Tag: 0-100

On March 31, 2022, Gilani, Saeedeh; Najafpour, Ghasem published an article.Application In Synthesis of 2-Chloroacetamide The title of the article was Evaluation of the extraction process parameters on bioactive compounds of cinnamon bark: A comparative study. And the article contained the following:

In recent times, there has been special attention to the antidiabetic properties of herbal medicine like cinnamon, because of its major compounds such as cinnamic acid and cinnamaldehyde. This study optimizes an effective technique for the extraction of cinnamic acid and cinnamaldehyde from cinnamon bark. The effective parameters of both microwave and ultrasound methods were considered and then compared with the soxhlet extraction method. The impact of different solvent types, temperature and process time, solid: solvent portion, particle size, on the yield of cinnamic acid and cinnamaldehyde extraction were investigated. In addition, all the obtained extraction samples were analyzed by the newly developed HPLC method via UV detector. Finally, the optimized extraction factors were obtained 85 % aqueous ethanol; solid: solvent portion, 1:40 g/mL; particle size of 0.18 mm; for both microwave and ultrasound extraction methods. The maximum yield of cinnamic acid and cinnamaldehyde in microwave extraction were gained 3.9 and 49.4 mg/g, resp. Both advanced extraction techniques with our obtained optimized conditions are suggested for cinnamon bark. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application In Synthesis of 2-Chloroacetamide

The Article related to cinnamic acid cinnamaldehyde bark bioactive antidiabetic agent, Placeholder for records without volume info and other aspects.Application In Synthesis of 2-Chloroacetamide

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Anchoori, Ravi K.; Tan, Marietta; Tseng, Ssu-Hsueh; Peng, Shiwen; Soong, Ruey-Shyang; Algethami, Aliyah; Foran, Palmer; Das, Samarjit; Wang, Chenguang; Wang, Tian-Li; Liang, Hong; Hung, Chien-Fu; Roden, Richard B. S. published an article in 2020, the title of the article was Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties.Name: 2-Chloroacetamide And the article contains the following content:

We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome鈥瞫 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a Michael acceptor that adducts Cysteine 88 of RPN13. In probing the pharmacophore, we showed the benefit of the central nitrogen-bearing piperidone ring moiety compared to a cyclohexanone, the importance of the span of the aromatic wings from the central enone-piperidone ring, the contribution of both wings, and that substituents with stronger electron withdrawing groups were more cytotoxic. Potency was further enhanced by coupling of a second warhead to the central nitrogen-bearing piperidone as RA375 exhibited ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead. Treatment with RA375 caused a rapid and profound accumulation of high mol. weight polyubiquitinated proteins and reduced intracellular glutathione levels, which produce endoplasmic reticulum and oxidative stress, and trigger apoptosis. RA375 was highly active against cell lines of multiple myeloma and diverse solid cancers, and demonstrated a wide therapeutic window against normal cells. For cervical and head and neck cancer cell lines, those associated with human papillomavirus were significantly more sensitive to RA375. While ARID1A-deficiency also enhanced sensitivity 4-fold, RA375 was active against all ovarian cancer cell lines tested. RA375 inhibited proteasome function in muscle for >72h after single i.p. administration to mice, and treatment reduced tumor burden and extended survival in mice carrying an orthotopic human xenograft derived from a clear cell ovarian carcinoma. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to rpn inhibitor antitumor activity structure function analysis, Placeholder for records without volume info and other aspects.Name: 2-Chloroacetamide

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On August 31, 2022, Mustafayev, Nazim; Novotorzhina, Nelya; Ramazanova, Yulduz; Musayeva, Bella; Safarova, Mehpara; Gakhramanova, Gariba; Ismayilov, Ingilab; Sujayev, Afsun published an article.Computed Properties of 79-07-2 The title of the article was Synthesis and Study of Novel Derivatives of 1,3-Dioxolane as Anti-Seizing Additives to Lubricating Oils. And the article contained the following:

The paper is focused on synthesis and study of novel derivatives of 1,3-dioxolane as anti-seizing additives to lubricating oils. By reacting 23, 2-dimethyl-4-hydroxymethyl-1,3-dioxolane with -chlorohydroxymethylchloroacetamide, 2,2-dimethyl-4-chloromethylcarbamoylmethyl-1,3-dioxolane was synthesized by reacting it with potassium S-butylxanthate and N,N-sodium diethylcarbamate synthesized 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane and 2,2-dimethyl-4-N,N-diethylcarbamatomethylcarbamoylmethyloxymethyl-1,3-dioxolane, resp. The structure of all synthesized compounds was proved by studying their physicochem. properties including the defermination of refractive indexes, sp. gr. and the calculation on their basis of mol. refraction (MRD calculate and MRD found.) with their subsequent comparison, elemental composition and IR spectroscopy. The anti-seize properties of the synthesized compounds were studied using a four-ball friction machine (FFM-1). It was found that the synthesized compounds have high extreme pressure properties in synthetic (penta erythritol ether – PEE) and compounded (SN-1200 gear oil and PEE synthetic oil taken 1:1) oils and can be used to make prototypes of synthetic gear oils used in various gears. Using 2,2-dimethyl-4-xantogenatomethylcarbamoylmethyloxymethyl-1,3-dioxolane as an example, the advantage of using a compounded oil to achieve higher extreme properties is shown. The dependence of the efficiency of the lubricating properties of the synthesized compounds on their structure was revealed. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Computed Properties of 79-07-2

The Article related to anti seizing additive lubricating oil dioxolane xanthogenate, Placeholder for records without volume info and other aspects.Computed Properties of 79-07-2

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On November 30, 2022, Ahmed, Ahmed A. M.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article.Safety of 2-Chloroacetamide The title of the article was New bis(pyrazolo[3,4-b]pyridines) and bis(thieno[2,3-b]pyridines) as potential acetylcholinesterase inhibitors: synthesis, in vitro and SwissADME prediction study. And the article contained the following:

The bis(pyridine-2(1H)-thione) was prepared and taken as a key synthon of this study. The target bis(pyrazolo[3,4-b]pyridines) was prepared in good yields, by the reaction of bis(pyridine-2(1H)-thione) with appropriate hydrazonyl chlorides to yield bis(hydrazonothioates) followed by their heating in ethanolic sodium ethoxide solution Addnl., bis(pyridine-2(1H)-thione) reacted with different 伪-halogenated reagents to afford a new series of bis(thieno[2,3-b]pyridines), in good to excellent yields. In general, the tested series of bis(thieno[2,3-b]pyridines) demonstrated greater acetylcholinesterase inhibitory activity as well as DPPH antioxidant activity than the other series of (pyrazolo[3,4-b]pyridines). At a concentration of 100 渭M, bis(thieno[2,3-b]pyridine-2-carbonitrile) showed the best acetylcholinesterase inhibitory activity with inhibition percentage of 83.2. In addition, the previous hybrid had the highest DPPH antioxidant activity, with an inhibition percentage of 82.6 when tested at a concentration of 25 渭g/mL. Furthermore, SwissADME was used to predict the physicochem. properties, lipophilicity, and drug likeness of the new products. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to pyrazolopyridine thienopyridine preparation acetylcholinesterase inhibitor antioxidant swissadme prediction, Placeholder for records without volume info and other aspects.Safety of 2-Chloroacetamide

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On October 31, 2020, Kaur, Ravneet; Goyal, Dinesh published an article.Recommanded Product: 79-07-2 The title of the article was Biodegradation of Butachlor by Bacillus altitudinis and Identification of Metabolites. And the article contained the following:

Butachlor is a chloroacetamide pre-emergence herbicide, with a half-life of 1.6 to 29 days. It is a suspected carcinogen, genotoxin, neurotoxin and persists in the environment having toxic effect on living systems. Butachlor degrading bacterial strain A16 was isolated from coal tar contaminated soil, which showed 99.38% similarity with Bacillus altitudinis 41KF2bT as revealed by 16S rRNA anal. B. altitudinis strain A16 utilized butachlor as a sole source of carbon and degraded 90% of 50 mg L-1 butachlor in 5 days at a rate constant and half-life (t1/2) of 0.02 h-1 and 34.65 h, resp., following the first-order reaction kinetics. Five metabolites (N-(butoxymethyl)-N-(2-chloroethyl)-2,6-diethylaniline, (N-(butoxymethyl))-2-chloro-N-(2-ethylphenyl) acetamide, N-(butoxymethyl)-2,6-diethyl-N-propylaniline, 2-chloro-N-(2,6-diethylphenyl) acetamide and 2,6-diethylaniline) were produced during the breakdown of butachlor by B. altitudinis A16 as identified by GC-MS anal., which are further mineralized to carbon dioxide and water. A metabolic pathway is proposed and compared with other bacteria. The findings have immense beneficial application since such microbes can be used on large scale for faster soil bioremediation and minimizing neg. impact of pesticide butachlor on health and environment. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 79-07-2

The Article related to butachlor contaminated soil bacillus altitudinis metabolite herbicide biodegradation, Placeholder for records without volume info and other aspects.Recommanded Product: 79-07-2

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Amide – Wikipedia,
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On August 5, 2021, Masulovic, Aleksandra D.; Ladjarevic, Jelena M.; Radovanovic, Lidija D.; Vitnik, Zeljko J.; Vitnik, Vesna D.; Rogan, Jelena R.; Mijin, Dusan Z. published an article.Application of 79-07-2 The title of the article was Charge assisted assembly of zwitterionic pyridone hydrates. And the article contained the following:

Two pyridone derivatives, bearing the pyridinium moiety (1), or dimethylpyridinium moiety (2) I and II, have been synthesized and their crystal structures have been determined The compounds crystalize in hydrated zwitterionic forms with either two (1路2H2O) or four (2路4H2O) water mols. The zwitterionic networks contain different types of water clusters, generated into channels, incorporating them into the network by sandwiching. The type of channel depends on the crystal lattice and the nature of non-covalent interactions established between zwitterions as well as the number of water mols. incorporated into the architecture. 1 affords tubes filled in with water channels formed by water tetramers, contrary to 2, which affords a layered network altering the zwitterionic layer and the layer formed by water tetramers and hexamers. A detailed study of intermol. interactions of both crystal structures and a quantification of interaction energies has been performed using PIXEL lattice energy calculations, giving an insight to a quant. evaluation of interactions through Coulombic, disperse, repulsion and polarization energies. The strongest pairwise, in both structures, is found to be a dipole-dipole interaction between oppositely charged heterocyclic rings. The differences in the crystal packings of these hydrates have been elucidated by the fingerplot anal. The comparative studies between exptl. and calculated (DFT) data of mols. 1路H2O and 2路4H2O for systems of different complexity are performed. Furthermore, correlations of exptl. and calculated bond lengths and the simulation of compound solvation with the CPCM model are done. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Application of 79-07-2

The Article related to crystallog charge assisted assembly zwitterionic pyridone hydrates preparation, Placeholder for records without volume info and other aspects.Application of 79-07-2

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Gan, Guohong; Xu, Xiao; Chen, Xi; Zhang, Xiu-Fang; Wang, Jinling; Zhong, Chuan-Qi published an article in 2021, the title of the article was SCASP: A Simple and Robust SDS-Aided Sample Preparation Method for Proteomic Research.Safety of 2-Chloroacetamide And the article contains the following content:

SDS is widely used in sample preparation for proteomic research. However, SDS is incompatible with LC and electrospray ionization. SDS depletion is therefore required ahead of LC-MS anal. Most of current SDS removal strategies are time consuming, laborious, and have low reproducibility. Here, we describe a method, SDS-cyclodextrin (CD)-assisted sample preparation, by which CD can bind to SDS and form CD-SDS complexes in solutions, allowing for direct tryptic digestion. We demonstrate that SDS-CD-assisted sample preparation is a simple, fast, and robust SDS-based sample preparation method for proteomics application. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Safety of 2-Chloroacetamide

The Article related to scasp sds sample preparation proteomic research, sdc, sds, sample preparation, Placeholder for records without volume info and other aspects.Safety of 2-Chloroacetamide

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On February 28, 2021, Chikineva, T. Yu.; Koshelev, D. S.; Medved鈥瞜o, A. V.; Vashchenko, A. A.; Lepnev, L. S.; Goloveshkin, A. S.; Utochnikova, V. V. published an article.Category: amides-buliding-blocks The title of the article was Ytterbium and Europium Complexes with Naphtho[1,2]thiazole-2-carboxylic and Naphtho[2,1]thiazole-2-carboxylic Acid Anions for Organic Light-Emitting Diodes (OLED). And the article contained the following:

An approach to the directed synthesis of aromatic lanthanide carboxylates as promising candidates for various luminescent applications, first of all, as emitting layers in light-emitting diodes, by varying the conjugation length with the introduction of a heteroatom and a neutral ligand was proposed. This approach enabled the synthesis of new europium and ytterbium complexes with naphtho[1,2]thiazole-2-carboxylic and naphtho[2,1]thiazole-2-carboxylic acid anions, which were successfully used in light-emitting diodes. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Category: amides-buliding-blocks

The Article related to naphtho thiazole carboxylic acid anion oled ytterbium europium complex, Placeholder for records without volume info and other aspects.Category: amides-buliding-blocks

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Patel, Harsh; Vyas, Piyush; Nishant, Yadav; Nayanaben, Parmar published an article in 2022, the title of the article was Synthesis, characterization and antimicrobial activity of novel pyrimido-triazine fused heterocyclic compounds.Reference of 2-Chloroacetamide And the article contains the following content:

Condensation of aminopyrimidinethione I (R = H) with chloroacetamide afforded the corresponding acetamide I (R = H2NCOCH2) which further cyclized under basic conditions to give pyrimido[1,2-b][1,2,4]triazin-3(2H)-one II (X = H2) containing an active methylene group. The latter reacted with diazonium salts of various sulfa drugs to afford the hydrazones II [X = 4-RSO2C6H4NHN; R = H2N, (H2N)2C:N, 2-pyrimidinylamino, 2,6-dimethoxypyrimidin-4-ylamino, 5-methylisoxazol-3-ylamino, etc.]. These compounds were screened for their in vitro antibacterial activity against Gram pos. bacteria (Bacillus Subtilis, Staphylococcus aureus), Gram-neg. bacteria (Klebsiella promioe, E. coli) and antifungal activity against plant pathogens (Botryodiplodia theobromae, Nigrospora Sp., Penicillium Expansum, Rhizopus Nigricans). The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Reference of 2-Chloroacetamide

The Article related to pyrimidotriazine furyl hydrazone sulfonamide antibacterial antifungal, Placeholder for records without volume info and other aspects.Reference of 2-Chloroacetamide

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