Category: 99733-18-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 99733-18-3

General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL×2). The combined organic phase was washed with water (20 mL×3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.

According to the analysis of related databases, 99733-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 99733-18-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-(4-((5-(((5-(/tvV-butyl (oxazol-2-yl (methyl (thio)thiazol -2- yl)carbamoyl)piperidin-l-yl)acetic acid (200 mg, 0. 46 mmol) in DMF (5 mL) was added tert- butyl (7-aminoheptyl)carbamate (126 mg, 0.55 mmol) and DIEA (118 mg, 0.92 mmol), followed by HOBt (93 mg, 0.69 mmol) and EDCTHCl (133 mg, 0.69 mmol). After overnight at RT, the mixture was diluted with H2O and extracted with EA. The combined organic layers were washed with saturated NaHC03, dried over Na2S04, filtered and concentrated to give the crude product, which was purified using silica gel eluting with MeOH/DCM (0% to 10%) to give /c/V-butyl (7- (2-(4-((5-(((5-(/er/-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)carbamoyl)piperidin-l- yl)acetamido)heptyl)carbamate (243 mg, 82% yield) as a solid. MS (ESI) m/z 651.2 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl (7-aminoheptyl)carbamate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BIOTHERYX, INC.; CHAN, Kyle W.H.; CHOURASIA, Aparajita Hoskote; ERDMAN, Paul E.; FUNG, Leah; HECHT, David Aaron; MERCURIO, Frank; SULLIVAN, Robert; VACCA, Joseph P.; (156 pag.)WO2020/23782; (2020); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 99733-18-3,Some common heterocyclic compound, 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, molecular formula is C12H26N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL¡Á2). The combined organic phase was washed with water (20 mL¡Á3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (7-aminoheptyl)carbamate, its application will become more common.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics