Tag: 100-200

《Synthesis of Sulfonyl Fluorides from Sulfonamides》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Perez-Palau, Marina; Cornella, Josep. Synthetic Route of C7H9NO2S The article mentions the following:

Aryl sulfonyl fluorides and selected alkylsulfonyl fluorides were prepared chemoselectively from the corresponding sulfonamides by treatment with pyrylium tetrafluoroborate, MgCl2, and KF in MeCN followed by quenching with H2O. Functionalized sulfonamides and sulfonamides derived from pharmaceutical agents underwent deamination and fluorination to sulfonyl fluorides. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Synthetic Route of C7H9NO2S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Xiao, Peihong; Cao, Yanjun; Gui, Yingying; Gao, Lu; Song, Zhenlei published 《Me3Si-SiMe2[oCON(iPr)2-C6H4]: An Unsymmetrical Disilane Reagent for Regio- and Stereoselective Bis-Silylation of Alkynes》.Angewandte Chemie, International Edition published the findings.Application In Synthesis of N-Methoxy-N-methylacetamide The information in the text is summarized as follows:

The air-stable unsym. disilane Me3Si-SiMe2[o-CON(iPr)2C6H4] was developed for bis-silylation of alkynes. This reagent tolerates a range of functional groups, providing Z-vinyl disilanes in high yields. It is proposed that the phenyl-ring-tethered amide group directs oxidative addition of Pd0 into the Si-Si bond, which might facilitate formation of a six-membered Pd cycle, generating products with good to excellent regioselectivity. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Application In Synthesis of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Application In Synthesis of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Nowak, Monika; Fornal, Emilia; Kontek, Renata; Sroczynski, Dariusz; Jozwiak, Andrzej; Augustowska, Ewelina; Warpas, Anna; Adamczyk, Marta; Malinowski, Zbigniew published 《Synthesis of acylnaphthylamines and their applications in the formation of benzoquinazolines》.ARKIVOC (Gainesville, FL, United States) published the findings.SDS of cas: 78191-00-1 The information in the text is summarized as follows:

The synthesis of acyl N-Boc-1-naphthylamines I (R1 = Me, t-Bu) and N-Boc-2-naphthylamines II (R2 = Me, i-Pr) and their transformation into alkyl substituted benzoquinazolines III (R3 = Me, t-Bu; X = H, Br) and alkyl substituted benzoquinazolinones IV (R4 = Me, i-Pr), V (R5 = Me, t-Bu) through the reaction with formamide or potassium cyanate in the presence of ammonium acetate is described. Presented acyl derivatives were obtained from the reactions of the corresponding lithiated N-Boc naphthylamines with various acetylating agents like AcCl, Ac2O, AcOEt, PivCl, i-PrCOCl and also Weinreb amides. Biol. screening of the potential cytotoxicity on the HT29 cell line and lymphocytes were demonstrated for some benzoquinazoline derivatives After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Relative stabilities of glycolanilide and thioglycolanilide chelates》 were Apte, K. P.; Bhattacharya, A. K.. And the article was published in Journal of Inorganic and Nuclear Chemistry in 1973. Quality Control of 2-Hydroxy-N-phenylacetamide The author mentioned the following in the article:

Equilibrium constants were determined by pH titrations for complexation of H+ and M3+ (M = Al, Cr) with L (LH = glycolanilide, thioglycolanilide). In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Quality Control of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.Quality Control of 2-Hydroxy-N-phenylacetamide In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Hydrogenative Cyclopropanation and Hydrogenative Metathesis》 were Peil, Sebastian; Guthertz, Alexandre; Biberger, Tobias; Fuerstner, Alois. And the article was published in Angewandte Chemie, International Edition in 2019. Formula: C4H9NO2 The author mentioned the following in the article:

The unusual geminal hydrogenation of a propargyl alc. derivative with [CpXRuCl] as the catalyst entails formation of piano stool ruthenium carbenes in the first place; these reactive intermediates can be intercepted with tethered alkenes to give either cyclopropanes or cyclic olefins as the result of a formal metathesis event. The course of the reaction is critically dependent on the substitution pattern of the alkene trap. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C4H9NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kondo, Mitsuru; Okubo, Takashi; Asami, Akiko; Noro, Shin-Ichiro; Yoshitomi, Tomomichi; Kitagawa, Susumu; Ishii, Tomohiko; Matsuzaka, Hiroyuki; Seki, Kenji published an article on January 15 ,1999. The article was titled 《Rational synthesis of stable channel-like cavities with methane gas adsorption properties: [{Cu2(pzdc)2(L)}n] (pzdc = pyrazine-2,3-dicarboxylate; L =a pillar ligand)》, and you may find the article in Angewandte Chemie, International Edition.Application of 64479-78-3 The information in the text is summarized as follows:

Porous coordination networks were designed in prepared copper complexes [{Cu2(pzdc)2(L)}n] (pzdc = pyrazine-2,3-dicarboxylate; L = pillar ligand pyrazine, 4,4′-bipyridyl, N-4-pyridinyl-4-pyridinecarboxamide). The structure of [{Cu2(pzdc)2(pyz)}.2H2O]n (1) was determined by x-ray crystallog. The complex consists of a pillared layer structure with a two-dimensional sheet of [Cu(pzdc)2]n and pillar pyrazine ligands that bridge each sheet. The channels are occupied by water mols. Thermal dehydration of 1 at 100-260° resulted in a stable phase which retained the porous network without decomposition (powder XRD study). Methane adsorption capabilities of the coordination networks were studied. Increased methane absorption activity for pillar ligands 4,4′-bipyridyl and N-4-pyridinyl-4-pyridinecarboxamide is consistent with the larger channel sizes of these complexes. The activity is comparable to that of zeolites and other reported stable porous coordination networks. The experimental process involved the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Application of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2017,Australian Journal of Chemistry included an article by Roxburgh, Matthew A. D.; Zaiter, Samantha; Hudson, Xina I. B.; Mullaney, Benjamin R.; Clements, John E.; Moubaraki, Boujemaa; Murray, Keith S.; Neville, Suzanne M.; Kepert, Cameron J.. Synthetic Route of C11H9N3O. The article was titled 《Structure and Magnetic Studies on a Series of Two-Dimensional Iron(II) Framework Materials with Varying Ligand Characteristics》. The information in the text is summarized as follows:

Targeting the general (4,4)-grid structural motif, the authors prepared seven new coordination polymers in the general family [Fe(NCX)2(L)2]·(guest) (L = bis-pyridyl-type bridging ligands; X = S, Se) as an extension of the well-established spin crossover framework (SCOF) family. In all cases, the (4,4)-grid topol. is formed by the bridging of octahedral Fe(II) sites in the equatorial plane by bis-pyridyl ligands of varying length, flexibility, and intermol. interaction capacity. In particular, the six ligands n-(4-pyridyl)isonicotinamide (pin), trans-1,2-bis(4-pyridyl)ethene (tvp), 1,2-dibromo-1,2-bis(4-pyridyl)ethane (dbbpe), bis(4-pyridyl)-1,2,4,5-tetrazine (bptz), 4,4′-bis(pyridyl)acetylene (bpac), and 1,4-bis(4-pyridylethynyl)benzene (bpeben) were used. The seven complexes, [Fe(NCS)2(pin)2]·2(MeCN) (pin-S), [Fe(tvp)2(NCS)2]·1/2(tvp)·(CH2CH2OH) (tvp-S), [Fe(dbbpe)2(NCS)2]·6(CH3CN) (dbbpe-S), [Fe(NCS)2(bptz)2]·2(CHCl3)·6(H2O) (bptz-S), [Fe(NCSe)2(bptz)2]·4(CHCl3)·(EtOH)·(H2O) (bptz-Se), [Fe(NCS)2(bpac)2]·2(PrOH) (bpac-S), and [Fe(NCS)2(bpeben)2]·2(CHCl3) (bpeben-S) all form (4,4)-grids of varying size that are arranged in a parallel stacked topol. Despite being in the [FeN6] coordination environment known to be conducive to spin crossover, these materials all remain high-spin with thermal variation. These results are discussed in context with the large family of SCOFs that show varied spin crossover behaviors. The results came from multiple reactions, including the reaction of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Synthetic Route of C11H9N3O)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Synthetic Route of C11H9N3O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Product Details of 70298-88-3On October 12, 2011 ,《Light-Induced Spin Change by Photodissociable External Ligands: A New Principle for Magnetic Switching of Molecules》 was published in Journal of the American Chemical Society. The article was written by Thies, Steffen; Sell, Hanno; Schuett, Christian; Bornholdt, Claudia; Naether, Christian; Tuczek, Felix; Herges, Rainer. The article contains the following contents:

Magnetic bistability in spin-crossover materials generally is a collective phenomenon that arises from the cooperative interaction of a large number of microscopic magnetic moments within the crystal lattice in the solid state. The authors now report on individual mols. in homogeneous solution that are switched between the diamagnetic and paramagnetic states at room temperature by light-driven coordination-induced spin-state switching (LD-CISSS). Switching of the coordination number (and concurrently of the spin state) was achieved by using Ni-porphyrin as a square-planar platform and azopyridines as photodissociable axial ligands. The square-planar Ni-porphyrin is diamagnetic (low-spin, S = 0), and all complexes with axial ligands are paramagnetic (high-spin, S = 1). Association constants were determined for all conceivable 1:1 and 1:2 porphyrin/azopyridine complexes. The binding constants of the trans azopyridines are larger than those of the corresponding cis isomers. Thus, upon irradiation with UV light (365 nm, trans → cis) and visible light (455 nm, cis → trans), switching of the magnetic properties was achieved. Upon substitution of the azopyridines at the 4- and 4′-positions with larger substituents, the difference in trans and cis association constants, and thus the switching efficiency, was increased. A photoinduced, reversible switching between 20 and 68% paramagnetic Ni species in solution was achieved with iso-Pr substituents at room temperature In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Product Details of 70298-88-3) was used in this study.

2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Product Details of 70298-88-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Introduction of the amide function into 1,3,2-dioxaphospholenes with pentavalent phosphorus》 was published in Journal of the American Chemical Society in 1970. These research results belong to Ramirez, Fausto; Bauer, J.; Telefus, C. David. Application In Synthesis of 2-Hydroxy-N-phenylacetamide The article mentions the following:

Carbamoyl-1,3,2-dioxaphospholenes with pentavalent P were synthesized from α-oxo aldehydes, isocyanates, and trialkyl phosphites. The phospholenes were converted into phosphate esters of β-oxo-α-hydroxyamides. These underwent rapid hydrolyses to β-oxo-α-hydroxyamides. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application In Synthesis of 2-Hydroxy-N-phenylacetamide)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application In Synthesis of 2-Hydroxy-N-phenylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Hydrogen-bonding one-dimensional arrangement in the crystal of N-phenyl-2-hydroxyacetamide》 was written by Perpetuo, Genivaldo Julio; Janczak, Jan. Application of 4746-61-6 And the article was included in Journal of Molecular Structure on August 27 ,2009. The article conveys some information:

The N-phenyl-2-hydroxyacetamide was obtained in crystalline form by a direct reaction of aniline with glycolic acid. The whole mol. in the crystal is nonplanar, but the planar 2-hydroxyacetamide group is inclined by 7.8(1)° to the plane of the Ph ring that is cis located to the carbonyl oxygen atom. The hydroxyl group is in trans position to the carbonyl oxygen atom. The mols. are linked by the N-H···O and O-H···O hydrogen bonds into 1-dimensional chains along the a-axis. Addnl., the C-H···π interactions interconnect the chains stabilizing the crystal structure. The x-ray geometry of the N-phenyl-2-hydroxyacetamide mol. was compared with that obtained by the ab-initio MO calculated results that represents the geometry in the gas-phase. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application of 4746-61-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics