Amides-buliding-blocks

Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms was written by Thapak, Pavan;Bishnoi, Mahendra;Sharma, Shyam Sunder. And the article was included in NeuroMolecular Medicine in 2022.SDS of cas: 53902-12-8 This article mentions the following:

Abstract: Alzheimer’s disease (AD) is associated with the accumulation of β-amyloid and leads to cognitive impairment. Numerous studies have established that neuronal calcium homeostasis is perturbed in AD. Recently, transient receptor potential vanilloid 2 (TRPV2) channels, a non-selective calcium-permeable channel, have been investigated in several diseases. However, the role of the TRPV2 channel has not been investigated in AD yet. In this study, intracerebroventricular administration of β-amyloid (10μg) to Sprague Dawley rats resulted in cognitive impairment which was evident from the assessment of cognitive tests. Also, TRPV2 mRNA and protein expression were found to be upregulated, while the expression of Ca^2+/calmodulin-dependent protein kinase II (p-CaMKII-Thr-286), glycogen synthase kinase 3β (p-GSK-3β-Ser-9), cAMP response element-binding protein (p-CREB-Ser-133), and postsynaptic d. protein 95 (PSD-95) were downregulated in the hippocampus of β-amyloid-treated animals. Even, β-amyloid-treated animals showed upregulation of mRNA level of calcium buffering proteins (parvalbumin and calsequestrin) and calcineurin A (PPP3CA) in the hippocampus. Acetylcholinesterase activity was also increased in the cortex of β-amyloid-treated animals. Three-week treatment with tranilast showed improvement in the cognitive parameters which was associated with a decrease in TRPV2 expression and AChE activity. Addnl., an increase in the protein expression of p-CaMKII, p-GSK-3β, p-CREB and PSD-95 in the hippocampus was found. Downregulation in the mRNA level of calcium buffering proteins (parvalbumin and calsequestrin) and calcineurin A in the hippocampus was also seen. These results reveal the importance of TRPV2 channels in the β-amyloid-induced cognitive deficits and suggest TRPV2 as a potential target for AD. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8SDS of cas: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.SDS of cas: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anionic ortho-Fries rearrangement, a facile route to arenol-based Mannich bases was written by Assimomytis, Nikos;Sariyannis, Yiannis;Stavropoulos, Georgios;Tsoungas, Petros G.;Varvounis, George;Cordopatis, Paul. And the article was included in Synlett in 2009.Safety of N,N-Diethylsalicylamide This article mentions the following:

Phenol and 1-naphthol-based carbamates undergo the anionic ortho-Fries rearrangement to their corresponding amides. Bulky substitution at position 8 of 1-naphthol-based carbamates makes the rearrangement an exclusive reaction, even at -90°, under a variety of conditions. The amides can be efficiently reduced to the corresponding Mannich bases. A novel route to 7-[(dialkylamino)methyl]-8-hydroxy-1-naphthaldehydes is presented. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Safety of N,N-Diethylsalicylamide).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of N,N-Diethylsalicylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Conformationally locked cis-1,2-diaminocyclohexane-based chiral ligands for asymmetric catalysis was written by van Beek, Carim;Samoshin, Vyacheslav V.. And the article was included in Tetrahedron Letters in 2022.SDS of cas: 2387-23-7 This article mentions the following:

An efficient synthesis for a new conformationally locked chiral cis-1,2-diaminocyclohexane scaffold was developed. The conformational lock allows for convenient sym. derivatization of the amino groups through the reductive amination strategy. A series of optically pure chiral ligands I [R = Bn, 2-HOC₆H₄CH₂, 2-MeOC₆H₄CH₂] based on the cis-DACH scaffold was generated to demonstrate a proof-of-concept for these ligands as chiral catalysts in the asym. Henry reaction. Excellent yields with moderate enantioselectivity were demonstrated at room temperature, with an increase in enantioselectivity at lower temperatures, showing the potential of this new type of cis-DACH ligand. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Selective Transformations of Carbonyl Functions in the Presence of α,β-Unsaturated Ketones: Concise Asymmetric Total Synthesis of Decytospolides A and B was written by Yahata, Kenzo;Minami, Masaki;Watanabe, Kei;Fujioka, Hiromichi. And the article was included in Organic Letters in 2014.Related Products of 192436-83-2 This article mentions the following:

Enones selectively react with a combination of PPh₃ and TMSOTf to produce phosphonium silyl enol ethers, which work as protective groups of enones during the reduction of other carbonyl functions and can be easily deprotected to regenerate parent enones at workup. Thus, enone PhCH:CHCOMe reacted with 3-decanone in the presence of PPh₃/TMSOTf followed by DIBAL-H reduction and K₂CO₃/MeOH to give 3-decanol in 96% yield. Treating keto-enones such as 4-MeCOC₆H₄CH:CHCOMe to the same reaction conditions gave the corresponding selectively reduced product, e.g., 4-MeCH(OH)C₆H₄CH:CHCOMe in 82% yield. Furthermore, the first ketone selective alkylations in the presence of enones were also accomplished. This in situ protection method was applied to concise asym. total syntheses of decytospolides A and B I (R = H, COMe, resp.). In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Related Products of 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Production of copper-graphene nanocomposite as a voltammetric sensor for determination of anti-diabetic metformin using response surface methodology was written by Hassasi, Shima;Hassaninejad-Darzi, Seyed Karim;Vahid, Amir. And the article was included in Microchemical Journal in 2022.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

In this paper, application of a sensitive electrochem. technique assisted with multivariate optimization methods is presented for measurement of anti-diabetic metformin (MET) drug in pharmaceutical and serum samples. The sensitive electrochem. sensor was modified carbon paste electrode by copper-graphene nanocomposite (Cu-G/CPE). Firstly, synthesis of graphene (G) and copper-graphene (Cu-G) were performed and X-ray diffraction, field emission SEM, transmission electron microscopy, Fourier transform IR spectroscopy, Raman spectroscopy and N₂ adsorption-desorption isotherm were applied to specify the structure of them. Field emission SEM of Cu-G shows carbon sheets were decorated with some dense layer of well-dispersed uniform CuNPs with a type size around 50 nm. Also, the X-ray diffraction pattern of Cu-G displays several peaks for Cu, which approves the formation of Cu-G nanocomposite. Next, the G and Cu-G are used for modification of a carbon paste electrode (CPE) surface. Results from response surface methodol. indicated that solution pH of 12, 11% of Cu-G nanocomposite in the modified CPE, accumulation potential (0.2 V) and accumulation time (80 s) outcomes in the maximal c.d. The electrochem. behavior of MET at the Cu-G/CPE surface are investigated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry techniques. The electron-transfer coefficient, catalytic rate constant and diffusion coefficient are found to be 0.84, 6.27 x 10⁶ cm³ mol^-1 s^-1 and 1.07 x 10^-8 cm² s^-1, resp. Under the optimum conditions, the detection limit and linear dynamic range were found to be 3.4μM and 10.4-1125.0μM by DPV technique, resp. The Cu-G/CPE exhibited good reproducibility, stability and high recovery and it has low cost, low background current, ease of surface renewal. The Cu-G/CPE has better poisoning tolerance ability than bare CPE for electro-oxidation of MET and is a superior sensor for the long-term action. Furthermore, the proposed method can be applied as a valorous anal. method in the quality control of the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Precise growth of polymer brushes on silica-based nanocomposites via visible-light-regulated controlled radical polymerization was written by Li, Xue;Ye, Sunjie;Huang, Ya;Li, Jia Le;Cai, Tao. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019.Category: amides-buliding-blocks This article mentions the following:

Precise control over mol. variables of grafted polymer brushes is of crucial importance for obtaining polymer nanocomposites with desirable architectures and physicochem. properties, yet it remains a significant synthetic challenge. Recent advances in photoinduced electron/energy transfer reversible addition fragmentation chain transfer (PET-RAFT) polymerization have enabled light-regulated polymer synthesis, in a well-controlled and environmentally friendly manner. However, the utilization of this modern synthetic technique for the precise control of polymer brushes is underdeveloped. Here, PET-RAFT polymerization has been proceeded in a spatiotemporally controlled manner upon light regulation, producing silica nanocomposites coated with well-defined polymer brushes of target mol. weights, narrow dispersities and high grafting densities. The versatility and robustness of this technique have been demonstrated by its extendibility to other monomers and silica-containing nanomaterials. In all examined cases, the resultant high-value polymer nanocomposites possess defined chain sequences and architectures, high uniformity, and can be further expanded to a library of complex nanostructures. This work represents the first demonstration of adopting the PET-RAFT approach for generating precisely controlled polymer brushes on silica-based nanomaterials, and opens a new avenue for developing polymer nanocomposites with sequence-controlled polymer brushes and complex architectures required for a variety of target applications. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Graphene Oxide: A Metal-Free Carbocatalyst for the Synthesis of Diverse Amides under Solvent-Free Conditions was written by Patel, Khushbu P.;Gayakwad, Eknath M.;Patil, Vilas V.;Shankarling, Ganapati S.. And the article was included in Advanced Synthesis & Catalysis in 2019.HPLC of Formula: 2387-23-7 This article mentions the following:

An environment-friendly, inexpensive, carbocatalyst, graphene oxide (GO) which promoted efficient, metal-free transamidation of various carboxamides RC(O)NH₂ (R = Ph, pyridin-2-yl, H, Me, etc.) with aliphatic, cyclic, and aromatic amines NH(R¹)(R²) [R¹ = H, Ph; R² = n-Bu, Ph, cyclohexyl, pyridin-2-yl, etc.; R¹R² = -(CH₂)₄-, -CH₂CH₂OCH₂CH₂-] and 2-aminothiophenol is demonstrated. The protocol is equally applicable to phthalimides such as 1H-isoindole-1,3(2H)-dione, 5-methyl-1H-isoindole-1,3(2H)-dione, ureas R³NHC(O)NH₂ (R³ = H, Ph), and thioamide determining its adaptability. The oxygenated functionalities such as carbonyl (-C=O), epoxy (-O-), carboxyl (-COOH) and hydroxyl (-OH), present on graphene oxide surface impart acidic properties to the catalyst. The graphene oxide being heterogeneous in nature, work efficiently under solvent-free reaction conditions providing desired products RC(O)N(R¹)(R²), I, R¹NHC(O)NHR² in good to excellent yields. The one-pot synthesis of 2,3-dihydro-5H-benzo[b]-1,4-thiazepin-4-one moiety by GO catalyzed Aza Michael addition followed by intramol. transamidation is also described. A plausible reaction mechanistic pathway involving H-bonding is discussed. The graphene oxide can be recycled and reused up to five cycles without much loss in catalytic activity. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Phytosterol recognition via rationally designed molecularly imprinted polymers was written by Schwarz, Lachlan J.;Leung, Brenda K. Y.;Danylec, Basil;Harris, Simon J.;Boysen, Reinhard I.;Hearn, Milton T. W.. And the article was included in C in 2018.Category: amides-buliding-blocks This article mentions the following:

Molecularly imprinted polymers (MIPs) prepared via a semi-covalent imprinting strategy using stigmasteryl methacrylate as a polymerizable template have been evaluated by static binding methods for their ability to selectively capture other valuable phytosterol targets, including campesterol and brassicasterol. Design criteria based on mol. modeling procedures and interaction energy calculations were employed to aid the selection of the co-monomer type, as well as the choice of co-monomer:template ratios for the formation of the pre-polymerization complex. These novel hybrid semi-covalently imprinted polymers employed N,N’-dimethylacryl-amide (N,N’-DMAAM) as the functional co-monomer and displayed specific binding capacities in the range 5.2-5.9 mg sterol/g MIP resin. Their binding attributes and selectivities towards phytosterol compounds were significantly different to the corresponding MIPs prepared via non-covalent procedures or when compared to non-imprinted polymers. Cross-reactivity studies using stigmasterol, ergosterol, cholesterol, campesterol, and brassicasterol as single analytes revealed the importance of the A-ring C-3-β-hydroxyl group and the orientational preferences of the D-ring alkyl chain structures in their interaction in the templated cavity with the N,N’-dimethylamide functional groups of the MIP. Finally, to obtain useful quantities of both campersterol and brassicasterol for these investigations, improved synthetic routes have been developed to permit the conversion of the more abundant, lower cost stigmasterol via a reactive aldehyde intermediate to these other sterols. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Category: amides-buliding-blocks).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide was written by Xu, Liang;Zhang, Suhong;Trudell, Mark L.. And the article was included in Synlett in 2004.Name: N-Isopropylbenzenesulfonamide This article mentions the following:

Chromium(III) acetate hydroxide was found to be an efficient catalyst for N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides to furnish sulfonamides in good to excellent yields with periodic acid in acetonitrile at room temperature In the experiment, the researchers used many compounds, for example, N-Isopropylbenzenesulfonamide (cas: 5339-69-5Name: N-Isopropylbenzenesulfonamide).

N-Isopropylbenzenesulfonamide (cas: 5339-69-5) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N-Isopropylbenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Low temperature bleaching of cotton cheese with peroxide activator TAED was written by Shi, Wen-zhao;Xing, Jian-wei;Ren, Zhi-gang;Xu, Cheng-shu;Liu, Jin-shu. And the article was included in Yinran in 2013.Reference of 10543-57-4 This article mentions the following:

This paper aiming at the high energy consumption and fiber damage in traditional high-temperature scouring and bleaching pretreatment of cotton cheese, low-temperature pretreatment process with tetra acetyl ethylene diamine (TAED) is introduced. The effect of dosages of hydrogen peroxide and TAED, caustic soda, temperature and time on whiteness, capillary effect and tensile strength is discussed and compared with that of traditional process. The results show that the optimal process conditions are NaOH 2 g/L, H₂O₂ (30%) 6 g/L, TAED 6 g/L, treating at 60 °C for 10 min, and then holding at 80 °C for 30 min. The yams pretreated with optimal process feature higher breaking strength, similar whiteness and capillary effect, shortened process time and procedure. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics