Category: 97-09-6

On August 28, 2012, Song, Li-feng; Guo, Lin; Tang, Yong; Yin, Yong-bo published an article.SDS of cas: 97-09-6 The title of the article was Preparation of N-Alkyl substituted 3-amino-4-chloro-benzenesulfonamides. And the article contained the following:

N-Alkyl substituted 3-amino-4-chloro-benzenesulfonamides were important intermediates for preparing acid dyes and disperse dyes in peculiar field. The synthesis routes and their advantages and disadvantages of 4-chloro-3-aminobenzenesulfonamide and its N-alkyl substituted compounds were evaluated. Chlorosulfonic acid was replaced by thionyl chloride in the preparation of sulfonic acid chloride and industrial waste acid was reduced largely. Sodium sulfide reduction or iron powder reduction were instead by hydrogenation reduction, the yield was improved with energy saving and environmental protection. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to preparation amino chloro benzenesulfonamide dye, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Dye Intermediates and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vasin, V. S.; Koldaeva, T. Yu.; Perevalov, V. P. published an article in 2012, the title of the article was Synthesis of derivatives of 2-(2-hydroxyphenyl)-2H-benzotriazole-4-carboxylic acid containing sulfonamide group in phenyl moiety.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

The method of synthesis of I from 3,5-diamino-4-chlorobenzoic acid and N-phenylamide of 3-amino-4-hydroxybenzenesulfonic acid was developed. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to hydroxyphenyl benzotriazolecarboxylic acid sulfonamide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 19, 2019, Ku, Yi-Yin; Chan, Vincent S.; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D. published an article.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor. And the article contained the following:

The process development of a new synthetic route leading to an efficient and robust synthetic process for venetoclax (1: the active pharmaceutical ingredient (API) in Venclexta) is described. The redesigned synthesis features a Buchwald-Hartwig amination to construct the core ester 23c (2 tert-Bu ester) in a convergent fashion by connecting two key building blocks (4c and 26), which is then followed by a uniquely effective saponification reaction of 23c using anhydrous hydroxide generated in situ to obtain 2. Finally, the coupling of the penultimate core acid 2 with sulfonamide 3 furnishes drug substance 1 with consistently high quality. The challenges and solutions for the key Pd-catalyzed C-N cross-coupling will also be discussed in detail. The improved synthesis overcomes many of the initial scale-up challenges and was accomplished in 46% overall yield from 3,3-dimethyldicyclohexanone (6), more than doubling the overall yield of the first generation route. The new process was successfully implemented for producing large quantities of 1 with >99% area purity. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to venetoclax large scale synthesis buchwald hartwig amination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2020, Hardouin, Christophe; Baillard, Sandrine; Bariere, Francois; Craquelin, Anthony; Grandjean, Mathieu; Janvier, Solenn; Le Roux, Stephane; Penloup, Christine; Russo, Olivier published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction. And the article contained the following:

This paper describes the synthesis of kilogram quantities of the sulfonamide moiety I involved in a coupling reaction with acid moiety II to provide batches of drug candidate III for preclin. studies and first-in-human clin. trials. A first approach relying on a chiral separation furnished the desired enantiomer of 1,3-diamine IV, precursor of sulfonamide I. An enantiomeric synthesis of IV using the Ellman’s chiral auxiliary coupled with an aza-Reformatsky reaction to control the stereochem. is also discussed. Coupling conditions of the final step involving EDCI to provide III under a cGMP process are detailed. An alternative approach using N-(1-methanesulfonyl)benzotriazole is also presented. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to acylsulfonamide diamine telescoped process aza reformatsky coupling chemoselective amination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 29, 1980, Elliott, Arthur J.; Gibson, Martin S. published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Hydrazides and thiohydrazides as sources of condensed oxadiazines and thiadiazines, including novel azo derivatives based on dithizone. And the article contained the following:

Condensation reactions of N’-phenylbenzohydrazide, N’-phenylbenzothiohydrazide, and dithizone with a variety of activated aromatic and heteroaromatic 1,2-dihalo and 1-halo-2-nitro compounds are described in which the hydrazide or thiohydrazide functions as a bidentate nucleophile. These reactions lead to derivatives of the 4H-1,3,4-benzoxadiazines e.g. I, and 4H-1,3,4-benzothiadiazines and analogous pyrimido-, pyrazino-, and quinoxalinooxadiazines and -thiadiazines, which are representative of new ring systems. The corresponding reaction of N’-phenylbenzothiohydrazide with chloranil proceeds with expulsion of S. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to cyclocondensation hydrazide thiohydrazide, oxadiazine condensed, thiadiazine condensed, benzoxadiazine, benzothiadiazine, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three, Four, Or Five Hetero Atoms and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 10, 2019, Liu, Kai; Li, Nian; Ning, Yunyun; Zhu, Chengjian; Xie, Jin published an article.Recommanded Product: 97-09-6 The title of the article was Gold-Catalyzed Oxidative Biaryl Cross-Coupling of Organometallics. And the article contained the following:

A general dimeric gold-catalyzed oxidative cross-coupling of arylboronates ArB(-OCH2C(CH3)2CH2O-) (Ar = 3-methoxyphenyl, naphthalen-2-yl, 8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2(7),3,5,9,11-hexaen-6-yl, etc.) and arylsilanes Ar1Si(CH3)3 (Ar1 = 4-iodophenyl, 4-(trifluoromethanesulfonyloxy)phenyl, 2,3-dimethylphenyl, etc.) without an external base for the synthesis, with excellent functional-group tolerance of asym. biaryls ArAr1 was reported. Both coupling partners are readily available, bench-stable, and non-toxic. A broad array of (pseudo)halogenated and borylated coupling partners can be successfully applied to this site-specific biaryl coupling with unprecedented versatility. Its synthetic value has been substantiated by concise preparation of several π-conjugated organic materials and pharmacophores. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

The Article related to biaryl preparation green chem, boronate aryl silane oxidative suzuki miyaura gold catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 97-09-6

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 1982, Plakidin, V. L.; Vostrova, V. N. published an article.Synthetic Route of 97-09-6 The title of the article was Reaction of 2,4-disubstituted chlorobenzenes with 3-alkylamino and 3-dialkylaminopropionitriles. And the article contained the following:

Reaction of I (R, R1 = H, NO2; NO2, NO2; NO2, Cl; NO2, SO2Me; NO2, SO2NH2; NO2, SO2NMe2; CN, NO2) with R22NCH2CH2CN (R2 = Me, Et) at 65-170° gave (via the quaternary salt) II (13 compounds), and with R2NHCH2CH2CN (R2 = Me, Et) at 20-130° gave III (11 compounds). At ∼130° cleavage of the cyanomethyl group from III was observed The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Synthetic Route of 97-09-6

The Article related to substituted chlorobenzene amino nitrile, aniline derivative, benzenamine derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Synthetic Route of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 2, 2002, Bhattacharya, Gautam; Salem, Manar M.; Werbovetz, Karl A. published an article.Formula: C6H5ClN2O4S The title of the article was Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. And the article contained the following:

Novel dinitroaniline sulfonamides based on the herbicide oryzalin were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound I displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S

The Article related to dinitroaniline sulfonamide preparation, antiparasitic leishmanial tubulin polymerization inhibiting aniline dinitro sulfonamide derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Dongsheng; Guo, Haijun; Chang, Yu; Ni, Yun; Li, Lin; Zhang, Zhi-Min; Hao, Piliang; Xu, Yong; Ding, Ke; Li, Zhengqiu published an article in 2018, the title of the article was Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.Category: amides-buliding-blocks And the article contains the following content:

Venetoclax (ABT-199) and idasanutlin (RG7388) are efficient anticancer drugs targeting two essential apoptosis markers, Bcl-2 and MDM2, resp. Recent studies have shown that the combination of these two drugs leads to remarkable enhancement of anticancer efficacy, both in vitro and in vivo. In an attempt to disclose the relationships of their protein targets, competitive affinity-based proteome profiling coupled with bioimaging was employed to characterize their protein targets in the same cancer cell line and tumor tissue. A series of protein hits, including ITPR1, GSR, RER1, PDIA3, Apoa1, and Tnfrsf17 were simultaneously identified by pull-down/LC-MS/MS with the two sets of affinity-based probes. Dual imaging was successfully carried out, with the simultaneous detection of Bcl-2 and MDM2 expression in various cancer cells. This could facilitate the novel diagnostic and therapeutic strategies of dual targeting of Bcl-2/MDM2. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Category: amides-buliding-blocks

The Article related to proteomics imaging apoptosis marker venetoclax idasanutlin drug target, affinity-based probes, antitumor agents, apoptosis biomarkers, combination drugs, target identification and other aspects.Category: amides-buliding-blocks

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VII. Structure-activity relations of sulfonamide carbonic anhydrase inhibitors. 2.Application of 97-09-6 And the article contains the following content:

Diuretic, natriuretic activities, and duration of the diuretic action in rats were studied with 22 sulfonamide derivatives To clarify the active form of the sulfonamides, the effect of pH of the rat body fluid on the diuretic activity was studied. The diuretic and natriuretic activities of the sulfonamides increased with an increase in their carbonic anhydrase inhibitory activity except for o-substituted benzenesulfonamides, disubstituted benzenesulfonamides, and 2-amino-1,3,4-thiadiazole-5-sulfonamide. A close relation between diuretic and natriuretic activities with the electronic characteristics of the sulfamoyl group, such as Hammett’s σ constant, pKa, NMR chem. shift of the sulfamoyl protons, and S:O valence-force constant was observed for the derivatives with some exceptions. A compound having a large partition coefficient and strong albumin binding ability showed long duration of the diuretic action. The diuretic and natriuretic activities of sulfonamides were enhanced by an increase in their dissociation constants The diuretic activity was enhanced under alkaline conditions. It was concluded that the active form of the sulfonamide carbonic anhydrase inhibitors was the ionized form. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to sulfonamides diuresis natriuresis, diuresis natriuresis sulfonamides, natriuresis sulfonamides diuresis, carbonic amhydrase drug, amhydrase carbonic drug, drug carbonic anhydrase and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics