Amides-buliding-blocks

The chemical industry reduces the impact on the environment during synthesis 22117-85-7, name is 2-Methoxy-5-sulfamoylbenzoic acid, I believe this compound will play a more active role in future production and life. 22117-85-7

example 35 by following general method D using 0.84 g. of 6-methoxy-3-sulfamoylbenzoic acid and 0.6 g. of N-benzyl-N-methylethylenediamine, 1.2 g. of N-[2-(N’-benzyl-N’-methylamino)ethyl]-6-methoxy-3-sulfamoylbenzamide was obtained. Melting point: 202-203 C. (recrystallized from a mixture of methanol and isopropanol). Elemental analysis for C18 H23 N3 O4 S:

The chemical industry reduces the impact on the environment during synthesis 22117-85-7. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4097487; (1978); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 14433-76-2, name is N,N-Dimethylcapramide, I believe this compound will play a more active role in future production and life. 14433-76-2

General procedure: The following experimental procedure for the chemoselective partial reduction of ethyl benzoate and N,N-dimethyl 3-toluamide is representative. A dry and argon-flushed flask, equipped with a magnetic stirring bar and a septum, was charged with ethyl benzoate (0.07mL, 0.5mmol), N,N-dimethyl 3-toluamide (0.08mL, 0.5mmol) and 5mL THF. After CDBBA (9.01mL, 0.44M soln. 4.0mmol) was slowly added and stirred for 12h at room temperature. The reaction was quenched by aqueous 1N HCl (10mL) and extracted with diethyl ether (2¡Á10mL). The combined organic layers were dried over MgSO4. GC analysis showed a 97% recovery yield of ethyl benzoate and 95% yield of 3-methylbenzaldehyde. All products in Table 2 were confirmed through comparison with GC data of authentic sample.

The chemical industry reduces the impact on the environment during synthesis 14433-76-2. I believe this compound will play a more active role in future production and life.

Reference:
Article; Im, So Hee; Shin, Won Kyu; Jaladi, Ashok Kumar; An, Duk Keun; Tetrahedron Letters; vol. 59; 24; (2018); p. 2335 – 2340;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

34801-09-7, These common heterocyclic compound, 34801-09-7, name is N-(2-Aminophenyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1.00 g (5.2 mmol) of compound 1a and 0.78 g (5.2 mmol) of N-(2-amino-phenyl)acetamide in 10 mL of ethanol was refluxed for 1 h. The mixture was cooled and evaporated by half, and the yellow solid was filtered off. Yield 1.20 g (71%), mp 130-132C (decomp., from EtOH). IR spectrum, nu, cm -1 : 3272 (NH, OH), 1715 (C=O). 1 H NMR spectrum, delta, ppm: 2.11 s (3H, Me), 6.38 s (1H, 3-H), 7.07 m (1H, H arom ), 7.17 m (2H, H arom ), 7.32 m (1H, H arom ), 7.49-7.60 m (3H, H arom ), 7.96 m (2H, H arom ), 9.82 s (1H, NH), 11.61 s (1H, NH). 13 C NMR spectrum, delta C , ppm: 22.8 (Me), 95.3 (C 3 ); 122.6, 125.1, 125.9, 127.1, 128.2, 128.5, 128.9, 130.3, 131.9, 138.5 (C arom ); 151.9 (C 2 ), 165.2 (COOH), 168.8 (CONH), 189.3 (COPh). Mass spectrum: m/z 325.15 [M + H] + . Found, %: C 66.59; H 4.87; N 8.44. C 18 H 16 N 2 O 4 . Calculated, %: C 66.66; H 4.97; N 8.64. [M + H] + 325.12

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34801-09-7.

Reference:
Article; Stepanova; Dmitriev; Maslivets; Russian Journal of Organic Chemistry; vol. 55; 3; (2019); p. 402 – 405; Zh. Org. Khim.; vol. 55; 3; (2019); p. 469 – 473,5;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

7341-96-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7341-96-0 as follows.

To a stirred solution of ethynylcarbamoyl (Method 74; 43g, 0. 62mol) in water (310ml) cooled in ice bath was added ammonium thiosulphate (92.35g, 0. 62mol) in one portion. The reaction was allowed to warm to room temperature over 5 hours. To the reaction mixture was added a solution of iodine (79.2g, 0. 31mol) in MeOH (11) rapidly over 10 minutes to yield a dark solution. Ammonium thiosuphate was added until a yellow solution was obtained. The solvent was evaporated to approximately 400ml and extracted ether (3 x 300ml). The ethereal solution was washed brine (100ml), passed through phase separation paper and evaporated in vacuo to yield the title compound as a pale orange solid (32.8g, 52%). Mpt: 70-71 C.

According to the analysis of related databases, Propiolamide, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76436; (2003); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

563-83-7,Some common heterocyclic compound, 563-83-7, name is Isobutyramide, molecular formula is C4H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 10 mL microwave vial, furopyrazine 8, 12a-c and 13 (0.3 mmol), amide (0.45 mmol, 1.5 equiv), Pd(OAc)2 (5 mol %), Xanthphos (7 mol %) and Cs2CO3 (3 equiv) were successively dissolved in THF (3 mL). The reaction tube was sealed and irradiated at a ceiling temperature of 140 C at 100 W maximum power for 30-45 min. After reaction, the mixture was cooled with an air flow for 2 min, extracted with ethylacetate (2¡Á50 mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was subjected to silica gel chromatography (from 5% to 20% EtOAC in heptane) to afford compounds 14a-j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Isobutyramide, its application will become more common.

Reference:
Article; Claerhout, Stijn; Sharma, Sweta; Skoeld, Christian; Cavaluzzo, Claudia; Sandstroem, Anja; Larhed, Mats; Thirumal, Meganathan; Parmar, Virinder S.; Van Der Eycken, Erik V.; Tetrahedron; vol. 68; 14; (2012); p. 3019 – 3029;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

68524-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68524-30-1, name is 2-[(Diphenylmethyl)thio]acetamide, A new synthetic method of this compound is introduced below.

2-(Benzhydrylthio)acetamide obtained according to Example 4 (30 g-HPLC 97.9%) and acetic acid (120 ml) are loaded into a 1000 ml round-bottom flask. The mixture is heated to 40 C., slowly added with 35% hydrogen peroxide (11.7 g) and reacted at 40 C. for about 6 hours. The mixture is then cooled to 30 C., added with water (900 ml) and further cooled to 15 C. The product is filtered and washed with water. The wet product (49.4 g) thus obtained (HPLC: 95.73%, 0.083% (sulfone)) is dried at 50 C. under reduced pressure. Yield: 29.7 g. Crude modafinil is recrystallized from methanol (193 ml), by heating under reflux and cooling then to 15 C. The precipitate is filtered, washed with cold methanol and dried at 50 C. under reduced pressure. Yield: 23.4 g (HPLC: 99.9%, 0.01% (sulfone)).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; PROCOS S.P.A.; US2004/106829; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

107017-73-2, A common compound: 107017-73-2, name is tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

d- Synthesis of Int. 37 : To a mixture of 36 (0.615 g, 1 .40 mmol ), l -(boc-amino)cyclopropylmethanol (0.275 g, 1.47 mmol) and diphenylphosphinopolystyrene (0.933 g, 2.80 mmol) in dry THF (12 mL) was added DBAD (0.644 g, 2.80 mmol). The mixture was stirred for 72 h at r.t. then filtered through a glass frit and washed with EtOAc. The filtrate was evaporated in vacuo to give 1.54 g of yellow oil. The residue was purified by prep. LC (Irregular SiOH, 15-40 mupiiota, 50 g Merck, mobile phase gradient: from DCM 100% to DCM 60%, EtOAc 40%) to give 636 mg of Int. 37 as a white foam (75%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (1-(hydroxymethyl)cyclopropyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; MEVELLEC, Laurence, Anne; PASQUIER, Elisabeth, Therese, Jeanne; DESCAMPS, Sophie; MERCEY, Guillaume, Jean, Maurice; WROBLOWSKI, Berthold; VIALARD, Jorge, Eduardo; MEERPOEL, Lieven; JEANTY, Matthieu, Ludovic; JOUSSEAUME, Thierry, Francois, Alain, Jean; WO2015/144799; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 402-46-0, name is 4-Fluorobenzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 402-46-0

EDCI (111 mg, 0.5 mmol) was added to a solution of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid (100 mg, 0.29 mmol) in DCM (4 mL) followed by DMAP (36 mg, 0.29 mmol) and 4-fluorobenzenesulfonamide (56 mg, 0.31 mmol) and stirring was continued at 20-35 C. for 20 h. Reaction mixture was quenched with water, extracted into EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the crude. The crude compound was purified by Preparative HPLC [Column: 21.2*150*5 um, Zorbax, Eclipse, C-18, Mobile phase-A: Water, B:ACN, Gradient (Time/% B): 0/30, 2/40, 10/80 and Flow rate: 20 mL/min] to afford 9.3 mg of the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 8.29 (1H, bs), 8.22-8.20 (2H, m), 8.12 (1H, d, J=7.6 Hz), 8.00 (1H, s), 7.26-7.20 (2H, m), 7.14-7.04 (2H, m), 6.96-6.88 (1H, m), 6.61 (1H, m), 6.18 (1H, d, J=7.6 Hz), 5.12-5.11 (1H, d, J=8 Hz), 3.80-3.74 (1H, m), 3.6-3.5 (1H, m), 2.5-2.4 (1H, m), 2.15-2.0 (3H, m). MS (ESI): m/z 501.8 (M+H).

The synthetic route of 402-46-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; Sasmal, Pradip Kumar; Ahmed, Shahadat; Tehim, Ashok; Pradkar, Vidyadhar; Dattatreya, Prasanna M.; Mavinahalli, Nanjegowda Jagadeesh; US2014/371217; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

108468-00-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, A new synthetic method of this compound is introduced below.

820 mg of tert-butyl N-[[4-(aminomethyl)-phenyl]-methyl]-carbamate and 421 mg of TEA was dissolved in 10 mL of DCM, cooled in an ice bath and 725 mg of thioacetic acid S-(4-chlorocarbonyl-phenyl) ester, dissolved in 5 mL of DCM, was slowly added. The mixture obtained was stirred for 30 min at rt, the phases were separated, the organic phase obtained was washed successively with 2N HCl and 5% aqueous NaHCO3 solution, dried over Na2SO4 and evaporated to dryness. The title compound was obtained in the form of pale brown crystals.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NABRIVA THERAPEUTICS AG; Thirring, Klaus; Heilmayer, Werner; Riedl, Rosemarie; Kollmann, Hermann; Ivezic-Schoenfeld, Zrinka; Wicha, Wolfgang; Paukner, Susanne; Strickmann, Dirk; (90 pag.)US2016/332963; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 20348-09-8, name is 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20348-09-8, 20348-09-8

PREPARATION B; Phenyl 3-[(diphenoxyphosphoryl)oxy]-2,3-dihydro-4H-pyrido-[3,2-b][1,4]oxazine-4-carboxylate; Step A: Phenyl 2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-3-one-4-carboxylate; Under an anhydrous atmosphere, a solution of 10 mmol of 2H-pyrido[3,2-b][1,4]oxazin-3-one in 50 ml of tetrahydrofuran is cooled to -78 C. At that temperature, 11 mmol of a 1.6M solution of n-butyllithium in hexane are added dropwise. After 30 minutes’ contact at -78 C., 11 mmol of phenyl chloroformate are added dropwise and stirring is maintained for a further 2 hours. After returning to ambient temperature, the solution is hydrolysed and then extracted with ethyl acetate. The organic phase is dried over magnesium sulphate, filtered and evaporated. After purification by chromatography on silica gel (petroleum ether/ethyl acetate: 8/2), the expected product is isolated. Melting point: 97 C. IR (KBr): vC=O=1717 cm-1; 1803 cm-1. Mass spectrum: m/z 271 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Coudert, Gerard; Lepifre, Franck; Caignard, Daniel-Henri; Renard, Pierre; Hickman, John; Pierre, Alain; Kraus-Berthier, Laurence; US2006/3997; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics