Category: 97-09-6

Khadikar, Padmakar V.; Joshi, Ashok; Jaliwala, Yusuf Ali; Joshi, Shoba; Thakral, Gurubhaj Sing published an article in 2007, the title of the article was First study on the use of valence force constant for modeling carbonic anhydrase inhibition robust multiple regression approach.Electric Literature of 97-09-6 And the article contains the following content:

The paper describes the novel use of valence force constant f (S = 0) as a mol. descriptor for modeling carbonic anhydrous (CA) inhibition by benzene sulfonamides using robust multiple regression approach. A variety of statistics are used for this purpose. The paper is the first study which evidence by means of QSAR calculations on isoenzyme-specific features of benzene sulfonamide CA inhibitors. The results have shown that excellent model is obtained in multiparametric regression upon introduction of indicator parameters. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6

The Article related to valence force constant qsar carbonic anhydrase inhibition computational model, Pharmacology: Structure-Activity and other aspects.Electric Literature of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 23, 2001, Meng, C. Q.; Zheng, X. S.; Holt, L. A.; Hoong, L. K.; Somers, P. K.; Hill, R. R.; Saxena, U. published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Nitrobenzene Compounds Inhibit Expression of VCAM-1. And the article contained the following:

A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to nitrobenzene compound structure activity cell adhesion mol vcam1, Pharmacology: Structure-Activity and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pandey, Asutosh Kumar published an article in 2013, the title of the article was On diuretic activity of benzene sulfonamide using 113 C NMR chemical shift as a molecular descriptor: regular vs ridge regression.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Diuretic activity p1/C of benzene sulfonamides was modeled using 13 C NMR chem. shift as a mol. descriptor. The regression analyses were carried out using regular as well as Ridge multiple regression analyses. Application of variety of statistics namely statistics, Ridge regression and parameter derived there were used for modeling the diuretic activity. Results have shown that 13 C NMR chem. shift yields an excellent model. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to benzene sulfonamide diuretic nmr chem shift mol descriptor qsar, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2005, Khadikar, Padmakar V.; Sharma, Vimukta; Karmarkar, Sneha; Supuran, Claudiu T. published an article.SDS of cas: 97-09-6 The title of the article was Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters. And the article contained the following:

A novel use of NMR chem. shift of the SO2NH2 protons (in dioxane as solvent) as a mol. descriptor is described for modeling the inhibition constant for benzene sulfonamides against the zinc enzyme carbonic anhydrase (CA, E.C. 4.2.1.1). The methodol. is extended to model diuretic activity and lipophilicity of benzene sulfonamide derivatives The regression anal. of the data has shown that the NMR chem. shift is incapable of modeling lipophilicity. However, it is quite useful for modeling the diuretic activity of these derivatives The results are compared with those obtained using distance-based topol. indexes: Wiener (W)-, Szeged (Sz)-, and PI (Padmakar-Ivan) indexes. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to nmr chem shift carbonic anhydrase inhibitor diuretic qsar, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 1989, Menziani, Maria Cristina; De Benedetti, Pier G.; Gago, Federico; Richards, W. Graham published an article.Related Products of 97-09-6 The title of the article was The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships. And the article contained the following:

Mol. mechanics methods were used to study the interaction between a series of 20 deprotonated benzenesulfonamides and the enzyme carbonic anhydrase. The different contributions to the binding energy were evaluated and correlated with exptl. inhibition data and MO indexes of the sulfonamides in their bound conformation. The results suggest that the discrimination shown by the enzyme towards these inhibitors is dominated by the short-range van der Waals forces. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to benzenesulfonamide binding carbonic anhydrase structure, Pharmacology: Structure-Activity and other aspects.Related Products of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khadikar, Padmakar V.; Jatiwala, Yusuf Ali; Lakhwani, Meenakshi; Thakur, Poornima; Joshi, Shobha; Joshi, Ashok published an article in 2006, the title of the article was QSAR studies on inhibitory properties of benzenesulfonamides towards CAI. Dominating role of Vander Waals repulsion energy.SDS of cas: 97-09-6 And the article contains the following content:

The structure-activity correlations as well as quant. structure activity relation (QSAR) study for benzene-sulfonamides possessing carbonic anhydrase (CA) inhibitory property towards CAI have been discussed using a series of distance-based topol. indexes together with binding energy of the sulfonamide to CA, Van der Waals repulsion energy and indicator parameters. Excellent results were obtained though multiple regression anal. The results are discussed with a variety of statistics. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to qsar carbonic anhydrase inhibitor benzenesulfonamide, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2017, Liu, Tingting; Wan, Yichao; Liu, Renshuai; Ma, Lin; Li, Minyong; Fang, Hao published an article.COA of Formula: C6H5ClN2O4S The title of the article was Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. And the article contained the following:

The B-cell lymphoma-2 (Bcl-2) family proteins are attractive targets for cancer therapy. In the previous work, the structure-activity relationship of WL-276 was studied. According to the results, rhodanine derivatives show potent binding affinity for Bcl-2 and Mcl-1 protein and show weaker activity against Bcl-XL protein. Based on the previous results, a new class of indole-3-carboxylic acid-based derivatives were designed and synthesized as Bcl-2/Mcl-1 dual inhibitors. Among them, compound I has a Ki value of 0.26 μM for Bcl-2 protein and is better than WL-276. Furthermore, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 72 nM. Especially, compound II can selectively acting on Bcl-2 and Mcl-1 protein but not Bcl-XL protein, which has great significance for developing dual inhibitors targeting Bcl-2 and Mcl-1 protein, as well as specific antitumor abilities in cells. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).COA of Formula: C6H5ClN2O4S

The Article related to indolecarboxylate bcl2 mcl1 inhibitor antitumor neoplasm, anti-tumor, bcl-2/mcl-1, indole-3-carboxylic acid-based derivatives, inhibitors, Pharmacology: Structure-Activity and other aspects.COA of Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2015, Wang, Gang; Wang, Yutao; Wang, Lei; Han, Leiqiang; Hou, Xuben; Fu, Huansheng; Fang, Hao published an article.Product Details of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. And the article contained the following:

Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Product Details of 97-09-6

The Article related to imidazolidine dione derivative preparation bcl2 inhibitor antitumor leukemia, antitumor, bcl-2, imidazolidine-2,4-dione, inhibitors, Pharmacology: Structure-Activity and other aspects.Product Details of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 1985, De Benedetti, Pier G.; Menziani, M. Cristina; Frassineti, Chiara published an article.Reference of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was A quantum chemical QSAR study of carbonic anhydrase inhibition by sulfonamides. Sulfonamide carbonic anhydrase inhibitors: quantum chemical QSAR. And the article contained the following:

MO indexes were computed (CNDO/2) for 3 series of sulfonamide inhibitors, (in their neutral and anionic forms) of carbonic anhydrase  [9001-03-0]. Linear regression analyses between the calculated indexes and both physico-chem. and enzyme inhibition data gave good correlations which allowed the testing of predictive and diagnostic aspects of the quant. structure-activity relationships employing quantum chem. indexes. Results indicated that the mol. size affects the inhibitory power among the different sulfonamide derivatives (aliphatic, arylic and bridged diarylic) but not significantly within each mol. series. Results indicated further that the MO indexes are good predictors of the various exptl. mol. properties and suggest that the less electron-rich the sulfamoyl group is, the more favored are both the hydrophobic and hydrophilic steps leading to enzyme inhibition. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to carbonic anhydrase inhibition sulfonamide qsar, qsar sulfonamide derivative, structure activity sulfonamide derivative, mo sulfonamide, Pharmacology: Structure-Activity and other aspects.Reference of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2020, Uslu, Azize Gizem; Maz, Tugce Gur; Nocentini, Alessio; Banoglu, Erden; Supuran, Claudiu T.; Caliskan, Burcu published an article.Formula: C6H5ClN2O4S The title of the article was Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors. And the article contained the following:

We describe the synthesis of a series of 2-arylbenzimidazole derivatives bearing sulfonamide functionality (4a-d, 7a-c and 10) as well as hydroxamic acid (15a-b), carboxylic acid (16a-b), carboxamide (17a-b) and boronic acid (22a-b and 26) functionalities, which act as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors. The newly synthesized benzimidazole derivatives were evaluated against 4 physiol. relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, resp. Notably, compound 4c was the most potent and selective CA IX (KI = 6.6 nM) and XII (KI = 9.9 nM) inhibitor with a significant selectivity ratio over cytosolic CA I and II isoforms in the range of 3.4-25.2. In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85μM for CA IX/XII). The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S

The Article related to benzimidazole derivative preparation carbonic anhydrase inhibitor cancer, benzimidazole, carbonic anhydrase, carboxylic acid, hydroxamic acid, sulfonamide, Pharmacology: Structure-Activity and other aspects.Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics