Tag: 0-100

On October 31, 2020, Baulina, T. V.; Kudryavtsev, I. Yu.; Artem’ev, A. V.; Bagryanskaya, I. Yu.; Pasechnik, M. P.; Brel, V. K. published an article.Reference of 2-Chloroacetamide The title of the article was Synthesis, Molecular, and Crystal Structure of Tris(2-carbamoylmethoxyphenyl)phosphine Oxide. And the article contained the following:

New tripodal ligand, tris(2-carbamoylmethoxyphenyl)phosphine oxide (I), has been synthesized via the alkylation of tris(2-hydroxyphenyl)phosphine oxide with chloroacetamide. The ligand structure has been studied by means of IR and NMR (1H, 31P) spectroscopy as well as X-ray diffraction. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to tris carbamoylmethoxyphenyl phosphine mol structure oxide, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Reference of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2022, Marae, Islam S.; Ibrahim, Omaima F.; Abdel-Hafez, Shams H.; Mohamed, Shaaban K.; Mague, Joel T.; Bakhite, Etify A.-G. published an article.Synthetic Route of 79-07-2 The title of the article was Synthesis, characterization and crystal structure of some novel partially hydrogenated isoquinolines and their fused heterocyclic systems. And the article contained the following:

Ketonic hydrolysis of 7-acetyl-4-cyano-1,6-dimethyl-6-hydroxy-8-phenyl-5,6,7,8-tetrahydro-isoquinoline-3(2H)-thione via heating with aqueous solution of potassium hydroxide resulted in both deacetylation and dehydration affording new 7,8-dihydroisoquinoline scaffold (7,8-DHISQ) I. Two simple mechanistic approaches are postulated for this synthesis. One of them was supported by converting II into I via heating with aqueous solution of potassium hydroxide. I was used as a key intermediate for synthesizing other 7,8-DHISQ’s III and IV, as well as 7,8-dihydrothienoisoquinoline. Reaction of compound II with 2-chloroacetamide by refluxing in ethanol containing sodium acetate gave 7-acetyl-1-amino-5,8-dimethyl-6-phenyl-6,7-dihydrothieno[2,3-c] isoquinoline-2-carboxamide which was converted into full aromatized pyrimidothienoisoquinoline on treatment with tri-Et orthoformate. Reaction of II with both hydrazine hydrate and hydroxylamine hydrochloride afforded tetrahydropyrazolo-isoquinoline and tetrahydroisoxazoloisoquinoline, resp. Reaction of tetrahydroisoxazoloisoquinoline with N-(4-chlorophenyl)-2-chloroacetamide produced (N-phenylcarbamoylmethylthio)tetra-hydroisoxazoloisoquinoline which was converted into tetrahydroisoxazolothieno-isoquinoline upon heating with sodium ethoxide. Also, crystal structures of compounds III and another tetrahydropyrazoloisoquinoline were determined via X-rays diffraction anal. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Synthetic Route of 79-07-2

The Article related to hydrogenated isoquinoline fused heterocyclic system preparation crystal structure, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Synthetic Route of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 19, 2022, Ma, Chao; Chen, Yan; Ren, Wen dong; Liu, Xing yu; Gu, Wen; Zhou, Hui li published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was Performance Evaluation of Composite Antisalt Agents and the Antisalt Dynamics Simulation Mechanism. And the article contained the following:

The conventional ferrocyanide complex ([Fe(CN)6]4-) has been widely used as a scale inhibitor under mild conditions, but its oxidation at high temperature compromises the subsequent wastewater treatment processes. To conquer the inadequacies of [Fe(CN)6]4-, aminotriacetamide (NTA) was synthesized using chloroacetic acid as an initial material and its mol. structure was characterized using FT-IR spectroscopy, H-NMR, and TGA. NTA was exploited in combination with polyaspartic acid (PASP) and sodium dodecyl benzene sulfonate (SDBS) to prepare a high-performance antisalt composite, and the scaling inhibitor performance was evaluated. The results revealed that as the concentration of the antisalt composite increased from 0.5 to 1.2 weight %, the solubility and inhibition rate increased by 95.6 and 12.33%, resp., at 100°C. The results from mol. simulation evidenced that the order of binding energy between a unit mass of the salt inhibitor and sodium chloride crystal increased in the following order; SDBS > NTA > PASP. The deformation strength between the salt inhibitor and sodium chloride crystal increased as follows: NTA > PASP > SDBS. In addition, the antisalt composite mainly hampered salt precipitation through strong adsorptions arising from both the nitrogen atom of NTA and oxygen atom of SDBS with the sodium atom of sodium chloride crystals, and as a result, it not only altered the crystalline form of sodium chloride but also reduced the adsorption of sodium atoms and eventually improved the salt solubility The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to composite antisalt dynamic simulation, Water: Composition and Properties Of Boiler Water and Other Industrial Waters and other aspects.Application In Synthesis of 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2020, Haggam, Reda A.; Soylem, Essam. A.; Assy, Mohamed. G.; Arastiedy, Marium. F. published an article.Category: amides-buliding-blocks The title of the article was Synthesis and antimicrobial evaluation of new series of quinazolin-5-one derivatives. And the article contained the following:

A new series of quinazolinone derivatives, e.g., I, were synthesized starting with anthranilic acid and cinnamoylisothiocyanate in high yields 55-99%. The study of the biol. activity of all the novel compounds is reported. The minimal inhibitory concentration of some quinazolin-5-one derivatives, e.g., I, showed potential activity against both Gram (+ve) and Gram (-ve) microorganisms more than the reference cefotaxime. In addition, some derivatives of quinazolin-5-one, e.g., I, can be considered as antifungal agents comparing with the standard drug nystatin. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Category: amides-buliding-blocks

The Article related to quinazolinone preparation antibacterial antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gobouri, Adil A. H. published an article in 2020, the title of the article was Synthetic access of new 6-purineselenyl and 8-(1,3,4-thiadiazolyl)-7-benzyl-1, 3-dimethyl-1H-purine-2,6-(3H,7H)-dione derivatives.Name: 2-Chloroacetamide And the article contains the following content:

New 6-purineselenyl I (X = CN, C(O)2Et, CONH2), 1,3,4-thiadiazols bearing 7-benzyl-1,3-dimethyl-1H-purine-2,6-(3H,7H)-diones and (8-[2-(3-phenyl-5-substituted-1,3,4-thiadiazol-2(3H)-ylidene)hydrazinyl)-7-benzyl-1,3-dimethyl]-1H-purine-2,6-(3H,7H)-diones derivatives II [R = Ph, C(O)Me, OC(O)Et, C(O)NHC6H5] were synthesized. The structures of the newly synthesized compounds were elucidated by spectroscopic methods (1H-NMR, 13C-NMR, and MS spectrometry) and elemental anal. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to selenylpurine thiadiazole preparation, purinedione dimethyl hydrazinyl thiadiazolylidene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sanad, Sherif M. H.; Ahmed, Ahmed A. M.; Mekky, Ahmed E. M. published an article in 2020, the title of the article was Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives.Product Details of 79-07-2 And the article contains the following content:

3-(Benzo[d][1,3]dioxol-5-yl)-1-(thiophen-2-yl)prop-2-en-1-one (chalcone) reacted with thiourea and 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one to give the corresponding 3,4-dihydro-1H-pyrimidine-2-thione and 2-thioxo-1H-pyrido[2,3-d]pyrimidin-4-one. Then, these compounds reacted with the appropriate hydrazonyl chlorides 4-R1C6H4NHN=C(Cl)R [R = C(O)Me, CO2Et; R1 = H, Me] in dioxane in presence of triethylamine to afford corresponding 1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidines I [R = C(O)Me, CO2Et; R1 = H, Me] and their related fused pyridines II. Moreover, chalcone was cyclocondensed with 2-cyanothioacetamide to give corresponding 2-thioxo-1H-pyridine-3-carbonitrile, which was used as key synthon to synthesize fused heterocyclic compounds III [R2 = C(O)NH2, R3 = NH2; R2R3 = C(O)NHC(S)NH, C(O)NHC(O)NH, C(O)NHCH=N, C(O)NHC(Me)=N, C(O)NHC(SMe)=N]. The compound III [R2R3 = C(O)NHC(SMe)=N] reacted with appropriate hydrazonyl chlorides in dioxane in presence of triethylamine to yield corresponding pyrido[3′,2′:4,5]thieno[3,2-d][1,2,4]triazolo[4,3-a]pyrimidines IV [R = C(O)Me, CO2Et; R1 = H, Me]. Study of the in vitro antimicrobial activities of newly synthesized pyrimidines against different pathogenic bacterial and fungal strains were performed. The compound III [R2R3 = C(O)NHCH=N] showed the highest inhibitory activity against all bacteria with MIC values of 3.9, 7.81, 7.81, and 15.62μg/mL, resp., against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus mutans, resp., as compared to reference drugs. Mol. docking was studied to predict the optimized conformation of pyrimidines as active ligands against Escherichia coli alk. phosphatase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to pyrimidine preparation antibacterial antifungal docking pharmacokinetic cytotoxicity human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 13, 2020, Cai, Yingjun; von Solms, Nicolas; Zhang, Suojiang; Thomsen, Kaj published an article.Related Products of 79-07-2 The title of the article was Density, Viscosity, and Conductivity of [VAIM][TFSI] in Mixtures for Lithium-Ion Battery Electrolytes. And the article contained the following:

A novel unsaturated and amide-based ionic liquid, [VAIM][TFSI] (3-(2-amino-2-oxoethyl)-1-vinylimidazolium bis(trifluoromethylsulfonyl)amide), was synthesized using a two-step method. Its structure was confirmed by NMR, and its water content was determined by Karl Fischer titration to be below 0.03 wt %. The d., viscosity, and conductivity of the pure ionic liquid and its binary mixtures with acetonitrile were measured at various temperatures and at ambient pressure. Both the d. and viscosity increase with the mole fraction of the ionic liquid and decrease with decreasing temperature Excess molar volumes and viscosity deviations were calculated from the exptl. results. The elec. conductivities in mixtures with different contents of the ionic liquid were investigated at different temperatures The highest conductivity of binary mixtures is achieved at 0.07 mol fraction, with a value of ∼3.32 S·m-1 at 298.15 K. The conductivity of an electrolyte consisting of acetonitrile, LiTFSI, and the ionic liquid was measured to determine the optimal ionic liquid content. The suggested concentration is 3 wt% ionic liquid in this electrolyte, giving a conductivity of ∼4.11 S·m-1 at 298.15 K. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Related Products of 79-07-2

The Article related to density viscosity conductivity vaimtfsi ionic liquid lithium battery electrolyte, Phase Equilibriums, Chemical Equilibriums, and Solutions: Electrolytic Solutions and other aspects.Related Products of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zaki, Remon M.; El-Ossaily, Yasser A.; Geies, Ahmed A. published an article in 2020, the title of the article was A convenient green synthetic approach to the synthesis of novel bioactive selenolo[2,3-c]pyrazoles as antibacterial and antifungal agents.Application of 79-07-2 And the article contains the following content:

A series of new pyrimidine, triazine, and isoindole heterocycles fused to the selenolopyrazole ring system, e.g., I, was synthesized by various condensation reactions of selenolopyrazole II, which was prepared by a new green methodol. The fused pyrimidinone compound I was used as a versatile precursor for several aromatic nucleophilic substitution reactions to produce sulfanyl- and amino-substituted pyrimidines. Furthermore, some of the compounds were screened against various pathogenic bacterial and fungal strains. Their results demonstrated that some of them revealed remarkable antimicrobial activities. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to selenolopyrazole green preparation antibacterial antifungal activity sar, pyrazoloselenolopyrimidine green preparation antibacterial antifungal activity sar, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2020, Khalil, Nadia A.; Ahmed, Eman M.; Zaher, Ashraf F.; El-Zoghbi, Mona S.; Sobh, Eman A. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. And the article contained the following:

A series of new benzothieno[3,2-d]pyrimidine derivatives were designed and synthesized. The National Cancer Institute (NCI, USA) evaluated all synthesized compounds against 60 human tumor cell lines. Most of the compounds showed good cytotoxicity against MCF-7 breast cancer cell line and UO-31 renal cancer cell line (growth inhibitory range: 17.88%-68.65%). IC50 of twelve most active compounds was determined against MCF-7 and UO-31 cell lines. IC50 against SIRT2 enzyme was evaluated for the most active compounds to explore the mechanism of antiproliferative activity. The best activity was displayed by compound I (IC50 = 2.10μg/mL), which is 6.6 more potent than cambinol as a reference Moreover, compound I displayed high selectivity against SIRT1 and SIRT2 over SIRT3 in the selectivity studies and displayed twice activity of cambinol in hyperacetylation of α-tubulin protein with IC50 = 32.05μg/mL. Mol. docking study of the synthesized compounds into SIRT2 active site was performed to rationalize the remarkable SIRT2 inhibitory activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide

The Article related to benzothienopyrimidine preparation antitumor sirutin inhibition mol docking sar, benzothieno[3,2-d]pyrimidines, cytotoxic activity, sirt2 inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 3, 2022, Younis, Osama; Sayed, Mostafa; Mohammed, Ahmed A. K.; Tolba, Mahmoud S.; Hassanien, Reda; Kamal El-Dean, Adel M.; Tsutsumi, Osamu; Ahmed, Mostafa published an article.Recommanded Product: 79-07-2 The title of the article was Solid-State Luminescent Materials Containing Both Indole and Pyrimidine Moieties: Design, Synthesis, and Density Functional Theory Calculations. And the article contained the following:

Heterocyclic compounds with effective solid-state luminescence offer a wide range of uses. It has been observed that combining pyrimidine and indole moieties in a single mol. can enhance material behavior dramatically. Here, different heterocyclic compounds with indole and pyrimidine moieties have been synthesized effectively, and their structures have been validated using NMR, IR, and mass spectroscopy. The photoluminescence behavior of two substances was investigated in powder form and solutions of varying concentrations After aggregation, one mol. displayed a red shifted luminescence spectrum, whereas another homolog showed a blueshift. Thus, d. functional theory calculations were carried out to establish that introducing a terminal group allows modifying of the luminescence behavior by altering the mol. packing. Because of the non-planarity, intermol. interactions, and tiny intermol. distances within the dimers, the materials demonstrated a good emission quantum yield (Φem) in the solid state (ex. 25.6%). At high temperatures, the compounds also demonstrated a stable emission characteristic. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to design synthesis luminescence dft indole pyrimidine derivative, solid state luminescent material aggregation indole pyrimidine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics