Category: 97-35-8

Adding a certain compound to certain chemical reactions, such as: 97-35-8, name is 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97-35-8, Product Details of 97-35-8

EXAMPLE 12 Synthesis of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonyl-aminocarbonyl)naphthalene STR22 3-Amino-4-methoxydiethylaminosulfonylbenzene (15.6 g), N-methyl-2-pyrrolidone (86.1 g) and toluene (34.3 g) were dissolved at room temperature and the acid chloride (5.4 g) obtained in Example 6 was gradually added, and then the mixture was amidated at 90 C. for 24 hours. After the reaction solution was cooled to 25 C. and filtered, toluene was distilled off under reduced pressure. Then, the solution was crystallized by using methanol (350.1 g). The resultant product was filtered and then dried to obtain 8.9 g of 2-hydroxy-3,6-bis(2-methoxy-5-diethylaminosulfonylphenyl-aminocarbonyl)naphthalene as a cream powdered crystal (DSC analysis value: 245.0 C.). An infrared spectrum (KBr method) of this compound is shown in FIG. 12.

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Reference:
Patent; Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo; US5786523; (1998); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 97-35-8,Some common heterocyclic compound, 97-35-8, name is 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide, molecular formula is C11H18N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 Production of 3-amino-N,N-diethyl-4-hydroxybenzenesulfonamide 3-Amino-N,N-diethyl-4-methoxybenzenesulfonamide (5 g) was dissolved in methylene chloride (150 mL). Under ice-cooling, boron tribromide (1.0 M methylene chloride solution, 38.7 mL) was added dropwise, and the mixture was stirred overnight at room temperature. Water (150 mL) was added dropwise to the reaction mixture under ice-cooling, and the aqueous layer was washed with chloroform. The obtained aqueous layer was weak acidified with 4N aqueous sodium hydroxide under ice-cooling. The precipitated solid was collected by filtration to give the title compound (4.0344 g) as a pale-beige solid.

The synthetic route of 97-35-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Japan Tobacco Inc.; US2008/64871; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics