Tag: 100-200

Cao, Shiming;Cao, Yijun;Ma, Zilong;Liao, Yinfei;Zhang, Xiaolin published 《Structural and electronic properties of bastnaesite and implications for surface reactions in flotation》. The research results were published in《Journal of Rare Earths》 in 2020.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

The structural and electronic properties of bastnaesite were studied by using the first-principles method based on the d. functional theory (DFT). The geometry structure of bastnaesite was first optimized, and then the Mulliken populations, electron d. and d. of states were calculated and further analyzed in detail. The calculation results reveal that it mainly ruptures along the ionic Ce-O and Ce-F bonds during the cleavage of bastnaesite, leaving ≈Ce⁺, ≈F^– and ≈CO^–₃ dangling bonds exposed on the cleavage surface of bastnaesite. Combined with contact angle measurement, surface complexation theory and XPS anal., the implications of structural and electronic properties on bastnaesite flotation reactions were studied. The hydration of exposed strong ionic bond on cleavage surface results in hydrophilic surface. According to surface complexation theory, the formed surface groups are ≈CeOH⁰, ≈CO₃H⁰ and ≈FH⁰ groups. The investigated metal ions and flotation reagents complex with surface ≈CeOH⁰ groups, while ≈CO₃H⁰ and ≈FH⁰ groups are not involved in the complexation. The high activity of Ce atoms facilitates these surface reactions.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Recommanded Product: N,2-DihydroxybenzamideIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ward, Cassandra L.;Allen, Matthew J.;Lutter, Jacob C. published 《Hexa-μ-acetato-chlorido(μ-N,2-dioxodobenzene-1-carboximidato)-μ₃-oxido-tetrairon(III)-water (1/1) and hexa-μ-acetato-(μ-N,2-dioxodobenzene-1-carboximidato)fluorido-μ₃-oxido-tripyridinetetrairon(III)-pyridine-water (1/1/0.24)》 in 2021. The article was appeared in 《Acta Crystallographica, Section E: Crystallographic Communications》. They have made some progress in their research.Application In Synthesis of N,2-Dihydroxybenzamide The article mentions the following:

The title compounds, [Fe₄(C₂H₃O₂)⁶(C₇H₄O₃)FO(C₅H₅N)₃]·C₅H₅N·0.24H₂O (1-F) and [Fe₄(C₂H₃O₂)₆(C₇H₄O₃)ClO(C₅H₅N)₃]·H₂O (1-Cl) were synthesized using a self-assembly reaction in methanol and pyridine with stoichiometric addition of salicylhydroxamic acid , acetic acid (HOAc), and the appropriate ferric halide salt. The compounds crystallize as solvates, where 1-F has one pyridine mol. that is disordered about a twofold axis and one water mol. with an occupancy of 0.24 (2); and 1-Cl has one water mol. that is disordered over two sites with occupancies of 0.71 (1) and 0.29 (1). The space groups for each analog differ as 1-F crystallizes in Fdd2 while 1-Cl crystallizes in P2₁. The difference in packing is due to changes in the intermol. interactions involving the different halides. The two mols. are mostly isostructural, differing only by the torsion of the pyrine ligands and slight orientation changes in the acetate ligands. All of the iron(III) ions are in six-coordinate octahedral ligand field geometries but each one exhibits a unique coordination environment with various numbers of O (four to six) and N (nought to two) atom donors. Bond-valence sums confirm each iron is trivalent. The hydroximate ligand is bound to three iron(III) ions using a fused chelate motif similar to those in metallacrown compounds The experimental procedure involved many compounds, such as N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Application In Synthesis of N,2-Dihydroxybenzamide This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Formula: C6H7N3O《Removal of retained electrospinning solvent prolongs drug release from electrospun PLLA fibers》 was published in 2017. The authors were D’Amato, Anthony R.;Schaub, Nicholas J.;Cardenas, Jesus M.;Fiumara, Andrew S.;Troiano, Paul M.;Fischetti, Andrea;Gilbert, Ryan J., and the article was included in《Polymer》. The author mentioned the following in the article:

A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small mol. drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small mol. drug, 6-aminonicotinamide (6AN), from PLLA fibers. Specifically, untreated fibers released 6AN over 9 days, and fibers that underwent a combined treatment of maintenance in a laboratory setting and heating released 6AN over 44 days. The unique and simple method presented here prolongs diffusive release of a small mol. drug from electrospun fibers and has potential to assist in lengthening small mol. drug release from a variety of polymeric nanomaterials. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Shengde;Fisher, Joan;Naciff, Jorge;Laufersweiler, Michael;Lester, Cathy;Daston, George;Blackburn, Karen published 《Framework for Identifying Chemicals with Structural Features Associated with the Potential to Act as Developmental or Reproductive Toxicants》. The research results were published in《Chemical Research in Toxicology》 in 2013.Electric Literature of C6H7N3O The article conveys some information:

Developmental and reproductive toxicity (DART) end points are important hazard end points that need to be addressed in the risk assessment of chems. to determine whether or not they are the critical effects in the overall risk assessment. These hazard end points are difficult to predict using current in silico tools because of the diversity of mechanisms of action that elicit DART effects and the potential for narrow windows of vulnerability. DART end points have been projected to consume the majority of animals used for compliance with REACH; thus, addnl. nonanimal predictive tools are urgently needed. This article presents an empirically based decision tree for determining whether or not a chem. has receptor-binding properties and structural features that are consistent with chem. structures known to have toxicity for DART end points. The decision tree is based on a detailed review of 716 chems. (664 pos., 16 neg., and 36 with insufficient data) that have DART end-point data and are grouped into defined receptor binding and chem. domains. When tested against a group of chems. not included in the training set, the decision tree is shown to identify a high percentage of chems. with known DART effects. It is proposed that this decision tree could be used both as a component of a screening system to identify chems. of potential concern and as a component of weight-of-evidence decisions based on structure-activity relationships (SAR) to fill data gaps without generating addnl. test data. In addition, the chem. groupings generated could be used as a starting point for the development of hypotheses for in vitro testing to elucidate mode of action and ultimately in the development of refined SAR principles for DART that incorporate mode of action (adverse outcome pathways). And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.

6-Aminonicotinamide (cas:329-89-5)Electric Literature of C6H7N3O is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme,6-phosphogluconate dehydrogenase, it interferes with glycolysis.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Travis, Jordan R.;Van Trieste, Gerard P. III;Zeller, Matthias;Zaleski, Curtis M. published 《Crystal structures of two dysprosium-aluminium-sodium [3.3.1] metallacryptates that form two-dimensional sheets》 in 2020. The article was appeared in 《Acta Crystallographica, Section E: Crystallographic Communications》. They have made some progress in their research.Category: amides-buliding-blocks The article mentions the following:

The two [3.3.1] metallacryptate complexes, namely, poly[[μ3-acetato-hexakis(μ-N,N-dimethylformamide)bis(N,N-dimethylformamide)bis[salicylhydroximato(2-)]heptakis[salicylhydroximato(3-)]hexaaluminium(III)dysprosium(III)pentasodium(I)] N,N-dimethylformamide tetrasolvate monohydrate], [DyAl6Na5(OAc)(Hshi)2(shi)7(DMF)8]·4DMF·H2O or {[DyAl6Na5(C7H5NO3)2(C7H4NO3)7(C2H3O2)(C3H7NO)8]·4C3H7NO·H2O}n, 1, and poly[[di-μ4-acetato-nonakis(μ-N,N-dimethylformamide)octakis(N,N-dimethylformamide)tetrakis[salicylhydroximato(2-)]tetradecakis[salicylhydroximato(3-)]dodecaaluminium(III)didysprosium(III)decasodium(I)] N,N-dimethylformamide 6.335-solvate], [DyAl6Na5(OAc)(Hshi)2(shi)7(DMF)8.5]2·6.335DMF or {[Dy2Al12Na10(C7H5NO3)4(C7H4NO3)14(C2H3O2)2(C3H7NO)17]·6.335C3H7NO}n, 2, where shi3- is salicylhydroximate and DMF is N,N-dimethylformamide, both consist of an aluminum-based metallacryptand. In 1 and 2, the metallacryptand encapsulates a dysprosium(III) ion in the central cavity, and the resulting metallacryptates are connected to each other via sodium-DMF linkages to generate a two-dimensional sheet. The metallacryptates of 1 and 2 are the three-dimensional analogs of metallacrowns as the metallacryptates contain a metal-nitrogen-oxygen cyclic repeat unit throughout the complexes. For 1 the building block of the two-dimensional sheet is comprised of only one type of metallacryptate, which is connected to four neighboring metallacryptates via four sodium-DMF linkages. In 2, the building block is a dimeric unit of two metallacryptates. Each dimeric metallacryptate unit is connected to four other dimeric units via six sodium-DMF linkages. The two metallacryptates of each dimeric unit can be considered enantiomers of each other. In both 1 and 2, chirality is imparted to the metallacryptate due to the Λ and Δ propeller configurations of the four octahedral aluminum ions of the metallacryptand shell.N,2-Dihydroxybenzamide (cas: 89-73-6) were involved in the experimental procedure.

N,2-Dihydroxybenzamide(cas: 89-73-6) is widely used for a variety of roles in biology and medicine as a chelating therapy.Category: amides-buliding-blocksIt inhibits bacterial or fungi growth by interfering with iron uptake. It is also active as a inhibitor of enzyme involved in tumour growths.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Luo, Liping;Xu, Longhua;Meng, Jinping;Lu, Jiahui;Wu, Houqin published 《New insights into the mixed anionic/cationic collector adsorption on ilmenite and titanaugite: An in situ ATR-FTIR/2D-COS study》 in 2021. The article was appeared in 《Minerals Engineering》. They have made some progress in their research.HPLC of Formula: 89-73-6 The article mentions the following:

Elucidation of the co-adsorption characteristics of multiple functional groups will help to screen suitable reagents to improve the floatability and comprehensive utilization of valuable minerals. Herein, salicylhydroxamic acid (SHA), an anionic collector with two functional groups, mixed with a cationic collector dodecylamine (DDA) in ilmenite-titanaugite flotation system was in-depth studied mainly using in-situ attenuated total reflectance Fourier transform IR spectroscopy (ATR-FTIR) combined with the two-dimensional correlation spectroscopic anal. (2D-COS) and XPS. The highest flotation separation performance, at pH 8-9, can be achieved using the SHA/DDA complex with a molar ratio of 6:1. Moreover, at. force microscope (AFM) anal. ulteriorly proved the selectivity of the mixed SHA/DDA collector in the ilmenite-titanaugite flotation system. In-situ ATR-FTIR combined with 2D-COS gave the characteristic sequential adsorption and interaction with the functional groups related to SHA/DDA, which was further confirmed in the results of XPS. The preferred adsorption configuration for the adsorption of the mixed collector were drew to explain the flotation separation between ilmenite and titanaugite. It is predictable that the detailed study into the hybrid collectors with multiple functional groups will provide new insights into the design, synthesis and development of more-powerful collectors. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. HPLC of Formula: 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

S., Nalumpang;T., Poti;K., Akimitsu published 《Effect of salicylhydroxamic acid on mycelial growth and baseline sensitivity to azoxystrobin in Phytophthora infestans causing potato late blight in Thailand》. The research results were published in《International Journal of Agricultural Technology》 in 2021.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:

Late blight of potato caused by Phytophthora infestans is proved to be an aggressive pathogen. Azoxystrobin, a broad spectrum quinone outside inhibitor (QoI), has been used in potato cultivation, but not directly recommended to use to control late blight disease. In this study, a suitable method to determine the sensitivity of P. infestans against azoxystrobin and azoxystrobin sensitivity to P. infestans population was recorded in Chiang Rai and Chiang Mai, Thailand. The toxicity of SHAM was proved a nessary of SHAM addition to artificial media for an efficient determination of azoxystrobin sensitivity. Increased of SHAM concentration led increased mycelial inhibition. SHAM at concentration of 5 to 10μg/mL showed less effect to mycelia growth of six representative isolates with means of 5.33 to 12.06% inhibition. Both concentrations of SHAM were applied with azoxystrobin for pre-in vitro sensitivity determination Effective concentration for 50% inhibition (EC50) of azoxystrobin without SHAM was 0.0873μg/mL, and the sensitivity were significantly increased in azoxystrobin amended with SHAM at 5 and 10μg/mL for 55.34 and 70.90%, resp. SHAM at 5μg/mL was used for in vitro sensitivity assay to azoxystrobin. The thirty-six isolates of P. infestans were determined their azoxystrobin sensitivities based on EC₅₀ evaluation. The mean EC50 value of isolate was 0.0531μg/mL and ranged from 0.0005 to 0.4415μg/mL indicating that azoxystrobin was very effective to control the mycelial growth of P. infestans isolated from Chiang Rai and Chiang Mai, Thailand. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Recommanded Product: N,2-Dihydroxybenzamide

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yuan, Yu;Shan, Xiaosong;Men, Weidong;Zhai, Hexin;Qiao, Xiaoxia;Geng, Lianting;Li, Chunhui published 《The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia》. The research results were published in《Biomedicine & Pharmacotherapy》 in 2020.Product Details of 89-73-6 The article conveys some information:

Although the memory- improving effect of crocin has been suggested by previous evidences, the association between this effect and hippocampal acetylcholine (Ach) level and apoptosis is not well investigated. This study aimed to determine the protective effects of crocin on memory, hippocampal Ach level, and apoptosis in a rat model of cerebral ischemia. Male Wistar rats were divided into sham group received saline, and other 3 groups underwent 4-vessel occlusion brain ischemia (4VOI), received oral administration of either saline or crocin in doses of 30 mg/day and 60 mg/day for 7 days. Outcomes were memory, determined by radial eight-arm maze (RAM) task and Morris water maze (MWM) test, Ach release in the dorsal hippocampus (evaluated by microdialysis-HPLC) and apoptosis (investigated by TUNEL assay). 4VOI impaired memory reduced dorsal hippocampus Ach level, and induced apoptosis. Crocin, significantly improved the memory (F = 343.20; P < 0.001 for RAM error choices and F = 182.5; P < 0.0001 for MWM), increased Ach level (F = 115.1; P < 0.001) and prevented hippocampal neuronal apoptosis (W = 183.50; P < 0.001) as compared statistically by ANOVA test. Crocin can be suggested as a promising therapy for ischemic cerebrovascular accidents by its memory preserving, Ach-increasing, and neuroprotective effects. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .

N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Product Details of 89-73-6

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Name: 6-Aminonicotinamide《L-Cysteine in vitro can restore cellular glutathione and inhibits the expression of cell adhesion molecules in G6PD-deficient monocytes》 was published in 2018. The authors were Parsanathan, Rajesh;Jain, Sushil K., and the article was included in《Amino Acids》. The author mentioned the following in the article:

L-Cysteine is a precursor of glutathione (GSH), a potent physiol. antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion mols. Using human U937 monocytes, this study examined the effect of GSH/G6PD deficiency and L-cysteine supplementation on monocyte adhesion mols. G6PD/GSH deficiency induced by either siRNA or inhibitors (6AN/BSO, resp.) significantly (p < 0.005) increased the levels of cell adhesion mols. (ICAM-1, VCAM-1, SELL, ITGB1 and 2); NADPH oxidase (NOX), reactive oxygen species (ROS) and MCP-1 were upregulated, and decreases in levels of GSH, and nitric oxide were observed The expression of ICAM-1 and VCAM-1 mRNA levels increased in high glucose, MCP-1 or TNF-α-treated G6PD-deficient compared to G6PD-normal cells. L-Cysteine treatment significantly (p < 0.005) increased G6PD activity and levels of GSH, and decreased NOX, ROS, and adhesion mols. Thus, GSH/G6PD deficiency increases susceptibility to monocyte adhesion processes, whereas L-cysteine supplementation can restore cellular GSH/G6PD and attenuates NOX activity and expression of cell adhesion mols. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Name: 6-Aminonicotinamide induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zamani, Shahrzad;Hoseini, Ahmad Zavaran;Namin, Alireza Mesbah published 《Glucose-6-phosphate dehydrogenase (G6PD) activity can modulate macrophage response to Leishmania major infection》. The research results were published in《International Immunopharmacology》 in 2019.Category: amides-buliding-blocks The article conveys some information:

Glucose-6-phosphate dehydrogenase (G6PDH) ultimately plays a critical role in macrophage functions used against infectious agents. The present study investigated whether changes in G6PDH activity could influence the resistance of infected macrophages against Leishmania major infection. Mouse peritoneal and J774 macrophages were infected, resp., ex vivo and in vitro, with L. major and then exposed to an inhibitor (6-aminonicotinamide) or activator (LPS + melatonin) of G6PDH activity for 24 h. Cell viability [using MTT assay] was measured to assess any direct toxicity from the doses of inhibitor/activator used for the macrophage treatments. Nitric oxide (NO) produced by the cells and released into culture supernatants was measured (Griess method) and cell G6PDH activity was also determined Moreover, the number of amastigotes form Leishmania in macrophages that developed over a 7-d period was evaluated. The results showed that an increase in G6PDH activity after treatment of both types of macrophages with a combination of LPS + melatonin caused significant increases in NO production and cell resistance against L. major amastigote formation/survival. However, exposure to 6-aminonicotinamide led to remarkable suppression of G6PDH activity and NO production, events that were associated with a deterioration in cell resistance against (and an increase in cell levels of) the parasites. The results suggested that activation or suppression of G6PDH activity could affect leishmanicidal function of both mouse peritoneal and J774 macrophages. Thus, regulation of macrophages via modulation of G6PDH activity appears to provide a novel window for those seeking to develop alternative therapies for the treatment of leishmaniasis. And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.

6-Aminonicotinamide (cas:329-89-5)Category: amides-buliding-blocks induces apoptosis in tumor cells. It is clinically used in disseminated neoplastic disease. It also acts as 6-phosphogluconate dehydrogenase inhibitor. It aids in the treatment of psoriasis. It is used as cancer chemotherapeutic drug in animals.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics