Category: 97-09-6

Somasekhara, S.; Trivedi, B. S.; Mukherjee, S. L. published an article in 1965, the title of the article was Sulfonation of 2-hydroxybenzimidazoles.Recommanded Product: 97-09-6 And the article contains the following content:

2-Hydroxybenzimidazole (1.5 g.), 2 g. NaCl, and 9 ml. ClSO3H was heated 4 hrs. at 130-40° to yield crude 5-chlorosulfonyl-2-hydroxybenzimidazole, which was treated with 20 ml. NH3 to yield 5-sulfamoyl-2-hydroxybenzimidazole (I), m. 325-8° (decomposition) (EtOH). Similarly, 4 g. 6-chloro-2-hydroxybenzimidazole, 4 g. NaCl, and 16 ml. ClSO2OH was heated 4 hrs. at 140-50°. Treatment of the crude 6-chloro-5-chlorosulfonyl-2-hydroxybenzimidazole thus obtained with 20 ml. NH3 yielded 6-chloro-5-sulfamoyl-2-hydroxybenzimidazole, m. 301-3° (EtOH). I was also prepared as follows: 2-Nitrochlorobenzene (31.5 g.), 5.83 g. NaCl, and 93 g. ClSO3H was heated 5 hrs. at 140-50° to yield 4-chlorosulfamoyl-2-nitrochlorobenzene as a gray powder, which was treated with 50 ml. NH3. The resulting solution was clarified (C) and acidified with HOAc (pH 5.5) to obtain 15 g. 4-sulfamoyl-2-nitrochlorobenzene (II), m. 172-3° (EtOH). II (2 g.) and 4 ml. NH3 was heated 4 hrs. at 110-20° in a sealed tube to yield 4-sulfamoyl-2-nitroaniline (III), m. 204-5° (EtOH). III (1 g.) was refluxed 4 hrs. in 100 ml. 5% aqueous HOAc containing 4 g. Zn dust to yield 4-sulfamoyl-2-aminoaniline (IV), m. 165-7° (EtOH). IV (1 g.) and 2 g. urea sulfate was heated 4 hrs. at 150° in a sealed Pyrex glass tube to yield I, m. 318-21° (EtOH). The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bourdais, Jacques; Meyer, Francois published an article in 1961, the title of the article was 1,3-Benzenedisulfonamides as carbonic anhydrase inhibitors.SDS of cas: 97-09-6 And the article contains the following content:

4,5,6-XYZC6H(SO2Cl)2 (I) were prepared from the appropriate benzene derivatives and ClSO3H, and converted to the corresponding diamides (II) by boiling with concentrated aqueous NH3. The following I were prepared (X, Y, Z, % yield, and m.p. given): Me, H, H, 85, 52°; H, COCl, H, 51, 90; OH, Me, H, 47, 85-6°; Cl, Me, H, 45, 78°; Me, H, Cl, 64, 122-5°; Cl, H, Cl, 75, 122-3°; Cl, H, F, 36, 105°; Cl, Me, Cl, 41, 163-4°; Cl, Cl, Cl, 31, 178°. II prepared were (X, Y, Z, % yield, m.p., pK1 and pK2 determined in H2O + 15% MeOH at 20°, and carbonic anhydrase inhibitory activity relative to 1.0 for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide given): Me, H, H, 57, 189°, 9.3, 10.3, 0.33; CO2H (by KMnO4 oxidation of the corresponding Me compound), H, H, 22, 283°, 9.51, 10.66, 0.025; H, CONH2, H, 85, -, 8.93, 10.02, 0.33; Cl, Me, H, 36, 235°, 8.97, 10.14, 0.25; Me, H, Cl, 31, 247°, 8.98, 10.1, 0.63; Cl, H, Cl, 53, 265°, 8.52, 9.78, 1.67; Cl, H, F, 38, 229°, 8.55, 9.76, 1.0; NH2, H, Cl, 64, 254-5°, 9.34, 10.36, 0.025; Cl, Me, Cl, 39, 296-7°, 8.80, 9.98, 0.125; Cl, Cl, Cl, 30, 295°, 8.73, 9.51, 2.0; NH2, Me, Cl, 64, 282-3°, -, -, -. Also prepared were (compound, % yield, m.p., pK1, pK2, and inhibitory activity as above): 4,3,1-Cl(O2N)C6H3SO2Cl, 92, 56, -, -, -; 4,3,1-Cl(O2N)C6H3SO2NH2, 64, 176°, 9.18, -, 0.33; 1,3,4,6-Cl2C6H2(SO2NHMe)2, 51, 186°, 9.83, 10.63, 0.025. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lavrishchev, V. A.; Kretov, A. E. published an article in 1962, the title of the article was Reaction of unsymmetric substituted ureas on melting with 4-chloro-3-nitrophenyl alkyl(aryl) sulfones and sulfonamides.Name: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

cf. CA 55, 18646h. Fusion of a sulfone or sulfonamide of general type 4,3-Cl(O2N)C6H3SO2R or 4,3-Cl(R2NSO2)C6H3NO2, resp., with unsym. substituted ureas in 1:4 molar ratio at 200° gave after treatment with EtOH some cyanuric acid and the following amines (urea derivative and the product shown, resp.): methylurea, 4-methylsulfonyl-2-nitrophenylmethylamine m. 190-1°, dimethylurea, 4-methylsulfonyl-2-nitrophenyldimethylamine m. 135-6°; phenylurea, 4-methylsulfonyl-2-nitrodiphenylamine m. 133-4°; p-anisylurea, 4-methylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 168-9°; p-ethoxyphenylurea, 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 130-1°; methylurea, 4-N-methylsulfonamido-2-nitrophenylmethylamine m. 180-1°; dimethylurea, 4-N-methylsulfonamido-2-nitrophenyldimethylamine m. 158-9°; p-anisylurea, 4-N-methylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 170-1°; p-ethoxyphenylurea, 4-N-methylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 179-80°; methylurea, 4-N-dimethylsulfonamido-2-nitrophenylmethylamine m. 149-50°; dimethylurea, 4-N-dimethylsulfonamido-2-nitrophenyldimethylamine m. 103-4°; p-anisylurea, 4-N-dimethylsulfonamido-2-nitro-4′-methoxydiphenylamine m. 124-5°; p-ethoxyphenylurea, 4-N-dimethylsulfonamido-2-nitro-4′-ethoxydiphenylamine m. 126-7°; methylurea, 4-sulfonamido-2-nitrophenylmethylamine m. 212-13°; dimethylurea, 4-sulfonamido-2-nitrophenyldimethylamine m. 147-8°; methylurea, 4-phenylsulfonyl-2-nitrophenylmethylamine m. 154-5°; dimethylurea, 4-phenylsulfonyl-2-nitrophenyldimethylamine m. 104-5°; phenylurea, 4-phenylsulfonyl-2-nitrodiphenylamine m. 147-8°; p-anisylurea, 4-phenylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 153-4°; p-ethoxyphenylurea, 4-phenylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 139-40°; methylurea, 4-benzylsulfonyl-2-nitrophenylmethylamine m. 182-3°; dimethylurea, 4-benzylsulfonyl-2-nitrophenyldimethylamine m. 121.5-2.5°; phenylurea, 4-benzylsulfonyl-2-nitrodiphenylamine m. 182.5-3°; p-anisylurea, 4-benzylsulfonyl-2-nitro-4′-methoxydiphenylamine m. 185-6°; p-ethoxyphenylurea, 4-benzylsulfonyl-2-nitro-4′-ethoxydiphenylamine m. 162.5-3.5°; dimethylurea, 2-N-methylsulfonamido-4-nitrophenyldimethylamine m. 127-8°. p-Phenetidine and 4-chloro-3-nitrophenyl methyl sulfone fused as above gave product, m. 130-1°, identical with 4-methylsulfonyl-2-nitro-4′-ethoxydiphenylamine shown above. 4-N-Dimethylsulfonamido-2-nitrophenyldimethylamine, m. 103-4°, was also prepared according to Eliel and Nelson (CA 50, 11965c); E. and N. reported 182-3°. Yields of the above amines are best with 1:4 reactant ratio; equimolar mixtures gave lower yields. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Aoki, Masaru; Kamada, Akira; Yata, Noboru published an article in 1969, the title of the article was Biological activities of drugs. VI. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors. 1.Application of 97-09-6 And the article contains the following content:

A study was made of the correlation of carbonic anhydrase inhibitory activity with the chem. structures of 19 derivatives of benzenesulfonamide and 3 heterocyclic sulfonamides, with reference to the physicochem. properties of the compounds A linear correlation was observed for Hammett’s σ factor against pKa, chem. shift of the sulfamoyl protons, and valence-force constant of the S:O bond. Inhibitory activity increased with a decrease of pKa, and with an increase of Hammett’s σ factor, chem. shift of the sulfamoyl protons, and the S:O valence-force constant of the sulfamoyl group. A close correlation was also found between the inhibitory activity and water solubility of the unionized mols. of benzenesulfonamides except for p-CH3NH and o-NO2 derivatives The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to structure activity drug, sulfonamides biol activity, carbonic anhydrase inhibitor, enzyme inhibitor structure, benzenesulfonamides enzyme, sulfonamides role: biol (biological study) and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VIII. Structure-activity relation of sulfonamide carbonic anhydrase inhibitors.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Hansch-Fujita’s method was applied to a structure-activity anal. of 22 sulfonamide derivatives with an inhibitory activity against carbonic anhydrase. Electronic parameters such as Hammett’s σ factor, ΔpKa, Dppm and Δfr , and hydrophobic parameters such as π, πc and β were employed. ΔpKa, Δppm, Δfr, π, πc and β were derived from dissociation constant, NM R chem. shift of sulfamoyl protons, S:O valence-force constant, n-oc tyl alc.-H2O partition coefficient, CHCl3-H2O partition coefficient and association constant to albumin, resp. This anal. proved to be useful in predicting not only the activity of substituted benzenesulfonamides except o-substituted derivatives but also that of 1,3,4-thiadiazole-5-sulfonamide derivatives The activity of o-substituted derivatives was satisfactorily predicted with the use of polar parameter σ* and steric constant ES. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to sulfonamides carbonic anhydrase, carbonic anhydrase sulfonamides, structure activity antienzymes, activity structure antienzymes, antienzymes structure activity, sulfonamides role: biol (biological study) and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kaiser, Emil Thomas; Lo, Kwok-Wing published an article in 1969, the title of the article was Carbonic anhydrase catalyzed hydrolysis of 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone.Application of 97-09-6 And the article contains the following content:

An ionizable group in bovine carbonic anhydrase (BCA) with a pK of 7.3 appears to be involved in the enzyme-catalyzed hydrolysis of 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone (I). Similar observations have been reported previously for the pH-rate behavior of the BCA-catalyzed hydration of CO2, hydration of carbonyl compounds, and hydrolysis of nitrophenyl esters of carboxylic acids. The BCA-catalyzed hydrolysis of I is subject to sulfonamide inhibition as are the other reactions mentioned above. Also, human carbonic anhydrases B and C have been demonstrated to be effective catalysts for the hydrolysis of I. On the basis of observations taken in conjunction with those of other investigations, it is proposed that a Zn-bound hydroxide ion is the active catalytic species in carbonic anhydrase action, and a cyclic mechanism for the carbonic anhydrase catalyzed solvolysis of I, involving no net proton transfer to the solvent is suggested. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to carbonic anhydrase, bovine carbonic anhydrase, catalytic species carbonic anhydrase, reaction kinetics and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lutskii, A. E.; Obukhova, E. M.; Kochergina, L. A. published an article in 1969, the title of the article was Dipole moments of some trisubstituted benzenes.Category: amides-buliding-blocks And the article contains the following content:

Dipole moments were calculated by a simplified formula from the dipole moments of the corresponding mono- and di-substituted benzenes. The data are tabulated for 16 1,2,4-trisubstituted compounds The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Category: amides-buliding-blocks

The Article related to dipole moment calculated, benzenes dipole moment, dipole moment and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lutskii, A. E.; Volchenok, S. A.; Kanevskaya, Z. M.; Sheina, G. G. published an article in 1970, the title of the article was Electron-vibrational spectra of trisubstituted benzenes.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

The energies Emax.(eV), the frequencies νmax.-(cm-1), logεmax.and oscillator strength f of the absorption bands of πR → πR*, πR → πA-*, and nD →A-* transitions (where R = benzene ring, A = electron acceptor substituent, D = electron-donor substituent) of 30 trisubstituted benzene derivatives in hexane and EtOH solutions were calculated from uv spectral curves. The data are discussed. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to benzenes trisubstituted spectra, electronic spectra benzenes trisubstituted, vibrational spectra benzenes trisubstituted, and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 9, 2022, Itelman, Edward; Vatury, Ori; Kuperstein, Rafael; Ben-Zekry, Sagit; Hay, Ilan; Fefer, Paul; Barbash, Israel; Klempfner, Robert; Segev, Amit; Feinberg, Micha; Guetta, Victor; Maor, Elad published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was The Association of Severe Tricuspid Regurgitation with Poor Survival Is Modified by Right Ventricular Pressure and Function: Insights from SHEBAHEART Big Data.. And the article contained the following:

BACKGROUND: Contemporary data on the independent association of severe tricuspid regurgitation (TR) with excess mortality are needed. The aims of this study were to describe contemporary outcomes of patients with severe TR and to identify outcome modifiers. METHODS: Consecutive echocardiographic reports linked to clinical data from the largest medical center in Israel (2007-2019) were reviewed. The primary outcome was all-cause mortality. Cox regression and propensity score matching models were applied. RESULTS: The final cohort included 97,096 patients. Mild, moderate, and severe TR was documented in 27,147 (28%), 2,844 (3%) and 1,805 (2%) patients, respectively. During a median follow-up period of 5 years (interquartile range, 2-8 years), 22,170 patients (23%) died. Kaplan-Meier survival analysis demonstrated an increased risk for death with an increasing degree of TR (log-rank P < .001). Propensity score matching of 1,265 patients with severe TR and matched control subjects showed that compared with those with nonsevere TR, patients with severe TR were 17% more likely to die (95% CI, 1.05-1.29; P = .003). The association of severe TR with survival was dependent on estimated right ventricular (RV) pressure, with a more pronounced effect among patients with estimated systolic pressure ≤ 40 mm Hg (hazard ratio, 2.12 vs 1.04; P for interaction < .001). A landmark subanalysis of 17,967 patients demonstrated that RV function deterioration on follow-up echocardiography modified the association of severe TR with survival. It was more significant among patients with preserved and stable RV function (P for interaction = .035). CONCLUSIONS: The outcome of severe TR is modified by RV pressure and function. Once RV function deteriorates, differences in the outcomes of patients with and without severe TR are less pronounced. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

3-Nitro-4-chlorobenzenesulfonamide(cas:97-09-6) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

King, Rodney William; Burgen, Arnold S. V. published an article in 1970, the title of the article was Sulfonamide complexes of human carbonic anhydrases ultraviolet difference spectroscopy.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Uv difference spectra are generated when human carbonic anhydrases B or C form complexes with aromatic sulfonamides. Difference spectra obtained using a variety of ring-substituted benzene sulfonamides show certain constant features; a broad peak, λmax 294-299 nm, a trough at 290-291 nm, a peak at 285-287 nm, and a peak at 232-234 nm. All the spectra obtained had other features, varying from sulfonamide to sulfonamide, not normally associated with protein perturbation difference spectra. A pH study using p-nitrobenzene sulfonamide has shown that these addnl. features may be accounted for by the dissociation of a proton from the amido group of the sulfonamide, causing changes in the uv absorption of the sulfonamide on formation of the complex. These results indicate that a conformational change takes place in the enzyme on binding the sulfonamide, exposing aromatic residues to the solvent, and that in the complex the sulfonamide is in the anionic state. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to carbonic anhydrases sulfonamides, anhydrases carbonic sulfonamides, sulfonamides carbonic anhydrases, uv spectra carbonic anhydrases, and other aspects.Recommanded Product: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics