Zhao, Qiang et al. published their research in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 10543-57-4

Research on FTIR analysis of Populus nigra L. lignin structure changes in different bleaching processes was written by Zhao, Qiang;Sun, Dezhi;Pu, Junwen;Jin, Xiaojuan;Xing, Mian. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2011.Reference of 10543-57-4 This article mentions the following:

To study the bleaching mechanisms of H2O2 bleaching, H2O2 displacement bleaching and H2O2/TAED bleaching, three kinds of lignin bleached with above processes were obtained. Three types of treated Populus nigra L lignins structure were identified and the functional groups were quantitied by FTIR. In contrast, the deacetylation and the breakage of ester bonds in H2O2/TAED bleaching system was much more significant. The total carbonyl group of H2O2 bleached lignin decreased 6.6% while displacement bleached lignin and H2O2/TAED bleached lignin decreased 9.2% and 15.8% resp. The PT bleaching process had stronger oxidability to destroy the syringyl units in lignin. The breakage of ether bonds and alc. hydroxyl dehydration in side chain increased after bleaching. In contrast, the stronger destroyed effect on guaiacyl dialkyl ether bond with PT bleaching processes. The conclusions obtained may interpret H2O2 displacement bleaching and H2O2/TAED bleaching systems have better bleaching efficiency than H2O2 bleaching system. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zubov, Alexander et al. published their research in Archives of Physiology and Biochemistry in 2022 | CAS: 10238-21-8

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C23H28ClN3O5S

Glibenclamide as a neuroprotective antidementia drug was written by Zubov, Alexander;Muruzheva, Zamira;Tikhomirova, Maria;Karpenko, Marina. And the article was included in Archives of Physiology and Biochemistry in 2022.Computed Properties of C23H28ClN3O5S This article mentions the following:

In the view of progressively aging human population and increased occurrence of dysmetabolic disorders, such as diabetes mellitus, cognitive impairment becomes a major threat to the national health. To date, the mol. mechanisms of cognitive dysfunction are partially described for diabetes and diseases of different nature, such as Alzheimer disease or Parkinson disease. The emergence of data pointing towards pleotropic effects of hypoglycemic medicines indicates involvement of their targets in pathogenesis of cognitive impairment. We are aiming here to review available data on the most widely used hypoglycemic drug, glibenclamide and find possible relationship of its targets to the pathogenesis of cognitive impairment. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Computed Properties of C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Computed Properties of C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liang, Xiao-ling et al. published their research in Yinran in 2012 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 10543-57-4

Cold pad-batch pretreatment of cotton fabrics with H2O2/TBCC activation system was written by Liang, Xiao-ling;Hou, Ai-qin. And the article was included in Yinran in 2012.Recommanded Product: 10543-57-4 This article mentions the following:

The hydrogen peroxide/TBCC activation system is used to cold pad-batch pretreatment of cotton fabrics. The influences of the dosage of activator, hydrogen peroxide and sodium hydroxide in hydrogen peroxide/TBCC system, temperature and time on fabric whiteness, capillary effect and breaking strength are investigated and compared with hydrogen peroxide/TAED activation system. The optimized cold pad-batch pretreatment of cotton fabric is as follows: H2O2 (30%) 40 g/L,TBCC 4 g/L, scouring agent LFD 5 g/L, NaOH 10 g/L, Na2SiO3 5 g/L, penetrating agent JFC 5 g/L, batching at 25 °C for 8 h. The effects of the hydrogen peroxide/TBCC activation system is better than those of hydrogen peroxide/TAED system. Compared with traditional process, hydrogen peroxide /TBCC process features less alkali dosage, shortened time and lower temperature in batching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shaifali et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 2670-38-4

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 2670-38-4

Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH3 surrogates was written by Shaifali;Sheetal;Bains, Rohit;Kumar, Ajay;Ram, Shankar;Das, Pralay. And the article was included in Organic & Biomolecular Chemistry in 2020.SDS of cas: 2670-38-4 This article mentions the following:

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd@PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH3 source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd@PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd@PS catalyst was easy to sep. and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodol. to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Isakova, A. P. et al. published their research in Zhurnal Organicheskoi Khimii in 1982 | CAS: 19311-91-2

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Reaction of phenol with diethylcarbamoyl chloride in the presence of Lewis acids was written by Isakova, A. P.;Naumov, Yu. A.;Nikeryasova, S. V.;Stepanova, A. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1982.Related Products of 19311-91-2 This article mentions the following:

In the presence of SnCl4 or AlCl3, Et2NCOCl reacted with PhOH to give Et2NCO2Ph, which at 175-80° underwent a Fries rearrangement to give I, II, and III, which were inactive as pesticides. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Related Products of 19311-91-2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Related Products of 19311-91-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhan, Chengchuang et al. published their research in Life Sciences in 2021 | CAS: 53902-12-8

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: 53902-12-8

Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats was written by Zhan, Chengchuang;Bai, Nan;Zheng, Min;Wang, Yanyan;Wang, Yuanqi;Zhang, Li;Li, Jianqiang;Li, Guangnan;Zhao, Hongyan;Liu, Guangzhong;Lou, Qi;Yang, Wen;Li, Tiankai;Li, Luyifei;Li, Weimin. And the article was included in Life Sciences in 2021.Recommanded Product: 53902-12-8 This article mentions the following:

An increase in oxidative stress is an important pathol. mechanism of heart injury induced by doxorubicin (DOX). Tranilast is an anti-allergy drug that has been shown to possess good antioxidant activity in previous studies. The overexpression and secretion of chymase by mast cells (MCs) increase the pathol. overexpression of angiotensin II (Ang II), which plays a crucial role in myocardial hypertrophy and the deterioration of heart disease. The MC stabilizer tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid; tran) prevents mast cells from degranulating, which may reduce DOX-induced Ang II synthesis. Therefore, in the present study, we hypothesized that tranilast will protect rats from DOX-induced myocardial damage via its antioxidant activity, thereby inhibiting Ang II expression. Thirty male Wistar rats were divided into three groups (n = 10 in each group) that received DOX, a combination of DOX and tranilast or saline (the control group) to test this hypothesis. Tranilast suppressed chymase expression, reduced Ang II levels and prevented the myocardial hypertrophy and the deterioration of heart function induced by DOX. Based on the findings of the present study, the suppression of chymase-dependent Ang-II production and the direct effect of tranilast on the inhibition of apoptosis and fibrosis because of its antioxidant stress capacity may contribute to the protective effect of tranilast against DOX-induced myocardial hypertrophy. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Recommanded Product: 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Recommanded Product: 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Fengjuan et al. published their research in Synlett in 2016 | CAS: 54166-95-9

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 6-Chloro-2-aminobenzamide

In-Water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides was written by Zhu, Fengjuan;Song, Runjiang;Li, Shen;Shao, Xusheng. And the article was included in Synlett in 2016.Recommanded Product: 6-Chloro-2-aminobenzamide This article mentions the following:

An efficient synthetic methodol. was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Recommanded Product: 6-Chloro-2-aminobenzamide).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Recommanded Product: 6-Chloro-2-aminobenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Schneller, Stewart W. et al. published their research in Journal of Organic Chemistry in 1986 | CAS: 54166-95-9

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Formula: C7H7ClN2O

The synthesis of proximal-benzoguanine and a simplified synthesis of proximal-benzohypoxanthine was written by Schneller, Stewart W.;Ibay, Augusto C.. And the article was included in Journal of Organic Chemistry in 1986.Formula: C7H7ClN2O This article mentions the following:

7-Aminoimidazo[4,5-f]quinazolin-9(8H)-one (proximal-benzoguanine I, R = NH2) was prepared in five steps from 2-amino-6-chlorobenzamide. Methylation of I (R = NH2) gave exclusively 7-amino-3-methylimidazo[4,5-f]quinazolin-9(8H)-one(II). (proximal-Benzohypoxanthine I(R = H) was available directly from 3-amino-2,6-dinitrobenzonitrile in a more efficient route than the one previously reported in the literature. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Formula: C7H7ClN2O).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Formula: C7H7ClN2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Weiming et al. published their research in Journal of Materials Research and Technology in 2020 | CAS: 10543-57-4

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Changes in physicomechanical properties and structures of jute fibers after tetraacetylethylenediamine activated hydrogen peroxide treatment was written by Wang, Weiming;Xu, Meng;Lou, Jiahao;Dong, Aixue. And the article was included in Journal of Materials Research and Technology in 2020.Category: amides-buliding-blocks This article mentions the following:

Tetraacetylethylenediamine (TAED) activated hydrogen peroxide (H2O2) was tentatively used in the bleaching of scoured jute fibers, and the effects of this method on the physicomech. properties, main chem. compositions, and structures during bleaching were evaluated and compared with conventional H2O2 bleaching. By comparing with H2O2 bleached jute fibers, the TAED-activated H2O2 bleached jute fibers were found to have a better storage stability of whiteness and yellowness, higher breaking tenacity, lower fineness value and breaking extension. The differences in morphol. structure and thermogravimetric anal. showed that the TAED-activated H2O2 bleaching system had a stronger ability for the removal of noncellulosic materials than conventional H2O2 bleaching system. The changes in main chem. compositions and Fourier transform IR spectra further indicated that the removal ability of TAED-activated bleaching for lignin was obviously stronger than that of conventional bleaching, but it had a similar removal ability for hemicellulose. Furthermore, when the whiteness and yellowness values were similar, the amount of H2O2, bleaching temperature, and time of TAED-activated H2O2 bleaching were obviously less than those of H2O2 bleaching. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Category: amides-buliding-blocks).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pushkareva, Z. V. et al. published their research in Zhurnal Obshchei Khimii in 1954 | CAS: 53297-70-4

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 53297-70-4

Dipole moments and structure of some sulfanilamide compounds was written by Pushkareva, Z. V.;Kokoshko, Z. Yu.. And the article was included in Zhurnal Obshchei Khimii in 1954.Recommanded Product: 53297-70-4 This article mentions the following:

Dipole moments of several sulfonamides were determined conventionally in dioxane (C6H6 was used as a reference liquid) at 25°; at. polarization was neglected; the electronic polarization (Pe) was calculated from the exptl. value of refraction of PhSO2NH2 (cf. Gur’yanova, C.A. 41, 6786a). The following values of the polarization at infinite dilution (P∞), Pe, and dipole moment (μ × 1018), resp., are reported for PhSO2NHR (R given): H, 571.39, 40.13, 5.09; Ph (m. 109-10°), 595.34, 64.22, 5.07; 3,5-Cl2C6H3 (m. 134-5°), 539.08, 73.85, 4.75; p-H2NSO2C6H4 (m. 148°), 714.82, 78.06, 5.55; Ac (m. 122°, from PhSO2NH2 and Ac2O), 558.14, 49.37, 4.96; 2-pyridyl (m. 171-2°), 573.51, 65.76, 4.95. Also p-H2NC6H4SO2NH2, -, -, 6.60; 3,4-Me(H2N)C6H3SO2NH2 (prepared by sulfonation of o-MeC6H4NHAc at 60-70° with HO3SCl 2 hrs., followed by aqueous NH4OH, yielding the crude amide, m. 202-4°; this heated to 80° in 1:3 H2SO4 1.5 hrs. and the filtrate treated with NH4OH gave the final product, m. 145-6°), 808.14, 48.27, 6.06; 1,4-H2NC10H6SO2NH2 (m. 212°), 943.94, 61.09, 6.53; p-H22NC6H4SO2NHAc (Albucide) (m. 182°), 1030.45, 58.80, 6.88; sulfapyridine (m. 192°), 1189.56, 69.08, 7.2; p-H2NC6H4SO2NHC6H4SO2NH2, 1090.78, 82.58, 6.99. Comparison of the moments so obtained with the vectorial addition of moments indicates an interaction between the p-groups NH2 and SO2NHR, with enhanced moment; no such enhancement exists in the m-derivatives The rotation of the NH2SO2 group is apparently restricted so that the H atom of the amide is located at the least distance from the O atoms of SO2. In the experiment, the researchers used many compounds, for example, 4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4Recommanded Product: 53297-70-4).

4-Amino-3-methylbenzenesulfonamide (cas: 53297-70-4) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 53297-70-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics