrication process allows the introduction of reaction mixtures directly into the reactors during the production, and also enables the manufacture of devices of varying scales and geometries unavailable in traditional equipment. The utility of these devices is shown by the use of 3D printed, high-throughput array reactors to discover two new coordination polymers, optimize the synthesis of one of these, and scale-up its synthesis using larger reactors produced on the same 3D printer. Reactors were also used to produce phase-pure samples of coordination polymers MIL-96 and HKUST-1, in yields comparable to synthesis in traditional apparatusN-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Quality Control of N-(Pyridin-4-yl)isonicotinamide) was used in this study.

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Quality Control of N-(Pyridin-4-yl)isonicotinamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Catalytic, Directed C-C Bond Functionalization of Styrenes》 was published in Journal of the American Chemical Society in 2020. These research results belong to Onodera, Shunsuke; Togashi, Ryo; Ishikawa, Soya; Kochi, Takuya; Kakiuchi, Fumitoshi. Application In Synthesis of N-Methoxy-N-methylacetamide The article mentions the following:

A method for catalytic conversion of C(aryl)-C(alkenyl) bonds in styrene derivatives R1-2-R2C6H3C(=CHR4)R3 (R1 = H, 4-Me, 3-Cl, 5-Me, etc.; R2 = 1-pyrazolyl, 2-pyridyl; R3 = H, Me, Ph, 4-methoxyphenyl, etc.; R4 = H, Ph, 4-chlorophenyl) to new C-C bonds is developed. In the presence of a rhodium catalyst, the alkenyl groups of styrenes bearing a pyrazolyl directing group were efficiently converted to other carbon substituents upon reacting with various alkenes RCH=CH2 (R = 4-methylhex-1-en-1-yl, 2-cyclohexylethenyl, 2-phenylethenyl, etc.) and allyl alcs. R5CH(OH)CH=CH2(R5 = cyclohexyl, Me, Et, etc.). It is also indicated that the C-C bond cleavage proceeded via a hydrometalation/β-carbon elimination pathway. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy》 was published in Bioorganic & Medicinal Chemistry Letters in 2011. These research results belong to Sherer, Brian A.; Hull, Kenneth; Green, Oluyinka; Basarab, Gregory; Hauck, Sheila; Hill, Pamela; Loch, James T. III; Mullen, George; Bist, Shanta; Bryant, Joanna; Boriack-Sjodin, Ann; Read, Jon; DeGrace, Nancy; Uria-Nickelsen, Maria; Illingworth, Ruth N.; Eakin, Ann E.. Synthetic Route of C6H4Cl2N2O The article mentions the following:

The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochem. activity and other drug-like properties through substitutions to the pyrrole, piperidine, and heterocycle portions of the mol. resulted in pyrrolamides with improved cellular activity and in vivo efficacy.2,6-Dichloroisonicotinamide(cas: 89281-13-0Synthetic Route of C6H4Cl2N2O) was used in this study.

2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C6H4Cl2N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Safety of N-Methoxy-N-methylacetamideIn 2016 ,《Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists》 was published in European Journal of Medicinal Chemistry. The article was written by Buil, Maria Antonia; Calbet, Marta; Castillo, Marcos; Castro, Jordi; Esteve, Cristina; Ferrer, Manel; Forns, Pilar; Gonzalez, Jacob; Lopez, Sara; Roberts, Richard S.; Sevilla, Sara; Vidal, Bernat; Vidal, Laura; Vilaseca, Pere. The article contains the following contents:

Monocyclic and bicyclic ring systems were studied as the “”core”” section of a series of diphenylsulfone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A Me group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximized potencies and residence times. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 1995,Journal of Chemical Research, Synopses included an article by Casadei, Maria Antonietta; Cesa, Stefania; Inesi, Achille; Moracci, Franco Micheletti. Application of 4746-61-6. The article was titled 《Electrochemical studies on haloamides. Part 11. Electrocarboxylation of carboxamides》. The information in the text is summarized as follows:

The electroreduction of C2-unsubstituted and C2-mono- and -di-substituted haloacetamides XCR1R2CONHR3 (X = Br, Cl, R1, R2 = H, Me, R3 = PhCH2, Ph), carried out in dipolar aprotic solvents and in the presence of CO2, yields synthetically used malonamates R4O2CCR1R2CONHR3 (R4 = Me, Bu) following in situ alkylation. In the experiment, the researchers used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

COA of Formula: C7H9NO2SIn 2019 ,《Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4》 was published in Angewandte Chemie, International Edition. The article was written by Gomez-Palomino, Alejandro; Cornella, Josep. The article contains the following contents:

Reported here is a simple and practical functionalization of primary sulfonamides, by a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention was focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities. In the experiment, the researchers used many compounds, for example, 4-Methylbenzenesulfonamide(cas: 70-55-3COA of Formula: C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: 78191-00-1In 2021 ,《Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles》 appeared in Angewandte Chemie, International Edition. The author of the article were Desaintjean, Alexandre; Haupt, Tobias; Bole, Leonie J.; Judge, Neil R.; Hevia, Eva; Knochel, Paul. The article conveys some information:

Using the bimetallic combination sBu2Mg·2 LiOR (R = 2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesium reagents. Assessing the role of Lewis donor additives in these reactions revealed that N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br/Mg exchange on dibromo-pyridines and quinolines. Combining spectroscopic with X-ray crystallog. studies, light has been shed on the mixed Li/Mg constitution of the organometallic intermediates accomplishing these transformations. These systems reacted effectively with a broad range of electrophiles, including allyl bromides, ketones, aldehydes, and Weinreb amides in good yields. The experimental part of the paper was very detailed, including the reaction process of N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Trabbic, Christopher J.; George, Sage M.; Alexander, Evan M.; Du, Shengnan; Offenbacher, Jennifer M.; Crissman, Emily J.; Overmeyer, Jean H.; Maltese, William A.; Erhardt, Paul W. published 《Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: effects on potency and mode of activity》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 78191-00-1 The information in the text is summarized as follows:

A series of [(pyridinylcarbonyl)vinyl]indoles I [R1 = 4-MeO, 6-MeO, 7-MeO, 5,6-(MeO)2, R2 = H, R3 = Me; R1 = 6-MeO, R2 = H, R3 = CF3; R1 = 5-MeO, R2 = R3 = Me; R4 = 4-pyridinyl] as well as their aroylvinyl analogs I [R1 = 5-MeO; R2 = H; R3 = Me; R4 = 2,4,6-(MeO)3C6H2, 3,4,5-(MeO)3C6H2] with methoxy groups on the indole ring have been synthesized and evaluated for anticancer activity. The location of the methoxy group was shown to alter both the potency and mechanism of cell death. Remarkably, changing the methoxy from the 5-position to the 6-position switched the biol. activity from induction of methuosis to disruption of microtubules. The latter may represent a prototype for a new class of mitotic inhibitors with potential therapeutic utility. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2016,Akalezi, Chris O.; Oguzie, Emeka E. published 《Evaluation of anticorrosion properties of Chrysophyllum albidum leaves extract for mild steel protection in acidic media》.International Journal of Industrial Chemistry published the findings.Related Products of 78191-00-1 The information in the text is summarized as follows:

Background The inhibition efficiency of Chrysophyllum albidum extract in controlling corrosion of mild steel in 1 M HCl has been evaluated by weight loss, potentiodynamic polarization and electrochem. impedance techniques at 303 K. The effect of immersion time and temperature on inhibition efficiency of the extract was also studied. Results Inhibition was found to increase with increasing concentration of the extract but decrease with increasing time and temperature Data from electrochem. measurements suggest that the extract functioned by adsorption of the organic matter on the metal/corrodent interface, inhibiting both the anodic and cathodic half reactions of the corrosion process. The increase in concentration of the inhibitor causes an increase in the activation energy and a decrease in the exponential factor k. Conclusion The plant extracts follow Langmuir adsorption isotherm. Moreover, the process of adsorption is spontaneous, stable and considered to be phys. adsorption. The thermodn. properties recorded suggest that the process of film formation is higher than the destruction of the metal surface and that the adsorption process is exothermic.N-Methoxy-N-methylacetamide(cas: 78191-00-1Related Products of 78191-00-1) was used in this study.

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 4-MethylbenzenesulfonamideIn 2020 ,《Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Binbin; Yang, Chao; Zhou, Jia; Xia, Wujiong. The article contains the following contents:

A straightforward protocol for approaching N-sulfonylamidines (E/Z)-RS(O)2N=CHN(R1)(R2) (R = Me, 2-fluorophenyl, thiophen-2-yl, etc.; R1 = Me; R2 = Et, cyclohexyl, benzyl, etc.; R1R2 = -(CH2)5-, -(CH2)2O(CH2)2-) and I via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulfonamides RS(O)2NH2 and tertiary amines CH3N(R1)(R2), which features exclusive N-CH3 selectivity for the amine partners was reported. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate. In the experiment, the researchers used 4-Methylbenzenesulfonamide(cas: 70-55-3Quality Control of 4-Methylbenzenesulfonamide)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 4-Methylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics