Category: 97-09-6

Nelson, G. L.; Webb, J. L. published an article in 1973, the title of the article was Oxygen index of liquids. Halogen compounds.Application of 97-09-6 And the article contains the following content:

The oxygen indices of 150 halogenated compounds are reported and the effectiveness of F, Cl, Br, and I substituents on fire retardancy compared. All halogens were more effective in aromatic compounds than in aliphatic materials. On average, the introduction of a single halogen atom into aromatic compounds increased the oxygen index 1.5 unit/F atom. 4.3 units/Cl atom, 7.4 units/Br atom, and 6.5 units/I atom. The introduction of greater numbers of halogen atoms in aromatic compounds led to a nonlinear increase in oxygen index. Particularly in the case of F and Cl, highly specific structural effects were seen. Halogen can be particularly effective for aromatic systems containing other electron-withdrawing groups. Perhaps this is due to the increased difficulty in oxidation imposed on an already electron-poor organic system. Polyacromaticity had a strong enhancement of fire retardancy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to oxygen index halogen compound, fire retardancy halogen compound, safety fire halogen compound, Propellants and Explosives: General and other aspects.Application of 97-09-6

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Tinland, Bernard published an article in 1973, the title of the article was Theoretical EHT [extended Hueckel theory] study of structure-activity relations in a series of sulfonamides.Electric Literature of 97-09-6 And the article contains the following content:

The carbonic anhydrase inhibitory activities of 17 sulfonamides were compared with their structures, based on quantum chem. calculations performed within the framework of the extended Hueckel theory. Correlations were found between the activity of mols. and the reduced Mulliken overlap populations relative to the SO2 group. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6

The Article related to sulfonamide structure activity, quantum chem drug activity, carbonic anhydrase sulfonamide, Pharmacodynamics: Structure-Activity and other aspects.Electric Literature of 97-09-6

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On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:

The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6

The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6

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On September 15, 2018, Liu, Renshuai; Liu, Lulu; Liu, Tingting; Yang, Xinying; Wan, Yichao; Fang, Hao published an article.Name: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors. And the article contained the following:

Anti-apoptotic Bcl-2 family proteins are vital for cancer cells to escape apoptosis, which make them attractive targets for cancer therapy. Recently, a lead compound I was found to modestly inhibit the binding of BH3 peptide to Bcl-2 protein with a Ki value of 5.2 μM. Based on this, a series of substituted tyrosine derivatives were developed and tested for their binding affinities to Bcl-2 protein. Results indicated that these compounds exhibited potent binding affinities to Bcl-2 and Mcl-1 protein but not to Bcl-XL protein. Promisingly, compound II inhibited the binding of BH3 peptide to Bcl-2 and Mcl-1 protein with a Ki value of 450 and 190 nM resp., and showed obvious anti-proliferative activities against tested cancer cells. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to tyrosine derivative synthesis anticancer bcl2 mcl1, anti-tumor, apoptosis, bcl-2, mcl-1, tyrosine, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Name: 3-Nitro-4-chlorobenzenesulfonamide

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On July 1, 2019, Chen, Chen; Nie, Yiming; Xu, Guangsen; Yang, Xinying; Fang, Hao; Hou, Xuben published an article.Computed Properties of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. And the article contained the following:

Bcl-2 family proteins, which divides into pro-apoptosis proteins and anti-apoptosis proteins, are involved in cell apoptosis progression. As numerous studies illustrated, targeting Bcl-2 family proteins is more and more attractive and practicable to cancer treatment. In this work, we designed and synthesized a series of indomethacin derivatives as new inhibitors for Bcl-2 family proteins. Our results of binding assay to Bcl-2 proteins, MTT assay and apoptotic assay indicated that some compounds had potent binding affinity to Bcl-2/Mcl-1 but not Bcl-xL. Furthermore, compound 8j showed improved anti-proliferative activity than known Bcl-2 inhibitor WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Computed Properties of 97-09-6

The Article related to apoptosis anticancer bcl2 mcl1 dual inhibitor indomethacin derivative, anticancer, apoptosis, bcl-2/mcl-1 dual inhibitor, indomethacin derivatives, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Computed Properties of 97-09-6

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Hardia, Sunita Patel; Khadikar, Padmakar V. published an article in 2008, the title of the article was QSAR study on diuretic activity of sulphonamides using force-constant.SDS of cas: 97-09-6 And the article contains the following content:

This is the first report on the use of valence force constant for modeling diuretic activity of benzene sulfonamides. The authors used both the regular as well as robust multiple regression analyses for this purpose. Statistically significant models are obtained in multi-parametric regression anal. upon introduction of indicator parameters. The results are discussed critically using variety of statistics. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to qsar diuretic sulfonamide force, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.SDS of cas: 97-09-6

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On February 1, 2016, Hopp, Jens; Trieloff, Mario; Ott, Ulrich published an article.Computed Properties of 97-09-6 The title of the article was I-Xe ages of enstatite chondrites. And the article contained the following:

In order to elucidate the early thermal history of enstatite chondrite parent bodies we determined 129I-129Xe whole rock ages of enstatite chondrites (5 EH, 2 EL, one EH impact melt) relative to the Shallowater reference meteorite (4562.3 ± 0.4 Ma, all errors are 1σ). I-Xe ages of both EL6 chondrites (LON 94100: -4.38 ± 0.60 Ma and Neuschwanstein: -3.87 ± 0.73 Ma – neg. sign indicates ages younger than Shallowater) agree well with data of other EL6 chondrites. LON 94100 displayed a second isochron at lower temperatures equivalent to a younger age of -5.25 ± 1.17 Ma, perhaps reflecting different retention temperatures of resp. carrier phases during sequential cooling. The enstatite chondrites Abee (EH4), Indarch (EH4), EET 96135 (EH4/5) and St. Marks (EH5) encompass a I-Xe age range of +0.57 ± 1.05 Ma (EET 96135 #1) to -0.45 ± 0.72 Ma (Abee), again in agreement with previously reported ages of EH chondrites. Only the age of St. Marks differs strongly from previously reported younger ages, now being more in accordance with other members of the EH clan. The EH3 chondrite Sahara 97096 showed the youngest I-Xe age of -7.87 ± 0.46 Ma distinctly younger than other I-Xe ages of EH chondrites, including other EH3s. Due to the apparent high retention temperature of the I-Xe system in enstatite (estimated >800 °C) this young age implies a later resetting of the I-Xe system by a severe thermal, likely impact-induced, event. The EH impact melt LAP 02225 records a similarly young thermal event. Though no isochron relationship could be established, the data fall within an apparent I-Xe age range of +5 to +15 Ma, similar to Sahara 97096. Overall, EH chondrite parent body experienced a thermal history determined by a complex interplay between impact disturbances and parent body metamorphism. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Computed Properties of 97-09-6

The Article related to iodine xenon age enstatite chondrite, Mineralogical and Geological Chemistry: Cosmochemistry and Meteorites and other aspects.Computed Properties of 97-09-6

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On May 31, 2010, Yoshida, Tatsusada; Munei, Yohei; Hitaoka, Seiji; Chuman, Hiroshi published an article.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Correlation Analyses on Binding Affinity of Substituted Benzenesulfonamides with Carbonic Anhydrase Using ab Initio MO Calculations on Their Complex Structures. And the article contained the following:

Quant. structure-activity relationship analyses on the free energy change during complex formation between substituted benzenesulfonamides (BSAs) and bovine carbonic anhydrase II (bCA II) were performed using generalized Born/surface area (GB/SA) and ab initio fragment MO (FMO) calculations for the whole complex structures. The result shows that the overall free energy change is governed by the contribution from solvation and dissociation free energy changes accompanying complex formation. The FMO-IFIE (interfragment interaction energy) anal. quant. revealed that the intrinsic interaction energy of bCA II with BSAs is mostly from interactions with amino acid residues in the active site of bCA II. The “Zn block” (Zn2+ and three histidine residues coordinated to Zn2+) in the active site shows the lowest interaction energy and the greatest variance of interaction energy with BSAs through their coordination interaction. The proposed procedure was demonstrated to provide a quant. basis for understanding a ligand-protein interaction at electronic and at. levels. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to binding affinity model benzenesulfonamide derivative carbonic anhydrase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
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On July 31, 1981, Kumar, Kamal; Bindal, Mahesh C.; Singh, Prithvi; Gupta, Satya P. published an article.SDS of cas: 97-09-6 The title of the article was Effect of molecular size on carbonic anhydrase inhibition by sulfonamides. And the article contained the following:

Mol. size plays an important role in carbonic anhydrase inhibition by sulfonamides. Significant correlation is obtained between the inhibitory power of meta-substituted analogs and the van der Waals volume of the substituents. This provides a theor. basis for mapping the active sites in the enzyme and determining the nature of sulfonamide-receptor binding. It is inferred that, in addition to the well-known binding of the sulfamyl group with the Zn2+ ion of the enzyme, the meta substituent of sulfonamides interacts with some secondary binding site; this interaction is argued to be of van der Waals type. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to carbonic anhydrase inhibition sulfonamide mol volume, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.SDS of cas: 97-09-6

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Amide – an overview | ScienceDirect Topics

On January 1, 2011, Munei, Yohei; Shimamoto, Kazunori; Harada, Masataka; Yoshida, Tatsusada; Chuman, Hiroshi published an article.Computed Properties of 97-09-6 The title of the article was Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II). And the article contained the following:

We proposed a novel QSAR (quant. structure-activity relationship) procedure called LERE (linear expression by representative energy terms)-QSAR involving mol. calculations such as ab initio fragment MO and generalized Born/surface area ones. We applied LERE-QSAR to two datasets for the free-energy changes during complex formation between carbonic anhydrase and a series of substituted benzenesulfonamides. The first compound set (Set I) and the second one (Set II) include relatively small substituents and alkyl chains of different lengths in the benzene ring, resp. Variation of the inhibitory activity in Set I is expressed as the combination of Hammett σ and the hydrophobic substituent constant π in classical QSAR, and variation in Set II only by π. LERE-QSAR analyses clearly revealed that effects of σ and π on the activity variations in Sets I and II are consistently explainable with the energy terms in the LERE formulation, and provide more detailed and direct information as to the binding mechanism. The proposed procedure was demonstrated to provide a quant. basis for understanding ligand-protein interactions at the electronic and at. levels. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Computed Properties of 97-09-6

The Article related to benzenesulfonamide carbonic anhydrase ab initio mo, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Computed Properties of 97-09-6

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Amide – an overview | ScienceDirect Topics