Amides-buliding-blocks

Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2 was written by Fahmy, Eslam K.;El-Sherbiny, Mohamed;Said, Eman;Elkattawy, Hany A.;Qushawy, Mona;Elsherbiny, Nehal. And the article was included in NeuroToxicology in 2021.COA of Formula: C18H17NO5 This article mentions the following:

Silver nanoparticles (AgNPs) are widely applied in various aspects of life. However, recent studies reported their potential toxicity both on environment and human health. The present study aimed to unravel the underlying mol. mechanisms involved in AgNPs-induced brain toxicity. Moreover, chemopreventive effect of tranilast, an analog of tryptophan metabolite and a mast cell membrane stabilizer was evaluated. Thirty Sprague Dawley rats were enrolled equally into Normal control group, AgNPs-intoxicated group (50 mg/kg, 3 times/wk) and tranilast (300 mg/kg, 3 times/wk)+AgNPs group. AgNPs administration triggered brain oxidative stress as depicted by reduced Nrf-2 expression, decreased TAC and GSH as well as upregulated brain lipid peroxidation The apparent brain oxidative damage was accompanied by elevated levels of inflammatory cytokines (IL-β1;, IL-6 and TNF-α). Moreover, brain levels of TLR4, NLRP3 and caspase-1 were up-regulated. Addnl., histol. study indicated marked cellular injury in cerebrum and cerebellum specimens. This was concomitant with elevated serum CK activity and CK-BB level. On the other hand, tanilast administration remarkably alleviated AgNPs-induced brain toxicity. The present study shed the light on implication of TLR4/NLRP3 axis and NrF2 in AgNPs-induced brain toxicity. In addition, it explored the potential protective effect of tranilast on AgNPs-induced brain injury via antioxidant and anti-inflammatory efficacies. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8COA of Formula: C18H17NO5).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.COA of Formula: C18H17NO5

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Providing a New Aniline Bioisostere through the Photochemical Production of 1-Aminonorbornanes was written by Staveness, Daryl;Sodano, Taylor M.;Li, Kangjun;Burnham, Elizabeth A.;Jackson, Klarissa D.;Stephenson, Corey R. J.. And the article was included in Chem in 2019.Formula: C13H24N2O This article mentions the following:

The photochem. conversion of aminocyclopropanes into 1-aminonorbornanes via formal [3 + 2] cycloadditions initiated by homolytic fragmentation of amine radical cation intermediates was described. Aligned with the modern movement toward sp³-rich motifs in drug discovery, this strategy provided access to a diverse array of substitution patterns on this saturated carbocyclic framework while offered the robust functional-group tolerance (e.g., -OH, -NHBoc) necessary for further derivatization. The metabolic stability was evaluated for selected morpholine-based 1-aminonorbornanes demonstrated a low propensity for oxidative processing and no proclivity toward reactive metabolite formation, suggested a potential bioisosteric role for 1-aminonorbornanes. Continuous-flow processing allowed for efficient operation on the gram scale, provided promise for translation to industrially relevant scales. This methodol. only required low loadings of a com. available, visible-light-active photocatalyst and a simple salt; thus, it stayed true to sustainability goals while readily delivered saturated building blocks that reduced metabolic susceptibility within drug development programs. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

I₂-Catalyzed cross dehydrogenative coupling: rapid access to benzoxazinones and quinazolinones was written by Chen, Kaili;Gao, Biao;Shang, Yanguo;Du, Jianyao;Gu, Qinlan;Wang, Jinxin. And the article was included in Organic & Biomolecular Chemistry in 2017.Computed Properties of C11H15NO2 This article mentions the following:

An efficient and applicable I₂-catalyzed intramol. dehydrogenative C-O/C-N coupling reaction via activating the C-H bond adjacent to the N atom has been developed to provide dozens of substituted benzoxazinones I (R¹ = H, 8-OMe, 6-F, etc.; R² = Me, Et, Bn, etc.; R³ = C₆H₅, 4-H₃CC₆H₄, 4-FC₆H₄, etc.; X = O, S) (31 examples) and quinazolinones, e.g. II (5 examples) in good to excellent yields (up to 98%). This one-pot methodol. has significant advantages, including a metal-free process, broad substrate scope, high atom economy, and simple operation. This strategy goes through an iminium intermediate followed by nucleophilic attack to provide the desired products. In the experiment, the researchers used many compounds, for example, N,N-Diethylsalicylamide (cas: 19311-91-2Computed Properties of C11H15NO2).

N,N-Diethylsalicylamide (cas: 19311-91-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Computed Properties of C11H15NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanically Flexible Organic Crystals Achieved by Introducing Weak Interactions in Structure: Supramolecular Shape Synthons was written by Krishna, Gamidi Rama;Devarapalli, Ramesh;Lal, Garima;Reddy, C. Malla. And the article was included in Journal of the American Chemical Society in 2016.Formula: C7H5Cl2NO This article mentions the following:

Controlling mech. properties of ordered organic materials remains a formidable challenge, despite their great potential for high performance mech. actuators, transistors, solar cells, photonics, and bioelectronics. A crystal engineering approach to design mech. reconfigurable, plastically flexible single crystals (of ∼10) of 3 unrelated types of compounds was demonstrated by introducing active slip planes in structures via different noninterfering supramol. weak interactions, van der Waals (vdW), π-stacking, and H bonding groups. Spherical hydrophobic groups, which assemble via shape complementarity (shape synthons), reliably form low energy slip planes, thus facilitating an impressive mech. flexibility, which allowed molding the crystals into alphabetical characters to spell out o r g a n i c c r y s t a l. The study, which reports the preparation of exotic plastic crystals by design, demonstrates the potential of soft interactions for tuning the mech. behavior of ordered mol. materials, including those from π-conjugated systems. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Formula: C7H5Cl2NO).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Formula: C7H5Cl2NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sequential One-pot Method for the Synthesis of 4-(Hydroxymethyl)oxazoles and their Application in Phosphonates Synthesis was written by Kajol, Km;Ramesh, Chintakunta. And the article was included in Asian Journal of Organic Chemistry in 2021.SDS of cas: 2670-38-4 This article mentions the following:

A sequential one-pot method for the synthesis of 4-(hydroxymethyl)oxazoles from readily available benzamides was developed. Various substituted benzamides well-tolerated and furnished 4-(hydroxymethyl)oxazoles in moderate to good yields under the present reaction conditions. In order to demonstrate the usefulness of the present methodol., the resulting 4-(hydroxymethyl)oxazoles were successfully transformed into its corresponding phosphonates under Michaelis-Arbuzov reaction conditions. This methodol. featured a broad substrate scope, step economy, ease of execution, and scalability. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4SDS of cas: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.SDS of cas: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanism of the cytostatic action of methylhydrazines. III was written by Weitzel, Guenther;Schneider, Friedhelm;Hirschmann, Wolf D.;Durst, Juergen;Thauer, Rudolf K.;Ochs, Hans Dieter;Kummer, Dieter. And the article was included in Zeitschrift fuer Physiologische Chemie in 1967.SDS of cas: 13255-50-0 This article mentions the following:

Hydrazine acetate (225-750 γ) injected i.v. into mice bearing Ehrlich ascites tumors reduced the incorporation rate of thymidine (I) and leucine (II) into the tumor cells dependent on dose; uridine (III) incorporation was not influenced. I.p. injections of Natulan (IV) (4-[(2-methylhydrazino)methyl]-N-isopropylbenzamide) and Azo-Natulan (4-(methylazomethyl)-N-isopropylbenzamide) (10 mg.) into mice bearing ascites tumors preferentially reduced the incorporation of III and also reduced I and II incorporation. Demethylated IV (4-(hydrazinomethyl)-N-isopropylbenzamide) reduced II and III, but not I incorporation. In the presence of NADPH, liver microsomes split IV to give HCHO. N-Isopropyl-4-formylbenzamide (1-2 × 10-3M) inhibited III and II and, to a lesser extent, I incorporation into ascites cells in vitro and produced similar results when injected at 15 mg. into ascitic mice. The biosynthesis of proteins in a cell-free system was not inhibited by hydrazine acetate, methylhydrazine, formalhydrazine, benzylhydrazine, 1-methyl-2-benzylhydrazine, IV, or demethylated IV. The spontaneous reaction of the IV degradation product, N-isopropyl-4-formylbenzamide, with amino acids produced Schiff bases, which could inhibit II incorporation by removing amino acids from protein synthesis. The synthesis of DNA and RNA was affected in the following manner. Hydrazine acetate (1-2 × 10-3M) inhibited the formation of purine deoxynucleosides. The HCHO resulting from the Me group of methylhydrazine inhibited the formation of deoxynucleoside diphosphates and deoxynucleoside triphosphates. The substituent N-isopropylcarbamide in the para position on the benzene ring inhibited the entrance of nucleosides and purines into the cell, resulting in a general lowering of the intracellular content of nucleosides and purines. In addition to condensation with amino acids, the aldehyde group of the N-isopropyl-4-formylbenzamide inhibited the formation of the nucleoside diphosphates and nucleoside triphosphates. All of these effects could be demonstrated simultaneously for IV and Azo-Natulan. 27 references. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0SDS of cas: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Use of product and ingredient tools to assess the environmental profile of automatic dishwashing detergents was written by Van Hoof, Gert;Fan, Ming;Lievens, Alain. And the article was included in Journal of Cleaner Production in 2017.COA of Formula: C10H16N2O4 This article mentions the following:

Sustainable use of resources is gaining more attention as demonstrated into recent policy goals by the United Nations and the European Union and becomes an integral part of many corporate sustainability visions. The case study shows the more efficient use of materials in P&G automatic dishwashing detergents (ADD) placed on the market in Europe, Middle East and Africa (EMEA) by replacing sodium tripolyphosphate (STPP) with Me glycine diacetic acid (MGDA). The use of phosphates in ADD in the European Union will be restricted as of 2017. This study is innovative as it combines several tools in a complementary way to enable data based decision making. Life Cycle Assessment (LCA) consistent with ISO 14040/44 standards compares environmental impacts for two ADD unit dose products (i.e. with and without STPP). Different assessment tools were used to evaluate the freshwater aquatic toxicity profile: the Critical Dilution Volume (CDV), USEtox, environmental risk assessment and the Environmental Safety Check (ESC). For the relevant LCA indicators, a significant reduction (i.e. > 10%) is observed on ADD products without phosphate vs. the phosphate containing product. CDV and USEtox scores on the down the drain emissions from the new product are reduced by 30% and 22% resp. as compared to the phosphate containing formula. Overall, no major trade-offs are observed with the replacement of STPP by MGDA. Benefits are due to a 20% reduction of the mass of ingredients per dose with the new product and the replacement of STPP by MGDA. The ESC evaluation and environmental risk assessment for MGDA show that a low environmental risk is expected per its favorable environmental fate and ecotoxicol. profiles. Based on the proven safety profile of MGDA, the reductions in LCA indicators and absence of trade-offs, it can be concluded that the new product has an improved environmental profile. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4COA of Formula: C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A₄ hydrolase aminopeptidase inhibitors was written by Zhang, Fan;Wu, Dang;Wang, Gao-Lei;Hou, Shuang;Ping, Ou-Yang;Huang, Jin;Xu, Xiao-Yong. And the article was included in Chinese Chemical Letters in 2017.Category: amides-buliding-blocks This article mentions the following:

A series of novel 1,2,3-benzotriazin-4-one derivatives I [R = H, 6-O₂N, 7-Cl, etc.; X = (CH₂)_n; n = 0, 1, 2, 3, 4] were designed, synthesized and their inhibitory activities against leukotriene A4 hydrolase aminopeptidase in-vitro were evaluated. Many compounds showed moderate to good activities at the concentration of 10 μmol/L. Among them, compound I [R = 7-Cl; X = (CH₂)₄ (II)] exhibited the highest inhibitory activity up to 80.6% with an IC₅₀ of 1.30 ± 0.20 μmol/L. The compound II was also tested for the proliferation inhibitory activities in THP1 human AML cell line and its binding model with LTA4H enzyme by mol. docking was studied. It indicated that 1,2,3-benzotriazin-4-one was a promising scaffold for further study. The relationship between structure and inhibitory activity was also preliminarily discussed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-fluorobenzamide (cas: 119023-25-5Category: amides-buliding-blocks).

2-Amino-4-fluorobenzamide (cas: 119023-25-5) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Benzo[1,2-b:6,5-b’]dithiophene(dithiazole)-4,5-dione derivatives: synthesis, electronic properties, crystal packing and charge transport was written by Getmanenko, Yulia A.;Fonari, Marina;Risko, Chad;Sandhu, Bhupinder;Galan, Elena;Zhu, Lingyun;Tongwa, Paul;Hwang, Do Kyung;Singh, Sanjeev;Wang, He;Tiwari, Shree Prakash;Loo, Yueh-Lin;Bredas, Jean-Luc;Kippelen, Bernard;Timofeeva, Tatiana;Marder, Seth R.. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2013.Application of 116332-61-7 This article mentions the following:

A series of dihalo- and bis-aroyl-substituted benzo[1,2-b:6,5-b’]dithiophene-4,5-diones were synthesized, and their electronic, electrochem., and elec. properties investigated. Synthetic strategies to increase (i) the conjugation length of the base mol. structure – through introduction of thiophene units bearing electronically neutral substituents (hydrogen or alkyl groups) or strong electron-withdrawing pentafluorobenzoyl group(s) – and (ii) the electron affinity – by moving to a benzo[1,2-d:4,3-d’]bis(thiazole)-4,5-dione structure – were developed. Mol. packing in the single crystal was studied by single-crystal x-ray structural anal., and this information was subsequently used in the determination of the electronic band structures, densities of states (DOS), effective transfer integrals, and effective charge-carrier masses via d. functional theory (DFT) methods. The charge-carrier transport properties of the benzo[1,2-b:6,5-b’]dithiophene-4,5-dione and benzo[1,2-d:4,3-d’]bis(thiazole)-4,5-dione derivatives were investigated through the fabrication and characterization of organic field-effect transistors (OFETs) via both solution-processed and vacuum-deposited films. 2,7-Bis-pentafluorobenzoyl-benzo[1,2-b:6,5-b’]dithiophene-4,5-dione (I) exhibited field-effect behavior with an average electron mobility μ_e = 4.4 (±1.7) × 10^-4 cm² V^-1 s^-1 when the active layer was vacuum-deposited, and a larger μ_e= 6.9 × 10^-3 cm² V^-1 s^-1 when the active layer was solution-processed. These results are in stark contrast with the DFT-determined electronic band structure and effective mass, which indicate that the material possesses good intrinsic charge-carrier transport characteristics. The combined results reveal the importance of thin-film processing and that further processing refinements could lead to improved device performance. Only one material with benzo[1,2-d:4,3-d’]bis(thiazole)-4,5-dione core, 2,7-bis-(4-n-hexyl-thiophene-2-yl)-benzo[1,2-d:4,3-d’]bis(thiazole)-4,5-dione (II), showed average μ_e = 8.2 × 10^-5 cm² V^-1 s^-1 in OFET with solution-processed active layer. Unexpectedly, measurable hole transport was observed for 2,7-bis-(5-n-nonyl-thiophen-2-yl)-benzo[1,2-b:6,5-b’]dithiophene-4,5-dione (III) (μ_h = 8.5 × 10^-5 cm² V^-1 s^-1) and 2,6-bis-(thiophen-2-yl)-3,5-di-n-hexyl-4H-cyclopenta[1,2-b:5,4-b’]dithiophen-4-one (IV) (μ_h = 3.7 × 10^-4 cm² V^-1 s^-1). In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Application of 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice was written by Biano, Laiza S.;Oliveira, Alan S.;Palmeira, David N.;Silva, Luis Andre;de Albuquerque-Junior, Ricardo L. C.;Duarte, Marcelo C.;Correa, Cristiane B.;Grespan, Renata;Batista, Josemar S.;Camargo, Enilton A.. And the article was included in Journal of Ethnopharmacology in 2022.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

Leonurus sibiricus L. (Lamiaceae) is a medicinal plant known in Brazil as “rubim” or “erva de macae”. It is used for various purposes, including stomach disorders. To evaluate the effect of the ethanol extract of the aerial parts of L. sibiricus (EELs) in models of gastric damage in mice. The effect of EELs (50, 100 and 300 mg/kg, p.o., 1 h before induction) was tested on acidified ethanol (ACEt)-induced gastric ulcers. Addnl., we tested the effect of EELs (by intraduodenal administration) in the pylorus ligation (PL) model. Pretreatment with EELs, at 300 mg/kg, but not 50 and 100 mg/kg, reduced the relative area of gastric ulcers induced by ACEt (p < 0.01) and lipoperoxidation (p < 0.001), and increased the sulfhydryl content (p < 0.01) in the stomach in comparison with the vehicle group. Pretreatment with N-ethylmaleimide (a blocker of non-protein sulfhydryl groups, 10 mg/kg, i.p.) or glibenclamide (a KATP channel blocker, 10 mg/kg, i.p.) inhibited the gastroprotective response caused by EELs (300 mg/kg; p < 0.001), but there were no alterations due to pretreatments with inhibitors of the synthesis of prostaglandins (indomethacin, 10 mg/kg), nitric oxide (L-NAME, 70 mg/kg) or hydrogen sulfide (DL-propargylglycine, 10 mg/kg). Treatment with EELs (300 mg/kg) reduced mucus production (p < 0.001) and the volume of gastric secretion (p < 0.001) after PL without affecting gastric acidity or pH. These results provide evidence that EELs exerts gastroprotective action in mice, with the participation of oxidative stress and mediation of NP-SH, KATP channels and mucus production In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics