Category: 96-30-0

Adding a certain compound to certain chemical reactions, such as: 96-30-0, name is 2-Chloro-N-methylacetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 96-30-0, Application In Synthesis of 2-Chloro-N-methylacetamide

The compound prepared in Reference Example 20 (50 mg)In DMF (0.5 mL)Potassium carbonate (33 mg)And tetrabutylammonium iodide(4.4 mg),Subsequently, 2-chloro-N-methylacetamide(25.7 mg) at room temperature.The reaction mixture was stirred at 50 C. overnight.The reaction mixture was diluted with ethyl acetate,Saturated ammonium chloride aqueous solution and water were added,And extracted with ethyl acetate. The obtained organic layer was washed with water,Washed with 20% brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (Yamazen automatic purification device) to obtain the title compound having the following physical property values(51 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-N-methylacetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ono Pharmaceutical Co., Ltd.; Asada, Masaki; Tani, Masaya; Hiroshi, Masaya; Higuchi, Satoru; Fuchibe, Kazuhiro; Oikawa, Rei; Otani, Toru; Takano, Hiroshi; (116 pag.)JP2018/87189; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 96-30-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 96-30-0 as follows.

In a sealed tube, intermediate 77 (287.19 mg, 2.67 mmol) was added to a solution of 6-chloro-4-nitroindole (350.00 mg, 1.78 mmol) and Cs2CO3 (870.11 mg, 2.67 mmol) in dryDMF (3.5 mL) under N2. The mixture was stirred at 90 C for 17 h. The reaction mixturewas diluted with EtOAc and water and the layers were separated. The organic layer waswashed with brine, dried over MgSO4 and filtered. The solvent was removed under reduced pressure to give 378 mg of intermediate 67 (79% yield, brown solid) which was directly engaged in the next step without further purification.

According to the analysis of related databases, 96-30-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (419 pag.)WO2018/2219; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 96-30-0, name is 2-Chloro-N-methylacetamide, molecular formula is C3H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 96-30-0

X-2 100 mg (0.288 mmol), 2-chloro-N-methylacetamide 37 mg (0.344 mmol), Cs2CO3281 mg (0.862 mmol) and 10 mL DMF were added to a 100 mL single-necked flask.The reaction was carried out at 50 degrees overnight, and the reaction was complete by TLC. The reaction solution was poured into 50 mL of water.EA was extracted with 30 mL*3, and the organic phase was combined with a sand column to obtain 80 mg of a white solid.Yield 66.4%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 96-30-0, its application will become more common.

Reference:
Patent; China Pharmaceutical University; Lu Tao; Zhang Li; Zhao Jingyun; Zhang Beichen; Chen Yadong; (19 pag.)CN109897054; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics