Tag: 100-200

Related Products of 50494-42-3On November 1, 2021 ,《Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Matsingos, Christos; Al-Adhami, Taha; Jamshidi, Shirin; Hind, Charlotte; Clifford, Melanie; Mark Sutton, J.; Rahman, Khondaker Miraz. The article conveys some information:

Antimicrobial resistance and lack of new antibiotics to treat multidrug-resistant (MDR) bacteria is a significant public health problem. There is a discovery void and the pipeline of new classes of antibiotics in clin. development is almost empty. Therefore, it is important to understand the structure activity relationships (SAR) of current chem. classes as that can help the drug discovery community in their efforts to develop new antibiotics by modifying existing antibiotic classes. We studied the SAR of the C5-acylaminomethyl moiety of the linezolid, an oxazolidinone antibiotic, by synthesizing 25 compounds containing various aromatic, heteroaromatic and aliphatic substitutions. Our findings suggest that this position is highly important for the function of this antibiotic class, since only smaller non-polar fragments are tolerated at this position while larger and polar ones lead to a decrease in activity compared to linezolid. Our findings have led us to construct a structure activity relationship, around the C5-acylaminomethyl moiety of linezolid, that provides valuable insight into the function of the oxazolidinone class of antibiotics. In the experimental materials used by the author, we found Cyclopent-3-enecarboxamide(cas: 50494-42-3Related Products of 50494-42-3)

Cyclopent-3-enecarboxamide(cas: 50494-42-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Related Products of 50494-42-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Nickel-Catalyzed Carbofluoroalkylation of 1,3-Enynes to Access Structurally Diverse Fluoroalkylated Allenes》 were Zhang, Kai-Fan; Bian, Kang-Jie; Li, Chao; Sheng, Jie; Li, Yan; Wang, Xi-Sheng. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of N-Methoxy-N-methylacetamide The author mentioned the following in the article:

A nickel-catalyzed 1,4-carbofluoroalkylation of 1,3-enynes R1CCC(R2)=CH2 [R1 = H, heptyl, cyclohexyl, Ph, thiophen-3-yl, etc.; R2 = Me, H, Ph, (CH2)2OC(O)CH3] to access structurally diverse fluoroalkylated allenes R3C(R1)=C=C(R2)CH2R4 [R3 = Ph, naphthalen-2-yl, 2-methylphenyl, etc.; R4 = CF2C(O)OCH2CH3, CF3, CF2C6H5, etc.;] has been established. This method has demonstrated high catalytic reactivity, mild reaction conditions, broad substrate scope, and excellent functional-group tolerance. The key to success is the use of a nickel catalyst to generate different fluoroalkyl radicals from readily available and structurally diverse fluoroalkyl halides R4X (X = Br, I) to access 1,4-difunctionalization of 1,3-enynes by a radical relay. This strategy provides facile synthesis of structurally diverse multisubstituted allenes, and offers a solution for batch production of various fluorinated bioactive mols. for drug discovery by further transformations. After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Safety of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Environmental Science and Pollution Research included an article by Qin, Li-Tang; Zhang, Xin; Chen, Yu-Han; Mo, Ling-Yun; Zeng, Hong-Hu; Liang, Yan-Peng; Lin, Hua; Wang, Dun-Qiu. Category: amides-buliding-blocks. The article was titled 《Predicting the cytotoxicity of disinfection by-products to Chinese hamster ovary by using linear quantitative structure-activity relationship models》. The information in the text is summarized as follows:

A suitable model to predict the toxicity of current and continuously emerging disinfection byproducts (DBPs) is needed. This study aims to establish a reliable model for predicting the cytotoxicity of DBPs to Chinese hamster ovary (CHO) cells. We collected the CHO cytotoxicity data of 74 DBPs as the endpoint to build linear quant. structure-activity relationship (QSAR) models. The linear models were developed by using multiple linear regression (MLR). The MLR models showed high performance in both internal (leave-one-out cross-validation, leave-many-out cross-validation, and bootstrapping) and external validation, indicating their satisfactory goodness of fit (R2 = 0.763-0.799), robustness (Q2LOO = 0.718-0.745), and predictive ability (CCC = 0.806-0.848). The generated QSAR models showed comparable quality on both the training and validation levels. Williams plot verified that the obtained models had wide application domains and covered the 74 structurally diverse DBPs. The mol. descriptors used in the models provided comparable information that influences the CHO cytotoxicity of DBPs. In conclusion, the linear QSAR models can be used to predict the CHO cytotoxicity of DBPs. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Category: amides-buliding-blocks)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2019,Environmental Toxicology and Chemistry included an article by Holmes, Breanne E.; Smeester, Lisa; Fry, Rebecca C.; Weinberg, Howard S.. Recommanded Product: 2-Bromoacetamide. The article was titled 《Disinfection byproducts bind human estrogen receptor-α》. The information in the text is summarized as follows:

Disinfection byproducts are formed during most drinking water treatment and presently number >800, some of which are implicated in human health outcomes including bladder cancer and infertility, with unknown mechanisms of action. In particular, it is not yet understood whether these compounds can disrupt the estrogen-signaling pathway through binding to the human estrogen receptor (ER). In the present study, 21 disinfection byproducts, selected for their predicted involvement in endocrine-related diseases and their structural diversity, were individually evaluated for their binding affinity to the human ER and in silico, and then a subset of these chems. was studied in binary mixtures with the known weak estrogen, 4-n-nonylphenol. Individually, 9 of the 21 disinfection byproducts were able to weakly bind to the ER, with affinities ranging from log median inhibitory concentration values of -3.83 to -2.19 M. In binary mixtures, the chems. followed concentration addition, with their weak binding affinities having little contribution to the overall mixture affinity. These results demonstrate the variety of small-mol. disinfection byproduct structures that are capable of binding to the ER, and that their weak binding can still be of importance when overall human exposure to mixtures of disinfection byproducts in disinfected drinking water is considered. Environ Toxicol Chem 2019;9999:1-9. © 2019 SETAC. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8Recommanded Product: 2-Bromoacetamide)

2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Recommanded Product: 2-Bromoacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2018,Science (Washington, DC, United States) included an article by Trost, Barry M.; Huang, Zhongxing; Murhade, Ganesh M.. HPLC of Formula: 78191-00-1. The article was titled 《Catalytic palladium-oxyallyl cycloaddition》. The information in the text is summarized as follows:

Exploration of intermediates that enable chemoselective cycloaddition reactions and expeditious construction of fused- or bridged-ring systems is a continuous challenge for organic synthesis. As an intermediate of interest, the oxyallyl cation was harnessed to synthesize architectures containing seven-membered rings via (4+3) cycloaddition However, its potential to access five-membered skeletons is underdeveloped, largely due to the thermally forbidden (3+2) pathway. Here, the combination of a tailored precursor and a Pd(0) catalyst generates a Pd-oxyallyl intermediate that cyclizes with conjugated dienes to produce a diverse array of THF skeletons. The cycloaddition overrides conventional (4+3) selectivity by proceeding through a stepwise pathway involving a Pd-allyl transfer and ring closure sequence. Subsequent treatment of the (3+2) adducts with a palladium catalyst converts the heterocycles to the carbocyclic cyclopentanones. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1HPLC of Formula: 78191-00-1)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 78191-00-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The author of 《Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. Pyridine-containing stilbenes and amides》 were Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Geahlen, Robert L.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 1991. Related Products of 64479-78-3 The author mentioned the following in the article:

A series of pyridine-containing stilbene and amide derivatives based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, were prepared and tested for inhibition of p56lck. The most potent of these compounds (I) is a competitive inhibitor of p56lck with respect to ATO. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)

N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Related Products of 64479-78-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Solubility and partitioning. I: Solubility of nonelectrolytes in water》 was written by Yalkowsky, Samuel H.; Valvani, Shri C.. HPLC of Formula: 4746-61-6 And the article was included in Journal of Pharmaceutical Sciences on August 31 ,1980. The article conveys some information:

Semiempirical anal. gave an equation that enables the estimation of the aqueous solubility of either liquid or crystalline organic nonelectrolytes: log Sw ≈ -1.00 log PC – 1.11[ΔSf(MP-25)/1364] + 0.54 where log PC and ΔSf are estimated from the chem. structure and MP is either known or exptl. determined Anal. of this equation provides a means of assessing the role of crystal structure [as reflected by the m.p. (MP) and the entropy of fusion (ΔSf)] and of the activity coefficient [as reflected by the octanol-water partition coefficient (PC)] in controlling the aqueous solubility of a drug. Techniques are also provided for estimating the entropy of fusion of organic compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6)

2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.HPLC of Formula: 4746-61-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ren, Zhiqiang; Sun, Zhongliu; Li, Yifei; Fan, Xin; Dai, Mingda; Wang, Yunxia; Hu, Xiangdong published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H》.Category: amides-buliding-blocks The article contains the following contents:

3-Deoxyfortalpinoid F, fortalpinoid A, and cephinoid H are members of the Cephalotaxus diterpenoids class of natural products, which feature diverse chem. structures and valuable biol. activities. We report herein the development of a diastereoselective Pauson-Khand reaction as an effective pathway to access the core tetracyclic skeleton, which is found widely in Cephalotaxus diterpenoids. Furthermore, we enabled the construction of the tropone moiety through a ring-closing metathesis/elimination protocol. Based on the developed strategy, asym. synthesis of the title compounds has been achieved for the first time. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Siddiki, S. M. A. Hakim; Rashed, Nurnobi Md.; Touchy, Abeda Sultana; Jamil, A. R. Md.; Jing, Yuan; Toyao, Takashi; Maeno, Zen; Shimizu, Ken-ichi published their research in Catalysis Science & Technology in 2021. The article was titled 《Hydrolysis of amides to carboxylic acids catalyzed by Nb2O5》.Reference of N-Methoxy-N-methylacetamide The article contains the following contents:

Hydrolysis of amides RC(O)N(R1)R2 (R = Me, cyclohexyl, Ph, Bn, furan-2-yl, etc.; R1 = H, Me, Et, OMe; R2 = H, Me, Et, Ph, Bn) to carboxylic acids RC(O)OH is an industrially important reaction but is challenging due to the difficulty of cleaving the resonance stabilized amidic C-N bond. Twenty-three heterogeneous and homogenous catalysts were examined in the hydrolysis of acetamide. Results showed that Nb2O5 was the most effective heterogeneous catalyst with the greatest yield of acetic acid. A series of Nb2O5 catalysts calcined at various temperatures were characterized and tested in the hydrolysis of acetamide to determine the effects of crystal phase and surface properties of Nb2O5 on catalytic performance. The high catalytic performance observed was attributed mainly to the facile activation of the carbonyl bond by Lewis acid sites that function even in the presence of basic inhibitors (NH3 and H2O). The catalytic studies showed the synthetic advantages of the present method, such as simple operation, catalyst recyclability, additive free, solvent-free, and wide substrate scope (>40 examples; up to 95% isolated yield). In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Reference of N-Methoxy-N-methylacetamide)

N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of N-Methoxy-N-methylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

《Nickel-Catalyzed Cross-Coupling of Sulfonamides With (Hetero)aryl Chlorides》 was written by McGuire, Ryan T.; Simon, Connor M.; Yadav, Arun A.; Ferguson, Michael J.; Stradiotto, Mark. Product Details of 70-55-3 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

The development of Ni-catalyzed C-N cross-couplings of sulfonamides with (hetero)aryl chlorides is reported. These transformations, which were previously achievable only with Pd catalysis, are enabled using air-stable (L)NiCl(o-tol) pre-catalysts (L = PhPAd-DalPhos and PAd2-DalPhos), without photocatalysis. The collective scope of (pseudo)halide electrophiles (X = Cl, Br, I, OTs, and OC(O)NEt2) demonstrated herein is unprecedented for any reported catalyst system for sulfonamide C-N cross-coupling (Pd, Cu, Ni, or other). Preliminary competition experiments and relevant coordination chem. studies are also presented. In the experimental materials used by the author, we found 4-Methylbenzenesulfonamide(cas: 70-55-3Product Details of 70-55-3)

4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 70-55-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics