Amides-buliding-blocks

Decolorization kinetics and properties of triphenodioxazine reactive dyes in sodium perborate-TAED bleaching system was written by Zhang, Jun;Zhu, Yang. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2012.Recommanded Product: 10543-57-4 This article mentions the following:

The decolorization behaviors of a triphenodioxazine reactive dye (C.I. Reactive Blue 198) in the activated oxygen bleach system containing sodium perborate (PB) and tetra-acetylethylenediamine (TAED) were investigated. The decolorization kinetics of the dye was found to follow the first-order kinetic model and the rate constant of decolorization increased significantly with increasing temperature The activation energy for decolorizing reaction was 50.41 kJ/mol. The highest rate constant appeared at pH 8. The triphenodioxazine reactive dye showed poor stability to activated oxygen washing. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Protective effects of tranilast on experimental colitis in rats was written by Seto, Yoshiki;Kato, Kouki;Tsukada, Ryota;Suzuki, Hiroki;Kaneko, Yuuki;Kojo, Yoshiki;Sato, Hideyuki;Onoue, Satomi. And the article was included in Biomedicine & Pharmacotherapy in 2017.Product Details of 53902-12-8 This article mentions the following:

The present study aimed to verify the efficacy of tranilast (TL) for treating inflammatory bowel disease (IBD) with the use of an exptl. colitis model. The exptl. colitis model was prepared by intrarectal instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 40 mg/kg) dissolved in water containing 25% ethanol. The pharmacol. effects of TL after repeated oral administration were evaluated by biomarker and histol. analyses, and the pharmacokinetic behavior of TL was also examined after single oral administration. The intrarectal instillation of TNBS solution caused colitis, as evidenced by ca. 2.2-, 5-, and 3-fold increases in myeloperoxidase (MPO) activity, infiltrated cell numbers, and the thickness of the submucosa in the colon, resp. However, orally-taken TL (10 mg/kg, twice a day for 9 days) led to a 92% reduction in the increase of the MPO level by TNBS enema, and cellular infiltration and thickened submucosa in the exptl. colitis model tended to also be suppressed by repeated oral administration of TL. The oral bioavailability of TL in TNBS-treated rats was calculated to be as low as ca. 6.5%, and the poor oral absorption of TL may be a limitation of the treatment for IBD. TL could attenuate TNBS-induced colitis on the basis of the obtained results, and the anti-inflammatory effects would have clin. relevance to the therapeutic outcomes of TL in IBD patients. Although further improvement in the oral bioavailability of TL might be required for better pharmacol. outcomes, TL would be an efficacious agent for treating IBD. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Product Details of 53902-12-8).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Product Details of 53902-12-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A Rapid Injection NMR Study of the Reaction of Organolithium Reagents with Esters, Amides, and Ketones was written by Plessel, Kristin N.;Jones, Amanda C.;Wherritt, Daniel J.;Maksymowicz, Rebecca M.;Poweleit, EricT.;Reich, Hans J.. And the article was included in Organic Letters in 2015.Related Products of 226260-01-1 This article mentions the following:

Unexpectedly high rates of reaction between alkyllithium reagents and amides, compared to esters and ketones, were observed by Rapid Inject NMR and competition experiments Spectroscopic investigations with 4-fluorophenyllithium (ArLi, mixture of monomer and dimer in THF) and a benzoate ester identified two reactive intermediates, a homodimer of the tetrahedral intermediate, stable below -100 °C, and a mixed dimer with ArLi. Direct formation of dimers suggested that the ArLi dimer may be the reactive aggregate rather than the usually more reactive monomer. In contrast, RINMR experiments with ketones demonstrated that the ArLi monomer was the reactive species. In the experiment, the researchers used many compounds, for example, 3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1Related Products of 226260-01-1).

3-Fluoro-N-methoxy-N-methylbenzamide (cas: 226260-01-1) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Related Products of 226260-01-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors was written by Colella, Marco;Tota, Arianna;Takahashi, Yusuke;Higuma, Ryosuke;Ishikawa, Susumu;Degennaro, Leonardo;Luisi, Renzo;Nagaki, Aiichiro. And the article was included in Angewandte Chemie, International Edition in 2020.HPLC of Formula: 116332-61-7 This article mentions the following:

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions were developed, opening new opportunities in the synthesis of fluorinated mols. using fluorinated organometallics. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7HPLC of Formula: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.HPLC of Formula: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of 3,4-difluorobenzonitrile was written by Chen, Qiang;Zhang, Shaohui;Cheng, Zhiming. And the article was included in Jingxi Huagong Zhongjianti in 2006.Recommanded Product: 2670-38-4 This article mentions the following:

3,4-Difluorobenzonitrile is an important intermediate of selective herbicide, cyhalofop Bu. 3,4-Difluorobenzonitrile was synthesized by 3,4-dichlorobenzoyl chloride through amidation, dehydration and fluorination. The yield was 39.8%, and the content was 99.0%. In the experiment, the researchers used many compounds, for example, 3,4-Dichlorobenzamide (cas: 2670-38-4Recommanded Product: 2670-38-4).

3,4-Dichlorobenzamide (cas: 2670-38-4) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 2670-38-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Global trends in research of gouty arthritis over past decade: a bibliometric analysis was written by Deng, Pin;Wang, Shulong;Sun, Xiaojie;Qi, Yinze;Ma, Zhanhua;Pan, Xuyue;Liang, Huan;Wu, Junde;Chen, Zhaojun. And the article was included in Frontiers in Immunology in 2022.Safety of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid This article mentions the following:

Gouty arthritis (GA), as a multifactorial disease, is characterised by intense pain, active inflammation symptoms, and swollen joints. It has utterly complex pathogenesis, of which the amount of research publications on GA has increased during the last few decades. A bibliometric anal. was carried out to investigate the trends, frontiers, and hot spots in global scientific output in GA research over the last decade. We retrieved the Science Citation Index Expanded (SCI-Expanded) of the Web of Science Core Collection (WoSCC) for publications and recorded information published from 2012 to 2021. we carried out the bibliometric anal. and visualisation anal. of the overall distribution of annual outputs, leading countries, active institutions, journals, authors, co-cited references, and keywords with the VOSviewer and CiteSpace. The impact and quality of papers were assessed using a global citation score (GCS). We retrieved 2052 articles and reviews in total. The annual number of publications (Np) related to GA research has increased during the latest decade. China published the most papers, and the USA achieved the highest H-index and number of citations (Nc). The League of European Research Universities (LERU) and Clin. Rheumatol. (Clin Rheumatol) are the most productive institutions and periodicals. The total GCS of the paper written by Kottgen, A. in 2013 was 479, ranking the first. The most common keywords were “Gout,” “hyperuricemia,” and “gouty arthritis.” This research revealed that though there was a slight fluctuation in publications related to GA, the Np raised on the whole. China was an enormous creator, and the USA was an influential nation in this domain. The top three contributor authors were Dalbeth, N., Singh, JA., and Choi, HK. There were few investigations on the treatment of GA by Chinese medicine monomer, and the “mechanism,” “pathway”, “nf- kappa-b”, “injury”, “receptor”, and “animal model” were growing research hotspots. Our research illustrated the hotspots of research and development trends in the research field of GA during the last decade. Recognition of the most critical indicators (researchers, countries, institutes, and journals for the release of GA research), hotspots in the research field of GA can be helpful for countries, scholars, and policymakers in this field to understand GA better make decisions. In the experiment, the researchers used many compounds, for example, 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8Safety of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid).

2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid (cas: 53902-12-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Safety of 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The Influence of Intravenous Transplantation of Mesenchymal Stem Cells on the Functional Activity of KATP Channels of Pial Arteries after Ischemia/Reperfusion of the Brain was written by Sokolova, I. B.;Gorshkova, O. P.;Pavlichenko, N. N.. And the article was included in Cell and Tissue Biology in 2022.Product Details of 10238-21-8 This article mentions the following:

The aim of this work was to study the effect of i.v. transplantation of human mesenchymal stem cells (hMSCs) on the functional state of KATP channels of smooth-muscle cells of cerebral arteries at different times of the postischemic period. Using a device for intravital visualization of pial vessels, the reaction of arteries to the KATP-channel blocker glibenclamide (GC), the activator of the same channels of pinacidil (PI), acetylcholine (ACh), and ACh against a background of GC action (ACh/GC) 7, 14, and 21 days after cerebral ischemia/reperfusion (I/R) and i.v. hMSC transplantation. On exposure to GC 7 days after I/R, two to five times fewer arteries narrowed than in the SO group and 1.5 times fewer expanded after PI. The introduction of hMSCs on the day of I/R of the brain after 7 days had no effect on the functioning of KATP channels: the constrictor reaction to GC and the dilator reaction to PI in this group were the same as in animals that underwent I/R. Fourteen days after I/R, the number of narrowed pial arteries on GC was 1.5-2 times less than in SO rats; the number of arteries that responded with dilatation to PI was 2-2.5 times less. In the cell-therapy group, for 14 days after I/R, the number of pial arteries that narrowed under the influence of GC and expanded under that of PI almost completely corresponded to those in SO rats. On day 21 after I/R, complete recovery of pial-artery responses to GC to the level in LO rats was observed In the cell-therapy group, the reactivity of the pial arteries fully corresponded to the indicators in the SO group of animals. The functional state of KATP channels after I/R of the brain was assessed by comparing the dilator reactions of the pial arteries when exposed to pure ACh and ACh against a background of KATP channels being blocked with glibenclamide (ACh/GC). In SO animals, GC blocked the dilator reaction to ACh. The application of ACh against the background of GC increased the number of dilatations 7-14 days after I/R. After 21 days, the number of dilated vessels on exposure to ACh and ACh/GC was the same. In animals with transplanted hMSCs, excluding the first 7 days, GC blocked the dilator reaction of the pial arteries to ACh in the same way as in the SO group. It can be concluded that I/R of the rat cerebral cortex reduces the contribution of KATP channels to maintaining the basal tone of the pial arterial vessels. Changes persist for 14 days after ischemic exposure. At the same time, in the period from 7 to 21 days after I/R, the role of KATP channels in the dilatation of pial arteries on ACh decreased and by day 21 channels practically did not participate in the dilator response. I.v. transplantation of hMSCs on the day of brain I/R results in earlier (as early as after 14 days) restoration of participation of SMC KATP channels in maintaining the basal tone and ACh-mediated dilatation of pial arteries. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Product Details of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation was written by Muir, Calum W.;Kennedy, Alan R.;Redmond, Joanna M.;Watson, Allan J. B.. And the article was included in Organic & Biomolecular Chemistry in 2013.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide This article mentions the following:

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochem. properties and which are emerging as key pharmacophores for a range of biol. targets. A tandem Horner-Wadsworth-Emmons olefination/cyclization method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups. E.g., tandem Horner-Wadsworth-Emmons olefination/cyclization of 1-phenyl-2-(pyridin-2-yl)ethanone (I) with tri-Et phosphonoacetate gave 92% 4H-quinolizin-4-one derivative (II). I was prepared as 3:1 keto:enol and approx. 3.8:1 enol olefin stereoisomers. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application In Synthesis of 4-Bromo-N-methoxy-N-methylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Novel and efficient one-pot tandem synthesis of tryptanthrin derivatives for biological activity was written by Rama Krishnam Raju, Addada;Venkata Reddy, Regalla;Venkateswara Rao, Anna. And the article was included in International Journal of Pharma Research and Health Sciences in 2018.Related Products of 54166-95-9 This article mentions the following:

The derivatives of tryptanthrins I [R = H, 1-Me, 2-Br, etc; R¹ = H, 8-OMe, 8-Br, etc.] were prepared from three schemes. Those tryptanthrin derivatives I were characterized by NMR study. Treatment of an equimolar mixture of anthranilamides and 2-bromoacetophenones afforded indolo[2,1-b]-quinazoline-6,12-diones (tryptanthrin). In the experiment, the researchers used many compounds, for example, 6-Chloro-2-aminobenzamide (cas: 54166-95-9Related Products of 54166-95-9).

6-Chloro-2-aminobenzamide (cas: 54166-95-9) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 54166-95-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

C-H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes was written by Massignan, Leonardo;Tan, Xuefeng;Meyer, Tjark H.;Kuniyil, Rositha;Messinis, Antonis M.;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2020.COA of Formula: C9H10BrNO2 This article mentions the following:

The catalytic generation of hypervalent iodine(III) reagents by anodic electrooxidation was orchestrated towards an unprecedented electrocatalytic C-H oxygenation of weakly coordinating aromatic amides and ketones. Thus, catalytic quantities of iodoarenes in concert with catalytic amounts of ruthenium(II) complexes set the stage for versatile C-H activations with ample scope and high functional group tolerance. Detailed mechanistic studies by experiment and computation substantiate the role of the iodoarene as the electrochem. relevant species towards C-H oxygenations with electricity as a sustainable oxidant and mol. hydrogen as the sole byproduct. Para-Selective C-H oxygenations likewise proved viable in the absence of directing groups. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2COA of Formula: C9H10BrNO2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.COA of Formula: C9H10BrNO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics