Amides-buliding-blocks

24243-71-8, Adding some certain compound to certain chemical reactions, such as: 24243-71-8, name is Propane-1-sulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24243-71-8.

A mixture of 2′-chloro-6′-(2,6-dimethylphenoxy)-1,5-dimethyl43,4′-bipyridin]-6(1H)-one (52 mg, 0.15 mmol), propane-1-sulfonamide (46 mg, 0.37 mmol), Pd2(dba)3 (7 mg, 5%), X-Phos (11 mg, 15%) and Cs2CO3 (68 mg, 0.21 mmol) was diluted with 1,4 dioxane (1 mL). After the mixture was purged with nitrogen for 5 min, it was sealed and heated to 90 C. for 3 hr. The cooled mixture was poured into H2O and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by prep-HPLC (10 min_10-95% ACN_0.1% formic acid, 20 ml/min) to afford the title compound (36 mg, 55%) as a tan solid. 1H NMR (400 MHz, DMSO-d6) delta 0.69-0.76 (m, 3H) 1.32-1.43 (m, 2H) 2.03-2.12 (m, 9H) 2.62-2.71 (m, 2H) 3.54 (s, 3H) 6.62 (s, 1H) 6.98 (s, 1H) 7.03-7.15 (m, 3H) 7.72 (s, 1H) 8.22 (s, 1H) 10.36 (br s, 1H). LCMS (M+H)+442.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24243-71-8.

Reference:
Patent; CELGENE QUANTICEL RESEARCH, INC.; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kanouni, Toufike; Stafford, Jeffrey Alan; Veal, James Marvin; Wallace, Michael Brennan; (250 pag.)US2017/298040; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 226260-01-1, name is 3-Fluoro-N-methoxy-N-methylbenzamide, A new synthetic method of this compound is introduced below., 226260-01-1

2. 35 ml of a 1 molar solution of vinylmagnesium bromide in THF is added dropwise under nitrogen to a solution, held at 0 C., of 5.80 g (31.6 mmol) of 3-fluoro-N-methoxy-N-methylbenzamide in 70 ml of THF.The reaction mixture is stirred at room temperature for 40 minutes, then saturated ammonium chloride solution is added, and the mixture is stirred at room temperature for a further 10 minutes. tert-Butyl methyl ether is added to the reaction mixture. The organic phase is separated off, washed with sodium hydrogencarbonate solution and water and dried in vacuo: 1-(3-fluorophenyl)-3-(methoxymethylamino)propan-1-one as yellow oil; ESI 212.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dorsch, Dieter; Schadt, Oliver; Blaukat, Andree; US2008/249095; (2008); A1;,
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Some common heterocyclic compound, 96-30-0, name is 2-Chloro-N-methylacetamide, molecular formula is C3H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 96-30-0

X-2 100 mg (0.288 mmol), 2-chloro-N-methylacetamide 37 mg (0.344 mmol), Cs2CO3281 mg (0.862 mmol) and 10 mL DMF were added to a 100 mL single-necked flask.The reaction was carried out at 50 degrees overnight, and the reaction was complete by TLC. The reaction solution was poured into 50 mL of water.EA was extracted with 30 mL*3, and the organic phase was combined with a sand column to obtain 80 mg of a white solid.Yield 66.4%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96-30-0, its application will become more common.

Reference:
Patent; China Pharmaceutical University; Lu Tao; Zhang Li; Zhao Jingyun; Zhang Beichen; Chen Yadong; (19 pag.)CN109897054; (2019); A;,
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These common heterocyclic compound, 6228-73-5, name is Cyclopropanecarboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6228-73-5

To a microwave tube was added 4-(4-bromo-lH-imidazo[4,5-c]pyridin-2-yl)-3,5- dichlorobenzonitrile (0.10 g, 0.27 mmol), cyclopropanecarboxamide (0.069 g, 0.81 mmol), Pd2(dba)3 (0.036 g, 0.040 mmol), XantPhos (0.017 g, 0.030 mmol), Cs2C03 (0.26 g, 0.81 mmol) and dioxane (3.0 mL). The mixture was degassed with N2 for 10 min. The resulting mixture was irradiated in a microwave reactor at 160 C for 2 hours and then cooled to room temperature. The mixture was filtered with Celite and the filtrate was concentrated and purified by prep-TLC to give the desired product as a white solid (15 mg, 15 % yield). ? NMR (MeOR-d4, 500 MHz): delta 7.95 (s, 2H), 7.54 (m, 1H), 7.45 (m, 1H), 1.90 (m, 1H), 1.23 – 1.18 (m, 2H), 1.00 – 0.88 (m, 2H). LCMS(ESI) m/z: 372.0 [M+H+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6228-73-5.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk; WO2011/113802; (2011); A2;,
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459817-82-4, Adding some certain compound to certain chemical reactions, such as: 459817-82-4, name is tert-Butyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 459817-82-4.

Step 1 : To an oven-dried flask containing 4,6-dichloro-2- (methylsulfanyl)pyrimidine (390 mg, 2.0 mmol) in anhydrous THF (7.5 mL) was added TMPMgCI LiCI (2.4 mL, 2.4 mmol; as a 1 M solution in THF) at r.t. After stirring for 30 min, tert-butyl 1 ,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (469 mg, 2.1 mmol) was added and the reaction was stirred for a further 1 h at r.t. To the mixture was added 1 M citric acid (7.5 mL) and EtOAc (7.5 mL) followed by vigorous stirring for 5 min. The organic layer concentrated to give tert-butyl N-{2- [4,6-dichloro-2-(methylsulfanyl)pyrimidin-5-yl]ethyl}.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 459817-82-4.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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A common heterocyclic compound, 141449-85-6, name is tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate, molecular formula is C11H20N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 141449-85-6.

The 5 – chloro – 1, 6 – naphthyridine (0.93 g, 5 . 65 mmol), hexahydro-pyrrolo [3, 4 – c] pyrrole -2 (1 H) – formic acid tert-butyl ester (1.00 g, 4 . 71 mmol), three (dibenzylidene acetone) two palladium (0.43 g, 0 . 47 mmol), 2 – dicyclohexyl phosphorus – 2, 4, 6 – triisopropyl biphenyl (0.46 g, 0 . 94 mmol), sodium tertiary butyl alcohol (1.40 g, 14.1 mmol) and toluene (20 ml) are added to the 100 ml single-port in the bottle, under the protection of nitrogen, reaction temperature to 120 C reaction 36 hours. Stopping the reaction, the reaction solution is distilled under reduced pressure to remove the solvent after purification by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=1/1) to obtain the title compound (light yellow liquid, 1.15 g, 71.7%).

The synthetic route of tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhang Yingjun; Xue Yaping; Lao Jinhua; Nie Biao; Xu Juan; (35 pag.)CN107759620; (2018); A;,
Amide – Wikipedia,
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The chemical industry reduces the impact on the environment during synthesis 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, I believe this compound will play a more active role in future production and life. 112257-19-9

To a solution of 2 (465mg, 2.66mmol) in CH2Cl2 (20mL) was added 8 (500mg, 2.66mmol) and sodium triacetoxyborohydride (1.13g, 5.32mmol) at 0¡ãC under argon and then stirred at room temperature for 12h. The reaction solution was quenched with saturated NH4Cl (20mL) and extracted with CH2Cl2 (30mL ¡Á 3), and the combined organic layers dried with Na2SO4. The residue was purified by column chromatography on silica gel using EtOAc/petroleum ether (1/2, V/V) as elunt to give 10 as colorless oil (750mg, 81percent); 1H NMR (400MHz, DMSO) delta 6.49 (d, J = 3.2Hz, 1H, Ar-H), 6.35 (d, J = 3.2Hz, 1H, Ar-H), 3.52 (s, 2H, CH2), 3.29-3.20 (m, 2H, CH2), 2.76 (d, J = 9.8Hz, 3H, CH3), 2.42 (t, J = 6.7Hz, 2H, CH2), 2.18 (s, 3H, CH3), 1.45 (s, 9H, (CH3)3); HRMS (ESI) m/z [M+H]+ Calcd for C14H24BrN2O3+: 347.0970. Found: 347.0974.

The chemical industry reduces the impact on the environment during synthesis 112257-19-9. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yang, Hao; Ouyang, Yifan; Ma, Hao; Cong, Hui; Zhuang, Chunlin; Lok, Wun-Taai; Wang, Zhe; Zhu, Xuanli; Sun, Yutong; Hong, Wei; Wang, Hao; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4635 – 4642;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics