Tag: 0-100

On August 31, 2022, Adel M. Kamal El-Dean; Geies, Ahmed A.; Hassanien, Reda; Abdel-Wadood, Fatma K.; El-Naeem, Eman E. Abd published an article.Formula: C2H4ClNO The title of the article was Novel Synthesis, Reactions, and Biological Study of New Morpholino-Thieno[2,3-c][2,7]Naphthyridines as Anti-Cancer and Anti-Microbial Agents. And the article contained the following:

The biol. uses of 2,7-naphthyridines have sparked great attention in recent years. For this reason, a series of novel 2,7-naphthyridines derivatives was synthesized and explored their spectrum and biol. properties in this study. Compound I was prepared by the reaction of 1-Me piperidin-4-one with CS2, malononitrile, and triethylamine. The condensed I be converted to II by reaction with morpholine. Composite II was used as a starter in heterocyclic compound a series, such as the thieno[2,3-c][2,7]naphthyridines III (R = CN, COOEt, COPh, etc.). Authors used III (R = COOEt), III (R = CONH2) and III (R = CHO) as a precursor to create original heterocyclic moieties, namely: pyrimidothienonaphthyridino and pyridothieno naphthyridino in compounds A number of compounds for antimicrobial activity were examined against a variety of bacterial and fungal strains. In addition, some of these compounds showed anticancer activity in liver and cells of breast cancer. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO

The Article related to morpholinothieno naphthyridine preparation antitumor antibacterial antifungal human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Formula: C2H4ClNO

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novotorzhina, Nelya N.; Ismailova, Gunay G.; Musayeva, Bella I.; Safarova, Mekhpara R.; Ismailov, Ingilab P. published an article in 2021, the title of the article was Synthesis of new derivatives of N,N-diethyldithiocarbamine acid and study of their anti-seize properties.Application In Synthesis of 2-Chloroacetamide And the article contains the following content:

By the reaction of sodium N,N-diethyldithiocarbamate and chloroacetamide, S-carbamoylmethyldiethyldithiocarbamate was obtained. The conditions of two different methods for producing S(N-2,2-dimethyl-4-methyloxymethyl-1,3 dioxolane) carbamoylmethyldiethyldithiocarbamate were proposed. One of which was based on the homocondensation of hydroxylmethylcarbamoyldiethyldithiocarbamate and 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, the other on the interaction of 2,2-dimethyl-4- chloromethylcarbamoylmethyloxymethyl-1,3-dioxolane and sodium N,N-diethyldithiocarbamate. At the first stage of the study, 4 starting reagents were synthesized, 2 of which were not previously described in the literature: 2,2-dimethyl-4-chloromethylcarbamoylmethoxymethyi-1,3-dioxolane and S-hydroxymethylcarbamoylethyldithiocarbamate. The structure of the synthesized compounds was proved by determining their elemental compositions, calculating mol. refractions based on refractive indexes and specific gravities, as well as recording IR absorption spectra on a spectrophotometer. The presence of comparatively high extreme pressure properties of the synthesized compounds in the mineral oil SN-1200 and synthetic oil consisting of penta erythritol of fatty acids was revealed and it was shown that they are superior to the known additives in the literature of tricresyl phosphate and N-allyl-5-hexyloxycarbocarbonylmethyl-1,3-thiazolidin-4-one-2-thione. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to diethyl carbamothioyl sulfanyl acetamide preparation antiwear, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Klimochkin, Yu. N.; Ivleva, E. A. published an article.COA of Formula: C2H4ClNO The title of the article was Synthesis and Chemical Transformations of N-Adamantylated Amides. And the article contained the following:

N-Adamantylated amides, e.g., I were synthesized from 1-adamantyl nitrate. The reactions were carried out in the sulfuric acid media. The proposed method was usefulness for the preparation of antiviral drug tromantadine. A number of new cage aminoamides were synthesized by reactions of N-(1-adamantyl)-2-chloroacetamide with nitrogen-containing nucleophiles with potential biol. activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).COA of Formula: C2H4ClNO

The Article related to adamantylated amide preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.COA of Formula: C2H4ClNO

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2021, Medo, Juraj; Makova, Jana; Medova, Janka; Lipkova, Nikola; Cinkocki, Renata; Omelka, Radoslav; Javorekova, Sona published an article.Name: 2-Chloroacetamide The title of the article was Changes in soil microbial community and activity caused by application of dimethachlor and linuron. And the article contained the following:

Soil microorganisms and their activities are essential for maintaining soil health and fertility. Microorganisms can be neg. affected by application of herbicides. Although effects of herbicides on microorganisms are widely studied, there is a lack of information for chloroacetamide herbicide dimethachlor. Thus, dimethachlor and well known linuron were applied to silty-loam luvisol and their effects on microorganisms were evaluated during112 days long laboratory assay. Dimethachlor and linuron were applied in doses 1.0 kg ha-1 and 0.8 kg ha-1 corresponding to 3.33 mg kg-1 and 2.66 mg kg-1 resp. Also 100-fold doses were used for magnification of impacts. Linuron in 100-fold dose caused minor increase of respiration, temporal increase of soil microbial biomass, decrease of soil dehydrogenase activity, and altered microbial community. Dimethachlor in 100-fold dose significantly increased respiration; microbial biomass and decreased soil enzymic activities. Microbial composition changed significantly, Proteobacteria abundance, particularly Pseudomonas and Achromobacter genera increased from 7 to 28th day. In-silico prediction of microbial gene expression by PICRUSt2 software revealed increased expression of genes related to xenobiotic degradation pathways. Evaluated characteristics of microbial community and activity were not affected by herbicides in recommended doses and the responsible use of both herbicides will not harm soil microbial community. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to dimethachlor linuron soil microbial community activity, Fertilizers, Soils, and Plant Nutrition: Fertilizer-Soil Relations, Including Amendments and other aspects.Name: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Simonov, A. Yu.; Panov, A. A.; Trenin, A. S.; Korolev, A. M.; Lavrenov, S. N. published an article.Product Details of 79-07-2 The title of the article was Optimization of the Synthesis of New Antibacterial Compounds with Tris(1-Alkylindol-3-yl)Methylium Fragments. And the article contained the following:

A new optimal synthetic scheme for new antibacterial compounds I (R = H, Me) combining tris-(1-alkyindol-3-yl)methylium and 3-(indol-1-yl)maleimide in their structures was developed. The proposed method provided a significant increase in the product yield, reduced the labor intensiveness and number of steps, and used readily accessible starting reagents. A good yield was achieved for 3-(formylindol-1-yl)-4-chloromaleimide, a universal precursor enabling two-step syntheses of target tri(indolyl)methanes II (R1 = H, NH2, NMe2) and production of an extensive library of analogous potentially active compounds from other 1-alkylindoles and various amines and thiols. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to aminomaleimido trisindolylmethylium chloride preparation antibacterial, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2020, Pokhodylo, N. T.; Savka, R. D.; Obushak, M. D. published an article.Product Details of 79-07-2 The title of the article was Synthesis of (1H-1,2,3-Triazol-1-yl)acetic Acid Derivatives. And the article contained the following:

A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to triazolyl acetic acid preparation acetamide, azidoacetamide ketoester acetylacetone alk hydrolysis cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ahmed, Ahmed A. M.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article in 2022, the title of the article was New piperazine-based bis(thieno[2,3-b]pyridine) and bis(pyrazolo[3,4-b]pyridine) hybrids linked to benzofuran units: Synthesis and in vitro screening of potential acetylcholinesterase inhibitors.Category: amides-buliding-blocks And the article contains the following content:

Two series of piperazine-based bis(thieno[2,3-b]pyridines) I (Y = CN, COMe, CONH2, COOEt, COPh) and bis(pyrazolo[3,4-b]pyridines) II (Z = H, Me, OMe, Cl, COOEt) were prepared in good yields, utilizing the appropriate bis(pyridinethione). The first series was obtained by reacting the previous synthon with different α-halogenated reagents, whereas the second series was produced by reacting the synthon with various hydrazonyl chlorides, and then cyclizing the resulting bis(hydrazonothioates). At 50 and 100μM concentrations, the two series were screened as potential acetylcholinesterase inhibitors. The reference donepezil had inhibition percentages of 90.7 and 93.5 at the tested concentrations Generally, bis(thieno[2,3-b]pyridine) series was found to be more effective than the other series of bis(pyrazolo[3,4-b]pyridine). Bis(thieno[2,3-b]pyridine-2-carbonitrile) inhibited acetylcholinesterase the best, with inhibition percentages of 55.2 and 88.4 at 50 and 100μM concentrations, resp. Furthermore, when tested at a concentration of 25μg/mL, the prior hybrid demonstrated the best DPPH antioxidant activity, with an inhibition percentage of 81.5 when compared to the reference ascorbic acid (inhibition percentage of 88.7). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Category: amides-buliding-blocks

The Article related to piperazine thienopyridine pyrazolopyridine benzofuran preparation acetylcholinesterase inhibitor antioxidant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 13, 2020, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Synthetic Route of 79-07-2 The title of the article was Novel Nicotinonitriles and Thieno[2,3-b]pyridines as Potent Biofilm and COX-2 Inhibitors: Synthesis, In Vitro and In Silico Studies. And the article contained the following:

(Cyano)diaryl-substituted pyridine-2(1H)-thiones were used to prepare two novel series of nicotinonitriles I (R1 = 2-thienyl, R2 = 4-ClC6H4; R1 = 1,3-benzodioxol-5-yl, R2 = 2-thienyl; R1 = 3,5-dibromo-4-ethoxyphenyl, R2 = 4-MeC6H4; R3 = MeCO, CN, H2NCO, 4-ClC6H4CO) and thieno[2,3-b]pyridines II (R1-R3 as above) using piperazine as an eco-friendly catalyst under ultrasonic irradiation The in vitro antibacterial activities of both series were estimated against different Gram-pos. and neg. bacterial strains. Moreover, the most potent antibacterial derivatives were subjected to further evaluation of their cytotoxic activity against HEPG2 and MCF-7 cell lines as well as their capability to inhibit COX-2 enzyme. The compound I (R1 = 1,3-benzodioxol-5-yl; R2 = 2-thienyl; R3 = H2NCO) gave the least MIC/MBC values of 4.8/9.6, 4.8/9.6 and 9.6/19.7μM against each of Staphylococcus aureus, Escherichia coli and Streptococcus mutans, resp., when compared with Ciprofloxacin. This compound I also showed the best biofilm inhibition activities with IC50 values in the range of 5.2-7.3μM against S. aureus, S. mutans and E. coli bacterial strains when compared with Ciprofloxacin, the best cytotoxic activity against HEPG2 and MCF-7 cell lines with IC50 of 23.9 and 29.8μM, resp., when compared with Doxorubicin and revealed nearly inhibition activity equipotent to Celecoxib with IC50 of 0.12μM. The in silico study was performed to predict the capability of the novel nicotinonitriles and thienopyridines as potent inhibitors of COX-2 enzyme. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Synthetic Route of 79-07-2

The Article related to nicotinonitrile thienopyridine preparation antibacterial antitumor antibiofilm cox2 inhibitor human, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mekky, Ahmed E. M.; Sanad, Sherif M. H.; Said, Ahmed Y.; Elneairy, Mohamed A. A. published an article in 2020, the title of the article was Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors.Quality Control of 2-Chloroacetamide And the article contains the following content:

A novel series of thieno[2,3-b]pyridines I [R = Me, MeO; R1 = acetyl, ethoxycarbonyl, aminocarbonyl, etc.] was prepared via an one-step protocol in excellent yields. The protocol involved the reaction of pyridine-2(1H)-thiones I with the appropriate halogen containing reagents in ethanolic sodium ethoxide solution under stirring at 80°C for 2 h. The new thienopyridines were screened against different bacterial and fungal strains. Thieno[2,3-b]pyridine-2-carboxylate I [R = Me; R1 = ethoxycarbonyl] showed the most effective antibacterial activities against each of Staphylococcus aureus and Escherichia coli with MIC/MBC values of 9.9/19.8 and 19.8/39.5μM, resp., when compared with Ciprofloxacin. I [R = Me; R1 = ethoxycarbonyl] was the most effective compound against MRSA with inhibition zone of 16.2 ± 0.6 mm, when compared with Gentamicin. Moreover, I [R = Me; R1 = ethoxycarbonyl] exhibited the best cytotoxic activity against each of HEPG2 and MCF-7 cell lines with IC50 values of 25.7 and 30.53μM, resp., when compared with Doxorubicin. The in-silico study was performed to predict the capability of new thienopyridines as potential inhibitors of pim-1 kinase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide

The Article related to thienopyridine preparation antibacterial activity antitumor pim kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 2-Chloroacetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Ratanaphain, Chatkrita; Viboonratanasri, Duangkamon; Prompinit, Panida; Krajangpan, Sita; Khan, Eakalak; Punyapalakul, Patiparn published an article.Product Details of 79-07-2 The title of the article was Reactivity characterization of SiO2-coated nano zero-valent iron for iodoacetamide degradation: The effects of SiO2 thickness, and the roles of dehalogenation, hydrolysis and adsorption. And the article contained the following:

The effect of SiO2-layer thickness in SiO2-coated nano zero-valent iron (nZVI) particles on the reactivity characteristics of iodoacetamide (IAcAm) degradation was evaluated. SiO2-layer thicknesses ranging from 3.6 to 27.3 nm were obtained through varying tetra-Et orthosilicate dosages of 0.001-1 M. The crystallinity, surface chem. composition, and physicochem. properties were evaluated for their effects on synergetic degradation mechanisms, dehalogenation, hydrolysis, and adsorption. At a thickness of 3.6 nm, the SiO2 layer offered the highest observed pseudo-first-order rate (kobs) and higher rates of IAcAm degradation were maintained under pH fluctuations (pH 5-7) and aerobic conditions compared to pristine nZVI. At this SiO2-layer thickness (3.6 nm), the rate of iron oxide-layer formation was reduced and the migration of reactive iron species (Fe0 and Fe2+) for the dehalogenation and hydrolysis reactions was enabled. In a single-solute solution, IAcAm elimination was greater than bromoacetamide and chloroacetamide elimination due to the weak ionic I-C bond. In mixed solute conditions, the hydrophobicity of chloroacetamide played a more significant role in competitive degradation through greater adsorption. The proportion of dehalogenation relative to hydrolysis during IAcAm degradation by pristine nZVI and SiO2-coated nZVI was approx. 0.6:0.4. Iodoacetic acid and acetic acid were detected as intermediates in the degradation pathway of IAcAm by pristine nZVI. In contrast, the SiO2 layer on nZVI can accelerate the transformation of IAcAm to acetamide and iodoacetic acid. The electrolyte background of tap water exhibited a slight inhibitory effect on the degradation of IAcAm for both nZVI and SiO2-coated nZVI. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to silica iron iodoacetamide dehalogenation hydrolysis adsorptive wastewater treatment, adsorption, dehalogenation, haloacetamide, hydrolysis, sio(2)-coated nano zero-valent iron and other aspects.Product Details of 79-07-2

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics